AU3196293A - Heteroaryl substituted biphenylmethyl benzimidazoles - Google Patents
Heteroaryl substituted biphenylmethyl benzimidazolesInfo
- Publication number
- AU3196293A AU3196293A AU31962/93A AU3196293A AU3196293A AU 3196293 A AU3196293 A AU 3196293A AU 31962/93 A AU31962/93 A AU 31962/93A AU 3196293 A AU3196293 A AU 3196293A AU 3196293 A AU3196293 A AU 3196293A
- Authority
- AU
- Australia
- Prior art keywords
- benzimidazoles
- heteroaryl substituted
- substituted biphenylmethyl
- biphenylmethyl
- formuala
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
The invention relates to benzimidazoles of the general formuala <IMAGE> in which R1 to R4 are as defined in Claim 1, and their salts, which have useful properties. The novel compounds are, in particular, angiotensin antagonists.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4201554 | 1992-01-22 | ||
DE4201554A DE4201554A1 (en) | 1992-01-22 | 1992-01-22 | New benzimidazol-1-yl-methyl-bi:phenyl derivs. |
DE4219782A DE4219782A1 (en) | 1992-01-22 | 1992-06-17 | New benzimidazol-1-yl-methyl-bi:phenyl derivs. |
DE4219782 | 1992-06-17 | ||
DE4225756 | 1992-08-04 | ||
DE4225756A DE4225756A1 (en) | 1992-01-22 | 1992-08-04 | Benzimidazoles, medicaments containing these compounds and process for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
AU3196293A true AU3196293A (en) | 1993-07-29 |
AU660209B2 AU660209B2 (en) | 1995-06-15 |
Family
ID=27203316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU31962/93A Ceased AU660209B2 (en) | 1992-01-22 | 1993-01-22 | Heteroaryl substituted biphenylmethyl benzimidazoles |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0552765B1 (en) |
JP (1) | JPH05279341A (en) |
AT (1) | ATE141270T1 (en) |
AU (1) | AU660209B2 (en) |
CA (1) | CA2087800A1 (en) |
CZ (1) | CZ394492A3 (en) |
DE (2) | DE4225756A1 (en) |
DK (1) | DK0552765T3 (en) |
ES (1) | ES2093286T3 (en) |
FI (1) | FI930236A (en) |
GR (1) | GR3021303T3 (en) |
HU (1) | HU217816B (en) |
IL (1) | IL104485A (en) |
MX (1) | MX9300306A (en) |
NO (1) | NO303689B1 (en) |
NZ (1) | NZ245741A (en) |
PL (1) | PL172782B1 (en) |
SK (1) | SK279409B6 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2115985A1 (en) * | 1993-02-25 | 1994-08-26 | Kohei Nishikawa | Vascular hypertrophy suppressor |
EP2448576A2 (en) | 2009-07-02 | 2012-05-09 | Mahmut Bilgic | Solubility enhancing pharmaceutical composition |
EP2448575A2 (en) | 2009-07-02 | 2012-05-09 | Bilgic Mahmut | Pharmaceutical composition increasing solubility and stability |
EP2377521A1 (en) | 2010-03-26 | 2011-10-19 | Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi | Pharmaceutical formulations of telmisartan and diuretic combination |
US9636328B2 (en) | 2013-06-21 | 2017-05-02 | Zenith Epigenetics Ltd. | Substituted bicyclic compounds as bromodomain inhibitors |
PT3010503T (en) | 2013-06-21 | 2020-06-16 | Zenith Epigenetics Corp | Novel bicyclic bromodomain inhibitors |
EP3027604B1 (en) | 2013-07-31 | 2019-02-20 | Zenith Epigenetics Ltd. | Novel quinazolinones as bromodomain inhibitors |
WO2016087936A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Corp. | Substituted pyridinones as bromodomain inhibitors |
CN107207474B (en) | 2014-12-11 | 2021-05-07 | 恒翼生物医药科技(上海)有限公司 | Substituted heterocycles as bromodomain inhibitors |
CN107406438B (en) | 2014-12-17 | 2021-05-14 | 恒翼生物医药科技(上海)有限公司 | Inhibitors of bromodomains |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3928177A1 (en) * | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | BENZIMIDAZOLE, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
CA2016710A1 (en) * | 1989-05-15 | 1990-11-15 | Prasun K. Chakravarty | Substituted benzimidazoles as angiotensin ii antagonists |
RU1836357C (en) * | 1990-07-23 | 1993-08-23 | Др.Карл Томэ ГмбХ | Benzimidazole derivatives, their isomers, mixtures of isomers, hydrates or their physiologically bearable salts possessing properties antagonistic to angiotenzine |
SI9210098B (en) | 1991-02-06 | 2000-06-30 | Dr. Karl Thomae | Benzimidazoles, drugs with this compounds, and process for their preparation |
-
1992
- 1992-08-04 DE DE4225756A patent/DE4225756A1/en not_active Withdrawn
- 1992-12-29 SK SK3944-92A patent/SK279409B6/en unknown
- 1992-12-29 CZ CS923944A patent/CZ394492A3/en unknown
-
1993
- 1993-01-20 PL PL93297472A patent/PL172782B1/en unknown
- 1993-01-21 NO NO930205A patent/NO303689B1/en unknown
- 1993-01-21 AT AT93100890T patent/ATE141270T1/en not_active IP Right Cessation
- 1993-01-21 CA CA002087800A patent/CA2087800A1/en not_active Abandoned
- 1993-01-21 DK DK93100890.8T patent/DK0552765T3/en active
- 1993-01-21 JP JP5008004A patent/JPH05279341A/en active Pending
- 1993-01-21 MX MX9300306A patent/MX9300306A/en not_active IP Right Cessation
- 1993-01-21 DE DE59303388T patent/DE59303388D1/en not_active Expired - Fee Related
- 1993-01-21 ES ES93100890T patent/ES2093286T3/en not_active Expired - Lifetime
- 1993-01-21 HU HU9300168A patent/HU217816B/en not_active IP Right Cessation
- 1993-01-21 FI FI930236A patent/FI930236A/en unknown
- 1993-01-21 EP EP93100890A patent/EP0552765B1/en not_active Expired - Lifetime
- 1993-01-22 AU AU31962/93A patent/AU660209B2/en not_active Ceased
- 1993-01-22 NZ NZ245741A patent/NZ245741A/en unknown
- 1993-01-22 IL IL10448593A patent/IL104485A/en not_active IP Right Cessation
-
1996
- 1996-10-09 GR GR960402674T patent/GR3021303T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
SK394492A3 (en) | 1998-11-04 |
JPH05279341A (en) | 1993-10-26 |
DE59303388D1 (en) | 1996-09-19 |
SK279409B6 (en) | 1998-11-04 |
PL172782B1 (en) | 1997-11-28 |
DK0552765T3 (en) | 1997-01-13 |
EP0552765A1 (en) | 1993-07-28 |
AU660209B2 (en) | 1995-06-15 |
PL297472A1 (en) | 1994-01-24 |
NZ245741A (en) | 1995-07-26 |
ES2093286T3 (en) | 1996-12-16 |
HUT63626A (en) | 1993-09-28 |
FI930236A0 (en) | 1993-01-21 |
ATE141270T1 (en) | 1996-08-15 |
CZ394492A3 (en) | 1993-11-17 |
NO930205L (en) | 1993-07-23 |
MX9300306A (en) | 1993-07-01 |
GR3021303T3 (en) | 1997-01-31 |
DE4225756A1 (en) | 1994-03-10 |
CA2087800A1 (en) | 1993-07-23 |
NO303689B1 (en) | 1998-08-17 |
HU9300168D0 (en) | 1993-04-28 |
IL104485A (en) | 1999-10-28 |
IL104485A0 (en) | 1993-05-13 |
EP0552765B1 (en) | 1996-08-14 |
HU217816B (en) | 2000-04-28 |
NO930205D0 (en) | 1993-01-21 |
FI930236A (en) | 1993-07-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU8122791A (en) | Benzimidazoles | |
IE901246L (en) | Benzimidazoles | |
AU4755393A (en) | Azaquinoxalines, processes for their preparation and their use | |
DK0530505T3 (en) | hydantoin derivatives | |
PH30006A (en) | 9-¬(Substituted glycol)amido¾-6.demethyl-6-deoxytetra-cyclines | |
IT1270882B (en) | FUNGICIDE-BASED OLIGOPEPTIDES | |
AU3196293A (en) | Heteroaryl substituted biphenylmethyl benzimidazoles | |
DK0623620T3 (en) | 5-HT 3 pyrrolopyrazinderivater | |
AU7610194A (en) | Thiocarbamoyl compounds used as antimicrobial agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |