PT1403277E - Novo processo de sintese de derivados do acido (2s, 3as, 7as)-1-((s)-alanil)-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese do perindopril - Google Patents
Novo processo de sintese de derivados do acido (2s, 3as, 7as)-1-((s)-alanil)-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese do perindoprilInfo
- Publication number
- PT1403277E PT1403277E PT03290486T PT03290486T PT1403277E PT 1403277 E PT1403277 E PT 1403277E PT 03290486 T PT03290486 T PT 03290486T PT 03290486 T PT03290486 T PT 03290486T PT 1403277 E PT1403277 E PT 1403277E
- Authority
- PT
- Portugal
- Prior art keywords
- alanyl
- octahydro
- indole
- application
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03290486A EP1403277B1 (fr) | 2003-02-28 | 2003-02-28 | Nouveau procédé de synthèse de dérives de l'acide (2S, 3aS, 7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylique, et application à la synthèse du perindopril |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1403277E true PT1403277E (pt) | 2005-11-30 |
Family
ID=31970534
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT03290486T PT1403277E (pt) | 2003-02-28 | 2003-02-28 | Novo processo de sintese de derivados do acido (2s, 3as, 7as)-1-((s)-alanil)-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese do perindopril |
Country Status (19)
Country | Link |
---|---|
US (1) | US7157485B2 (pt) |
EP (1) | EP1403277B1 (pt) |
JP (1) | JP4279871B2 (pt) |
CN (1) | CN1331883C (pt) |
AR (1) | AR043410A1 (pt) |
AT (1) | ATE305939T1 (pt) |
AU (1) | AU2004218202B2 (pt) |
DE (1) | DE60301774T2 (pt) |
DK (1) | DK1403277T3 (pt) |
EA (1) | EA009062B1 (pt) |
ES (1) | ES2249691T3 (pt) |
HK (1) | HK1086280A1 (pt) |
MY (1) | MY136851A (pt) |
NZ (1) | NZ541423A (pt) |
PL (1) | PL211506B1 (pt) |
PT (1) | PT1403277E (pt) |
SI (1) | SI1403277T1 (pt) |
WO (1) | WO2004078708A2 (pt) |
ZA (1) | ZA200505780B (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60301980T2 (de) * | 2003-02-28 | 2006-07-27 | Les Laboratoires Servier | Verfahren zur Synthese des (2S,3aS,7aS)-perhydroindol-2-carbonsäures und seiner Estern, Verwendung in der Synthese von Perindopril |
DE60301774T2 (de) * | 2003-02-28 | 2006-07-20 | Les Laboratoires Servier | Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril |
EP2200981B1 (en) * | 2007-10-17 | 2011-12-07 | DSM IP Assets B.V. | Novel carbamoylglycine derivatives |
WO2009098251A1 (en) * | 2008-02-07 | 2009-08-13 | Dsm Ip Assets B.V. | NOVEL CYCLOALKANONE β-SUBSTITUTED ALANINE DERIVATIVES |
ES2686298T3 (es) * | 2010-04-20 | 2018-10-17 | Chiral Quest, Inc. | Procedimiento enantioselectivo para alaninas beta sustituidas con cicloalquenilo |
CN106657507B (zh) * | 2015-11-03 | 2019-07-02 | 中移(杭州)信息技术有限公司 | 一种声学回声消除方法及装置 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ202903A (en) * | 1981-12-29 | 1988-01-08 | Hoechst Ag | 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions |
NL1008302C2 (nl) * | 1998-02-13 | 1999-08-16 | Dsm Nv | Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan. |
WO2001016336A1 (en) * | 1999-09-02 | 2001-03-08 | Lexicon Genetics Incorporated | Human calcium dependent proteases and polynucleotides encoding the same |
FR2807431B1 (fr) * | 2000-04-06 | 2002-07-19 | Adir | Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables |
FR2827860B1 (fr) * | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
DE60301774T2 (de) * | 2003-02-28 | 2006-07-20 | Les Laboratoires Servier | Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril |
-
2003
- 2003-02-28 DE DE60301774T patent/DE60301774T2/de not_active Expired - Lifetime
- 2003-02-28 EP EP03290486A patent/EP1403277B1/fr not_active Expired - Lifetime
- 2003-02-28 AT AT03290486T patent/ATE305939T1/de active
- 2003-02-28 PT PT03290486T patent/PT1403277E/pt unknown
- 2003-02-28 SI SI200330092T patent/SI1403277T1/sl unknown
- 2003-02-28 DK DK03290486T patent/DK1403277T3/da active
- 2003-02-28 ES ES03290486T patent/ES2249691T3/es not_active Expired - Lifetime
-
2004
- 2004-02-27 MY MYPI20040681A patent/MY136851A/en unknown
- 2004-02-27 EA EA200501257A patent/EA009062B1/ru not_active IP Right Cessation
- 2004-02-27 WO PCT/FR2004/000445 patent/WO2004078708A2/fr active Application Filing
- 2004-02-27 AR ARP040100610A patent/AR043410A1/es not_active Application Discontinuation
- 2004-02-27 JP JP2006500162A patent/JP4279871B2/ja not_active Expired - Fee Related
- 2004-02-27 NZ NZ541423A patent/NZ541423A/en not_active IP Right Cessation
- 2004-02-27 PL PL377220A patent/PL211506B1/pl unknown
- 2004-02-27 CN CNB2004800054063A patent/CN1331883C/zh not_active Expired - Fee Related
- 2004-02-27 US US10/547,132 patent/US7157485B2/en not_active Expired - Fee Related
- 2004-02-27 AU AU2004218202A patent/AU2004218202B2/en not_active Ceased
- 2004-02-27 ZA ZA200505780A patent/ZA200505780B/en unknown
-
2006
- 2006-05-29 HK HK06106194A patent/HK1086280A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2249691T3 (es) | 2006-04-01 |
EA009062B1 (ru) | 2007-10-26 |
JP4279871B2 (ja) | 2009-06-17 |
CN1331883C (zh) | 2007-08-15 |
DE60301774D1 (de) | 2006-02-16 |
AU2004218202A1 (en) | 2004-09-16 |
US20060149082A1 (en) | 2006-07-06 |
DE60301774T2 (de) | 2006-07-20 |
AU2004218202B2 (en) | 2009-07-30 |
JP2006519176A (ja) | 2006-08-24 |
EP1403277A1 (fr) | 2004-03-31 |
ATE305939T1 (de) | 2005-10-15 |
HK1086280A1 (en) | 2006-09-15 |
EA200501257A1 (ru) | 2006-04-28 |
PL377220A1 (pl) | 2006-01-23 |
ZA200505780B (en) | 2006-09-27 |
WO2004078708A3 (fr) | 2004-10-14 |
CN1753907A (zh) | 2006-03-29 |
US7157485B2 (en) | 2007-01-02 |
WO2004078708A2 (fr) | 2004-09-16 |
SI1403277T1 (sl) | 2005-12-31 |
DK1403277T3 (da) | 2005-11-21 |
PL211506B1 (pl) | 2012-05-31 |
EP1403277B1 (fr) | 2005-10-05 |
MY136851A (en) | 2008-11-28 |
NZ541423A (en) | 2008-03-28 |
AR043410A1 (es) | 2005-07-27 |
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