ATE349545T1 - Enzymatisches verfahren zur herstellung von substituierter 2-amino-3-(2-amino-phenylsulfanyl)-propionsäure - Google Patents
Enzymatisches verfahren zur herstellung von substituierter 2-amino-3-(2-amino-phenylsulfanyl)-propionsäureInfo
- Publication number
- ATE349545T1 ATE349545T1 AT02779375T AT02779375T ATE349545T1 AT E349545 T1 ATE349545 T1 AT E349545T1 AT 02779375 T AT02779375 T AT 02779375T AT 02779375 T AT02779375 T AT 02779375T AT E349545 T1 ATE349545 T1 AT E349545T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- amino
- phenylsulfanyl
- propionic acid
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- MYHSTGDTIRTLEG-UHFFFAOYSA-N 2-amino-3-(2-aminophenyl)sulfanylpropanoic acid Chemical class OC(=O)C(N)CSC1=CC=CC=C1N MYHSTGDTIRTLEG-UHFFFAOYSA-N 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 239000004365 Protease Substances 0.000 abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 2
- KJFRSZASZNLCDF-UHFFFAOYSA-N 1,5-benzothiazepine Chemical class S1C=CC=NC2=CC=CC=C12 KJFRSZASZNLCDF-UHFFFAOYSA-N 0.000 abstract 1
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
- 102000008873 Angiotensin II receptor Human genes 0.000 abstract 1
- 108050000824 Angiotensin II receptor Proteins 0.000 abstract 1
- 102100035904 Caspase-1 Human genes 0.000 abstract 1
- 108090000426 Caspase-1 Proteins 0.000 abstract 1
- 102100025841 Cholecystokinin Human genes 0.000 abstract 1
- 101800001982 Cholecystokinin Proteins 0.000 abstract 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 abstract 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 abstract 1
- 102000016387 Pancreatic elastase Human genes 0.000 abstract 1
- 108010067372 Pancreatic elastase Proteins 0.000 abstract 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 229940107137 cholecystokinin Drugs 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P11/00—Preparation of sulfur-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01122906 | 2001-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE349545T1 true ATE349545T1 (de) | 2007-01-15 |
Family
ID=8178714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02779375T ATE349545T1 (de) | 2001-09-25 | 2002-09-19 | Enzymatisches verfahren zur herstellung von substituierter 2-amino-3-(2-amino-phenylsulfanyl)-propionsäure |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7011960B2 (de) |
| EP (1) | EP1434870B1 (de) |
| JP (1) | JP4359142B2 (de) |
| KR (1) | KR100882972B1 (de) |
| CN (1) | CN100413972C (de) |
| AT (1) | ATE349545T1 (de) |
| CA (1) | CA2461296C (de) |
| DE (1) | DE60217145T2 (de) |
| DK (1) | DK1434870T3 (de) |
| ES (1) | ES2278061T3 (de) |
| HU (1) | HU228360B1 (de) |
| IL (2) | IL160527A0 (de) |
| JO (1) | JO2426B1 (de) |
| MX (1) | MXPA04002694A (de) |
| WO (1) | WO2003029477A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2659632A1 (en) | 2006-08-01 | 2008-02-07 | Applera Corporation | Detection of analytes and nucleic acids |
| US8765817B1 (en) | 2008-12-03 | 2014-07-01 | Arrowhead Center, Inc. | Selective inhibitors of EG5 motors and methods of use |
| US8349899B1 (en) | 2008-12-03 | 2013-01-08 | Arrowhead Center, Inc. | Selective inhibitors of EG5 motors and methods of use |
| DK3067430T3 (da) * | 2013-11-01 | 2020-09-21 | Glytech Inc | Fremgangsmåde til fremstilling af d-form-eller l-form-aminosyrederivat med en thiolgruppe |
| CN104404098A (zh) * | 2014-12-15 | 2015-03-11 | 苏州汉酶生物技术有限公司 | 一种硫辛酸的生物制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2804892A1 (de) * | 1977-02-09 | 1978-08-10 | Procter & Gamble | Verfahren zur herstellung von l-threonin und dessen n-acylderivat |
| DE3438189A1 (de) * | 1984-10-18 | 1986-04-24 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung aromatisch substituierter l-aminosaeuren |
| CN87108140A (zh) * | 1987-12-17 | 1988-10-19 | 山西省生物研究所 | D-α氨基酸类物质的制造方法 |
| US5106750A (en) * | 1988-08-30 | 1992-04-21 | G. D. Searle & Co. | Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents |
| US5108916A (en) * | 1989-06-05 | 1992-04-28 | Rhone-Poulenc Rorer, S.A. | Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa |
| DE4009891A1 (de) * | 1990-03-28 | 1991-10-02 | Guenter Erich Prof Dr Jeromin | Verfahren zur herstellung von optisch aktiven alkoholen und optisch aktiven kohlensaeurediestern mit hilfe von lipasen |
| ZA925360B (en) * | 1991-07-17 | 1993-06-14 | Smithkline Beecham Corp | Retroviral protease inhibitors. |
| US5215918A (en) * | 1992-06-19 | 1993-06-01 | Bend Research, Inc. | Enantiomeric enrichment of (R,S)-3-quinuclidinol |
| DE4445954A1 (de) * | 1994-12-22 | 1996-06-27 | Abb Management Ag | Verfahren zur Verbrennung von Abfällen |
| CZ298144B6 (cs) * | 1997-11-27 | 2007-07-04 | Lonza Ag | Zpusob výroby (1S,4R)- nebo (1R,4S)-4-(2-amino-6-chlor-9-H-purin-9-yl)-2-cyklopenten-1-methanolu |
| ATE341642T1 (de) * | 2000-04-19 | 2006-10-15 | Basilea Pharmaceutica Ag | Verfahren zur herstellung von d- asparaginderivaten |
-
2002
- 2002-09-19 DK DK02779375T patent/DK1434870T3/da active
- 2002-09-19 DE DE60217145T patent/DE60217145T2/de not_active Expired - Lifetime
- 2002-09-19 AT AT02779375T patent/ATE349545T1/de active
- 2002-09-19 CN CNB02817772XA patent/CN100413972C/zh not_active Expired - Fee Related
- 2002-09-19 ES ES02779375T patent/ES2278061T3/es not_active Expired - Lifetime
- 2002-09-19 EP EP02779375A patent/EP1434870B1/de not_active Expired - Lifetime
- 2002-09-19 HU HU0401500A patent/HU228360B1/hu not_active IP Right Cessation
- 2002-09-19 CA CA2461296A patent/CA2461296C/en not_active Expired - Fee Related
- 2002-09-19 IL IL16052702A patent/IL160527A0/xx unknown
- 2002-09-19 JP JP2003532690A patent/JP4359142B2/ja not_active Expired - Fee Related
- 2002-09-19 KR KR1020047004254A patent/KR100882972B1/ko not_active Expired - Fee Related
- 2002-09-19 MX MXPA04002694A patent/MXPA04002694A/es active IP Right Grant
- 2002-09-19 WO PCT/EP2002/010511 patent/WO2003029477A1/en not_active Ceased
- 2002-09-23 US US10/252,971 patent/US7011960B2/en not_active Expired - Lifetime
- 2002-09-24 JO JO200294A patent/JO2426B1/en active
-
2004
- 2004-02-23 IL IL160527A patent/IL160527A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04002694A (es) | 2004-06-18 |
| US20030119152A1 (en) | 2003-06-26 |
| HUP0401500A2 (hu) | 2005-02-28 |
| CN1553959A (zh) | 2004-12-08 |
| CA2461296A1 (en) | 2003-04-10 |
| HUP0401500A3 (en) | 2005-11-28 |
| EP1434870A1 (de) | 2004-07-07 |
| DE60217145T2 (de) | 2007-10-25 |
| JP2005503830A (ja) | 2005-02-10 |
| WO2003029477A1 (en) | 2003-04-10 |
| JO2426B1 (en) | 2008-04-17 |
| KR20040044979A (ko) | 2004-05-31 |
| IL160527A (en) | 2010-05-31 |
| EP1434870B1 (de) | 2006-12-27 |
| CN100413972C (zh) | 2008-08-27 |
| JP4359142B2 (ja) | 2009-11-04 |
| ES2278061T3 (es) | 2007-08-01 |
| IL160527A0 (en) | 2004-07-25 |
| DK1434870T3 (da) | 2007-04-30 |
| CA2461296C (en) | 2011-07-05 |
| KR100882972B1 (ko) | 2009-02-12 |
| US7011960B2 (en) | 2006-03-14 |
| HU228360B1 (en) | 2013-03-28 |
| DE60217145D1 (de) | 2007-02-08 |
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| UEP | Publication of translation of european patent specification |
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