RU92004593A - Производные гетероциклилметил-хромана в виде смеси изомеров или отдельных изомеров или их соли, способ их получения и лекарственное средство - Google Patents
Производные гетероциклилметил-хромана в виде смеси изомеров или отдельных изомеров или их соли, способ их получения и лекарственное средствоInfo
- Publication number
- RU92004593A RU92004593A RU92004593/04A RU92004593A RU92004593A RU 92004593 A RU92004593 A RU 92004593A RU 92004593/04 A RU92004593/04 A RU 92004593/04A RU 92004593 A RU92004593 A RU 92004593A RU 92004593 A RU92004593 A RU 92004593A
- Authority
- RU
- Russia
- Prior art keywords
- isomers
- heterocyclylmethyl
- medicine
- salts
- mixture
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 239000011780 sodium chloride Substances 0.000 title 1
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4140540.4 | 1991-12-09 | ||
DE4140540A DE4140540A1 (de) | 1991-12-09 | 1991-12-09 | Neue azaheterocyclylmethyl-chromane |
Publications (2)
Publication Number | Publication Date |
---|---|
RU92004593A true RU92004593A (ru) | 1997-04-10 |
RU2089549C1 RU2089549C1 (ru) | 1997-09-10 |
Family
ID=6446618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU9292004593A RU2089549C1 (ru) | 1991-12-09 | 1992-12-08 | Производные гетероциклилметилхромана в виде смеси изомеров или отдельных изомеров или их соли |
Country Status (22)
Country | Link |
---|---|
US (5) | US5371094A (ru) |
EP (1) | EP0546388B1 (ru) |
JP (1) | JP3220266B2 (ru) |
AT (1) | ATE136030T1 (ru) |
AU (1) | AU650182B2 (ru) |
CA (1) | CA2084542A1 (ru) |
CZ (1) | CZ283680B6 (ru) |
DE (2) | DE4140540A1 (ru) |
DK (1) | DK0546388T3 (ru) |
ES (1) | ES2086623T3 (ru) |
FI (1) | FI925549A (ru) |
GR (1) | GR3019450T3 (ru) |
HU (1) | HUT65427A (ru) |
IL (1) | IL104006A (ru) |
MX (1) | MX9206817A (ru) |
NO (1) | NO303174B1 (ru) |
NZ (1) | NZ245381A (ru) |
PH (1) | PH31072A (ru) |
RU (1) | RU2089549C1 (ru) |
SK (1) | SK278553B6 (ru) |
TW (1) | TW210339B (ru) |
ZA (1) | ZA929498B (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2652119C1 (ru) * | 2016-12-14 | 2018-04-25 | федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный технический университет" | Способ получения производных хроман-2-аминов |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4140542A1 (de) * | 1991-12-09 | 1993-06-17 | Bayer Ag | Piperdylmethyl substituierte chormanderivate |
DE4319038A1 (de) * | 1993-06-08 | 1994-12-15 | Bayer Ag | Verwendung von teilweise bekannten substituierten Chromanen als Arzneimittel, neue Wirkstoffe und Verfahren zu ihrer Herstellung |
US5478934A (en) * | 1994-11-23 | 1995-12-26 | Yuan; Jun | Certain 1-substituted aminomethyl imidazole and pyrrole derivatives: novel dopamine receptor subtype specific ligands |
US6096763A (en) * | 1995-02-23 | 2000-08-01 | Merck & Co., Inc. | α1a adrenergic receptor antagonists |
US5541199A (en) * | 1995-06-02 | 1996-07-30 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
US5658796A (en) * | 1995-06-07 | 1997-08-19 | Seprachem, Inc. | Optical resolution of alkyl chroman-2-carboxylates |
US5684039A (en) * | 1995-07-25 | 1997-11-04 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
US5670667A (en) * | 1995-07-25 | 1997-09-23 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
US5663194A (en) * | 1995-07-25 | 1997-09-02 | Mewshaw; Richard E. | Chroman-2-ylmethylamino derivatives |
