DK1403277T3 - Fremgangsmåde til syntest af (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse heraf ved syntese i perindopril - Google Patents

Fremgangsmåde til syntest af (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse heraf ved syntese i perindopril

Info

Publication number
DK1403277T3
DK1403277T3 DK03290486T DK03290486T DK1403277T3 DK 1403277 T3 DK1403277 T3 DK 1403277T3 DK 03290486 T DK03290486 T DK 03290486T DK 03290486 T DK03290486 T DK 03290486T DK 1403277 T3 DK1403277 T3 DK 1403277T3
Authority
DK
Denmark
Prior art keywords
synthesis
perindopril
alanyl
octahydro
indole
Prior art date
Application number
DK03290486T
Other languages
English (en)
Inventor
Thiery Dubuffet
Pascal Langlois
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK1403277T3 publication Critical patent/DK1403277T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
DK03290486T 2003-02-28 2003-02-28 Fremgangsmåde til syntest af (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse heraf ved syntese i perindopril DK1403277T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03290486A EP1403277B1 (fr) 2003-02-28 2003-02-28 Nouveau procédé de synthèse de dérives de l'acide (2S, 3aS, 7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylique, et application à la synthèse du perindopril

Publications (1)

Publication Number Publication Date
DK1403277T3 true DK1403277T3 (da) 2005-11-21

Family

ID=31970534

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03290486T DK1403277T3 (da) 2003-02-28 2003-02-28 Fremgangsmåde til syntest af (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indol-2-carboxylsyrederivater og anvendelse heraf ved syntese i perindopril

Country Status (19)

Country Link
US (1) US7157485B2 (da)
EP (1) EP1403277B1 (da)
JP (1) JP4279871B2 (da)
CN (1) CN1331883C (da)
AR (1) AR043410A1 (da)
AT (1) ATE305939T1 (da)
AU (1) AU2004218202B2 (da)
DE (1) DE60301774T2 (da)
DK (1) DK1403277T3 (da)
EA (1) EA009062B1 (da)
ES (1) ES2249691T3 (da)
HK (1) HK1086280A1 (da)
MY (1) MY136851A (da)
NZ (1) NZ541423A (da)
PL (1) PL211506B1 (da)
PT (1) PT1403277E (da)
SI (1) SI1403277T1 (da)
WO (1) WO2004078708A2 (da)
ZA (1) ZA200505780B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1403277T1 (sl) * 2003-02-28 2005-12-31 Servier Lab NOV POSTOPEK ZA SINTEZO DERIVATOV (2S, 3aS, 7aS)-1-((S)-ALANIL)-OKTAHIDRO-1H-INDOL-2-KARBOKSILNE KISLINE IN UPORABA PRI SINTEZI PERINDOPRILA
EP1338591B1 (fr) * 2003-02-28 2005-10-26 Les Laboratoires Servier Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril
ATE536342T1 (de) * 2007-10-17 2011-12-15 Dsm Ip Assets Bv Neue carbamoylglycinderivate
WO2009098251A1 (en) * 2008-02-07 2009-08-13 Dsm Ip Assets B.V. NOVEL CYCLOALKANONE β-SUBSTITUTED ALANINE DERIVATIVES
US8558023B2 (en) * 2010-04-20 2013-10-15 Chiral Quest, Inc. Enantioselective process for cycloalkenyl β-substituted alanines
CN106657507B (zh) * 2015-11-03 2019-07-02 中移（杭州）信息技术有限公司 一种声学回声消除方法及装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR78413B (da) 1981-12-29 1984-09-27 Hoechst Ag
NL1008302C2 (nl) * 1998-02-13 1999-08-16 Dsm Nv Werkwijze voor de bereiding van een optisch actief indoline-2-carbonzuur of derivaat daarvan.
AU7101700A (en) * 1999-09-02 2001-03-26 Lexicon Genetics Incorporated Human calcium dependent proteases and polynucleotides encoding the same
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
SI1403277T1 (sl) * 2003-02-28 2005-12-31 Servier Lab NOV POSTOPEK ZA SINTEZO DERIVATOV (2S, 3aS, 7aS)-1-((S)-ALANIL)-OKTAHIDRO-1H-INDOL-2-KARBOKSILNE KISLINE IN UPORABA PRI SINTEZI PERINDOPRILA

Also Published As

Publication number Publication date
EP1403277B1 (fr) 2005-10-05
AU2004218202A1 (en) 2004-09-16
US7157485B2 (en) 2007-01-02
AU2004218202B2 (en) 2009-07-30
WO2004078708A3 (fr) 2004-10-14
US20060149082A1 (en) 2006-07-06
CN1753907A (zh) 2006-03-29
JP4279871B2 (ja) 2009-06-17
EA009062B1 (ru) 2007-10-26
DE60301774T2 (de) 2006-07-20
WO2004078708A2 (fr) 2004-09-16
JP2006519176A (ja) 2006-08-24
PL211506B1 (pl) 2012-05-31
PT1403277E (pt) 2005-11-30
ZA200505780B (en) 2006-09-27
PL377220A1 (pl) 2006-01-23
AR043410A1 (es) 2005-07-27
ATE305939T1 (de) 2005-10-15
EA200501257A1 (ru) 2006-04-28
ES2249691T3 (es) 2006-04-01
CN1331883C (zh) 2007-08-15
SI1403277T1 (sl) 2005-12-31
HK1086280A1 (en) 2006-09-15
MY136851A (en) 2008-11-28
EP1403277A1 (fr) 2004-03-31
NZ541423A (en) 2008-03-28
DE60301774D1 (de) 2006-02-16

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