SG10201508623RA - Crystals of laquinimod sodium, and process for the manufacture thereof - Google Patents
Crystals of laquinimod sodium, and process for the manufacture thereofInfo
- Publication number
- SG10201508623RA SG10201508623RA SG10201508623RA SG10201508623RA SG10201508623RA SG 10201508623R A SG10201508623R A SG 10201508623RA SG 10201508623R A SG10201508623R A SG 10201508623RA SG 10201508623R A SG10201508623R A SG 10201508623RA SG 10201508623R A SG10201508623R A SG 10201508623RA
- Authority
- SG
- Singapore
- Prior art keywords
- crystals
- manufacture
- laquinimod sodium
- laquinimod
- sodium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72865705P | 2005-10-19 | 2005-10-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201508623RA true SG10201508623RA (en) | 2015-11-27 |
Family
ID=37963287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201508623RA SG10201508623RA (en) | 2005-10-19 | 2006-10-18 | Crystals of laquinimod sodium, and process for the manufacture thereof |
Country Status (24)
Country | Link |
---|---|
US (4) | US7884208B2 (en) |
EP (2) | EP1937642B1 (en) |
JP (3) | JP5832716B2 (en) |
KR (1) | KR101440982B1 (en) |
CN (3) | CN107176923A (en) |
AR (1) | AR056708A1 (en) |
AU (1) | AU2006304672B2 (en) |
BR (1) | BRPI0617477A2 (en) |
CA (1) | CA2625287C (en) |
DK (1) | DK1937642T3 (en) |
ES (1) | ES2523762T3 (en) |
HK (1) | HK1117160A1 (en) |
HR (1) | HRP20141160T1 (en) |
IL (1) | IL190137A (en) |
NZ (2) | NZ567088A (en) |
PL (1) | PL1937642T3 (en) |
PT (1) | PT1937642E (en) |
RS (1) | RS53666B1 (en) |
RU (1) | RU2415841C2 (en) |
SG (1) | SG10201508623RA (en) |
SI (1) | SI1937642T1 (en) |
UA (1) | UA92761C2 (en) |
WO (1) | WO2007047863A2 (en) |
ZA (1) | ZA200803527B (en) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8314124B2 (en) * | 2004-02-06 | 2012-11-20 | Active Biotech Ab | Crystalline salts of quinoline compounds and methods for preparing them |
NZ567088A (en) * | 2005-10-19 | 2012-06-29 | Teva Pharma | Crystals of laquinimod sodium, and process for the manufacture thereof |
KR101495327B1 (en) * | 2006-06-12 | 2015-02-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | Stable laquinimod preparations |
WO2009082471A1 (en) | 2007-12-20 | 2009-07-02 | Teva Pharmaceutical Industries, Ltd. | Stable laquinimod preparations |
US8354428B2 (en) | 2008-07-01 | 2013-01-15 | Actavis Group Ptc Ehf | Solid state forms of laquinimod and its sodium salt |
WO2010028015A2 (en) * | 2008-09-03 | 2010-03-11 | Auspex Pharmaceuticals, Inc | 2-oxo-1,2-dihydro-quinoline modulators of immune function |
WO2010070449A2 (en) | 2008-12-17 | 2010-06-24 | Actavis Group Ptc Ehf | Highly pure laquinimod or a pharmaceutically acceptable salt thereof |
DE102009008851A1 (en) | 2009-02-13 | 2010-08-19 | Amw Gmbh | Transdermal system, useful for treating multiple sclerosis and Crohn's disease, comprises an immunomodulator comprising e.g. quinoline, active agent impermeable protective layer, active agent reservoir and a carrier |
DE102010048788A1 (en) | 2009-02-13 | 2011-05-19 | Amw Gmbh | Transdermal system, useful e.g. as monotherapy for indicating e.g. multiple sclerosis, comprises immunomodulator as active agent and active agent-impermeable removable protective coating, adhesive layer and active agent permeable membrane |
RS54328B1 (en) | 2009-06-19 | 2016-02-29 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with laquinimod |
MX2012001333A (en) * | 2009-07-30 | 2012-06-01 | Teva Pharma | Treatment of crohn's disease with laquinimod. |
EP3064206B1 (en) * | 2009-08-10 | 2019-03-20 | Active Biotech AB | Treatment of huntington's disease using laquinimod |
DE102010026879A1 (en) | 2010-02-11 | 2011-08-11 | AMW GmbH, 83627 | Transdermal system, useful for indicating and preventing multiple sclerosis, immunomodulator including quinolines or isoxazoles, metabolite forming groups, skin protective layer, a reservoir and a carrier impermeable to active substance |
NZ602512A (en) * | 2010-03-03 | 2014-07-25 | Teva Pharma | Treatment of lupus arthritis using laquinimod |
EA201290837A1 (en) | 2010-03-03 | 2013-05-30 | Тева Фармасьютикал Индастриз Лтд. | TREATMENT OF SHIPPING JADE WITH LAQUINIMODE |
AU2011223697B2 (en) * | 2010-03-03 | 2016-07-14 | Teva Pharmaceutical Industries Ltd. | Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate |
CN102985090B (en) | 2010-07-09 | 2014-11-26 | 泰华制药工业有限公司 | 5-chloro-4-hydroxy-1-methyl-2-oxo-n-phenyl-1,2-dihydroquinoline-3-carboxamide, salts and uses thereof |
WO2012006538A1 (en) * | 2010-07-09 | 2012-01-12 | Teva Pharmaceutical Industries Ltd. | Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof |
EP2642855A4 (en) | 2010-11-28 | 2014-05-28 | Mapi Pharma Ltd | Intermediate compounds and processes for the preparation of quinoline derivatives such as laquinimod sodium |
BR112014008731A2 (en) | 2011-10-12 | 2017-04-25 | Teva Pharma | multiple sclerosis treatment with combination of laquinimode and fingolimode |
JP2015505564A (en) | 2012-02-03 | 2015-02-23 | テバ ファーマシューティカル インダストリーズ リミティド | Use of laquinimod to treat patients with Crohn's disease who have failed first-line anti-TNEα therapy |
KR20140138725A (en) | 2012-02-16 | 2014-12-04 | 테바 파마슈티컬 인더스트리즈 리미티드 | N-ethyl-n-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinoline carboxamide, preparation and uses thereof |
US20130259856A1 (en) | 2012-03-27 | 2013-10-03 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
TW201350467A (en) | 2012-05-08 | 2013-12-16 | Teva Pharma | N-ethyl-4-hydroxyl-1-methyl-5-(methyl(2,3,4,5,6-pentahydroxyhexyl)amino)-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide |
TW201400117A (en) | 2012-06-05 | 2014-01-01 | Teva Pharma | Treatment of ocular inflammatory disease using laquinimod |
AR091706A1 (en) * | 2012-07-11 | 2015-02-25 | Teva Pharma | LAQUINIMOD FORMULATIONS WITHOUT ALKALINIZING AGENTS |
TW201410244A (en) | 2012-08-13 | 2014-03-16 | Teva Pharma | Laquinimod for treatment of GABA mediated disorders |
CN103626701A (en) * | 2012-08-28 | 2014-03-12 | 天津药物研究院 | Quinoline derivative preparation method |
CN103626702A (en) * | 2012-08-30 | 2014-03-12 | 天津药物研究院 | Preparation method for quinolinone derivatives |
EP2894619A4 (en) | 2012-09-03 | 2016-03-16 | Toyota Motor Co Ltd | Collision determination device and collision determination method |
MX2015005632A (en) | 2012-11-07 | 2016-02-05 | Teva Pharma | Amine salts of laquinimod. |
WO2014152009A1 (en) | 2013-03-14 | 2014-09-25 | Teva Pharmaceutical Industries Ltd. | Transdermal formulations of laquinimod |
NZ630427A (en) * | 2013-03-14 | 2017-06-30 | Teva Pharma | Crystals of laquinimod sodium and improved process for the manufacture thereof |
MX2021001169A (en) | 2013-11-15 | 2023-02-10 | Akebia Therapeutics Inc | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl] amino}acetic acid, compositions, and uses thereof. |
EP3137092A4 (en) | 2014-04-29 | 2017-10-11 | Teva Pharmaceutical Industries Ltd. | Laquinimod for the treatment of relapsing-remitting multiple sclerosis (rrms) patients with a high disability status |
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NZ567088A (en) * | 2005-10-19 | 2012-06-29 | Teva Pharma | Crystals of laquinimod sodium, and process for the manufacture thereof |
KR101495327B1 (en) | 2006-06-12 | 2015-02-24 | 테바 파마슈티컬 인더스트리즈 리미티드 | Stable laquinimod preparations |
WO2009082471A1 (en) | 2007-12-20 | 2009-07-02 | Teva Pharmaceutical Industries, Ltd. | Stable laquinimod preparations |
US8354428B2 (en) | 2008-07-01 | 2013-01-15 | Actavis Group Ptc Ehf | Solid state forms of laquinimod and its sodium salt |
WO2010028015A2 (en) * | 2008-09-03 | 2010-03-11 | Auspex Pharmaceuticals, Inc | 2-oxo-1,2-dihydro-quinoline modulators of immune function |