IL119483A (en) | 1995-11-06 | 1999-06-20 | American Home Prod | 2-(Aminomethyl)-3,4,7,9- tetrahydro- 2H-pyrano-2[3,3-e]indol-8-ones their derivatives and pharmaceutical compositions containing them |
DE69722020T2 (de) * | 1996-10-15 | 2004-01-22 | Wyeth | Azaheterocyclylmethyl-derivate von 2,3,8,9-tetrahydro-7h-1,4-dioxino[2,3-e]indol-8-on |
US5869490A (en) * | 1996-10-15 | 1999-02-09 | American Home Products Corporation | Azaheterocyclymethyl derivatives of 2,3,8,9-tetrahydro-7h-1,4-dioxino (2,3-e) indol-8-one |
US5750556A (en) * | 1996-10-30 | 1998-05-12 | American Home Products Corporation | 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano- 2,3-E!indol-8-ones and derivatives |
US6331543B1 (en) * | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
SE9702716D0 (sv) * | 1997-07-15 | 1997-07-15 | Ross Nicholas Waters | Substituted phenylazacycloalkanes in the treatment of cognitive disorders |
US6004982A (en) * | 1997-09-15 | 1999-12-21 | Hoechst Marion Roussel, Inc. | 4-piperidinyl) H-2-benzopyran derivatives useful as antipsychotic agents |
US6133277A (en) * | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
US6169185B1 (en) | 1999-02-25 | 2001-01-02 | Day-Glo Color Corp. | Ink jet printing inks |
DK1187829T3 (da) * | 1999-06-02 | 2004-04-13 | Janssen Pharmaceutica Nv | Aminoalkylsubstituerede (benzodioxan, benzofuran eller benzopyran) derivater |
ES2231189T3 (es) * | 1999-06-02 | 2005-05-16 | Janssen Pharmaceutica N.V. | Derivados de benzodioxano o benzopirano sustituidos con pirrolidinilo, piperidinilo u homopiperidinilo. |
JO2654B1 (en) * | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
JO2409B1 (en) * | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
US6458802B1 (en) | 2001-03-14 | 2002-10-01 | Wyeth | Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-dioxino [2,3-f]quinoline |
US7041683B2 (en) * | 2001-04-24 | 2006-05-09 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan |
EP1381600A1 (en) | 2001-04-24 | 2004-01-21 | Wyeth, A Corporation of the State of Delaware | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan |
US6803368B2 (en) | 2001-04-25 | 2004-10-12 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta[a]naphthalene |
US6573283B2 (en) | 2001-04-26 | 2003-06-03 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalene |
US6627639B2 (en) | 2001-04-26 | 2003-09-30 | Wyeth | Uses for indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino-[2,3-e]indole |
WO2002088129A1 (en) | 2001-04-26 | 2002-11-07 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline |
US6821981B2 (en) | 2001-04-26 | 2004-11-23 | Wyeth | Azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]-quinoline as 5-HT1A antagonists |
US7008944B2 (en) * | 2001-04-26 | 2006-03-07 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-Dioxino[2,3-f]quinoxaline |
US6593350B2 (en) | 2001-04-26 | 2003-07-15 | Wyeth | Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole |
DE60213576T2 (de) | 2001-04-26 | 2007-10-18 | Wyeth | ANTIDEPRESSIVE AZAHETEROCYCLYLMETHYL-DERIVATE VON 2,3-DIHYDRO-1,4-DIOXINO-(2,3f)CHINOXALIN |
US6800641B2 (en) | 2001-04-26 | 2004-10-05 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene |
US6861427B2 (en) * | 2001-04-26 | 2005-03-01 | Wyeth | Azabicyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoline as 5-HT1A antagonists |
US6706736B2 (en) | 2001-04-26 | 2004-03-16 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans |
US6927226B2 (en) * | 2001-04-26 | 2005-08-09 | Wyeth | Antidepressant azaheterocyclymethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalene |
US6800648B2 (en) | 2001-04-26 | 2004-10-05 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one |
US6800642B2 (en) | 2001-04-26 | 2004-10-05 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-2,6,9-trioxa-3-aza-cyclopenta[a]naphthalene |
WO2002088145A1 (en) | 2001-04-26 | 2002-11-07 | Wyeth | AZABICYCLYLMETHYL DERIVATIVES OF 7,8-DIHYDRO-1,6,9-TRIOXA-3-AZACYCLOPENTA[a]NAPHTHALENE AS 5-HT1A ANTAGONISTS |
US6861434B2 (en) | 2001-04-26 | 2005-03-01 | Wyeth | Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one |
JP2004532236A (ja) | 2001-04-26 | 2004-10-21 | ワイス | 抗うつ作用を持つ、オキサヘテロ環結合[1、4]−ベンゾジオキサンのアザヘテロシクリルメチル誘導体 |
TR200402753T4 (tr) | 2001-04-30 | 2004-11-22 | Wyeth | 7,8-Dihidro-1,6,9-trioksa-3-aza-siklopenta[a]naftalen'in antidepresan azaheterosiklmetil türevleri. |
US6617334B2 (en) | 2001-04-30 | 2003-09-09 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene |
US6555560B2 (en) | 2001-04-30 | 2003-04-29 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene |
US6906206B2 (en) * | 2001-04-30 | 2005-06-14 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene |
US6815448B2 (en) | 2001-05-07 | 2004-11-09 | Wyeth | Azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene as 5-HT1A antagonists |
IL158879A0 (en) * | 2001-05-17 | 2004-05-12 | Wyeth Corp | PROCESSES FOR THE SYNTHESIS OF DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO-(2,3-f) QUINOLINE |
US6541502B1 (en) | 2001-07-20 | 2003-04-01 | Wyeth | 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity |
US6541501B2 (en) | 2001-07-20 | 2003-04-01 | Wyeth | 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]-naphthalenyl derivatives with antipsychotic activity |
AR035083A1 (es) * | 2001-07-25 | 2004-04-14 | Wyeth Corp | Derivados azaheterociclilmetilicos de 7,8-dihidro-6h-5-oxa-1-aza-fenantreno, composiciones farmaceuticas, el uso de dichos derivados para la preparacion de un medicamento antidepresivo e intermediarios |
US6667322B2 (en) | 2001-10-05 | 2003-12-23 | Wyeth | Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole |
WO2003031429A1 (en) | 2001-10-05 | 2003-04-17 | Wyeth | A process for the stereoselective synthesis of 2-hydroxymethyl-chromans |
CN1561337A (zh) | 2001-10-05 | 2005-01-05 | 惠氏公司 | 2-基苯并二氢吡喃衍生物的立体有择合成方法 |
US20050014818A1 (en) * | 2001-11-09 | 2005-01-20 | Masaru Mitsuda | Process for producing optically active chroman derivative and intermediate |
US7115644B2 (en) * | 2002-09-13 | 2006-10-03 | Boehringer Ingelheim Pharmaceuticals Inc. | Heterocyclic compounds |
KR100602191B1 (ko) * | 2004-03-10 | 2006-07-19 | 한국화학연구원 | 5-라이폭시게네이즈 저해활성을 가지는2,2'-이중치환-3,4-디하이드로-7,8-이중치환-6-알킬아미노벤조피란 유도체 |
KR100704009B1 (ko) * | 2005-08-30 | 2007-04-04 | 한국화학연구원 | 염증억제 활성을 가지는6-알킬아미노-2-메틸-2'-(n-메틸치환술폰아미도)메틸-2h-1-벤조피란 유도체 |
AU2007221049A1 (en) * | 2006-02-28 | 2007-09-07 | Amgen Inc. | Cinnoline and quinazoline derivates as phosphodiesterase 10 inhibitors |
TW200811182A (en) * | 2006-05-25 | 2008-03-01 | Wyeth Corp | Oxindoledioxans, synthesis thereof, and intermediates thereto |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3826835A (en) * | 1971-01-08 | 1974-07-30 | Ciba Geigy Corp | 8-benzofurylmethyl-1,3,8-triazaspiro(4,5)decanes as neuroleptics |
US4711960A (en) * | 1977-10-31 | 1987-12-08 | The Upjohn Company | Isochromans |
US4179510A (en) * | 1977-10-31 | 1979-12-18 | The Upjohn Company | Methods of treating psychosis |
US4153612A (en) * | 1977-10-31 | 1979-05-08 | The Upjohn Company | 2-Benzoxepins |
US4556656A (en) * | 1978-10-23 | 1985-12-03 | The Upjohn Company | 2-Benzoxepins |
DE3124366A1 (de) * | 1981-06-20 | 1982-12-30 | Hoechst Ag, 6000 Frankfurt | N-oxacyclyl-alkylpiperidin-derivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und deren verwendung |
US4826848A (en) * | 1985-04-15 | 1989-05-02 | Janssen Pharmaceutica N.V. | Antidepressive substituted N-[(4-piperidinyl)alkyl] bicyclic condensed oxazol- and thiazolamines |
GB8515389D0 (en) * | 1985-06-18 | 1985-07-17 | Ici Plc | Heterocyclic compounds |
US4957928A (en) * | 1986-06-26 | 1990-09-18 | Ciba-Geigy Corporation | Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds |
DE3718317A1 (de) * | 1986-12-10 | 1988-06-16 | Bayer Ag | Substituierte basische 2-aminotetraline |
US5300523A (en) * | 1988-07-28 | 1994-04-05 | Bayer Aktiengesellschaft | Substituted aminomethyltetralins and their heterocyclic analogues |
DE3901814A1 (de) * | 1988-07-28 | 1990-02-01 | Bayer Ag | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
DE4140542A1 (de) * | 1991-12-09 | 1993-06-17 | Bayer Ag | Piperdylmethyl substituierte chormanderivate |
-
1991
- 1991-12-09 DE DE4140540A patent/DE4140540A1/de not_active Withdrawn
-
1992
- 1992-11-07 TW TW081108902A patent/TW210339B/zh active
- 1992-11-25 NO NO924546A patent/NO303174B1/no unknown
- 1992-11-26 DE DE59205846T patent/DE59205846D1/de not_active Expired - Fee Related
- 1992-11-26 MX MX9206817A patent/MX9206817A/es not_active IP Right Cessation
- 1992-11-26 EP EP92120187A patent/EP0546388B1/de not_active Expired - Lifetime
- 1992-11-26 DK DK92120187.7T patent/DK0546388T3/da active
- 1992-11-26 ES ES92120187T patent/ES2086623T3/es not_active Expired - Lifetime
- 1992-11-26 AT AT92120187T patent/ATE136030T1/de not_active IP Right Cessation
- 1992-11-30 US US07/984,076 patent/US5371094A/en not_active Expired - Lifetime
- 1992-12-04 CA CA002084542A patent/CA2084542A1/en not_active Abandoned
- 1992-12-07 FI FI925549A patent/FI925549A/fi unknown
- 1992-12-07 NZ NZ245381A patent/NZ245381A/en unknown
- 1992-12-07 IL IL10400692A patent/IL104006A/xx not_active IP Right Cessation
- 1992-12-07 AU AU29938/92A patent/AU650182B2/en not_active Ceased
- 1992-12-08 JP JP35143792A patent/JP3220266B2/ja not_active Expired - Fee Related
- 1992-12-08 RU RU9292004593A patent/RU2089549C1/ru active
- 1992-12-08 ZA ZA929498A patent/ZA929498B/xx unknown
- 1992-12-08 PH PH45383A patent/PH31072A/en unknown
- 1992-12-09 CZ CS923613A patent/CZ283680B6/cs not_active IP Right Cessation
- 1992-12-09 SK SK3613-92A patent/SK278553B6/sk unknown
- 1992-12-09 HU HU9203894A patent/HUT65427A/hu unknown
-
1994
- 1994-08-18 US US08/292,639 patent/US5545643A/en not_active Expired - Fee Related
-
1995
- 1995-06-02 US US08/459,071 patent/US5696136A/en not_active Expired - Fee Related
- 1995-06-02 US US08/459,076 patent/US5693653A/en not_active Expired - Fee Related
- 1995-06-02 US US08/460,475 patent/US5696137A/en not_active Expired - Fee Related
-
1996
