DE69804743D1 - Pyrazolo[4,3-d]pyrimidin-Derivate und diese enthaltende pharmazeutische Zubereitungen - Google Patents
Pyrazolo[4,3-d]pyrimidin-Derivate und diese enthaltende pharmazeutische ZubereitungenInfo
- Publication number
- DE69804743D1 DE69804743D1 DE69804743T DE69804743T DE69804743D1 DE 69804743 D1 DE69804743 D1 DE 69804743D1 DE 69804743 T DE69804743 T DE 69804743T DE 69804743 T DE69804743 T DE 69804743T DE 69804743 D1 DE69804743 D1 DE 69804743D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrazolo
- pharmaceutical preparations
- preparations containing
- pyrimidine derivatives
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9722520.5A GB9722520D0 (en) | 1997-10-24 | 1997-10-24 | Compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69804743D1 true DE69804743D1 (de) | 2002-05-16 |
DE69804743T2 DE69804743T2 (de) | 2002-08-08 |
Family
ID=10821059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69804743T Expired - Fee Related DE69804743T2 (de) | 1997-10-24 | 1998-10-08 | Pyrazolo[4,3-d]pyrimidin-Derivate und diese enthaltende pharmazeutische Zubereitungen |
Country Status (12)
Country | Link |
---|---|
US (1) | US6235742B1 (de) |
EP (1) | EP0911333B1 (de) |
JP (1) | JP3270830B2 (de) |
AT (1) | ATE215954T1 (de) |
BR (1) | BR9804214A (de) |
CA (1) | CA2251453C (de) |
DE (1) | DE69804743T2 (de) |
DK (1) | DK0911333T3 (de) |
ES (1) | ES2175624T3 (de) |
GB (1) | GB9722520D0 (de) |
MX (1) | MXPA98008897A (de) |
PT (1) | PT911333E (de) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6403597B1 (en) | 1997-10-28 | 2002-06-11 | Vivus, Inc. | Administration of phosphodiesterase inhibitors for the treatment of premature ejaculation |
US6548490B1 (en) * | 1997-10-28 | 2003-04-15 | Vivus, Inc. | Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
EP1120120A4 (de) * | 1998-10-05 | 2009-04-29 | Eisai R&D Man Co Ltd | Tableten die sich unmittelbar in der mundhöhle auflösen |
US6242444B1 (en) | 1999-06-04 | 2001-06-05 | The Jordanian Pharmaceutical Manufacturing And Medical Equipment Co., Ltd. | Compounds and pharmaceutical compositions containing the same |
IL139457A0 (en) | 1999-11-08 | 2001-11-25 | Pfizer | Compounds for the treatment of female sexual dysfunction |
US20050020547A1 (en) * | 1999-11-08 | 2005-01-27 | Pfizer Inc. | Compounds for the treatment of female sexual dysfunction |
CA2395418A1 (en) * | 1999-12-24 | 2001-07-05 | Bayer Aktiengesellschaft | Isoxazolo pyrimidinones and the use thereof |
US20040043904A1 (en) * | 2000-09-22 | 2004-03-04 | Hiroshi Yamaguchi | N-(4-pyrazolyl) amide derivatives, chemicals for agricultural and horticultural use, and usage of the same |
WO2002094793A1 (de) * | 2001-05-23 | 2002-11-28 | Basf Aktiengesellschaft | Acylierte 4-aminopyrazole |
US20030073711A1 (en) * | 2001-08-23 | 2003-04-17 | Whitehead Clark M. | Methods for treatment of scleroderma |
US6479493B1 (en) | 2001-08-23 | 2002-11-12 | Cell Pathways, Inc. | Methods for treatment of type I diabetes |
IL160307A0 (en) * | 2001-08-31 | 2004-07-25 | Univ Rockefeller | Phosphodiesterase activity and regulation of phosphodiesterase 1-b-mediated signaling in brain |
PL370599A1 (en) * | 2001-11-02 | 2005-05-30 | Pfizer Products Inc. | Treatment of insulin resistance syndrome and type 2 diabetes with pde9 inhibitors |
