SG10201508623RA - Crystals of laquinimod sodium, and process for the manufacture thereof - Google Patents

Crystals of laquinimod sodium, and process for the manufacture thereof

Info

Publication number
SG10201508623RA
SG10201508623RA SG10201508623RA SG10201508623RA SG10201508623RA SG 10201508623R A SG10201508623R A SG 10201508623RA SG 10201508623R A SG10201508623R A SG 10201508623RA SG 10201508623R A SG10201508623R A SG 10201508623RA SG 10201508623R A SG10201508623R A SG 10201508623RA
Authority
SG
Singapore
Prior art keywords
crystals
manufacture
laquinimod sodium
laquinimod
sodium
Prior art date
Application number
SG10201508623RA
Inventor
Anton Frenkel
Eduard Gurevich
Avital Laxer
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of SG10201508623RA publication Critical patent/SG10201508623RA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47042-Quinolinones, e.g. carbostyril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
SG10201508623RA 2005-10-19 2006-10-18 Crystals of laquinimod sodium, and process for the manufacture thereof SG10201508623RA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72865705P 2005-10-19 2005-10-19

Publications (1)

Publication Number Publication Date
SG10201508623RA true SG10201508623RA (en) 2015-11-27

Family

ID=37963287

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201508623RA SG10201508623RA (en) 2005-10-19 2006-10-18 Crystals of laquinimod sodium, and process for the manufacture thereof

Country Status (24)

Country Link
US (4) US7884208B2 (en)
EP (2) EP1937642B1 (en)
JP (3) JP5832716B2 (en)
KR (1) KR101440982B1 (en)
CN (3) CN107176923A (en)
AR (1) AR056708A1 (en)
AU (1) AU2006304672B2 (en)
BR (1) BRPI0617477A2 (en)
CA (1) CA2625287C (en)
DK (1) DK1937642T3 (en)
ES (1) ES2523762T3 (en)
HK (1) HK1117160A1 (en)
HR (1) HRP20141160T1 (en)
IL (1) IL190137A (en)
NZ (2) NZ567088A (en)
PL (1) PL1937642T3 (en)
PT (1) PT1937642E (en)
RS (1) RS53666B1 (en)
RU (1) RU2415841C2 (en)
SG (1) SG10201508623RA (en)
SI (1) SI1937642T1 (en)
UA (1) UA92761C2 (en)
WO (1) WO2007047863A2 (en)
ZA (1) ZA200803527B (en)

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RS54328B1 (en) 2009-06-19 2016-02-29 Teva Pharmaceutical Industries Ltd. Treatment of multiple sclerosis with laquinimod
MX2012001333A (en) * 2009-07-30 2012-06-01 Teva Pharma Treatment of crohn's disease with laquinimod.
EP3064206B1 (en) * 2009-08-10 2019-03-20 Active Biotech AB Treatment of huntington's disease using laquinimod
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NZ602512A (en) * 2010-03-03 2014-07-25 Teva Pharma Treatment of lupus arthritis using laquinimod
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US20130259856A1 (en) 2012-03-27 2013-10-03 Teva Pharmaceutical Industries, Ltd. Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate
TW201350467A (en) 2012-05-08 2013-12-16 Teva Pharma N-ethyl-4-hydroxyl-1-methyl-5-(methyl(2,3,4,5,6-pentahydroxyhexyl)amino)-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
TW201400117A (en) 2012-06-05 2014-01-01 Teva Pharma Treatment of ocular inflammatory disease using laquinimod
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TW201410244A (en) 2012-08-13 2014-03-16 Teva Pharma Laquinimod for treatment of GABA mediated disorders
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Also Published As

Publication number Publication date
KR20080064978A (en) 2008-07-10
AU2006304672A1 (en) 2007-04-26
US8673322B2 (en) 2014-03-18
ES2523762T3 (en) 2014-12-01
NZ567088A (en) 2012-06-29
CA2625287C (en) 2016-07-26
IL190137A0 (en) 2008-08-07
US8647646B2 (en) 2014-02-11
PL1937642T3 (en) 2015-02-27
JP5832716B2 (en) 2015-12-16
AR056708A1 (en) 2007-10-17
RU2008119456A (en) 2009-11-27
HK1117160A1 (en) 2009-01-09
CN101291911A (en) 2008-10-22
AU2006304672B2 (en) 2013-01-10
JP2009512708A (en) 2009-03-26
BRPI0617477A2 (en) 2011-07-26
JP2016020353A (en) 2016-02-04
KR101440982B1 (en) 2014-09-17
DK1937642T3 (en) 2014-12-15
CN103333107A (en) 2013-10-02
RU2415841C2 (en) 2011-04-10
SI1937642T1 (en) 2015-01-30
US20140171647A1 (en) 2014-06-19
US20110112141A1 (en) 2011-05-12
ZA200803527B (en) 2009-09-30
JP2013100299A (en) 2013-05-23
UA92761C2 (en) 2010-12-10
PT1937642E (en) 2014-11-25
IL190137A (en) 2015-06-30
EP1937642A4 (en) 2009-03-18
RS53666B1 (en) 2015-04-30
WO2007047863A3 (en) 2007-06-28
EP1937642B1 (en) 2014-09-10
EP1937642A2 (en) 2008-07-02
CN107176923A (en) 2017-09-19
CA2625287A1 (en) 2007-04-26
NZ592897A (en) 2012-12-21
US20070088050A1 (en) 2007-04-19
CN101291911B (en) 2014-08-13
WO2007047863A2 (en) 2007-04-26
HRP20141160T1 (en) 2015-01-16
US20110118308A1 (en) 2011-05-19
US7884208B2 (en) 2011-02-08
EP2687512A1 (en) 2014-01-22

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