RU93041055A - Новые 4-арилпиперазины и 4-арилпиперидины - Google Patents

Новые 4-арилпиперазины и 4-арилпиперидины

Info

Publication number
RU93041055A
RU93041055A RU93041055/04A RU93041055A RU93041055A RU 93041055 A RU93041055 A RU 93041055A RU 93041055/04 A RU93041055/04 A RU 93041055/04A RU 93041055 A RU93041055 A RU 93041055A RU 93041055 A RU93041055 A RU 93041055A
Authority
RU
Russia
Prior art keywords
new
arylpiperidines
arylpiperazines
compounds
general formula
Prior art date
Application number
RU93041055/04A
Other languages
English (en)
Other versions
RU2139867C1 (ru
Inventor
Р.Рейтц Аллен
Original Assignee
Мак Нейшэб, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мак Нейшэб, Инк. filed Critical Мак Нейшэб, Инк.
Priority claimed from PCT/US1992/007754 external-priority patent/WO1993004682A1/en
Publication of RU93041055A publication Critical patent/RU93041055A/ru
Application granted granted Critical
Publication of RU2139867C1 publication Critical patent/RU2139867C1/ru

Links

Claims (1)

  1. Соединения общей формулы
    Figure 00000001

    раскрыты в качестве новых антипсихотических агентов.
RU93041055A 1991-09-11 1992-09-11 Новые 4-арилпиперазины и 4-арилпиперидины, фармацевтическая композиция, способ ингибирования допамин-2-рецепторов RU2139867C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75788191A 1991-09-11 1991-09-11
US757,881 1991-09-11
US757881 1991-09-11
PCT/US1992/007754 WO1993004682A1 (en) 1991-09-11 1992-09-11 Novel 4-arylpiperazines and 4-arylpiperidines

Publications (2)

Publication Number Publication Date
RU93041055A true RU93041055A (ru) 1996-02-27
RU2139867C1 RU2139867C1 (ru) 1999-10-20

Family

ID=25049613

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93041055A RU2139867C1 (ru) 1991-09-11 1992-09-11 Новые 4-арилпиперазины и 4-арилпиперидины, фармацевтическая композиция, способ ингибирования допамин-2-рецепторов

Country Status (21)

