IT1252180B - 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono - Google Patents

5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono

Info

Publication number
IT1252180B
IT1252180B ITMI913305A ITMI913305A IT1252180B IT 1252180 B IT1252180 B IT 1252180B IT MI913305 A ITMI913305 A IT MI913305A IT MI913305 A ITMI913305 A IT MI913305A IT 1252180 B IT1252180 B IT 1252180B
Authority
IT
Italy
Prior art keywords
bis
propandiil
etandiil
benzendicarboxy
acetylimine
Prior art date
Application number
ITMI913305A
Other languages
English (en)
Inventor
Pierlucio Anelli
Marino Brocchetta
Fulvio Uggeri
Massimo Visigalli
Original Assignee
Bracco Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Ind Chimica Spa filed Critical Bracco Ind Chimica Spa
Publication of ITMI913305A0 publication Critical patent/ITMI913305A0/it
Priority to ITMI913305A priority Critical patent/IT1252180B/it
Priority to AU30836/92A priority patent/AU3083692A/en
Priority to PCT/EP1992/002770 priority patent/WO1993012071A1/en
Priority to JP5510558A priority patent/JPH07502031A/ja
Priority to AT92924632T priority patent/ATE142615T1/de
Priority to DE69213768T priority patent/DE69213768T2/de
Priority to US08/244,598 priority patent/US5464607A/en
Priority to CZ941339A priority patent/CZ133994A3/cs
Priority to SK658-94A priority patent/SK65894A3/sk
Priority to EP92924632A priority patent/EP0642492B1/en
Publication of ITMI913305A1 publication Critical patent/ITMI913305A1/it
Priority to NO942028A priority patent/NO942028L/no
Application granted granted Critical
Publication of IT1252180B publication Critical patent/IT1252180B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Abstract

I composti di formula I (FORMULA I) dove R1, R2, R3, R'1, R2', R'3 hanno i significati dati nella rivendicazione 1, sono utili come mezzi di contrasto roentgenografici.
ITMI913305A 1991-12-10 1991-12-10 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono IT1252180B (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ITMI913305A IT1252180B (it) 1991-12-10 1991-12-10 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
US08/244,598 US5464607A (en) 1991-12-10 1992-12-01 5,5'-/(1,3-propanediyl) bis-/imino(2-oxo-2,1-ethanediyl)acetylimino/bis(2,4,6-triiodo-1,3-benzenedicarboxylamides), and contrast media containing them
PCT/EP1992/002770 WO1993012071A1 (en) 1991-12-10 1992-12-01 5,5'-/(1,3-propanediyl) bis-/imino(2-oxo-2,1-ethanediyl)acetylimino/bis(2,4,6-triiodo-1,3-benzenedicarboxyamides), and contrast media containing them
JP5510558A JPH07502031A (ja) 1991-12-10 1992-12-01 ５，５’−／（１，３−プロパンジイル）ビスー／イミノ（２−オキソー２，１−エタンジイル）アセチルイミノ／ビス（２，４，６−トリヨードー１，３−ベンゼンジカルボキシアミド）類，およびこれらを含有する造影剤
AT92924632T ATE142615T1 (de) 1991-12-10 1992-12-01 5,5'-((1,3-propandiyl)bis-(imino(2-oxo-2,1- ethandiyl)acetylimino>>bis(2,4,6-triiodo-1,3- benzenedicarboxyamide), und diese verbindungen enthaltendes kontrastmittel
DE69213768T DE69213768T2 (de) 1991-12-10 1992-12-01 5,5'-[(1,3-propandiyl)bis-[imino(2-oxo-2,1-ethandiyl)acetylimino]]bis(2,4,6-triiodo-1,3-benzenedicarboxyamide), und diese verbindungen enthaltendes kontrastmittel
AU30836/92A AU3083692A (en) 1991-12-10 1992-12-01 5,5'-/(1,3-propanediyl) bis-/imino(2-oxo-2,1-ethanediyl)acetylimino/bis(2,4,6-triiod o-1,3-benzenedicarboxyamides), and contrast media containing them
CZ941339A CZ133994A3 (en) 1991-12-10 1992-12-01 Symmetrical and asymmetrical derivatives of 5,5' -/(1,3-propanediyl) bis-/imino(2-oxo-2,1-ethanediyl)acetylimino)/-bis(2,4,6-triiodo-1,3 -benzenedicarboxyamides), process of their preparation and contrast media containing thereof
SK658-94A SK65894A3 (en) 1991-12-10 1992-12-01 5,5'-{(1,3-propanediyl)bis-[imino(2-oxo-2,1-ethanediyl) acetylamino]}bis(2,4,6-triiodo-1,3-benzenedicarboxyamides) and contrast media containing them
EP92924632A EP0642492B1 (en) 1991-12-10 1992-12-01 5,5'-/(1,3-propanediyl) bis-/imino(2-oxo-2,1-ethanediyl)acetylimino/bis(2,4,6-triiodo-1,3-benzenedicarboxyamides), and contrast media containing them
NO942028A NO942028L (no) 1991-12-10 1994-06-01 5,5'-/(1,3-propandiyl)bis/imino-(2-okso-2,1-etandiyl)-acetylimino/-bis(2,4,6-trijod-1,3-benzendikarboksy-amider), og kontrastmedier inneholdende dem

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI913305A IT1252180B (it) 1991-12-10 1991-12-10 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono

Publications (3)

Publication Number Publication Date
ITMI913305A0 ITMI913305A0 (it) 1991-12-10
ITMI913305A1 ITMI913305A1 (it) 1993-06-10
IT1252180B true IT1252180B (it) 1995-06-05

Family

ID=11361297

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI913305A IT1252180B (it) 1991-12-10 1991-12-10 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono

Country Status (11)

Country Link
US (1) US5464607A (it)
EP (1) EP0642492B1 (it)
JP (1) JPH07502031A (it)
AT (1) ATE142615T1 (it)
AU (1) AU3083692A (it)
CZ (1) CZ133994A3 (it)
DE (1) DE69213768T2 (it)
IT (1) IT1252180B (it)
NO (1) NO942028L (it)
SK (1) SK65894A3 (it)
WO (1) WO1993012071A1 (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1271134B (it) * 1994-12-01 1997-05-26 Bracco Spa Derivati iodurati del bifenile e loro impiego diagnostico
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
WO2006002873A2 (en) 2004-07-02 2006-01-12 Bracco Imaging Spa 1 , 4 -bis (carboxymethyl) -6- ' bis ( carboxymethyl) amino ! -6 -methyl- perhydro-1 , 4 diazepine (aazta) derivatives as ligands in high relaxivity contrast agents for use in magnetic resonance imaging (mri )
WO2006039505A2 (en) * 2004-09-30 2006-04-13 Molecular Devices Corporation Luminescent lanthanide complexes
EP1986993B1 (en) * 2006-02-14 2012-12-05 Ge Healthcare As Contrast agents
CN105294472A (zh) * 2015-11-17 2016-02-03 浙江海洲制药有限公司 碘帕醇杂质c的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE315975B (it) * 1967-12-28 1969-10-13 Pharmacia Ab
AR207465A1 (es) * 1974-05-31 1976-10-08 Guerbet Lab Andre Procedimiento de preparacion de derivados de acido triiodoi2,4,6-(triiodo-2,4,6-benzoil)-amino-alcanoilaminobenzoico de acido triiodo-2,4,6-(triiodo-2,4,6-(triiodo-2,4,6-benzoil)-aminoalcanoilaminobenzoil)-amino-alcanoil-aminobenzoico y de acido triiodo-2,4,6-bis((triiodo-2,4,6-fenil)-carbamoil-metil)-aminoalcanoil-aminobenzoico
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
DE2852094A1 (de) * 1978-11-30 1980-06-12 Schering Ag Neue roentgenkontrastmittel
DK273280A (da) * 1979-06-28 1980-12-29 Schering Ag Trijoderede 5-aminoisophthalsyrederivater
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
EP0108638B1 (en) * 1982-11-08 1986-07-16 NYEGAARD & CO. A/S X-ray contrast agents
DE3739098A1 (de) * 1987-11-16 1989-05-24 Schering Ag Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel

Also Published As

Publication number Publication date
ATE142615T1 (de) 1996-09-15
ITMI913305A1 (it) 1993-06-10
WO1993012071A1 (en) 1993-06-24
AU3083692A (en) 1993-07-19
NO942028L (no) 1994-08-05
CZ133994A3 (en) 1994-12-15
EP0642492A1 (en) 1995-03-15
EP0642492B1 (en) 1996-09-11
NO942028D0 (no) 1994-06-01
JPH07502031A (ja) 1995-03-02
SK65894A3 (en) 1994-12-07
DE69213768T2 (de) 1997-01-23
DE69213768D1 (de) 1996-10-17
US5464607A (en) 1995-11-07
ITMI913305A0 (it) 1991-12-10

Similar Documents

Publication Publication Date Title
ATE187724T1 (de) Azachinoxaline, verfahren zu ihrer herstellung und ihre verwendung
ATE175201T1 (de) Mono-n-substituierte 1,4,7,10- tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
ATE236886T1 (de) 2,4-dioxo-imidazolidin-derivate
ATE148610T1 (de) Antimikrobielle mittel sowie substituierte 2- cyclohexan-1-yl-amin-derivate und deren herstellung
MX9605128A (es) Nuevos derivados de aminoacidos, procedimientos para su preparacion y composiciones farmaceuticas que contienen estos compuestos.
BG103310A (en) Benzonaphthyridins as bronchial therapeutical means
ATE206130T1 (de) Methylphosphonsäureester, verfahren zu deren herstellung und deren verwendung
ATE205837T1 (de) Chinoxaline, verfahren zu ihrer herstellung und ihre verwendung
DK0548794T3 (da) Polyaspartamidderivater som adsorptionsmidler for galdesyrer, polyaspartamidderivater ladet med galdesyrer, fremgangsmåder
RU93047920A (ru) Замещенные (пиридиниламино)-бензизоксазолы и бензо-[в]тиофены, способ их получения и фармацевтическая композиция
IT1252180B (it) 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
CA2183050A1 (en) Sulfonyl- or sulfinylbenzoylguanidine derivatives
IT1274038B (it) Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
ATE66209T1 (de) Dihydropyridinamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
CA2157143A1 (en) Alkylbenzoylguanidine derivatives
EP0331092A3 (en) Alpha-amino-carboxylic-acid derivatives, their preparation and use
AU3196293A (en) Heteroaryl substituted biphenylmethyl benzimidazoles
DK464586A (da) Phosphorforbindelser
BG98238A (en) Substituted benzothiazole derivatives, methods for their preparation and their application as herbicides
ATE163402T1 (de) Substituierte ortho- ethenylphenylessigsäurederivate
BG101221A (en) N-substituted azabicycloheptane derivatives useful as neuroleptics
DE69112432D1 (de) Derivate von methylpiperazinoazepin, verfahren zu ihrer herstellung und verwendung.
RU94021365A (ru) Производные метилпиперазиназепина, способ их получения, фармацевтическая композиция на их основе и использование производных в качестве фармацевтически активного вещества
IT1255179B (it) Azaciclo e azabiciclo alchiliden idrossilamine
DE59001431D1 (de) 1-methoxypyrimidinyl-1h-1,2,4-triazol-3-sulfonsaeurenitroanilide, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider wirkung.

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19951227