IT1283651B1 - Chelati paramagnetici ad alta relassivita' in siero - Google Patents
Chelati paramagnetici ad alta relassivita' in sieroInfo
- Publication number
- IT1283651B1 IT1283651B1 IT96MI001685A ITMI961685A IT1283651B1 IT 1283651 B1 IT1283651 B1 IT 1283651B1 IT 96MI001685 A IT96MI001685 A IT 96MI001685A IT MI961685 A ITMI961685 A IT MI961685A IT 1283651 B1 IT1283651 B1 IT 1283651B1
- Authority
- IT
- Italy
- Prior art keywords
- serum
- high relaxation
- paramagnetic chelates
- chelates
- paramagnetic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/48—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI001685A IT1283651B1 (it) | 1996-08-02 | 1996-08-02 | Chelati paramagnetici ad alta relassivita' in siero |
PCT/EP1997/003997 WO1998005626A1 (en) | 1996-08-02 | 1997-07-24 | Diagnostic imaging contrast agent with improved in-serum-relaxivity |
EP97938855A EP0920411A1 (en) | 1996-08-02 | 1997-07-24 | Diagnostic imaging contrast agent with improved in-serum-relaxivity |
JP50563698A JP4070241B2 (ja) | 1996-08-02 | 1997-07-24 | 改善された血清緩和性(In―Serum―Relaxivity)を有する診断用画像造影剤 |
AU41159/97A AU4115997A (en) | 1996-08-02 | 1997-07-24 | Diagnostic imaging contrast agent with improved in-serum-relaxivity |
ZA9706889A ZA976889B (en) | 1996-08-02 | 1997-08-01 | Diagnostic imaging contrast agent. |
US09/620,594 US6458337B1 (en) | 1996-08-02 | 2000-07-20 | Diagnostic imaging contrast agent with improved in serum relaxivity |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI001685A IT1283651B1 (it) | 1996-08-02 | 1996-08-02 | Chelati paramagnetici ad alta relassivita' in siero |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI961685A0 ITMI961685A0 (it) | 1996-08-02 |
ITMI961685A1 ITMI961685A1 (it) | 1998-02-02 |
IT1283651B1 true IT1283651B1 (it) | 1998-04-23 |
Family
ID=11374756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT96MI001685A IT1283651B1 (it) | 1996-08-02 | 1996-08-02 | Chelati paramagnetici ad alta relassivita' in siero |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0920411A1 (it) |
JP (1) | JP4070241B2 (it) |
AU (1) | AU4115997A (it) |
IT (1) | IT1283651B1 (it) |
WO (1) | WO1998005626A1 (it) |
ZA (1) | ZA976889B (it) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1298613B1 (it) | 1998-03-10 | 2000-01-12 | Bracco Spa | Chelati complessi di manganese ad alta relassivita' in siero |
US6342598B1 (en) | 1998-11-26 | 2002-01-29 | Bracco International B.V. | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents |
US6549798B2 (en) | 2001-02-07 | 2003-04-15 | Epix Medical, Inc. | Magnetic resonance angiography data |
TWI221406B (en) | 2001-07-30 | 2004-10-01 | Epix Medical Inc | Systems and methods for targeted magnetic resonance imaging of the vascular system |
EP1369134A1 (en) * | 2002-06-05 | 2003-12-10 | Bracco Imaging S.p.A. | New agents for magnetic imaging method |
WO2006026038A1 (en) * | 2004-08-26 | 2006-03-09 | Mallinckrodt Inc. | Luminescent metal complexes for monitoring renal function |
JP5064761B2 (ja) * | 2005-12-21 | 2012-10-31 | 富士フイルム株式会社 | ジエチレントリアミン型金属キレート構造を有する高級脂肪酸トリエステル及びアミド誘導体 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4341724A1 (de) * | 1993-12-03 | 1995-06-08 | Schering Ag | Halogenaryl-substituierte Metallkomplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel |
DE19508058A1 (de) * | 1995-02-21 | 1996-08-22 | Schering Ag | Verfahren zur Herstellung von DTPA-Tetraestern der terminalen Carbonsäuren und deren Verwendung zur Herstellung pharmazeutischer Mittel |
-
1996
- 1996-08-02 IT IT96MI001685A patent/IT1283651B1/it active IP Right Grant
-
1997
- 1997-07-24 WO PCT/EP1997/003997 patent/WO1998005626A1/en not_active Application Discontinuation
- 1997-07-24 JP JP50563698A patent/JP4070241B2/ja not_active Expired - Fee Related
- 1997-07-24 AU AU41159/97A patent/AU4115997A/en not_active Abandoned
- 1997-07-24 EP EP97938855A patent/EP0920411A1/en not_active Withdrawn
- 1997-08-01 ZA ZA9706889A patent/ZA976889B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP0920411A1 (en) | 1999-06-09 |
ITMI961685A1 (it) | 1998-02-02 |
JP4070241B2 (ja) | 2008-04-02 |
WO1998005626A1 (en) | 1998-02-12 |
ITMI961685A0 (it) | 1996-08-02 |
JP2001522348A (ja) | 2001-11-13 |
ZA976889B (en) | 1998-05-11 |
AU4115997A (en) | 1998-02-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted |