IL104485A0 - Benzimidazoles,their preparation and pharmaceutical compositions containing them - Google Patents
Benzimidazoles,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL104485A0 IL104485A0 IL104485A IL10448593A IL104485A0 IL 104485 A0 IL104485 A0 IL 104485A0 IL 104485 A IL104485 A IL 104485A IL 10448593 A IL10448593 A IL 10448593A IL 104485 A0 IL104485 A0 IL 104485A0
- Authority
- IL
- Israel
- Prior art keywords
- benzimidazoles
- preparation
- pharmaceutical compositions
- compositions containing
- formuala
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
The invention relates to benzimidazoles of the general formuala <IMAGE> in which R1 to R4 are as defined in Claim 1, and their salts, which have useful properties. The novel compounds are, in particular, angiotensin antagonists.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4201554A DE4201554A1 (en) | 1992-01-22 | 1992-01-22 | New benzimidazol-1-yl-methyl-bi:phenyl derivs. |
DE4219782A DE4219782A1 (en) | 1992-01-22 | 1992-06-17 | New benzimidazol-1-yl-methyl-bi:phenyl derivs. |
DE4225756A DE4225756A1 (en) | 1992-01-22 | 1992-08-04 | Benzimidazoles, medicaments containing these compounds and process for their preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
IL104485A0 true IL104485A0 (en) | 1993-05-13 |
IL104485A IL104485A (en) | 1999-10-28 |
Family
ID=27203316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10448593A IL104485A (en) | 1992-01-22 | 1993-01-22 | Benzimidazole derivatives their preparation and pharmaceutical compositions containing them |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0552765B1 (en) |
JP (1) | JPH05279341A (en) |
AT (1) | ATE141270T1 (en) |
AU (1) | AU660209B2 (en) |
CA (1) | CA2087800A1 (en) |
CZ (1) | CZ394492A3 (en) |
DE (2) | DE4225756A1 (en) |
DK (1) | DK0552765T3 (en) |
ES (1) | ES2093286T3 (en) |
FI (1) | FI930236A (en) |
GR (1) | GR3021303T3 (en) |
HU (1) | HU217816B (en) |
IL (1) | IL104485A (en) |
MX (1) | MX9300306A (en) |
NO (1) | NO303689B1 (en) |
NZ (1) | NZ245741A (en) |
PL (1) | PL172782B1 (en) |
SK (1) | SK279409B6 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2115985A1 (en) * | 1993-02-25 | 1994-08-26 | Kohei Nishikawa | Vascular hypertrophy suppressor |
EP2448576A2 (en) | 2009-07-02 | 2012-05-09 | Mahmut Bilgic | Solubility enhancing pharmaceutical composition |
EP2448575A2 (en) | 2009-07-02 | 2012-05-09 | Bilgic Mahmut | Pharmaceutical composition increasing solubility and stability |
EP2377521A1 (en) | 2010-03-26 | 2011-10-19 | Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi | Pharmaceutical formulations of telmisartan and diuretic combination |
PT3010503T (en) | 2013-06-21 | 2020-06-16 | Zenith Epigenetics Corp | Novel bicyclic bromodomain inhibitors |
WO2015004534A2 (en) | 2013-06-21 | 2015-01-15 | Zenith Epigenetics Corp. | Novel substituted bicyclic compounds as bromodomain inhibitors |
US9855271B2 (en) | 2013-07-31 | 2018-01-02 | Zenith Epigenetics Ltd. | Quinazolinones as bromodomain inhibitors |
WO2016087936A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Corp. | Substituted pyridinones as bromodomain inhibitors |
