HUP0401500A2 - Enzimes eljárás helyettesített 2-amino-3-(2-amino-fenilszulfanil)-propionsavak előállítására - Google Patents
Enzimes eljárás helyettesített 2-amino-3-(2-amino-fenilszulfanil)-propionsavak előállításáraInfo
- Publication number
- HUP0401500A2 HUP0401500A2 HU0401500A HUP0401500A HUP0401500A2 HU P0401500 A2 HUP0401500 A2 HU P0401500A2 HU 0401500 A HU0401500 A HU 0401500A HU P0401500 A HUP0401500 A HU P0401500A HU P0401500 A2 HUP0401500 A2 HU P0401500A2
- Authority
- HU
- Hungary
- Prior art keywords
- amino
- phenylsulfanyl
- substituted
- preparation
- group
- Prior art date
Links
- MYHSTGDTIRTLEG-UHFFFAOYSA-N 2-amino-3-(2-aminophenyl)sulfanylpropanoic acid Chemical class OC(=O)C(N)CSC1=CC=CC=C1N MYHSTGDTIRTLEG-UHFFFAOYSA-N 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
- KJFRSZASZNLCDF-UHFFFAOYSA-N 1,5-benzothiazepine Chemical class S1C=CC=NC2=CC=CC=C12 KJFRSZASZNLCDF-UHFFFAOYSA-N 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 2
- 239000004365 Protease Substances 0.000 abstract 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000008873 Angiotensin II receptor Human genes 0.000 abstract 1
- 108050000824 Angiotensin II receptor Proteins 0.000 abstract 1
- 102000015427 Angiotensins Human genes 0.000 abstract 1
- 108010064733 Angiotensins Proteins 0.000 abstract 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 abstract 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 abstract 1
- 102000016387 Pancreatic elastase Human genes 0.000 abstract 1
- 108010067372 Pancreatic elastase Proteins 0.000 abstract 1
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P11/00—Preparation of sulfur-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Az (I) általános képletű vegyületek (mely képletben R1 jelentésehidrogénatom vagy alkilcsoport; R2 jelentése valamely amino-védőcsoport; mindegyik R3 jelentése egymástól függetlenül halogénatom,karboxi-, alkoxi-karbonil-, alkeniloxi-karbonil- vagy benziloxi-karbonil-csoport; és n értéke 1 vagy 2) 1,5-benzotiazepin-származékokelőállításánál alkalmazhatók. Ezek az 1,5-benzotiazepinszármazékokértékes enzim-inhibitorok (pl. proteáz, interleukin-1b-átalakítóenzim, elasztáz vagy angiotenzin-enzim) és GPCR antagonisták(kolecisztokinon, angiotenzin II receptor) A találmány tárgya újeljárás az (I) általános képletű vegyületek előállítására oly módon,hogy valamely (II) általános képletű vegyületet (ahol Rl, R2, R3 és njelentése a fent megadott estben R4 jelentése alkil- vagybenzilcsoport szerves ko-oldószert tartalmazó vizes rendszerbenvalamely proteázzal reagáltatnak. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01122906 | 2001-09-25 | ||
PCT/EP2002/010511 WO2003029477A1 (en) | 2001-09-25 | 2002-09-19 | Enzymatic process for the preparation of substituted 2-amino-3-(2-amino-phenylsulfanyl)-propionic acid |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0401500A2 true HUP0401500A2 (hu) | 2005-02-28 |
HUP0401500A3 HUP0401500A3 (en) | 2005-11-28 |
HU228360B1 HU228360B1 (en) | 2013-03-28 |
Family
ID=8178714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0401500A HU228360B1 (en) | 2001-09-25 | 2002-09-19 | Enzymatic process for the preparation of substituted 2-amino-3-(2-amino-phenylsulfanyl)-propionic acid |
Country Status (15)
Country | Link |
---|---|
US (1) | US7011960B2 (hu) |
EP (1) | EP1434870B1 (hu) |
JP (1) | JP4359142B2 (hu) |
