PL377832A1 - Nowy proces syntezy kwasu (2s)-indolino-2-karboksylowego oraz jego zastosowanie do syntezy perindoprilu - Google Patents

Nowy proces syntezy kwasu (2s)-indolino-2-karboksylowego oraz jego zastosowanie do syntezy perindoprilu

Info

Publication number
PL377832A1
PL377832A1 PL377832A PL37783204A PL377832A1 PL 377832 A1 PL377832 A1 PL 377832A1 PL 377832 A PL377832 A PL 377832A PL 37783204 A PL37783204 A PL 37783204A PL 377832 A1 PL377832 A1 PL 377832A1
Authority
PL
Poland
Prior art keywords
synthesis
perindopril
indoline
application
carboxylic acid
Prior art date
Application number
PL377832A
Other languages
English (en)
Other versions
PL212544B1 (pl
Inventor
Jean-Claude Souvie
Jean-Pierre Lecouve
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of PL377832A1 publication Critical patent/PL377832A1/pl
Publication of PL212544B1 publication Critical patent/PL212544B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B55/00—Racemisation; Complete or partial inversion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
PL377832A 2003-04-09 2004-04-07 Nowy proces syntezy kwasu (2s)-indolino-2-karboksylowego oraz jego zastosowanie do syntezy perindoprilu PL212544B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03290879A EP1348684B1 (fr) 2003-04-09 2003-04-09 Nouveau procédé de synthèse de l'acide (2S)-indoline-2-carboxilique, et application à la synthèse du perindopril

Publications (2)

Publication Number Publication Date
PL377832A1 true PL377832A1 (pl) 2006-02-20
PL212544B1 PL212544B1 (pl) 2012-10-31

Family

ID=27798985

Family Applications (1)

Application Number Title Priority Date Filing Date
PL377832A PL212544B1 (pl) 2003-04-09 2004-04-07 Nowy proces syntezy kwasu (2s)-indolino-2-karboksylowego oraz jego zastosowanie do syntezy perindoprilu

Country Status (28)

Country Link
US (2) US7196204B2 (pl)
EP (1) EP1348684B1 (pl)
JP (1) JP5111849B2 (pl)
KR (1) KR100722079B1 (pl)
CN (1) CN100337996C (pl)
AR (1) AR043993A1 (pl)
AT (1) ATE319668T1 (pl)
AU (1) AU2004230294B2 (pl)
BR (1) BRPI0409095B1 (pl)
CA (1) CA2521877C (pl)
DE (1) DE60303904T2 (pl)
DK (1) DK1348684T3 (pl)
EA (1) EA008929B1 (pl)
EG (1) EG24152A (pl)
ES (1) ES2260585T3 (pl)
GE (1) GEP20074257B (pl)
HK (1) HK1086816A1 (pl)
MA (1) MA27633A1 (pl)
MX (1) MXPA05010398A (pl)
MY (1) MY138698A (pl)
NO (1) NO334199B1 (pl)
NZ (1) NZ542396A (pl)
PL (1) PL212544B1 (pl)
PT (1) PT1348684E (pl)
SI (1) SI1348684T1 (pl)
UA (1) UA80040C2 (pl)
WO (1) WO2004092095A1 (pl)
ZA (1) ZA200507567B (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1348684T3 (da) * 2003-04-09 2006-07-03 Servier Lab Fremgangsmåde til syntese af (2S)-indolin-2-carboxylsyre og anvendelse heraf til syntese af perindopril
CA2575912C (en) * 2004-11-22 2011-10-11 Apotex Pharmachem Inc. Process for the preparation of optically pure indoline-2-carboxylic acid
CN100391945C (zh) * 2005-05-31 2008-06-04 浙江大学 一种s-(-)-吲哚啉-2-羧酸的合成方法
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
JP5176452B2 (ja) * 2007-09-27 2013-04-03 住友化学株式会社 光学活性なテトラヒドロピラニルグリシン化合物の製造方法
CN101774960B (zh) * 2009-12-31 2011-08-03 安徽美诺华药物化学有限公司 一种(2s)-二氢吲哚-2-甲酸的制备方法
CN101823993A (zh) * 2010-03-31 2010-09-08 安徽世华化工有限公司 L-八氢吲哚啉-2-甲酸的制备方法
CN104672124B (zh) * 2014-12-31 2017-08-22 浙江昌明药业有限公司 对映体富集的二氢吲哚‑2‑甲酸的合成方法
CN112321538A (zh) * 2020-10-28 2021-02-05 都创(上海)医药开发有限公司 一种合成单胺保护的哌嗪-（r/s）2-甲酸酯的方法
CN112375028A (zh) * 2020-12-14 2021-02-19 安徽美诺华药物化学有限公司 合成（2s）-二氢吲哚-甲酸的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS535134A (en) * 1976-06-30 1978-01-18 Sumitomo Chem Co Ltd Racemization of optical active 2-(4)chlorophenyl)-3-methylbutylic acid
JPS58216147A (ja) * 1982-06-11 1983-12-15 Banyu Pharmaceut Co Ltd 光学活性なｎ−アセチル−３−ヒドロキシ−４−（ヒドロキシメチル）フエニルグリシンのラセミ化方法
EP0163094B1 (en) * 1984-05-30 1989-08-02 E.I. Du Pont De Nemours And Company Preparation of optically-active alpha-substituted phenylacetic acids
DE3727411A1 (de) * 1986-08-19 1988-03-24 Ciba Geigy Ag Verfahren zur herstellung von 2-indolincarbonsaeure
JPH0780823B2 (ja) * 1986-08-26 1995-08-30 東ソー株式会社 光学活性フェニルアラニンのラセミ化方法
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
JP2513001B2 (ja) * 1988-11-01 1996-07-03 山川薬品工業株式会社 光学活性テトラヒドロフラン−２−カルボン酸のラセミ化方法
JP3010694B2 (ja) * 1990-07-09 2000-02-21 日産化学工業株式会社 ２―（３―ベンゾイル）フェニルプロピオン酸のラセミ化法
NL9001703A (nl) * 1990-07-27 1992-02-17 Westspur Investment Ltd Werkwijze voor de bereiding van s(+)-6-methoxy-alfa-methyl-2-naftaleen-azijnzuur.
US5220053A (en) * 1992-01-24 1993-06-15 Ethyl Corporation Preparation of optically active aliphatic carboxylic acids
ES2061403B1 (es) * 1993-04-16 1995-06-16 Medichem Sa Procedimiento de obtencion del acido d-(-) -3 acetiltio-2- metilpropionico.
JPH08151344A (ja) * 1994-09-26 1996-06-11 Nagase & Co Ltd ２−（３−ベンゾイルフェニル）プロピオン酸の光学分割方法
US5677469A (en) * 1995-05-18 1997-10-14 Sepracor, Inc. Process for resolving chiral acids with 1-aminoindan-2-ols
DK1348684T3 (da) * 2003-04-09 2006-07-03 Servier Lab Fremgangsmåde til syntese af (2S)-indolin-2-carboxylsyre og anvendelse heraf til syntese af perindopril

Also Published As

Publication number Publication date
AR043993A1 (es) 2005-08-17
ZA200507567B (en) 2006-11-29
HK1086816A1 (en) 2006-09-29
JP2006522014A (ja) 2006-09-28
PT1348684E (pt) 2006-05-31
EP1348684A1 (fr) 2003-10-01
JP5111849B2 (ja) 2013-01-09
EA008929B1 (ru) 2007-08-31
US20060183919A1 (en) 2006-08-17
DE60303904T2 (de) 2006-12-28
KR100722079B1 (ko) 2007-05-25
NO334199B1 (no) 2014-01-13
SI1348684T1 (sl) 2006-06-30
DK1348684T3 (da) 2006-07-03
ES2260585T3 (es) 2006-11-01
AU2004230294A1 (en) 2004-10-28
US20070112204A1 (en) 2007-05-17
MXPA05010398A (es) 2005-11-04
CN1768019A (zh) 2006-05-03
US7196204B2 (en) 2007-03-27
PL212544B1 (pl) 2012-10-31
CA2521877C (fr) 2010-06-22
BRPI0409095A (pt) 2006-04-11
EP1348684B1 (fr) 2006-03-08
BRPI0409095B1 (pt) 2016-05-31
GEP20074257B (en) 2007-12-10
AU2004230294B2 (en) 2010-06-17
UA80040C2 (en) 2007-08-10
US7323575B2 (en) 2008-01-29
MA27633A1 (fr) 2005-11-01
WO2004092095A1 (fr) 2004-10-28
ATE319668T1 (de) 2006-03-15
KR20050111637A (ko) 2005-11-25
EG24152A (en) 2008-08-19
CA2521877A1 (fr) 2004-10-28
DE60303904D1 (de) 2006-05-04
EA200501557A1 (ru) 2006-04-28
NZ542396A (en) 2010-03-26
MY138698A (en) 2009-07-31
CN100337996C (zh) 2007-09-19
NO20055257L (no) 2005-11-09

Similar Documents

Publication Publication Date Title
EG24152A (en) Novel method for the synthesis of s-indoline-2-carboxylic acid and application thereof in synthesis of perindopril
HK1076101A1 (en) Process for the preparation of high purity perindopril and intermediates useful in the synthesis
EG26629A (en) A new process for the synthesis of pyridopril and its pharmaceutically acceptable salts
HK1089187A1 (en) Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
HK1089188A1 (en) Novel method of synthesising perindopril and the pharmaceutically- acceptable salts thereof
HK1096409A1 (en) Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
SI1256590T1 (sl) NOV POSTOPEK ZA SINTEZO DERIVATOV (2S, 3aS, 7aS)-1-(S)-ALANIL-OKTAHIDRO-1H-INDOL-2-KARBOKSILNE KISLINE IN UPORABA ZA SINTEZO PERINDOPRILA
HK1095839A1 (en) Method for the synthesis of perindopril and the pharmaceutically-acceptable salts thereof
HK1096408A1 (en) Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
HK1086280A1 (en) Novel method for synthesising derivtives (2S, 3AS,7AS)-1-Ä(S)-alanylÜ-octahydro,-1hindole-2-carboxy lic acid and the use thereof for perindopril synthesis
HK1086262A1 (en) Novel method for synthesising (2s, 3as,7as)-perhydroindole-2-carboxylic acid and the esters thereof and the use thereof for perindopril synthesis
ZA200601426B (en) Novel method for the synthesis of perindopril and the pharmaceutically-acceptable salts thereof
DK1354876T3 (da) Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og dennes estere og anvendelse heraf i syntesen af perindopril
HK1096406A1 (en) Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
HK1096407A1 (en) Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
SI1323729T1 (en) Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril
SI1354875T1 (en) Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril
SI1354874T1 (en) Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril
EP1362845A3 (fr) Nouveau procédé de synthèse des esters de la N-((S)-1-carboxybutyl)-(S)-alanine et application à la synthèse du perindopril
SI1400531T1 (sl) Postopek za sintezo n-((s)-1-karbetoksibutil)-(s)-alanina in uporaba pri sintezi perindoprila
AU2003262544A1 (en) Isotopically labelled indolinone derivatives and process for their preparation
SI1403278T1 (en) Process for the synthesis of N-((S)-1-(ethoxycarbonyl)butyl)-(S)-alanine and use in the synthese of perindopril
MY136937A (en) NEW PROCESS FOR THE SYNTHESIS OF (2S, 3aS, 7aS)-1-[(S)-ALANYL]-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID COMPOUNDS AND APPLICATION IN THE SYNTHESIS OF PERINDOPRIL