RS54328B1 (en) | 2009-06-19 | 2016-02-29 | Teva Pharmaceutical Industries Ltd. | Treatment of multiple sclerosis with laquinimod |
MX2012001333A (en) | 2009-07-30 | 2012-06-01 | Teva Pharma | Treatment of crohn's disease with laquinimod. |
EP3064206B1 (en) | 2009-08-10 | 2019-03-20 | Active Biotech AB | Treatment of huntington's disease using laquinimod |
EA201290837A1 (en) | 2010-03-03 | 2013-05-30 | Тева Фармасьютикал Индастриз Лтд. | TREATMENT OF SHIPPING JADE WITH LAQUINIMODE |
AU2011223697B2 (en) | 2010-03-03 | 2016-07-14 | Teva Pharmaceutical Industries Ltd. | Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate |
NZ602512A (en) * | 2010-03-03 | 2014-07-25 | Teva Pharma | Treatment of lupus arthritis using laquinimod |
WO2012006538A1 (en) | 2010-07-09 | 2012-01-12 | Teva Pharmaceutical Industries Ltd. | Deuterated n-ethyl-n-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxoquinoline-3-carboxamide, salts and uses thereof |
CN102985090B (en) | 2010-07-09 | 2014-11-26 | 泰华制药工业有限公司 | 5-chloro-4-hydroxy-1-methyl-2-oxo-n-phenyl-1,2-dihydroquinoline-3-carboxamide, salts and uses thereof |
US20120055072A1 (en) * | 2010-09-08 | 2012-03-08 | Rankin Sammy D | Directional guide for fishing lures |
CA2820586A1 (en) * | 2010-12-07 | 2012-06-14 | Teva Pharmaceutical Industries Ltd. | Use of laquinimod for reducing fatigue, improving functional status, and improving quality of life in multiple sclerosis patients |
-
2006
- 2006-10-18 NZ NZ567088A patent/NZ567088A/en unknown
- 2006-10-18 CN CN201710533188.XA patent/CN107176923A/en active Pending
- 2006-10-18 JP JP2008536806A patent/JP5832716B2/en not_active Expired - Fee Related
- 2006-10-18 RS RS20140629A patent/RS53666B1/en unknown
- 2006-10-18 US US11/583,282 patent/US7884208B2/en not_active Expired - Fee Related
- 2006-10-18 RU RU2008119456/04A patent/RU2415841C2/en not_active IP Right Cessation
- 2006-10-18 EP EP06826297.1A patent/EP1937642B1/en active Active
- 2006-10-18 SG SG10201508623RA patent/SG10201508623RA/en unknown
- 2006-10-18 CA CA2625287A patent/CA2625287C/en not_active Expired - Fee Related
- 2006-10-18 KR KR1020087011727A patent/KR101440982B1/en not_active IP Right Cessation
- 2006-10-18 CN CN200680039201.6A patent/CN101291911B/en not_active Expired - Fee Related
- 2006-10-18 PL PL06826297T patent/PL1937642T3/en unknown
- 2006-10-18 PT PT68262971T patent/PT1937642E/en unknown
- 2006-10-18 SI SI200631860T patent/SI1937642T1/en unknown
- 2006-10-18 DK DK06826297.1T patent/DK1937642T3/en active
- 2006-10-18 ZA ZA200803527A patent/ZA200803527B/en unknown
- 2006-10-18 UA UAA200806003A patent/UA92761C2/en unknown
- 2006-10-18 EP EP13153698.9A patent/EP2687512A1/en not_active Withdrawn
- 2006-10-18 ES ES06826297.1T patent/ES2523762T3/en active Active
- 2006-10-18 WO PCT/US2006/040925 patent/WO2007047863A2/en active Application Filing
- 2006-10-18 BR BRPI0617477-9A patent/BRPI0617477A2/en not_active Application Discontinuation
- 2006-10-18 CN CN2013102471796A patent/CN103333107A/en active Pending
- 2006-10-18 NZ NZ592897A patent/NZ592897A/en unknown
- 2006-10-18 AU AU2006304672A patent/AU2006304672B2/en not_active Ceased
- 2006-10-19 AR ARP060104574A patent/AR056708A1/en unknown
-
2008
- 2008-03-13 IL IL190137A patent/IL190137A/en not_active IP Right Cessation
- 2008-11-03 HK HK08112048.9A patent/HK1117160A1/en not_active IP Right Cessation
-
2011
- 2011-01-21 US US13/011,233 patent/US8647646B2/en not_active Expired - Fee Related
- 2011-01-21 US US13/011,187 patent/US8673322B2/en not_active Expired - Fee Related
-
2012
- 2012-12-19 JP JP2012277069A patent/JP2013100299A/en not_active Withdrawn
-
2014
- 2014-02-20 US US14/185,470 patent/US20140171647A1/en not_active Abandoned
- 2014-11-28 HR HRP20141160TT patent/HRP20141160T1/en unknown
-
2015
- 2015-07-31 JP JP2015152209A patent/JP2016020353A/en active Pending
Also Published As
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