KR (1) | KR100882972B1 (hu) |
CN (1) | CN100413972C (hu) |
AT (1) | ATE349545T1 (hu) |
CA (1) | CA2461296C (hu) |
DE (1) | DE60217145T2 (hu) |
DK (1) | DK1434870T3 (hu) |
ES (1) | ES2278061T3 (hu) |
HU (1) | HU228360B1 (hu) |
IL (2) | IL160527A0 (hu) |
JO (1) | JO2426B1 (hu) |
MX (1) | MXPA04002694A (hu) |
WO (1) | WO2003029477A1 (hu) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8765817B1 (en) | 2008-12-03 | 2014-07-01 | Arrowhead Center, Inc. | Selective inhibitors of EG5 motors and methods of use |
US8349899B1 (en) | 2008-12-03 | 2013-01-08 | Arrowhead Center, Inc. | Selective inhibitors of EG5 motors and methods of use |
WO2015064453A1 (ja) * | 2013-11-01 | 2015-05-07 | 株式会社糖鎖工学研究所 | チオール基を有するd-体またはl-体アミノ酸誘導体の製造方法 |
CN104404098A (zh) * | 2014-12-15 | 2015-03-11 | 苏州汉酶生物技术有限公司 | 一种硫辛酸的生物制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2804892A1 (de) * | 1977-02-09 | 1978-08-10 | Procter & Gamble | Verfahren zur herstellung von l-threonin und dessen n-acylderivat |
DE3438189A1 (de) * | 1984-10-18 | 1986-04-24 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung aromatisch substituierter l-aminosaeuren |
CN87108140A (zh) * | 1987-12-17 | 1988-10-19 | 山西省生物研究所 | D-α氨基酸类物质的制造方法 |
US5106750A (en) * | 1988-08-30 | 1992-04-21 | G. D. Searle & Co. | Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents |
US5108916A (en) * | 1989-06-05 | 1992-04-28 | Rhone-Poulenc Rorer, S.A. | Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa |
DE4009891A1 (de) * | 1990-03-28 | 1991-10-02 | Guenter Erich Prof Dr Jeromin | Verfahren zur herstellung von optisch aktiven alkoholen und optisch aktiven kohlensaeurediestern mit hilfe von lipasen |
ZA925360B (en) * | 1991-07-17 | 1993-06-14 | Smithkline Beecham Corp | Retroviral protease inhibitors. |
US5215918A (en) * | 1992-06-19 | 1993-06-01 | Bend Research, Inc. | Enantiomeric enrichment of (R,S)-3-quinuclidinol |
DE4445954A1 (de) * | 1994-12-22 | 1996-06-27 | Abb Management Ag | Verfahren zur Verbrennung von Abfällen |
CZ298102B6 (cs) * | 1997-11-27 | 2007-06-20 | Lonza Ag | Zpusob výroby aminoalkoholu |
ES2272372T3 (es) * | 2000-04-19 | 2007-05-01 | Basilea Pharmaceutica Ag | Procedimiento para la preparacion de derivados de asparagina. |
-
2002
- 2002-09-19 CA CA2461296A patent/CA2461296C/en not_active Expired - Fee Related
- 2002-09-19 CN CNB02817772XA patent/CN100413972C/zh not_active Expired - Fee Related
- 2002-09-19 AT AT02779375T patent/ATE349545T1/de active
- 2002-09-19 IL IL16052702A patent/IL160527A0/xx unknown
- 2002-09-19 ES ES02779375T patent/ES2278061T3/es not_active Expired - Lifetime
- 2002-09-19 EP EP02779375A patent/EP1434870B1/en not_active Expired - Lifetime
- 2002-09-19 HU HU0401500A patent/HU228360B1/hu not_active IP Right Cessation
- 2002-09-19 KR KR1020047004254A patent/KR100882972B1/ko not_active IP Right Cessation
- 2002-09-19 DK DK02779375T patent/DK1434870T3/da active
- 2002-09-19 JP JP2003532690A patent/JP4359142B2/ja not_active Expired - Fee Related
- 2002-09-19 MX MXPA04002694A patent/MXPA04002694A/es active IP Right Grant
- 2002-09-19 DE DE60217145T patent/DE60217145T2/de not_active Expired - Lifetime
- 2002-09-19 WO PCT/EP2002/010511 patent/WO2003029477A1/en active IP Right Grant
- 2002-09-23 US US10/252,971 patent/US7011960B2/en not_active Expired - Lifetime
- 2002-09-24 JO JO200294A patent/JO2426B1/en active
-
2004