- 1996-03-28 GR GR960400784T patent/GR3019450T3/el unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2652119C1 (ru) * | 2016-12-14 | 2018-04-25 | федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный технический университет" | Способ получения производных хроман-2-аминов |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU92004593A (ru) | Производные гетероциклилметил-хромана в виде смеси изомеров или отдельных изомеров или их соли, способ их получения и лекарственное средство | |
RU93055882A (ru) | Производные n-сульфонил-2-оксоиндола, способ их получения, исходные для их получения, фармацевтическая композиция на их основе | |
RU93048636A (ru) | 7-/замещенные/-8-/замещенные/-9-/замещенные амино/-6-диметил-6-дезокситетрациклины, промежуточные соединения, способы получения соединений, способ профилактики и лечения и фармацевтическая композиция | |
RU94019972A (ru) | Гетероариламины, способ их получения, фармацевтическая композиция и способ ингибирования ацетилхолинэстеразы | |
RU93005057A (ru) | Фармацевтические соединения, производные тиенобензодиазепина, способ их получения, фармкомпозиция и их использование | |
RU93004417A (ru) | Новые арилциклоалкильные производные, способы их получения и использования | |
RU93005256A (ru) | ПРОИЗВОДНЫЕ ЦИКЛОПЕПТАН-И ПЕНТЕН- β -АМИНОКИСЛОТ И ИХ СОЛИ, СПОСОБ ИХ ПОЛУЧЕНИЯ И АНТИБАКТЕРИАЛЬНОЕ СРЕДСТВО | |
RU94027570A (ru) | Способ получения замещенных пиперидинов, способ получения промежуточных продуктов, промежуточные продукты | |
PT91302A (pt) | Processo para a preparacao de composicoes farmaceuticas contendo imidazo {2,1-a} isoquinolinas substituidas por 5-heteroarilo ou 5-arilo | |
DE68920896D1 (de) | N2-(1-Carboxy-3-phenylpropyl)-L-lysinderivate und Verfahren für die Herstellung von Lysinopril mit Hilfe dieser Verbindung. | |
RU92004359A (ru) | Гидразоны | |
RU92004562A (ru) | Новые цефалоспорины, имеющие в положении 7 замещенный оксииминный радикал, метод их получения и их использование в качестве медикаментов, фармацевтический состав на их основе | |
IT8319958A0 (it) | Composizioni farmaceutiche adattivita' antineoplastica. | |
RU94011321A (ru) | Способ профилактики и лечения заболеваний кожи | |
ITMI910320A1 (it) | Processo per la preaparazione di 1. 3-diossoli | |
IT1230068B (it) | Procedimento per la preparazione di n sulfoniluree. | |
ES2096099T3 (es) | Perhidro-1h-pirido(1,2,a)pirazinas 2-sustituidas neurolepticas. | |
RU92004377A (ru) | Производные бис-(фенил)этана | |
RU92016589A (ru) | Производные изоксазолилимидазола, способ их получения и их использование в лекарственных средствах | |
DE59106607D1 (de) | Verfahren zur Herstellung von 2,2-disubstituierten Pentan-1,5-diaminen. | |
RU92004582A (ru) | Этанольные аддукты, способ их получения и применение в качестве средств ингаляции при заболеваниях | |
RU92016209A (ru) | Бензофуранилимидазольные производные, способ их получения и терапевтические композиции, содержащие названные производные | |
IT8322118A0 (it) | Composizioni farmaceutiche comprendenti epinina o un suo sale farmaceuticamente accettabile eloro uso terapeutico. | |
IT8667516A1 (it) | Procedimento perfezionato per la confezione di libri composti di segnature cucite. | |
RU93004708A (ru) | Производные замещенного пирролидина и их терапевтически приемлемые соли, способ их получения и фармацевтическая композиция |