HN2002000317A (es) * | 2001-11-02 | 2003-05-21 | Pfizer | Inhibidores de pde9 para tratamiento de trastornos cardiovasculares |
EP1476425A4 (de) * | 2002-01-30 | 2010-05-05 | Amgen Inc | Heterocyclische arylsulfonamidobenzyl verbindungen |
US20040220186A1 (en) * | 2003-04-30 | 2004-11-04 | Pfizer Inc. | PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease |
WO2005028480A2 (en) * | 2003-09-03 | 2005-03-31 | Neurogen Corporation | 5-aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds |
BRPI0502411A (pt) * | 2005-03-31 | 2006-11-28 | Univ Minas Gerais | processo de desenvolvimento de substáncias como inibidores potentes e seletivos de isoformas de fosfodiesterases dos tipos 1 a 5 (pde1,pde2,pde3, pde4, pde5) na base de diocleìna, fluranol ou análogos e suas composições farmacêuticas para o estudo e tratamento de doenças cardiovasculares e produtos associados |
ES2645371T3 (es) | 2005-06-06 | 2017-12-05 | Intra-Cellular Therapies, Inc. | Compuestos orgánicos |
EP1901725A2 (de) * | 2005-06-17 | 2008-03-26 | Nycomed GmbH | Verwendung von pde1c und seiner hemmer |
EP1919287A4 (de) * | 2005-08-23 | 2010-04-28 | Intra Cellular Therapies Inc | Organische verbindungen zur behandlung einer verringerten dopamin-rezeptorsignalisierungs-aktivität |
US9255099B2 (en) | 2006-06-06 | 2016-02-09 | Intra-Cellular Therapies, Inc. | Pyrazolo[3,4-D]pyrimidine-4,6(5H,7H)-diones as phosphodiesterase 1 inhibitors |
EP2081431B1 (de) | 2006-11-13 | 2013-01-16 | Intra-Cellular Therapies, Inc. | Organische verbindungen |
WO2008070095A1 (en) | 2006-12-05 | 2008-06-12 | Intra-Cellular Therapies, Inc. | Novel uses |
KR20100094551A (ko) | 2007-12-06 | 2010-08-26 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
CN101970444A (zh) | 2007-12-06 | 2011-02-09 | 细胞内治疗公司 | 有机化合物 |
EP2370080A1 (de) * | 2008-12-02 | 2011-10-05 | University of Utah Research Foundation | Pde1 als zieltherapeutikum bei herzkrankheiten |
US8664207B2 (en) | 2008-12-06 | 2014-03-04 | Intra-Cellular Therapies, Inc. | Organic compounds |
SG171776A1 (en) | 2008-12-06 | 2011-07-28 | Intra Cellular Therapies Inc | Organic compounds |
MX2011005933A (es) | 2008-12-06 | 2011-12-16 | Intra Cellular Therapies Inc | Compuestos organicos. |
BRPI0922809A2 (pt) | 2008-12-06 | 2018-05-29 | Intracellular Therapies Inc | compostos orgânicos |
SG171777A1 (en) | 2008-12-06 | 2011-07-28 | Intra Cellular Therapies Inc | Organic compounds |
EP2367431B1 (de) | 2008-12-06 | 2015-08-05 | Intra-Cellular Therapies, Inc. | Organische verbindungen |
US20130213393A1 (en) | 2009-12-22 | 2013-08-22 | Evoke Pharma, Inc. | Nasal formulations of metoclopramide |
TWI404721B (zh) * | 2009-01-26 | 2013-08-11 | Pfizer | 胺基-雜環化合物 |
US11464781B2 (en) | 2009-02-25 | 2022-10-11 | Intra-Cellular Therapies, Inc. | PDE1 inhibitors for ophthalmic disorders |
US9468637B2 (en) | 2009-05-13 | 2016-10-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
SG10201507362TA (en) | 2009-08-05 | 2015-10-29 | Intra Cellular Therapies Inc | Novel Regulatory Proteins And Inhibitors |
EP2576551A4 (de) | 2010-05-31 | 2014-04-16 | Intra Cellular Therapies Inc | Organische verbindungen |
TW201206937A (en) | 2010-05-31 | 2012-02-16 | Intra Cellular Therapies Inc | Organic compounds |
US9371327B2 (en) | 2010-05-31 | 2016-06-21 | Intra-Cellular Therapies, Inc. | PDE1 inhibitor compounds |
