WO2007004165A3 - Process for the preparation of perindopril - Google Patents
Process for the preparation of perindopril Download PDFInfo
- Publication number
- WO2007004165A3 WO2007004165A3 PCT/IB2006/052191 IB2006052191W WO2007004165A3 WO 2007004165 A3 WO2007004165 A3 WO 2007004165A3 IB 2006052191 W IB2006052191 W IB 2006052191W WO 2007004165 A3 WO2007004165 A3 WO 2007004165A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preparation
- perindopril
- improved process
- carboxyperhydroindole
- silylated
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 title abstract 2
- 229960002582 perindopril Drugs 0.000 title abstract 2
- CQYBNXGHMBNGCG-FXQIFTODSA-N (2s,3as,7as)-2,3,3a,4,5,6,7,7a-octahydro-1h-indol-1-ium-2-carboxylate Chemical compound C1CCC[C@@H]2[NH2+][C@H](C(=O)[O-])C[C@@H]21 CQYBNXGHMBNGCG-FXQIFTODSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1896—Compounds having one or more Si-O-acyl linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
The present invention relates to an improved process for the preparation of silylated (2S, 3aS, 7aS)-2-carboxyperhydroindole. Also provided is an improved process for the preparation of perindopril and its pharmaceutically acceptable salts.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1694DE2005 | 2005-06-30 | ||
IN1694/DEL/2005 | 2005-06-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007004165A2 WO2007004165A2 (en) | 2007-01-11 |
WO2007004165A3 true WO2007004165A3 (en) | 2007-03-22 |
Family
ID=37434326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2006/052191 WO2007004165A2 (en) | 2005-06-30 | 2006-06-29 | Process for the preparation of perindopril |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2007004165A2 (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004075889A1 (en) * | 2003-02-28 | 2004-09-10 | Lupin Limited | Process for preparation of perindopril and salts thereof |
-
2006
- 2006-06-29 WO PCT/IB2006/052191 patent/WO2007004165A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004075889A1 (en) * | 2003-02-28 | 2004-09-10 | Lupin Limited | Process for preparation of perindopril and salts thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2007004165A2 (en) | 2007-01-11 |
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