WO2007004165A3 - Process for the preparation of perindopril - Google Patents

Process for the preparation of perindopril Download PDF

Info

Publication number
WO2007004165A3
WO2007004165A3 PCT/IB2006/052191 IB2006052191W WO2007004165A3 WO 2007004165 A3 WO2007004165 A3 WO 2007004165A3 IB 2006052191 W IB2006052191 W IB 2006052191W WO 2007004165 A3 WO2007004165 A3 WO 2007004165A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
perindopril
improved process
carboxyperhydroindole
silylated
Prior art date
Application number
PCT/IB2006/052191
Other languages
French (fr)
Other versions
WO2007004165A2 (en
Inventor
Asok Nath
Mohan Prasad
Original Assignee
Ranbaxy Lab Ltd
Asok Nath
Mohan Prasad
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Asok Nath, Mohan Prasad filed Critical Ranbaxy Lab Ltd
Publication of WO2007004165A2 publication Critical patent/WO2007004165A2/en
Publication of WO2007004165A3 publication Critical patent/WO2007004165A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1896—Compounds having one or more Si-O-acyl linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to an improved process for the preparation of silylated (2S, 3aS, 7aS)-2-carboxyperhydroindole. Also provided is an improved process for the preparation of perindopril and its pharmaceutically acceptable salts.
PCT/IB2006/052191 2005-06-30 2006-06-29 Process for the preparation of perindopril WO2007004165A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1694DE2005 2005-06-30
IN1694/DEL/2005 2005-06-30

Publications (2)

Publication Number Publication Date
WO2007004165A2 WO2007004165A2 (en) 2007-01-11
WO2007004165A3 true WO2007004165A3 (en) 2007-03-22

Family

ID=37434326

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/052191 WO2007004165A2 (en) 2005-06-30 2006-06-29 Process for the preparation of perindopril

Country Status (1)

Country Link
WO (1) WO2007004165A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004075889A1 (en) * 2003-02-28 2004-09-10 Lupin Limited Process for preparation of perindopril and salts thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004075889A1 (en) * 2003-02-28 2004-09-10 Lupin Limited Process for preparation of perindopril and salts thereof

Also Published As

Publication number Publication date
WO2007004165A2 (en) 2007-01-11

Similar Documents

Publication Publication Date Title
WO2006118955A3 (en) Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles
WO2006049835A3 (en) Indole and benzimidazole derivatives
TW200716525A (en) Process for preparation of sulfamide derivatives
WO2009044245A3 (en) Production of monatin enantiomers
MXPA05010174A (en) Sustituted indoline and indole derivatives.
WO2003082857A3 (en) Lansoprazole polymorphs and processes for preparation thereof
HUP0202437A3 (en) New process for the preparation of (2s,3as,7as)-1-[(s)-alanile]octahydro-1h-indole-2-carboxy acid derivatives and their use for synthesing perindopril
UA83139C2 (en) Process for the preparation of perindopril and salts thereof (variants), intermediate, process for the preparation (variants) and use thereof
HK1086280A1 (en) Novel method for synthesising derivtives (2S, 3AS,7AS)-1-Ä(S)-alanylÜ-octahydro,-1hindole-2-carboxy lic acid and the use thereof for perindopril synthesis
MY136938A (en) New process for the synthesis of perindopril and its pharmaceutically acceptable salts
WO2007026373A3 (en) Process for preparing rivastigmine
MY138550A (en) Method for synthesis of perindopril and its pharmaceutically acceptable salts
MY139159A (en) Method for synthesis of perindopril and its pharmaceutically acceptable salts
HK1086262A1 (en) Novel method for synthesising (2s, 3as,7as)-perhydroindole-2-carboxylic acid and the esters thereof and the use thereof for perindopril synthesis
MY138698A (en) Method for synthesis of (2s)-indoline-2-carboxylic acid, and use in the synthesis of perindopril
WO2007004165A3 (en) Process for the preparation of perindopril
WO2006045120A3 (en) Purification of tegaserod maleate
WO2006097809A3 (en) Novel tyrosine derivatives
MY139348A (en) Method for synthesis of perindopril and its pharmaceutically acceptable salts
MY135359A (en) New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
WO2006066923A3 (en) Indole derivatives with antitumor activity
MY142634A (en) Method for synthesis of (2s,3as,7as)-perhydroindole-2-carboxylic acid and esters thereof, and use in the synthesis of perindopril
UA92613C2 (en) Process for the preparation of crystalline form d of perindopril erbumine
WO2004018466A3 (en) A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives
GB0408258D0 (en) Process

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Ref document number: DE

WWE Wipo information: entry into national phase

Ref document number: 4537/DELNP/2008

Country of ref document: IN

122 Ep: pct application non-entry in european phase

Ref document number: 06765957

Country of ref document: EP

Kind code of ref document: A2