BRPI0409095A - processos de sìntese do ácido (2s)-indolina-2-carboxìlico, e aplicação para a sìntese do perindopril - Google Patents
processos de sìntese do ácido (2s)-indolina-2-carboxìlico, e aplicação para a sìntese do perindoprilInfo
- Publication number
- BRPI0409095A BRPI0409095A BRPI0409095-0A BRPI0409095A BRPI0409095A BR PI0409095 A BRPI0409095 A BR PI0409095A BR PI0409095 A BRPI0409095 A BR PI0409095A BR PI0409095 A BRPI0409095 A BR PI0409095A
- Authority
- BR
- Brazil
- Prior art keywords
- synthesis
- application
- carboxylic acid
- perindopril
- indoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
"PROCESSOS DE SìNTESE DO áCIDO (2S)INDOLINA-2-CARBOXìLICO, E APLICAçãO PARA A SìNTESE DO PERINDOPRIL". A presente invenção refere-se a um processo de síntese do ácido (2S) indolina 2-carboxílico de fórmula (I). Aplicação para a síntese do perindopril e de seus sais farmaceuticamente aceitáveis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03290879A EP1348684B1 (fr) | 2003-04-09 | 2003-04-09 | Nouveau procédé de synthèse de l'acide (2S)-indoline-2-carboxilique, et application à la synthèse du perindopril |
PCT/FR2004/000857 WO2004092095A1 (fr) | 2003-04-09 | 2004-04-07 | Nouveau procede de synthese de l'acide (2s)-indoline-2- carboxylique, et application a la synthese du perindopril |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI0409095A true BRPI0409095A (pt) | 2006-04-11 |
BRPI0409095B1 BRPI0409095B1 (pt) | 2016-05-31 |
Family
ID=27798985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0409095A BRPI0409095B1 (pt) | 2003-04-09 | 2004-04-07 | processos de síntese do ácido (2s)-indolina-2-carboxílico, e aplicação para a síntese do perindopril |
Country Status (28)
Country | Link |
---|---|
US (2) | US7196204B2 (pt) |
EP (1) | EP1348684B1 (pt) |
JP (1) | JP5111849B2 (pt) |
KR (1) | KR100722079B1 (pt) |
CN (1) | CN100337996C (pt) |
AR (1) | AR043993A1 (pt) |
AT (1) | ATE319668T1 (pt) |
AU (1) | AU2004230294B2 (pt) |
BR (1) | BRPI0409095B1 (pt) |
CA (1) | CA2521877C (pt) |
DE (1) | DE60303904T2 (pt) |
DK (1) | DK1348684T3 (pt) |
EA (1) | EA008929B1 (pt) |
EG (1) | EG24152A (pt) |
ES (1) | ES2260585T3 (pt) |
GE (1) | GEP20074257B (pt) |
HK (1) | HK1086816A1 (pt) |
MA (1) | MA27633A1 (pt) |
MX (1) | MXPA05010398A (pt) |
MY (1) | MY138698A (pt) |
NO (1) | NO334199B1 (pt) |
NZ (1) | NZ542396A (pt) |
PL (1) | PL212544B1 (pt) |
PT (1) | PT1348684E (pt) |
SI (1) | SI1348684T1 (pt) |
UA (1) | UA80040C2 (pt) |
WO (1) | WO2004092095A1 (pt) |
ZA (1) | ZA200507567B (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1348684B1 (fr) * | 2003-04-09 | 2006-03-08 | Les Laboratoires Servier | Nouveau procédé de synthèse de l'acide (2S)-indoline-2-carboxilique, et application à la synthèse du perindopril |
CA2488324A1 (en) * | 2004-11-22 | 2006-05-22 | Apotex Pharmachem Inc. | Optical resolution of n-acetyl-indoline-2-carboxylic acid with phenylglycinol |
CN100391945C (zh) * | 2005-05-31 | 2008-06-04 | 浙江大学 | 一种s-(-)-吲哚啉-2-羧酸的合成方法 |
EP1792896A1 (en) | 2005-12-01 | 2007-06-06 | KRKA, tovarna zdravil, d.d., Novo mesto | Process for the preparation of perindopril and salts thereof |
JP5176452B2 (ja) * | 2007-09-27 | 2013-04-03 | 住友化学株式会社 | 光学活性なテトラヒドロピラニルグリシン化合物の製造方法 |
CN101774960B (zh) * | 2009-12-31 | 2011-08-03 | 安徽美诺华药物化学有限公司 | 一种(2s)-二氢吲哚-2-甲酸的制备方法 |
CN101823993A (zh) * | 2010-03-31 | 2010-09-08 | 安徽世华化工有限公司 | L-八氢吲哚啉-2-甲酸的制备方法 |
CN104672124B (zh) * | 2014-12-31 | 2017-08-22 | 浙江昌明药业有限公司 | 对映体富集的二氢吲哚‑2‑甲酸的合成方法 |
CN112321538A (zh) * | 2020-10-28 | 2021-02-05 | 都创(上海)医药开发有限公司 | 一种合成单胺保护的哌嗪-(r/s)2-甲酸酯的方法 |