US9434730B2 (en) | 2010-05-31 | 2016-09-06 | Intra-Cellular Therapies, Inc. | PDE1 inhibitor compounds |
WO2012131539A1 (en) | 2011-03-31 | 2012-10-04 | Pfizer Inc. | Novel bicyclic pyridinones |
US10561656B2 (en) | 2011-06-10 | 2020-02-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
WO2012172449A1 (en) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactams as beta secretase inhibitors |
EP2751116B1 (de) | 2011-08-31 | 2016-10-12 | Pfizer Inc | Hexahydropyrano [3,4-d][1,3] thiazin-2-aminverbindungen |
UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
US9801882B2 (en) | 2013-02-17 | 2017-10-31 | Intra-Cellular Therapies, Inc. | Phosphodiesterase-1 inhibitors and their use in treatment of cardiovascular diseases |
AP2015008663A0 (en) | 2013-02-19 | 2015-08-31 | Pfizer | Azabenzimidazole compounds as inhibitors of PDE4 isozymes for the treatment of cns and other disorders |
JP2016518343A (ja) | 2013-03-15 | 2016-06-23 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規使用 |
JP6437519B2 (ja) | 2013-03-15 | 2018-12-12 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
ES2742078T3 (es) | 2013-10-04 | 2020-02-13 | Pfizer | Piridonas bicíclicas novedosas como moduladores de gamma-secretasa |
CN103721102B (zh) * | 2013-12-27 | 2017-06-23 | 南阳理工学院 | 一种治疗血管性痴呆的中成药及其制备方法 |
WO2015106032A1 (en) | 2014-01-08 | 2015-07-16 | Intra-Cellular Therapies, Inc. | Products and pharmaceutical compositions |
KR101886945B1 (ko) | 2014-04-01 | 2018-08-08 | 화이자 인코포레이티드 | 감마-세크레타제 조절제로서의 크로멘 및 1,1a,2,7b-테트라히드로시클로프로파[c]크로멘 피리도피라진디온 |
CN103992241B (zh) * | 2014-06-05 | 2016-08-24 | 雅本化学股份有限公司 | N-取代苯基甘氨酸的制备方法 |
JP6810613B2 (ja) | 2014-06-20 | 2021-01-06 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
JP6713982B2 (ja) | 2014-07-24 | 2020-06-24 | ファイザー・インク | ピラゾロピリミジン化合物 |
CU20170007A7 (es) | 2014-08-06 | 2017-06-05 | Pfizer | Compuestos de imidazopiridazina |
TWI686394B (zh) | 2014-08-07 | 2020-03-01 | 美商內胞醫療公司 | 有機化合物 |
US9546175B2 (en) | 2014-08-07 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10285992B2 (en) | 2014-08-07 | 2019-05-14 | Intra-Cellular Therapies, Inc. | Combinations of PDE1 inhibitors and NEP inhibitors and associated methods |
EP3725789B1 (de) | 2014-09-17 | 2022-03-09 | Intra-Cellular Therapies, Inc. | 7,8-dihydro-[2h]-imidazo-[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5h)-on-derivate als phosphodiesterase 1 (pde1) inhibitoren zur behandlung von erkrankungen, störungen oder verletzungen des zentralen nervensystems (zns) |
CN107205993B (zh) | 2014-12-06 | 2021-03-09 | 细胞内治疗公司 | 有机化合物 |
AU2015357496B2 (en) | 2014-12-06 | 2019-09-19 | Intra-Cellular Therapies, Inc. | Organic compounds |
MX368391B (es) | 2015-02-03 | 2019-09-30 | Pfizer | Ciclopropabenzofuranil-piridopirazindionas novedosas. |
CN107787322B (zh) | 2015-06-17 | 2023-07-07 | 辉瑞大药厂 | 三环化合物以及它们作为磷酸二酯酶抑制剂的用途 |
TN2017000507A1 (en) | 2015-07-07 | 2019-04-12 | H Lundbeck As | Pde9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases |
EP3419979B1 (de) | 2016-02-23 | 2020-01-29 | Pfizer Inc | 6,7-dihydro-5h-pyrazolo[5,1-b] [1,3]oxazin-2-carboxamidverbindungen |
WO2017172795A1 (en) | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
EP3872078A1 (de) | 2016-07-01 | 2021-09-01 | Pfizer Inc. | 5,7-dihydro-pyrrolo-pyridin-derivate zur verwendung für die behandlung von depression, angst oder panikstörungen |
