SI1753720T1 - Postopek za pripravo perindoprila in njegovih soli - Google Patents

Postopek za pripravo perindoprila in njegovih soli

Info

Publication number
SI1753720T1
SI1753720T1 SI200531867T SI200531867T SI1753720T1 SI 1753720 T1 SI1753720 T1 SI 1753720T1 SI 200531867 T SI200531867 T SI 200531867T SI 200531867 T SI200531867 T SI 200531867T SI 1753720 T1 SI1753720 T1 SI 1753720T1
Authority
SI
Slovenia
Prior art keywords
perindopril
salts
preparation
Prior art date
Application number
SI200531867T
Other languages
English (en)
Inventor
Marjo Merslavic
Janja Smid
Zdenka Tomsic
Original Assignee
Les Laboratoires Servier S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier S.A. filed Critical Les Laboratoires Servier S.A.
Publication of SI1753720T1 publication Critical patent/SI1753720T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI200531867T 2004-05-14 2005-05-10 Postopek za pripravo perindoprila in njegovih soli SI1753720T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SI200400143A SI21800A (sl) 2004-05-14 2004-05-14 Nov postopek sinteze perindoprila
SI200400235A SI21852A (sl) 2004-05-14 2004-08-05 Nov postopek sinteze perindoprila
PCT/EP2005/005048 WO2005113500A1 (en) 2004-05-14 2005-05-10 Process for the preparation of perindopril and salts thereof
EP05748048.5A EP1753720B1 (en) 2004-05-14 2005-05-10 Process for the preparation of perindopril and salts thereof

Publications (1)

Publication Number Publication Date
SI1753720T1 true SI1753720T1 (sl) 2014-08-29

Family

ID=34969318

Family Applications (3)

Application Number Title Priority Date Filing Date
SI200400143A SI21800A (sl) 2004-05-14 2004-05-14 Nov postopek sinteze perindoprila
SI200400235A SI21852A (sl) 2004-05-14 2004-08-05 Nov postopek sinteze perindoprila
SI200531867T SI1753720T1 (sl) 2004-05-14 2005-05-10 Postopek za pripravo perindoprila in njegovih soli

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SI200400143A SI21800A (sl) 2004-05-14 2004-05-14 Nov postopek sinteze perindoprila
SI200400235A SI21852A (sl) 2004-05-14 2004-08-05 Nov postopek sinteze perindoprila

Country Status (17)

Country Link
US (1) US7674814B2 (sl)
EP (1) EP1753720B1 (sl)
JP (1) JP5032983B2 (sl)
AU (1) AU2005245087B2 (sl)
CA (1) CA2566754C (sl)
CY (1) CY1115222T1 (sl)
DK (1) DK1753720T3 (sl)
EA (1) EA011322B1 (sl)
ES (1) ES2466248T3 (sl)
HR (1) HRP20140487T1 (sl)
NO (1) NO337892B1 (sl)
PL (1) PL1753720T3 (sl)
PT (1) PT1753720E (sl)
SI (3) SI21800A (sl)
UA (1) UA83139C2 (sl)
WO (1) WO2005113500A1 (sl)
ZA (1) ZA200609915B (sl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2603856T3 (es) * 2004-03-29 2017-03-01 Les Laboratoires Servier Procedimiento para preparar una composición farmacéutica sólida
US7291745B2 (en) 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
SI22543A (sl) 2007-06-27 2008-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove soli perindoprila
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
JP7070831B2 (ja) 2018-05-31 2022-05-18 株式会社富士通ゼネラル 天井埋込型空気調和機

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4508729A (en) 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
US4350704A (en) 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
IE52663B1 (en) 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4425355A (en) 1981-02-17 1984-01-10 Warner-Lambert Company Substituted acyl derivatives of chair form of octahydro-1H-indole-2-carboxylic acids
US4743450A (en) 1987-02-24 1988-05-10 Warner-Lambert Company Stabilized compositions
FR2620699B1 (fr) 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620703B1 (fr) 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620700B1 (fr) 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
US5258525A (en) 1991-03-27 1993-11-02 Mcneilab, Inc. Processes for preparing [2S-(2α,3aβ,7aβ)]octahydro-1H-indole-2-carboxylic acid and esters
SI9111842A (sl) 1991-11-25 1998-04-30 Krka Stabilna formulacija soli enalaprila, postopek za njeno pripravo in njena uporaba
SI9600169A (en) * 1996-05-22 1997-12-31 Krka Tovarna Zdravil Process for preparation of compounds with ace inhibitory effect
FR2771010B1 (fr) 1997-11-19 2003-08-15 Adir Utilisation d'une combinaison d'un inhibiteur de l'enzyme de conversion de l'angiotensine et d'un diuretique pour le traitement des desordres microcirculatoires
FR2807037B1 (fr) 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2807431B1 (fr) 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2807430B1 (fr) 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
FR2811320B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline alpha du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811318B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline gamma du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2811319B1 (fr) 2000-07-06 2002-08-23 Adir Nouvelle forme cristalline beta du sel de tert-butylamine du perindopril, son procede de preparation et les compositions pharmaceutiques qui la contiennent
DE10131217A1 (de) 2001-06-28 2003-01-09 Solvay Pharm Gmbh 3-Phenyl-3,7-diazabicyclo 3,3,1 nonan-Verbindungen sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
PT1443912E (pt) 2001-10-12 2007-11-28 Elan Pharma Int Ltd Composições tendo uma combinação de características de libertação imediata e de libertação controlada
DE60312857T2 (de) 2002-01-15 2008-01-17 Actavis Group Hf. Formulierungen von quinapril und verwandte ace-hemmer
DE60220877T2 (de) 2002-01-30 2008-04-10 Les Laboratoires Servier Verfahren zur Herstellung von hochreinem Perindopril und Zwischenverbindungen nützlich in der Synthese
WO2003075842A2 (en) 2002-03-08 2003-09-18 Teva Pharmeceuticals Usa, Inc. Stable formulations of angiotensin converting enzyme (ace) inhibitors
FR2838648B1 (fr) 2002-04-18 2004-05-21 Servier Lab Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
CA2488498A1 (en) 2002-06-10 2003-12-18 Elan Pharma International Limited Nanoparticulate polycosanol formulations and novel polycosanol combinations
US7010438B2 (en) * 2002-12-23 2006-03-07 Power Measurement Ltd. Integrated circuit with power monitoring/control and device incorporating same
SI1603558T1 (sl) * 2003-02-28 2008-12-31 Servier S A Lab Postopek za pripravo perindoprila in njegovih soli
EP1338591B1 (fr) 2003-02-28 2005-10-26 Les Laboratoires Servier Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril
ES2231760T3 (es) 2003-03-12 2005-05-16 Les Laboratoires Servier Nuevo procedimiento de sintesis del acido(2s, 3as,7as)perhidroindol-2-carboxilico y de sus esteres, y su aplicacion a la sintesis de perindopril.
ATE315043T1 (de) * 2003-06-30 2006-02-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen
US6869963B2 (en) 2003-07-11 2005-03-22 Sandoz Ag Stable pharmaceutical compositions containing an ACE inhibitor
GB2404336A (en) 2003-07-30 2005-02-02 Cipla Ltd Stabilisation of therapeutic agents using a carbonate salt of an amino acid, preferably in the presence of a saccharide, & pharmaceutical compositions thereof
DK1367062T3 (da) * 2003-07-31 2007-01-02 Servier Lab Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
EP1367063B1 (fr) * 2003-07-31 2006-08-23 Les Laboratoires Servier Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
ES2334900T3 (es) 2003-09-01 2010-03-17 Les Laboratoires Servier Nuevo procedimiento de sintesis de esteres de n-((s)-1-carboxibutil)-(s)-alanina y su aplicacion a la sintesis de perindopril.
ES2256693T3 (es) 2003-09-30 2006-07-16 Les Laboratoires Servier Procedimiento de sintesis de n-((s)-1-(etoxicarbonil)butil)-(s)-alanina y su utilizacion en la sintesis de perindopril.
SI1403278T1 (sl) 2003-09-30 2005-10-31 Les Laboratoires Servier Postopek sinteze n-((s)-1-(etoksikarbonil)butil)-(s)-alanina in uporaba pri sintezi perindoprila
GB2394660A (en) 2003-12-17 2004-05-05 Niche Generics Ltd Stabilisation of pharmaceutical compositions comprising ACE inhibitor by absence of acidic excipients having large specific surface area, eg silicon dioxide
ES2603856T3 (es) 2004-03-29 2017-03-01 Les Laboratoires Servier Procedimiento para preparar una composición farmacéutica sólida

Also Published As

Publication number Publication date
PT1753720E (pt) 2014-08-04
CY1115222T1 (el) 2017-01-04
EP1753720A1 (en) 2007-02-21
US7674814B2 (en) 2010-03-09
US20080051584A1 (en) 2008-02-28
JP5032983B2 (ja) 2012-09-26
DK1753720T3 (da) 2014-06-30
NO20065695L (no) 2006-12-11
ES2466248T3 (es) 2014-06-09
CA2566754C (en) 2012-09-18
AU2005245087A1 (en) 2005-12-01
JP2007537189A (ja) 2007-12-20
AU2005245087B2 (en) 2010-12-16
HRP20140487T1 (hr) 2014-07-04
WO2005113500A1 (en) 2005-12-01
PL1753720T3 (pl) 2014-09-30
UA83139C2 (uk) 2008-06-10
SI21852A (sl) 2006-02-28
EA011322B1 (ru) 2009-02-27
EA200602117A1 (ru) 2007-04-27
NO337892B1 (no) 2016-07-04
CA2566754A1 (en) 2005-12-01
EP1753720B1 (en) 2014-05-07
SI21800A (sl) 2005-12-31
ZA200609915B (en) 2008-05-28

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