CY1115222T1 - Μεθοδος για την παρασκευη περινδοπριλης και αλατων αυτης - Google Patents

Μεθοδος για την παρασκευη περινδοπριλης και αλατων αυτης

Info

Publication number
CY1115222T1
CY1115222T1 CY20141100483T CY141100483T CY1115222T1 CY 1115222 T1 CY1115222 T1 CY 1115222T1 CY 20141100483 T CY20141100483 T CY 20141100483T CY 141100483 T CY141100483 T CY 141100483T CY 1115222 T1 CY1115222 T1 CY 1115222T1
Authority
CY
Cyprus
Prior art keywords
salts
preparing perindopril
perindopril
preparing
oxopropyl
Prior art date
Application number
CY20141100483T
Other languages
English (en)
Inventor
Marjo Merslavic
Janja Smid
Zdenka Tomsic
Original Assignee
Les Laboratoires Servier S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier S.A. filed Critical Les Laboratoires Servier S.A.
Publication of CY1115222T1 publication Critical patent/CY1115222T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε μια μέθοδο για την παρασκευή του αναστολέα ACE, (2S,3aS,7aS)-1-((2S)-2-(((1S)-1-(αιθοξυκαρβονυλ) βουτυλ) αμινο)-1 -οξοπροπυλ)οκταϋδρο-1H-ινδολ-2-καρβοξυλικού οξέος και φαρμακευτικώς αποδεκτών αλάτων αυτού, καθώς επίσης ενδιαμέσων χρήσιμων στην εν λόγω μέθοδο.
CY20141100483T 2004-05-14 2014-07-01 Μεθοδος για την παρασκευη περινδοπριλης και αλατων αυτης CY1115222T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI200400143A SI21800A (sl) 2004-05-14 2004-05-14 Nov postopek sinteze perindoprila
SI200400235A SI21852A (sl) 2004-05-14 2004-08-05 Nov postopek sinteze perindoprila
EP05748048.5A EP1753720B1 (en) 2004-05-14 2005-05-10 Process for the preparation of perindopril and salts thereof

Publications (1)

Publication Number Publication Date
CY1115222T1 true CY1115222T1 (el) 2017-01-04

Family

ID=34969318

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100483T CY1115222T1 (el) 2004-05-14 2014-07-01 Μεθοδος για την παρασκευη περινδοπριλης και αλατων αυτης

Country Status (17)

Country Link
US (1) US7674814B2 (el)
EP (1) EP1753720B1 (el)
JP (1) JP5032983B2 (el)
AU (1) AU2005245087B2 (el)
CA (1) CA2566754C (el)
CY (1) CY1115222T1 (el)
DK (1) DK1753720T3 (el)
EA (1) EA011322B1 (el)
ES (1) ES2466248T3 (el)
HR (1) HRP20140487T1 (el)
NO (1) NO337892B1 (el)
PL (1) PL1753720T3 (el)
PT (1) PT1753720E (el)
SI (3) SI21800A (el)
UA (1) UA83139C2 (el)
WO (1) WO2005113500A1 (el)
ZA (1) ZA200609915B (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE031058T2 (en) * 2004-03-29 2017-06-28 Servier Lab A method of producing a solid pharmaceutical composition
US7291745B2 (en) 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
JP7070831B2 (ja) 2018-05-31 2022-05-18 株式会社富士通ゼネラル 天井埋込型空気調和機

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FR2811318B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811319B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
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DE60307721T2 (de) * 2003-07-31 2007-10-18 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
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PT1362845E (pt) 2003-09-01 2009-11-05 Servier Lab Novo processo de síntese dos ésteres da n-((s)-1- carboxibutil)-(s)-alanina e aplicação à síntese do perindopril
ATE315046T1 (de) 2003-09-30 2006-02-15 Servier Lab Verfahren zur herstellung von n-((s)-1- (etoxycarbonyl)butyl)-(s)-alanin und verwendung in der synthese von perindopril
SI1403278T1 (en) 2003-09-30 2005-10-31 Les Laboratoires Servier Process for the synthesis of N-((S)-1-(ethoxycarbonyl)butyl)-(S)-alanine and use in the synthese of perindopril
GB2394660A (en) 2003-12-17 2004-05-05 Niche Generics Ltd Stabilisation of pharmaceutical compositions comprising ACE inhibitor by absence of acidic excipients having large specific surface area, eg silicon dioxide
HUE031058T2 (en) 2004-03-29 2017-06-28 Servier Lab A method of producing a solid pharmaceutical composition

Also Published As

Publication number Publication date
EP1753720B1 (en) 2014-05-07
AU2005245087B2 (en) 2010-12-16
AU2005245087A1 (en) 2005-12-01
EP1753720A1 (en) 2007-02-21
US7674814B2 (en) 2010-03-09
US20080051584A1 (en) 2008-02-28
JP2007537189A (ja) 2007-12-20
NO20065695L (no) 2006-12-11
PL1753720T3 (pl) 2014-09-30
HRP20140487T1 (hr) 2014-07-04
UA83139C2 (uk) 2008-06-10
CA2566754C (en) 2012-09-18
EA011322B1 (ru) 2009-02-27
SI21852A (sl) 2006-02-28
ES2466248T3 (es) 2014-06-09
CA2566754A1 (en) 2005-12-01
EA200602117A1 (ru) 2007-04-27
ZA200609915B (en) 2008-05-28
WO2005113500A1 (en) 2005-12-01
SI21800A (sl) 2005-12-31
NO337892B1 (no) 2016-07-04
JP5032983B2 (ja) 2012-09-26
PT1753720E (pt) 2014-08-04
DK1753720T3 (da) 2014-06-30
SI1753720T1 (sl) 2014-08-29

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