CN112375028A (zh) * | 2020-12-14 | 2021-02-19 | 安徽美诺华药物化学有限公司 | 合成(2s)-二氢吲哚-甲酸的方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS535134A (en) * | 1976-06-30 | 1978-01-18 | Sumitomo Chem Co Ltd | Racemization of optical active 2-(4)chlorophenyl)-3-methylbutylic acid |
JPS58216147A (ja) * | 1982-06-11 | 1983-12-15 | Banyu Pharmaceut Co Ltd | 光学活性なn−アセチル−3−ヒドロキシ−4−(ヒドロキシメチル)フエニルグリシンのラセミ化方法 |
DE3571969D1 (en) * | 1984-05-30 | 1989-09-07 | Du Pont | Preparation of optically-active alpha-substituted phenylacetic acids |
DE3727411A1 (de) * | 1986-08-19 | 1988-03-24 | Ciba Geigy Ag | Verfahren zur herstellung von 2-indolincarbonsaeure |
JPH0780823B2 (ja) * | 1986-08-26 | 1995-08-30 | 東ソー株式会社 | 光学活性フェニルアラニンのラセミ化方法 |
FR2620709B1 (fr) * | 1987-09-17 | 1990-09-07 | Adir | Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese |
JP2513001B2 (ja) * | 1988-11-01 | 1996-07-03 | 山川薬品工業株式会社 | 光学活性テトラヒドロフラン−2−カルボン酸のラセミ化方法 |
JP3010694B2 (ja) * | 1990-07-09 | 2000-02-21 | 日産化学工業株式会社 | 2―(3―ベンゾイル)フェニルプロピオン酸のラセミ化法 |
NL9001703A (nl) * | 1990-07-27 | 1992-02-17 | Westspur Investment Ltd | Werkwijze voor de bereiding van s(+)-6-methoxy-alfa-methyl-2-naftaleen-azijnzuur. |
US5220053A (en) * | 1992-01-24 | 1993-06-15 | Ethyl Corporation | Preparation of optically active aliphatic carboxylic acids |
ES2061403B1 (es) * | 1993-04-16 | 1995-06-16 | Medichem Sa | Procedimiento de obtencion del acido d-(-) -3 acetiltio-2- metilpropionico. |
JPH08151344A (ja) * | 1994-09-26 | 1996-06-11 | Nagase & Co Ltd | 2−(3−ベンゾイルフェニル)プロピオン酸の光学分割方法 |
US5677469A (en) * | 1995-05-18 | 1997-10-14 | Sepracor, Inc. | Process for resolving chiral acids with 1-aminoindan-2-ols |
EP1348684B1 (fr) * | 2003-04-09 | 2006-03-08 | Les Laboratoires Servier | Nouveau procédé de synthèse de l'acide (2S)-indoline-2-carboxilique, et application à la synthèse du perindopril |
-
2003
- 2003-04-09 EP EP03290879A patent/EP1348684B1/fr not_active Expired - Lifetime
- 2003-04-09 PT PT03290879T patent/PT1348684E/pt unknown
- 2003-04-09 SI SI200330204T patent/SI1348684T1/sl unknown
- 2003-04-09 AT AT03290879T patent/ATE319668T1/de active
- 2003-04-09 DE DE60303904T patent/DE60303904T2/de not_active Expired - Lifetime
- 2003-04-09 DK DK03290879T patent/DK1348684T3/da active
- 2003-04-09 ES ES03290879T patent/ES2260585T3/es not_active Expired - Lifetime
-
2004
- 2004-04-07 CA CA2521877A patent/CA2521877C/fr not_active Expired - Fee Related
- 2004-04-07 US US10/552,676 patent/US7196204B2/en not_active Expired - Fee Related
- 2004-04-07 BR BRPI0409095A patent/BRPI0409095B1/pt not_active IP Right Cessation
- 2004-04-07 CN CNB200480009239XA patent/CN100337996C/zh not_active Expired - Fee Related
- 2004-04-07 KR KR1020057019123A patent/KR100722079B1/ko not_active IP Right Cessation
- 2004-04-07 AU AU2004230294A patent/AU2004230294B2/en not_active Ceased
- 2004-04-07 MX MXPA05010398A patent/MXPA05010398A/es active IP Right Grant
- 2004-04-07 PL PL377832A patent/PL212544B1/pl unknown
- 2004-04-07 WO PCT/FR2004/000857 patent/WO2004092095A1/fr active Application Filing
- 2004-04-07 EA EA200501557A patent/EA008929B1/ru not_active IP Right Cessation
- 2004-04-07 ZA ZA200507567A patent/ZA200507567B/xx unknown
- 2004-04-07 NZ NZ542396A patent/NZ542396A/en not_active IP Right Cessation
- 2004-04-07 GE GEAP20049046A patent/GEP20074257B/en unknown
- 2004-04-07 AR ARP040101173A patent/AR043993A1/es not_active Application Discontinuation
- 2004-04-07 JP JP2006500165A patent/JP5111849B2/ja not_active Expired - Fee Related
- 2004-04-08 MY MYPI20041284A patent/MY138698A/en unknown
