IT1298613B1 - Chelati complessi di manganese ad alta relassivita' in siero - Google Patents

Chelati complessi di manganese ad alta relassivita' in siero

Info

Publication number
IT1298613B1
IT1298613B1 IT98MI000476A ITMI980476A IT1298613B1 IT 1298613 B1 IT1298613 B1 IT 1298613B1 IT 98MI000476 A IT98MI000476 A IT 98MI000476A IT MI980476 A ITMI980476 A IT MI980476A IT 1298613 B1 IT1298613 B1 IT 1298613B1
Authority
IT
Italy
Prior art keywords
serum
manganese complex
high relaxation
complex chelates
chelates
Prior art date
Application number
IT98MI000476A
Other languages
English (en)
Inventor
Fulvio Uggeri
Marino Brocchetta
Luisella Calabi
Lino Paleari
Daniela Palano
Original Assignee
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Spa filed Critical Bracco Spa
Priority to IT98MI000476A priority Critical patent/IT1298613B1/it
Priority to DE69904450T priority patent/DE69904450T2/de
Priority to US09/601,576 priority patent/US6337064B1/en
Priority to JP2000535380A priority patent/JP4643824B2/ja
Priority to PCT/EP1999/001490 priority patent/WO1999045967A1/en
Priority to EP99910335A priority patent/EP1061956B1/en
Publication of ITMI980476A1 publication Critical patent/ITMI980476A1/it
Application granted granted Critical
Publication of IT1298613B1 publication Critical patent/IT1298613B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
IT98MI000476A 1998-03-10 1998-03-10 Chelati complessi di manganese ad alta relassivita' in siero IT1298613B1 (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT98MI000476A IT1298613B1 (it) 1998-03-10 1998-03-10 Chelati complessi di manganese ad alta relassivita' in siero
DE69904450T DE69904450T2 (de) 1998-03-10 1999-03-08 Mangan-chelat mit hoher relaxivität im serum
US09/601,576 US6337064B1 (en) 1998-03-10 1999-03-08 Manganese chelates with high relaxivity in serum
JP2000535380A JP4643824B2 (ja) 1998-03-10 1999-03-08 血清中で高い緩和性を有するマンガンキレート
PCT/EP1999/001490 WO1999045967A1 (en) 1998-03-10 1999-03-08 Manganese chelates with high relaxivity in serum
EP99910335A EP1061956B1 (en) 1998-03-10 1999-03-08 Manganese chelates with high relaxivity in serum

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT98MI000476A IT1298613B1 (it) 1998-03-10 1998-03-10 Chelati complessi di manganese ad alta relassivita' in siero

Publications (2)

Publication Number Publication Date
ITMI980476A1 ITMI980476A1 (it) 1999-09-10
IT1298613B1 true IT1298613B1 (it) 2000-01-12

Family

ID=11379241

Family Applications (1)

Application Number Title Priority Date Filing Date
IT98MI000476A IT1298613B1 (it) 1998-03-10 1998-03-10 Chelati complessi di manganese ad alta relassivita' in siero

Country Status (6)

Country Link
US (1) US6337064B1 (it)
EP (1) EP1061956B1 (it)
JP (1) JP4643824B2 (it)
DE (1) DE69904450T2 (it)
IT (1) IT1298613B1 (it)
WO (1) WO1999045967A1 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9746985B1 (en) 2008-02-25 2017-08-29 Georgetown University System and method for detecting, collecting, analyzing, and communicating event-related information
GB201403248D0 (en) * 2014-02-25 2014-04-09 Univ Singapore Contrast agent and applications thereof
KR20200143701A (ko) 2018-04-04 2020-12-24 신소닉스, 인코포레이티드 메탈로-리오티로닌

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980148A (en) * 1985-02-06 1990-12-25 Mallinckrodt, Inc. Methods for enhancing magnetic resonance imaging
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
IT1283650B1 (it) 1996-08-02 1998-04-23 Bracco Spa Chelati paramagnetici ad alta relassivita' in siero
IT1283651B1 (it) 1996-08-02 1998-04-23 Bracco Spa Chelati paramagnetici ad alta relassivita' in siero

Also Published As

Publication number Publication date
EP1061956B1 (en) 2002-12-11
JP2002506049A (ja) 2002-02-26
EP1061956A1 (en) 2000-12-27
DE69904450T2 (de) 2003-04-17
WO1999045967A1 (en) 1999-09-16
US6337064B1 (en) 2002-01-08
ITMI980476A1 (it) 1999-09-10
DE69904450D1 (de) 2003-01-23
JP4643824B2 (ja) 2011-03-02

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Legal Events

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0001 Granted