US10292968B2 (en) | 2014-12-11 | 2019-05-21 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
CN107406438B (en) | 2014-12-17 | 2021-05-14 | 恒翼生物医药科技(上海)有限公司 | Inhibitors of bromodomains |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3928177A1 (en) * | 1989-04-08 | 1991-02-28 | Thomae Gmbh Dr K | BENZIMIDAZOLE, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
EP0400835A1 (en) * | 1989-05-15 | 1990-12-05 | Merck & Co. Inc. | Substituted benzimidazoles as angiotensin II antagonists |
RU1836357C (en) * | 1990-07-23 | 1993-08-23 | Др.Карл Томэ ГмбХ | Benzimidazole derivatives, their isomers, mixtures of isomers, hydrates or their physiologically bearable salts possessing properties antagonistic to angiotenzine |
SI9210098B (en) | 1991-02-06 | 2000-06-30 | Dr. Karl Thomae | Benzimidazoles, drugs with this compounds, and process for their preparation |
-
1992
- 1992-08-04 DE DE4225756A patent/DE4225756A1/en not_active Withdrawn
- 1992-12-29 CZ CS923944A patent/CZ394492A3/en unknown
- 1992-12-29 SK SK3944-92A patent/SK279409B6/en unknown
-
1993
- 1993-01-20 PL PL93297472A patent/PL172782B1/en unknown
- 1993-01-21 DK DK93100890.8T patent/DK0552765T3/en active
- 1993-01-21 ES ES93100890T patent/ES2093286T3/en not_active Expired - Lifetime
- 1993-01-21 HU HU9300168A patent/HU217816B/en not_active IP Right Cessation
- 1993-01-21 AT AT93100890T patent/ATE141270T1/en not_active IP Right Cessation
- 1993-01-21 MX MX9300306A patent/MX9300306A/en not_active IP Right Cessation
- 1993-01-21 NO NO930205A patent/NO303689B1/en unknown
- 1993-01-21 JP JP5008004A patent/JPH05279341A/en active Pending
- 1993-01-21 EP EP93100890A patent/EP0552765B1/en not_active Expired - Lifetime
- 1993-01-21 DE DE59303388T patent/DE59303388D1/en not_active Expired - Fee Related
- 1993-01-21 FI FI930236A patent/FI930236A/en unknown
- 1993-01-21 CA CA002087800A patent/CA2087800A1/en not_active Abandoned
- 1993-01-22 NZ NZ245741A patent/NZ245741A/en unknown
- 1993-01-22 IL IL10448593A patent/IL104485A/en not_active IP Right Cessation
- 1993-01-22 AU AU31962/93A patent/AU660209B2/en not_active Ceased
-
1996
- 1996-10-09 GR GR960402674T patent/GR3021303T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX9300306A (en) | 1993-07-01 |
HU9300168D0 (en) | 1993-04-28 |
NO303689B1 (en) | 1998-08-17 |
FI930236A (en) | 1993-07-23 |
ATE141270T1 (en) | 1996-08-15 |
SK394492A3 (en) | 1998-11-04 |
HUT63626A (en) | 1993-09-28 |
SK279409B6 (en) | 1998-11-04 |
HU217816B (en) | 2000-04-28 |
CZ394492A3 (en) | 1993-11-17 |
NO930205D0 (en) | 1993-01-21 |
PL172782B1 (en) | 1997-11-28 |
AU3196293A (en) | 1993-07-29 |
GR3021303T3 (en) | 1997-01-31 |
NO930205L (en) | 1993-07-23 |
DE59303388D1 (en) | 1996-09-19 |
IL104485A (en) | 1999-10-28 |
AU660209B2 (en) | 1995-06-15 |
ES2093286T3 (en) | 1996-12-16 |
EP0552765B1 (en) | 1996-08-14 |
FI930236A0 (en) | 1993-01-21 |
CA2087800A1 (en) | 1993-07-23 |
DE4225756A1 (en) | 1994-03-10 |
DK0552765T3 (en) | 1997-01-13 |
EP0552765A1 (en) | 1993-07-28 |
JPH05279341A (en) | 1993-10-26 |
PL297472A1 (en) | 1994-01-24 |
NZ245741A (en) | 1995-07-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
RH | Patent void |