- 2004-07-04 UA UAA200510564A patent/UA80040C2/uk unknown
-
2005
- 2005-09-19 MA MA28504A patent/MA27633A1/fr unknown
- 2005-10-09 EG EGNA2005000629 patent/EG24152A/xx active
- 2005-11-09 NO NO20055257A patent/NO334199B1/no not_active IP Right Cessation
-
2006
- 2006-06-19 HK HK06106955A patent/HK1086816A1/xx not_active IP Right Cessation
-
2007
- 2007-01-05 US US11/649,980 patent/US7323575B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0312729A (pt) | Novos derivados de indol-3-enxofre | |
BRPI0410711A (pt) | novos compostos | |
BR0109836A (pt) | Processo de sìntese de perindopril e de seus sais farmaceuticamente aceitáveis | |
BR0307721A (pt) | Processo para preparação de derivados de indolinona | |
MXPA05010174A (es) | Derivados de indol e indolina sustituidos. | |
NO20055257L (no) | Ny fremgangsmate for syntesen av s-indolin-2-karboksylsyre og anvendelse derav i syntesen av perindopril | |
BRPI0414436A (pt) | processo para a preparação de derivados de 2-oxo-1-pirrolidina e seus sais | |
BRPI0416746A (pt) | processo de sìntese do perindopril e de seus sais farmaceuticamente aceitáveis | |
BR0211334A (pt) | Processo de sìntese de derivados do ácido (2s, 3as, 7as)-1-[(s)alanil]-octahidro-lh-indol-2-carboxìlico e aplicação a sìntese do perindopril | |
MY136938A (en) | New process for the synthesis of perindopril and its pharmaceutically acceptable salts | |
EA200501925A1 (ru) | Новый способ синтеза периндоприла и его фармацевтически приемлемых солей | |
MY135359A (en) | New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof | |
BRPI0417423A (pt) | processo de sìntese de perindopril e de seus sais farmaceuticamente aceitáveis | |
MY139348A (en) | Method for synthesis of perindopril and its pharmaceutically acceptable salts | |
MY136288A (en) | New process for the synthesis of perindopril and its pharmaceutically acceptable salts | |
MY136638A (en) | New process for the synthesis of perindopril and its pharmaceutically acceptable salts | |
BRPI0413169A (pt) | processo de sìntese do perindopril e de seus sais farmaceuticamente aceitáveis | |
MY142634A (en) | Method for synthesis of (2s,3as,7as)-perhydroindole-2-carboxylic acid and esters thereof, and use in the synthesis of perindopril | |
MY135652A (en) | NEW PROCESS FOR THE SYNTHESIS OF (2S, 3aS, 7aS)-PERHYDROINDOLE-2-CARBOXYLIC ACID AND ESTERS THEREOF, AND APPLICATION IN THE SYNTHESIS OF PERINDOPRIL | |
EA200501257A1 (ru) | Новый способ синтеза соединений (2s,3as,7as)-1-[(s)-аланил]октагидро-1h-индол-2-карбоновой кислоты и их применение для синтеза периндоприла | |
WO2004082357A3 (fr) | NOUVEAU PROCEDE DE SYNTHESE DE DERIVES DE L'ACIDE (2S, 3aS, 7aS)-1-[(S)-ALANYL]-OCTAHYDRO-lH-INDOLE-2- CARBOXYLIQUE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL | |
EA200501256A1 (ru) | НОВЫЙ СПОСОБ СИНТЕЗА (2S,3aS,7aS)-ПЕРГИДРОИНДОЛ-2-КАРБОНОВОЙ КИСЛОТЫ И ЕЁ СЛОЖНЫХ ЭФИРОВ, А ТАКЖЕ ИХ ПРИМЕНЕНИЕ ДЛЯ СИНТЕЗА ПЕРИНДОПРИЛА | |
MY136989A (en) | New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof | |
MY149837A (en) | New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof | |
BRPI0417540A (pt) | processo de sìntese de derivados do ácido (2s, 3as, 7as)-1-[(s)-alanil]-octahidro-1h-indol-2-carboxìlico e aplicação para sìntese do perindopril |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI. |
|
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 31/05/2016, OBSERVADAS AS CONDICOES LEGAIS. |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 15A ANUIDADE. |
|
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2509 DE 05-02-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |