PT1319668E - Novo processo de sintese de derivados do acido (2s,3as,7as)-1-[(s)-alanil]-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese de perindopril - Google Patents

Novo processo de sintese de derivados do acido (2s,3as,7as)-1-[(s)-alanil]-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese de perindopril

Info

Publication number
PT1319668E
PT1319668E PT03290606T PT03290606T PT1319668E PT 1319668 E PT1319668 E PT 1319668E PT 03290606 T PT03290606 T PT 03290606T PT 03290606 T PT03290606 T PT 03290606T PT 1319668 E PT1319668 E PT 1319668E
Authority
PT
Portugal
Prior art keywords
alanyl
octahydro
indole
application
carboxylic acid
Prior art date
Application number
PT03290606T
Other languages
English (en)
Inventor
Jean-Pierre Lecouve
Dubuffet Thierry
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of PT1319668E publication Critical patent/PT1319668E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT03290606T 2003-03-12 2003-03-12 Novo processo de sintese de derivados do acido (2s,3as,7as)-1-[(s)-alanil]-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese de perindopril PT1319668E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03290606A EP1319668B1 (fr) 2003-03-12 2003-03-12 Nouveau procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS)-1-[(S)]-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril

Publications (1)

Publication Number Publication Date
PT1319668E true PT1319668E (pt) 2005-02-28

Family

ID=8185878

Family Applications (1)

Application Number Title Priority Date Filing Date
PT03290606T PT1319668E (pt) 2003-03-12 2003-03-12 Novo processo de sintese de derivados do acido (2s,3as,7as)-1-[(s)-alanil]-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese de perindopril

Country Status (10)

Country Link
EP (1) EP1319668B1 (pt)
AR (1) AR043568A1 (pt)
AT (1) ATE280775T1 (pt)
DE (1) DE60300106T2 (pt)
DK (1) DK1319668T3 (pt)
ES (1) ES2231759T3 (pt)
MY (1) MY135358A (pt)
PT (1) PT1319668E (pt)
SI (2) SI1319668T1 (pt)
WO (1) WO2004082357A2 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60307925T2 (de) * 2003-07-31 2007-05-24 Les Laboratoires Servier Verfahren für die Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salzen
DK1371659T3 (da) * 2003-08-29 2005-11-21 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
ATE310012T1 (de) 2003-08-29 2005-12-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salzen
SI1380590T1 (sl) * 2003-08-29 2006-12-31 Servier Lab Postopek za sintezo perindoprila in njenih farmacevtsko sprejemljivih soli
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ202903A (en) * 1981-12-29 1988-01-08 Hoechst Ag 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril

Also Published As

Publication number Publication date
ES2231759T3 (es) 2005-05-16
SI1323729T1 (en) 2005-02-28
DE60300106D1 (de) 2004-12-02
DE60300106T2 (de) 2005-10-13
EP1319668B1 (fr) 2004-10-27
AR043568A1 (es) 2005-08-03
SI1319668T1 (en) 2005-02-28
EP1319668A1 (fr) 2003-06-18
MY135358A (en) 2008-03-31
DK1319668T3 (da) 2005-02-14
WO2004082357A3 (fr) 2004-10-28
WO2004082357A2 (fr) 2004-09-30
ATE280775T1 (de) 2004-11-15

Similar Documents

Publication Publication Date Title
DE60336314D1 (de) Substituierte indole
DE60332151D1 (de) Stromerzeugengssystem zur verbindung
SI1256590T1 (sl) NOV POSTOPEK ZA SINTEZO DERIVATOV (2S, 3aS, 7aS)-1-(S)-ALANIL-OKTAHIDRO-1H-INDOL-2-KARBOKSILNE KISLINE IN UPORABA ZA SINTEZO PERINDOPRILA
CY1115222T1 (el) Μεθοδος για την παρασκευη περινδοπριλης και αλατων αυτης
PT1319668E (pt) Novo processo de sintese de derivados do acido (2s,3as,7as)-1-[(s)-alanil]-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese de perindopril
HK1086280A1 (en) Novel method for synthesising derivtives (2S, 3AS,7AS)-1-Ä(S)-alanylÜ-octahydro,-1hindole-2-carboxy lic acid and the use thereof for perindopril synthesis
HK1086262A1 (en) Novel method for synthesising (2s, 3as,7as)-perhydroindole-2-carboxylic acid and the esters thereof and the use thereof for perindopril synthesis
PT1348684E (pt) Novo processo de sintese do acido (2s)-indolina-2-carboxilico e aplicacao a sintese do perindopril
PT1354876E (pt) Novo processo de sintese do acido (2s,3as,7as)-per-hidroindole-2-carboxilico e dos seus esteres e aplicacao a sintese do perindopril
PT1323729E (pt) Novo processo de sintese do acido (2s,3as, 7as)-per-hidroindole-2-carboxilico e os seus esteres e aplicacao a sintese do perindopril
PT1354874E (pt) Novo processo de sintese do acido (2s,3as,7as)-per-hidroindole-2-carboxilico e dos seus esteres e aplicacao a sintese do processo perindopril
PT1354875E (pt) Novo processo de sintese do acido (2s, 3as, 7as)-per-hidroindole-2-carboxilico e dos seus esteres e aplicacao a sintese do perindopril
MY136937A (en) NEW PROCESS FOR THE SYNTHESIS OF (2S, 3aS, 7aS)-1-[(S)-ALANYL]-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID COMPOUNDS AND APPLICATION IN THE SYNTHESIS OF PERINDOPRIL
AU2003233688A1 (en) Ultrasonic rotary horn repair
ITRM20030091A0 (it) Procedimento per la produzione di una connessione a tenuta di umidita'.
DE60323130D1 (de) Indolderivaten
AU2003243248A1 (en) Nanolithography molecular beam machine
AU2003221848A1 (en) Packet error signal generator
NO20013192L (no) Metode for monitering av T-celler
WO2007004165A3 (en) Process for the preparation of perindopril
FR2836296B1 (fr) Source laser multilongueur d'onde
AU2003232367A1 (en) Synthesis of the peptide cgggqrlgdqwavghlmnh2, labelling method