SI1323729T1 - Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril - Google Patents

Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril

Info

Publication number
SI1323729T1
SI1323729T1 SI200330007T SI200330007T SI1323729T1 SI 1323729 T1 SI1323729 T1 SI 1323729T1 SI 200330007 T SI200330007 T SI 200330007T SI 200330007 T SI200330007 T SI 200330007T SI 1323729 T1 SI1323729 T1 SI 1323729T1
Authority
SI
Slovenia
Prior art keywords
synthesis
perhydroindole
perindopril
esters
derivatives
Prior art date
Application number
SI200330007T
Other languages
English (en)
Slovenian (sl)
Inventor
Thierry Dubuffet
Jean-Pierre Lecouve
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of SI1323729T1 publication Critical patent/SI1323729T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SI200330007T 2003-03-12 2003-03-12 Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril SI1323729T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03290606A EP1319668B1 (fr) 2003-03-12 2003-03-12 Nouveau procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS)-1-[(S)]-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril

Publications (1)

Publication Number Publication Date
SI1323729T1 true SI1323729T1 (en) 2005-02-28

Family

ID=8185878

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200330008T SI1319668T1 (en) 2003-03-12 2003-03-12 Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril
SI200330007T SI1323729T1 (en) 2003-03-12 2003-03-12 Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI200330008T SI1319668T1 (en) 2003-03-12 2003-03-12 Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril

Country Status (10)

Country Link
EP (1) EP1319668B1 (xx)
AR (1) AR043568A1 (xx)
AT (1) ATE280775T1 (xx)
DE (1) DE60300106T2 (xx)
DK (1) DK1319668T3 (xx)
ES (1) ES2231759T3 (xx)
MY (1) MY135358A (xx)
PT (1) PT1319668E (xx)
SI (2) SI1319668T1 (xx)
WO (1) WO2004082357A2 (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE338058T1 (de) 2003-07-31 2006-09-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutischen annehmbaren salzen
PT1380590E (pt) * 2003-08-29 2006-12-29 Servier Lab Novo processo de síntese do perindopril e dos seus sais aceitáveis sob o ponto de vista farmacêutico.
DE60301820T2 (de) * 2003-08-29 2006-07-13 Les Laboratoires Servier Verfahren zur Synthese von Perindopril und seiner pharmazeutischen annehmbaren Salze
DK1380591T3 (da) * 2003-08-29 2006-01-23 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutiske acceptable salte heraf
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE55867B1 (en) * 1981-12-29 1991-02-14 Hoechst Ag New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril

Also Published As

Publication number Publication date
MY135358A (en) 2008-03-31
SI1319668T1 (en) 2005-02-28
ATE280775T1 (de) 2004-11-15
DK1319668T3 (da) 2005-02-14
ES2231759T3 (es) 2005-05-16
AR043568A1 (es) 2005-08-03
DE60300106D1 (de) 2004-12-02
PT1319668E (pt) 2005-02-28
EP1319668B1 (fr) 2004-10-27
WO2004082357A2 (fr) 2004-09-30
DE60300106T2 (de) 2005-10-13
EP1319668A1 (fr) 2003-06-18
WO2004082357A3 (fr) 2004-10-28

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