- 2004-02-23 IL IL160527A patent/IL160527A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR100882972B1 (ko) | 2009-02-12 |
JP4359142B2 (ja) | 2009-11-04 |
CN100413972C (zh) | 2008-08-27 |
US7011960B2 (en) | 2006-03-14 |
US20030119152A1 (en) | 2003-06-26 |
JP2005503830A (ja) | 2005-02-10 |
HU228360B1 (en) | 2013-03-28 |
DE60217145T2 (de) | 2007-10-25 |
ATE349545T1 (de) | 2007-01-15 |
EP1434870B1 (en) | 2006-12-27 |
KR20040044979A (ko) | 2004-05-31 |
IL160527A (en) | 2010-05-31 |
MXPA04002694A (es) | 2004-06-18 |
ES2278061T3 (es) | 2007-08-01 |
IL160527A0 (en) | 2004-07-25 |
CN1553959A (zh) | 2004-12-08 |
CA2461296C (en) | 2011-07-05 |
EP1434870A1 (en) | 2004-07-07 |
WO2003029477A1 (en) | 2003-04-10 |
DK1434870T3 (da) | 2007-04-30 |
DE60217145D1 (de) | 2007-02-08 |
CA2461296A1 (en) | 2003-04-10 |
JO2426B1 (en) | 2008-04-17 |
HUP0401500A3 (en) | 2005-11-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE326454T1 (de) | Neue bernsteinsäure derivative als cysteine- protease-inhibitoren | |
NO20050650L (no) | Fremgangsmate for selektiv fremstilling av aryl-5-tio- -D-aldoheksopyranosider | |
ATE445400T1 (de) | Hydantion-derivate als hemmer von matrix- metalloproteinasen | |
MY136789A (en) | Metalloproteinase inhibitors | |
HUP0101470A2 (hu) | Kinoxalinon-származékok, mint szerin-proteáz, azaz Xa. faktor és trombin inhibitorok, valamint a vegyületeket tartalmazó gyógyszerkészítmények | |
MX338829B (es) | Metodo para preparar 3-halo-4,5-dihidro-1h-pirazoles. | |
ATE457981T1 (de) | 3-amido-1,2-benzisoxazolderivate, herstellungsverfahren und deren verwendung | |
BRPI0414738A (pt) | derivados de ácido acético substituìdos | |
WO2004012663A3 (en) | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme | |
HUP0401500A2 (hu) | Enzimes eljárás helyettesített 2-amino-3-(2-amino-fenilszulfanil)-propionsavak előállítására | |
BR0213779A (pt) | Molécula de ácido nucleico isolada, vetor, célula hospedeira, e, método para a preparação de um composto de quìmica fina | |
RS20050294A (en) | Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenases | |
DK1325923T3 (da) | Cephem-forbindelser og ESBL-detekterende reagenser indeholdende disse | |
GB0215392D0 (en) | Chemical compounds | |
HUP0102666A2 (hu) | Eljárás 2,4-imidazolidindion-származék előállítására | |
MXPA02007973A (es) | Compuestos de aminoacidos y su uso como inhibidores de nep, ace y ece. | |
EA200501188A1 (ru) | Промышленный способ получения 2-замещенных 1-(гидроксиэтилиден)-1,1-бисфосфоновых кислот и их солей высокой чистоты | |
ATE289992T1 (de) | Geschützte tyrosinderivate, verfahren zu deren herstellung und deren verwendung zur herstellung von o-(2- ?18 f)-fluorethyl)-l-tyrosin | |
EE05136B1 (et) | Asendatud imidasopridiinhendite valmistamise meetod | |
HUP0001596A2 (hu) | Eljárás 5-(amino-metil)-2-klór-piridin-származékok előállítására | |
MXPA03012073A (es) | Amidoderivados heterociclicos. | |
NO20023432D0 (no) | Fremgangsmåte til fremstilling av heterosykliske forbindelser | |
DK1098901T3 (da) | Nye 6-deoxyerythromycinderivater, fremgangsmåde til deres fremstilling samt deres anvendelse som lægemidler | |
DE69840360D1 (de) | Testverfahren für fungizide | |
CA2308478A1 (en) | Indole derivatives useful as endothelin receptor antagonist |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of definitive patent protection due to non-payment of fees |