SI1753720T1 - Postopek za pripravo perindoprila in njegovih soli - Google Patents

Postopek za pripravo perindoprila in njegovih soli

Info

Publication number
SI1753720T1
SI1753720T1 SI200531867T SI200531867T SI1753720T1 SI 1753720 T1 SI1753720 T1 SI 1753720T1 SI 200531867 T SI200531867 T SI 200531867T SI 200531867 T SI200531867 T SI 200531867T SI 1753720 T1 SI1753720 T1 SI 1753720T1
Authority
SI
Slovenia
Prior art keywords
perindopril
salts
preparation
Prior art date
Application number
SI200531867T
Other languages
English (en)
Inventor
Marjo Merslavic
Janja Smid
Zdenka Tomsic
Original Assignee
Les Laboratoires Servier S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier S.A. filed Critical Les Laboratoires Servier S.A.
Publication of SI1753720T1 publication Critical patent/SI1753720T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI200531867T 2004-05-14 2005-05-10 Postopek za pripravo perindoprila in njegovih soli SI1753720T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SI200400143A SI21800A (sl) 2004-05-14 2004-05-14 Nov postopek sinteze perindoprila
SI200400235A SI21852A (sl) 2004-05-14 2004-08-05 Nov postopek sinteze perindoprila
EP05748048.5A EP1753720B1 (en) 2004-05-14 2005-05-10 Process for the preparation of perindopril and salts thereof
PCT/EP2005/005048 WO2005113500A1 (en) 2004-05-14 2005-05-10 Process for the preparation of perindopril and salts thereof

Publications (1)

Publication Number Publication Date
SI1753720T1 true SI1753720T1 (sl) 2014-08-29

Family

ID=34969318

Family Applications (3)

Application Number Title Priority Date Filing Date
SI200400143A SI21800A (sl) 2004-05-14 2004-05-14 Nov postopek sinteze perindoprila
SI200400235A SI21852A (sl) 2004-05-14 2004-08-05 Nov postopek sinteze perindoprila
SI200531867T SI1753720T1 (sl) 2004-05-14 2005-05-10 Postopek za pripravo perindoprila in njegovih soli

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SI200400143A SI21800A (sl) 2004-05-14 2004-05-14 Nov postopek sinteze perindoprila
SI200400235A SI21852A (sl) 2004-05-14 2004-08-05 Nov postopek sinteze perindoprila

Country Status (17)

Country Link
US (1) US7674814B2 (sl)
EP (1) EP1753720B1 (sl)
JP (1) JP5032983B2 (sl)
AU (1) AU2005245087B2 (sl)
CA (1) CA2566754C (sl)
CY (1) CY1115222T1 (sl)
DK (1) DK1753720T3 (sl)
EA (1) EA011322B1 (sl)
ES (1) ES2466248T3 (sl)
HR (1) HRP20140487T1 (sl)
NO (1) NO337892B1 (sl)
PL (1) PL1753720T3 (sl)
PT (1) PT1753720E (sl)
SI (3) SI21800A (sl)
UA (1) UA83139C2 (sl)
WO (1) WO2005113500A1 (sl)
ZA (1) ZA200609915B (sl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE031058T2 (en) * 2004-03-29 2017-06-28 Servier Lab A method of producing a solid pharmaceutical composition
US7291745B2 (en) 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
JP7070831B2 (ja) 2018-05-31 2022-05-18 株式会社富士通ゼネラル 天井埋込型空気調和機

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4508729A (en) 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
IE52663B1 (en) 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4350704A (en) 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4425355A (en) 1981-02-17 1984-01-10 Warner-Lambert Company Substituted acyl derivatives of chair form of octahydro-1H-indole-2-carboxylic acids
US4743450A (en) 1987-02-24 1988-05-10 Warner-Lambert Company Stabilized compositions
FR2620703B1 (fr) 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620700B1 (fr) 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620699B1 (fr) 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
US5258525A (en) 1991-03-27 1993-11-02 Mcneilab, Inc. Processes for preparing [2S-(2α,3aβ,7aβ)]octahydro-1H-indole-2-carboxylic acid and esters
SI9111842A (sl) 1991-11-25 1998-04-30 Krka Stabilna formulacija soli enalaprila, postopek za njeno pripravo in njena uporaba
SI9600169A (en) 1996-05-22 1997-12-31 Krka Tovarna Zdravil Process for preparation of compounds with ace inhibitory effect
FR2771010B1 (fr) 1997-11-19 2003-08-15 Adir Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires
FR2807037B1 (fr) 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
FR2811320B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811319B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
DE10131217A1 (de) 2001-06-28 2003-01-09 Solvay Pharm Gmbh 3-Phenyl-3,7-diazabicyclo 3,3,1 nonan-Verbindungen sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
EP1443912B1 (en) 2001-10-12 2007-08-29 Elan Pharma International Limited Compositions having a combination of immediate release and controlled release characteristics
ATE357933T1 (de) 2002-01-15 2007-04-15 Actavis Group Hf Formulierungen von quinapril und verwandte ace- hemmer
PT1333026E (pt) 2002-01-30 2007-09-17 Servier Lab ''processo para a preparação de perindopril com elevado grau de pureza e intermediários úteis para a sua síntese''
WO2003075842A2 (en) 2002-03-08 2003-09-18 Teva Pharmeceuticals Usa, Inc. Stable formulations of angiotensin converting enzyme (ace) inhibitors
FR2838648B1 (fr) 2002-04-18 2004-05-21 Servier Lab Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
AU2003241477A1 (en) 2002-06-10 2003-12-22 Elan Pharma International, Ltd. Nanoparticulate polycosanol formulations and novel polycosanol combinations
EP1583976A1 (en) * 2002-12-23 2005-10-12 Power Measurement Ltd Power monitoring integrated circuit with communication interface
DE60321233D1 (de) * 2003-02-28 2008-07-03 Servier S A Lab Verfahren zur herstellung von perindopril
DE60301980T2 (de) 2003-02-28 2006-07-27 Les Laboratoires Servier Verfahren zur Synthese des (2S,3aS,7aS)-perhydroindol-2-carbonsäures und seiner Estern, Verwendung in der Synthese von Perindopril
PT1323729E (pt) 2003-03-12 2005-02-28 Servier Lab Novo processo de sintese do acido (2s,3as, 7as)-per-hidroindole-2-carboxilico e os seus esteres e aplicacao a sintese do perindopril
ATE315043T1 (de) * 2003-06-30 2006-02-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen
US6869963B2 (en) 2003-07-11 2005-03-22 Sandoz Ag Stable pharmaceutical compositions containing an ACE inhibitor
GB2404336A (en) 2003-07-30 2005-02-02 Cipla Ltd Stabilisation of therapeutic agents using a carbonate salt of an amino acid, preferably in the presence of a saccharide, & pharmaceutical compositions thereof
DE60307721T2 (de) * 2003-07-31 2007-10-18 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
SI1367062T1 (sl) * 2003-07-31 2006-12-31 Servier Lab Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
PT1362845E (pt) 2003-09-01 2009-11-05 Servier Lab Novo processo de síntese dos ésteres da n-((s)-1- carboxibutil)-(s)-alanina e aplicação à síntese do perindopril
ATE315046T1 (de) 2003-09-30 2006-02-15 Servier Lab Verfahren zur herstellung von n-((s)-1- (etoxycarbonyl)butyl)-(s)-alanin und verwendung in der synthese von perindopril
SI1403278T1 (sl) 2003-09-30 2005-10-31 Les Laboratoires Servier Postopek sinteze n-((s)-1-(etoksikarbonil)butil)-(s)-alanina in uporaba pri sintezi perindoprila
GB2394660A (en) 2003-12-17 2004-05-05 Niche Generics Ltd Stabilisation of pharmaceutical compositions comprising ACE inhibitor by absence of acidic excipients having large specific surface area, eg silicon dioxide
HUE031058T2 (en) 2004-03-29 2017-06-28 Servier Lab A method of producing a solid pharmaceutical composition

Also Published As

Publication number Publication date
EP1753720B1 (en) 2014-05-07
AU2005245087B2 (en) 2010-12-16
AU2005245087A1 (en) 2005-12-01
EP1753720A1 (en) 2007-02-21
US7674814B2 (en) 2010-03-09
US20080051584A1 (en) 2008-02-28
JP2007537189A (ja) 2007-12-20
NO20065695L (no) 2006-12-11
PL1753720T3 (pl) 2014-09-30
HRP20140487T1 (hr) 2014-07-04
CY1115222T1 (el) 2017-01-04
UA83139C2 (uk) 2008-06-10
CA2566754C (en) 2012-09-18
EA011322B1 (ru) 2009-02-27
SI21852A (sl) 2006-02-28
ES2466248T3 (es) 2014-06-09
CA2566754A1 (en) 2005-12-01
EA200602117A1 (ru) 2007-04-27
ZA200609915B (en) 2008-05-28
WO2005113500A1 (en) 2005-12-01
SI21800A (sl) 2005-12-31
NO337892B1 (no) 2016-07-04
JP5032983B2 (ja) 2012-09-26
PT1753720E (pt) 2014-08-04
DK1753720T3 (da) 2014-06-30

Similar Documents

Publication Publication Date Title
IL192241A (en) A process for making 4 - (benzimidazolylmethylamino) - benzamides and their salts
ZA200803527B (en) Crystals of laquinimod sodium, and process for the manufacture thereof
EP1922309A4 (en) N-PHENYL-2-PYRIMDINAMINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
EP2086945A4 (en) NOVEL PROCESS FOR THE PRODUCTION OF STATINES AND THEIR PHARMACEUTICAL ACCEPTIC SALTS
EP1968943A4 (en) IMPROVED METHOD FOR THE PRODUCTION OF MONTELUCASTAST AND THE PHARMACEUTICALLY SAFE SALTS
TWI367257B (en) Process for the preparation of 2-butanol
ZA200509103B (en) Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamideor salts thereof
EP1893625A4 (en) PROCESS FOR THE PREPARATION OF 9-DEAZAPURINE DERIVATIVES
HK1089187A1 (en) Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
EP2038282A4 (en) SALTS OF PYRROLOPYRIMIDINONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
SI1753720T1 (sl) Postopek za pripravo perindoprila in njegovih soli
HK1102395A1 (en) Indene derivatives and process for the preparation thereof
EP1883619A4 (en) PROCESS FOR THE PREPARATION OF SUBSTITUTED TETRAFLUOROBENZYLANILINE COMPOUND AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
PL1763508T3 (pl) Sposób wytwarzania mocznika
HK1096409A1 (en) Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
HK1096408A1 (en) Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
EP1756036A4 (en) INDENED DERIVATIVES AND PROCESS FOR THEIR PREPARATION
IL191052A0 (en) Process for the preparation of tamsulosin and related compounds
HK1086281A1 (en) Novel method for synthesising perindopril and the pharmaceutically acceptable salt thereof
EP2147916A4 (en) PROCESS FOR THE PREPARATION OF SYNTHETIC TAXANES
HK1096406A1 (en) Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
HK1096407A1 (en) Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
HUP0401379A2 (en) Process for the preparation of risperidon
TWI365874B (en) One-pot process for the preparation of 1,2-benz-isoxazole-3-methanesulfonamide
ZA200610483B (en) Process for the preparation of nateglinide