Country Link
EP (2) EP0562049A4 (ru)
JP (2) JPH06502183A (ru)
KR (1) KR100196249B1 (ru)
AT (1) ATE219938T1 (ru)
AU (2) AU1363392A (ru)
CA (2) CA2095826A1 (ru)
DE (1) DE69232665T2 (ru)
DK (1) DK0563345T3 (ru)
ES (1) ES2179822T3 (ru)
FI (2) FI932103A (ru)
HU (2) HU217068B (ru)
IE (1) IE914218A1 (ru)
MX (1) MX9102407A (ru)
NO (2) NO303780B1 (ru)
NZ (1) NZ240863A (ru)
PT (1) PT99700A (ru)
RU (1) RU2139867C1 (ru)
SG (1) SG70980A1 (ru)
TW (1) TW209867B (ru)
WO (2) WO1993004684A1 (ru)
ZA (1) ZA919629B (ru)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681830A (en) * 1992-02-03 1997-10-28 Delta Pharmaceuticals, Inc. Opioid compounds
US5985880A (en) * 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
US5332743A (en) * 1992-06-12 1994-07-26 Mcneilab, Inc. Benzyl and benzhydryl alcohols
US5314885A (en) * 1992-09-11 1994-05-24 Mcneilab, Inc. Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents
PT711289E (pt) * 1993-07-30 2001-02-28 Delta Pharmaceuticals Inc Compostos piperazina utilizados em terapia
IL112099A (en) * 1993-12-23 1999-07-14 Ortho Pharma Corp N-oxides of 4-arylpiperazines and 4-arylpiperidines and pharmaceutical compositions containing them
CA2250347C (en) * 1996-03-29 2006-02-21 Duphar International Research B.V. Piperazine and piperidine compounds with high affinity for dopamine-d2 and serotonin-5ht1a receptors
US5859246A (en) 1997-01-30 1999-01-12 Neurogen Corporation 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands
TW530054B (en) * 1997-09-24 2003-05-01 Duphar Int Res New piperazine and piperidine compounds
EP0982304B1 (en) * 1998-06-30 2002-10-02 Eli Lilly And Company Piperidine derivatives having effects on serotonin related systems
GB2352240A (en) * 1999-07-13 2001-01-24 Lilly Co Eli Novel sulphonamides useful in treating CNS disorders
SE9904724D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission I
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
SE9904723D0 (sv) 1999-12-22 1999-12-22 Carlsson A Research Ab New modulators of dopamine neurotransmission II
US6727264B1 (en) 2001-07-05 2004-04-27 Synaptic Pharmaceutical Corporation Substituted anilinic piperidines as MCH selective antagonists
CA2500115A1 (en) * 2002-09-26 2004-04-08 Warner-Lambert Company Llc Heterocyclic substituted piperazines for the treatment of schizophrenia
JP2006508101A (ja) * 2002-11-08 2006-03-09 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー フェニルアルキルおよびピリジルアルキルピペラジン誘導体
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
SE0401465D0 (sv) 2004-06-08 2004-06-08 Carlsson A Research Ab New substituted piperdines as modulators of dopamine neurotransmission
US7851629B2 (en) 2004-06-08 2010-12-14 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
DE602005017784D1 (de) 2004-06-08 2009-12-31 Nsab, Filial Af Neurosearch Sweden Ab Neue disubstituierte phenylpiperidine als modulatoren der dopamin- und serotoninneurotransmission
HUE029790T2 (hu) 2004-10-13 2017-04-28 Teva Pharmaceuticals Int Gmbh Eljárás 4-(3-metánszulfonil-fenil)-l-N-propil-piperidin elõállítására
CA2589748C (en) 2004-12-24 2013-08-13 Astrazeneca Ab Heterocyclic compounds as ccr2b antagonists
EA014370B1 (ru) 2005-09-16 2010-10-29 Янссен Фармацевтика Н.В. Циклопропиламины в качестве модуляторов рецептора гистамина н
SE529246C2 (sv) 2005-10-13 2007-06-12 Neurosearch Sweden Ab Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission
GB0525957D0 (en) 2005-12-21 2006-02-01 Astrazeneca Ab Methods
US20080221116A1 (en) * 2006-09-15 2008-09-11 Baxter Ellen W ISOXAZOLINE ALPHA 1a/1d ADRENORECEPTOR ANTAGONISTS
AR068509A1 (es) * 2007-09-19 2009-11-18 Jerini Ag Antagosnistas del receptor de bradiquinina b1
AU2010266018B2 (en) 2009-06-25 2014-01-09 Alkermes Pharma Ireland Limited Heterocyclic compounds for the treatment of neurological and psychological disorders
US8697911B2 (en) 2010-07-07 2014-04-15 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
US9079880B2 (en) 2010-07-07 2015-07-14 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
US8609672B2 (en) 2010-08-27 2013-12-17 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
US9000154B2 (en) 2010-10-19 2015-04-07 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
CN103130737B (zh) * 2011-12-05 2015-12-02 江苏恒谊药业有限公司 环己烷胺类化合物及其作为抗精神分裂症药物的应用
UY34503A (es) 2011-12-08 2013-07-31 Ivax Int Gmbh ?sal de bromhidrato de pridopidina?
AU2013243461A1 (en) 2012-04-04 2014-11-06 Teva Pharmaceuticals International Gmbh Pharmaceutical compositions for combination therapy

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3988371A (en) * 1972-03-09 1976-10-26 Hansl Nikolaus R Meta-[2-(benzylamino)-ethyl] benzoic acid amides
DE2926472A1 (de) * 1979-06-30 1981-01-15 Thomae Gmbh Dr K Neue benzoylderivate, deren herstellung und deren verwendung als arzneimittel
ZA825719B (en) * 1981-09-03 1983-06-29 Recordati Chem Pharm Alkanoylanilides
US4666924A (en) * 1982-07-26 1987-05-19 E. I. Du Pont De Nemours & Co. Certain pyridyl substituted aminomethyl benzene derivatives having anti-arrhythmic activity
DE3571436D1 (en) * 1984-12-21 1989-08-17 Duphar Int Res New pharmaceutical compositions having anti-psychotic properties
GB8603120D0 (en) * 1986-02-07 1986-03-12 Pfizer Ltd Anti-dysrhythmia agents
CA1279645C (en) * 1986-02-27 1991-01-29 Ineke Van Wijngaarden Aryl-substituted (n-piperidinyl)methyl- and (n-piperazinyl)methylazoles having antipsychotic properties
JPS62246560A (ja) * 1986-04-18 1987-10-27 Kanebo Ltd 新規なビペラジン誘導体および該化合物を有効成分とする抗潰瘍薬
US4931443A (en) * 1986-10-27 1990-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Piperazine compound and pharmaceutical use thereof
US4782062A (en) * 1987-05-11 1988-11-01 Merck & Co., Inc. 9-(2-hydroxymethyl)cycloalkylmethyl) guanines
US4992441A (en) * 1987-10-14 1991-02-12 Mcneilab, Inc. 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
ATE187718T1 (de) * 1989-04-22 2000-01-15 American Home Prod Tertiäre alkyl funktionalisierte piperazin- derivate
KR0173310B1 (ko) * 1989-04-22 1999-02-01 폴 에이 리쳐 피페라진 유도체
DE69021645T2 (de) * 1989-05-19 1996-02-22 Hoechst-Roussel Pharmaceuticals Inc., Somerville, N.J. N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
FR2670491B1 (fr) * 1990-12-14 1993-02-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.

Similar Documents

Publication Publication Date Title
RU93041055A (ru) Новые 4-арилпиперазины и 4-арилпиперидины
RU93055138A (ru) 3-/2-ацилоксиэтоксифенил/ бензофуран-2-оны в качестве стабилизаторов
MX9102407A (es) 4 arilpiperazinas y 4-arilpiperidinas novedosas.
RU93055882A (ru) Производные n-сульфонил-2-оксоиндола, способ их получения, исходные для их получения, фармацевтическая композиция на их основе
IT1242184B (it) Utensile per l'applicazione di elementi di fissaggio.
FI914723A0 (fi) 17b-substituerade 4-aza-5a-androstan -3-jon-derivat och foerfarande foer framstaellning av desamma.
NO179353C (no) Anvendelse av mikrobicide forbindelser av dimetylamin-epiklorhydrinaminer
DE69232042D1 (de) Positiv-arbeitende lichtempfindliche Zusammensetzung
RU93005057A (ru) Фармацевтические соединения, производные тиенобензодиазепина, способ их получения, фармкомпозиция и их использование
DE69329256D1 (de) Kompensation von Nachleuchtzeit aus den vorhergehenden Computertomographieabtastungen
RU93004417A (ru) Новые арилциклоалкильные производные, способы их получения и использования
DK163287D0 (da) 1,4-diazepiner og farmaceutiske midler med indhold af saadanne forbindelser
SE9004060D0 (sv) Bensazepin- och bensotiazepin-derivat
NO943100D0 (no) Forbindelser for anvendelse i kontrastmidler for radiografi
NO971248D0 (no) 5<alfa>-reduktaseinhibitorer
RU92016230A (ru) Тиазолидиновые соединения, фармацевтическая композиция, способ лечения и способы получения соединений
IT8921492A0 (it) Procedimento per l'ossidazione di composti paraffinici.
BR9305855A (pt) Micobacteriófagos repórteres de espécies micobacterianas especificas
IS1605B (is) Botnv”rpuutbunathur
MX9100508A (es) Composicion fotoresistente electrodepositable fotoreproducible
DE69130265D1 (de) Positive arbeitende Photolackzusammensetzung
FI102745B (fi) Uusia jodattuja ei-ionisia trijodibentseeniyhdisteitä ja niitä sisältä viä varjoaineita
ITMI910256A1 (it) Agitatore per cilindri di mentecazione
RU92004377A (ru) Производные бис-(фенил)этана
ITMI912654A1 (it) Combinazione di estrusore-calandra