EP3509589B1 (de) | 2016-09-12 | 2021-11-17 | Intra-Cellular Therapies, Inc. | Neuartige verwendungen |
ES2967489T3 (es) * | 2016-10-18 | 2024-04-30 | H Lundbeck As | Imidazopirazinonas, pirazolopirimidinonas y pirazolopiridinonas como inhibidores de PDE1 |
WO2018112061A1 (en) | 2016-12-15 | 2018-06-21 | Evoke Pharma, Inc. | Treatment of moderate and severe gastroparesis |
KR102590848B1 (ko) | 2016-12-28 | 2023-10-19 | 다트 뉴로사이언스, 엘엘씨 | Pde2 억제제로서 치환된 피라졸로피리미디논 화합물 |
JP7263266B2 (ja) | 2017-06-22 | 2023-04-24 | ファイザー・インク | ジヒドロ-ピロロ-ピリジン誘導体 |
JP7254078B2 (ja) | 2017-11-27 | 2023-04-07 | ダート・ニューロサイエンス・エルエルシー | Pde1阻害剤としての置換フラノピリミジン化合物 |
US11839614B2 (en) | 2018-01-31 | 2023-12-12 | Intra-Cellular Therapies, Inc. | Methods for treating or mitigating cardiotoxicity characterized by inhibition of adenosine A2 signaling and/or adenosine A2 receptor expression |
WO2019183636A1 (en) | 2018-03-23 | 2019-09-26 | Pfizer Inc. | Piperazine azaspiro derivaves |
WO2022159745A1 (en) * | 2021-01-22 | 2022-07-28 | Hibercell, Inc. | Gcn2 modulating compounds and uses thereof |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4663326A (en) | 1985-04-04 | 1987-05-05 | Warner-Lambert Company | Pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)dione or -5-thione-7-one analogs |
US4666908A (en) * | 1985-04-05 | 1987-05-19 | Warner-Lambert Company | 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use |
US5075310A (en) | 1988-07-01 | 1991-12-24 | Smith Kline & French Laboratories, Ltd. | Pyrimidone derivatives as bronchodilators |
GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
US5250534A (en) | 1990-06-20 | 1993-10-05 | Pfizer Inc. | Pyrazolopyrimidinone antianginal agents |
GB9114760D0 (en) | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
GB9119704D0 (en) | 1991-09-14 | 1991-10-30 | Pfizer Ltd | Therapeutic agents |
GB9121028D0 (en) | 1991-10-03 | 1991-11-13 | Pfizer Ltd | Therapeutic agents |
GB9126260D0 (en) | 1991-12-11 | 1992-02-12 | Pfizer Ltd | Therapeutic agents |
GB9213623D0 (en) | 1992-06-26 | 1992-08-12 | Pfizer Ltd | Therapeutic agents |
US5734053A (en) | 1992-06-26 | 1998-03-31 | Pfizer Inc | Purinone antianginal agents |
GB9218322D0 (en) | 1992-08-28 | 1992-10-14 | Pfizer Ltd | Therapeutic agents |
GB9301192D0 (en) | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
GB9315017D0 (en) | 1993-07-20 | 1993-09-01 | Glaxo Lab Sa | Chemical compounds |
GB9423910D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
GB9423911D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
US5656629A (en) | 1995-03-10 | 1997-08-12 | Sanofi Winthrop, Inc. | 6-substituted pyrazolo (3,4-d)pyrimidin-4-ones and compositions and methods of use thereof |
HUP9801394A3 (en) | 1995-03-10 | 2000-07-28 | Sanofi Pharmaceuticals Inc New | 6-phenyl-pyrazolo[3,4-d]pyrimidin-4-one derivatives and pharmaceutical compositions containing them |
GB9612514D0 (en) | 1996-06-14 | 1996-08-14 | Pfizer Ltd | Novel process |
PL336586A1 (en) | 1997-04-25 | 2000-07-03 | Pfizer | Pyrazoylpyrimidinones inhibiting the cyclic guanosine 3',5'-monophosphate phosphodiesterase of type 5 (cgmp pde5) for treating sexual disorders |
HUP0102543A3 (en) | 1998-04-20 | 2002-01-28 | Pfizer | Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction and medicaments containing them |
-
1997
- 1997-10-24 GB GBGB9722520.5A patent/GB9722520D0/en not_active Ceased
-
1998
- 1998-10-08 DK DK98308177T patent/DK0911333T3/da active
- 1998-10-08 AT AT98308177T patent/ATE215954T1/de not_active IP Right Cessation
- 1998-10-08 EP EP98308177A patent/EP0911333B1/de not_active Expired - Lifetime
- 1998-10-08 DE DE69804743T patent/DE69804743T2/de not_active Expired - Fee Related
- 1998-10-08 PT PT98308177T patent/PT911333E/pt unknown
- 1998-10-08 ES ES98308177T patent/ES2175624T3/es not_active Expired - Lifetime
- 1998-10-21 US US09/176,166 patent/US6235742B1/en not_active Expired - Fee Related
- 1998-10-23 CA CA002251453A patent/CA2251453C/en not_active Expired - Fee Related
- 1998-10-26 JP JP30407698A patent/JP3270830B2/ja not_active Expired - Fee Related
- 1998-10-26 BR BR9804214-9A patent/BR9804214A/pt not_active Application Discontinuation
- 1998-10-26 MX MXPA98008897A patent/MXPA98008897A/es not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0911333A1 (de) | 1999-04-28 |
MXPA98008897A (es) | 2002-03-11 |
ES2175624T3 (es) | 2002-11-16 |
US6235742B1 (en) | 2001-05-22 |
CA2251453C (en) | 2002-03-19 |
GB9722520D0 (en) | 1997-12-24 |
EP0911333B1 (de) | 2002-04-10 |
JP3270830B2 (ja) | 2002-04-02 |
DK0911333T3 (da) | 2002-07-01 |
PT911333E (pt) | 2002-08-30 |
JPH11217383A (ja) | 1999-08-10 |
CA2251453A1 (en) | 1999-04-24 |
ATE215954T1 (de) | 2002-04-15 |
BR9804214A (pt) | 1999-12-14 |
DE69804743T2 (de) | 2002-08-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69804743D1 (de) | Pyrazolo[4,3-d]pyrimidin-Derivate und diese enthaltende pharmazeutische Zubereitungen | |
FI20000516A (fi) | Bis-indolyylimaleimidijohdannaiset ja niiden valmistus | |
ATE380031T1 (de) | Pyrrolo 2,3-d pyrimidinderivate enthaltende zusammensetzungen | |
CA2296665A1 (en) | Triazolo[4,5-d]pyrimidine derivatives as anti-thromobotic agents | |
ATE320436T1 (de) | Dimere pyrrolobenzodiazepine | |
CA2272705A1 (en) | Fused bicyclic pyrimidine derivatives | |
DE69827419D1 (de) | Pharmazeutische Zusammensetzung, enthaltend 2,3-Diaryl-Pyrazolo[1,5-b]Pyridazin Derivate | |
SE9702001D0 (sv) | Novel compounds | |
AU1608397A (en) | Heterocyclic compounds useful as pharmaceutical agents | |
HUP0401083A3 (en) | 4-amino-6-phenyl-pyrrolo [2,3-d] pyrimidine derivatives, pharmaceutical compositions containing them and process for the preparation of the compounds | |
ATE284404T1 (de) | Pyrazolo(4,3-d)pyrimidinderivate | |
DE60204452D1 (de) | Pyrazolo[1,5]pyridinderivate | |
IL157940A0 (en) | Drugs containing triazaspiro [5.5] undecane derivatives as the active ingredient | |
HUP9801587A3 (en) | 5h-thiazolo[3,2-a]pyrimidine derivatives, process for their preparation, intermediates, use of the compounds and pharmaceutical compositions containing them | |
ATE251162T1 (de) | Triazolo(4,5-d)pyrimidin-verbindungen | |
EE200000537A (et) | Pürasolo[4,3-d]pürimidiin-7-oon-3-püridüülsulfonüülühendite ja nende vaheühendite valmistamise protsess | |
NO20002321L (no) | Bifenylderivater som farmasøytiske midler | |
ATE272642T1 (de) | Thieno(2,3-d)pyrimidindione und ihre verwendung als pharmazeutische mittel | |
SE9803277D0 (sv) | Novel compounds | |
MY133139A (en) | N-substituted azabicycloheptane derivatives, their preparation and use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |