NO930205L - BENZIMIDAZOLES, PHARMACEUTICALS CONTAINING THESE, AND PROCEDURE FOR THEIR PREPARATION - Google Patents

BENZIMIDAZOLES, PHARMACEUTICALS CONTAINING THESE, AND PROCEDURE FOR THEIR PREPARATION

Info

Publication number
NO930205L
NO930205L NO93930205A NO930205A NO930205L NO 930205 L NO930205 L NO 930205L NO 93930205 A NO93930205 A NO 93930205A NO 930205 A NO930205 A NO 930205A NO 930205 L NO930205 L NO 930205L
Authority
NO
Norway
Prior art keywords
benzimidazoles
procedure
preparation
pharmaceuticals containing
pharmaceuticals
Prior art date
Application number
NO93930205A
Other languages
Norwegian (no)
Other versions
NO930205D0 (en
NO303689B1 (en
Inventor
Norbert Hauel
Berthold Narr
Uwe Ries
Jacques Van Meel
Wolfgang Wienen
Michael Entzeroth
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4201554A external-priority patent/DE4201554A1/en
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO930205D0 publication Critical patent/NO930205D0/en
Publication of NO930205L publication Critical patent/NO930205L/en
Publication of NO303689B1 publication Critical patent/NO303689B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Toys (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Instructional Devices (AREA)

Abstract

The invention relates to benzimidazoles of the general formuala <IMAGE> in which R1 to R4 are as defined in Claim 1, and their salts, which have useful properties. The novel compounds are, in particular, angiotensin antagonists.
NO930205A 1992-01-22 1993-01-21 Benzimidazoles and medicines containing them NO303689B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4201554A DE4201554A1 (en) 1992-01-22 1992-01-22 New benzimidazol-1-yl-methyl-bi:phenyl derivs.
DE4219782A DE4219782A1 (en) 1992-01-22 1992-06-17 New benzimidazol-1-yl-methyl-bi:phenyl derivs.
DE4225756A DE4225756A1 (en) 1992-01-22 1992-08-04 Benzimidazoles, medicaments containing these compounds and process for their preparation

Publications (3)

Publication Number Publication Date
NO930205D0 NO930205D0 (en) 1993-01-21
NO930205L true NO930205L (en) 1993-07-23
NO303689B1 NO303689B1 (en) 1998-08-17

Family

ID=27203316

Family Applications (1)

Application Number Title Priority Date Filing Date
NO930205A NO303689B1 (en) 1992-01-22 1993-01-21 Benzimidazoles and medicines containing them

Country Status (18)

Country Link
EP (1) EP0552765B1 (en)
JP (1) JPH05279341A (en)
AT (1) ATE141270T1 (en)
AU (1) AU660209B2 (en)
CA (1) CA2087800A1 (en)
CZ (1) CZ394492A3 (en)
DE (2) DE4225756A1 (en)
DK (1) DK0552765T3 (en)
ES (1) ES2093286T3 (en)
FI (1) FI930236A (en)
GR (1) GR3021303T3 (en)
HU (1) HU217816B (en)
IL (1) IL104485A (en)
MX (1) MX9300306A (en)
NO (1) NO303689B1 (en)
NZ (1) NZ245741A (en)
PL (1) PL172782B1 (en)
SK (1) SK394492A3 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2115985A1 (en) * 1993-02-25 1994-08-26 Kohei Nishikawa Vascular hypertrophy suppressor
EP2448576A2 (en) 2009-07-02 2012-05-09 Mahmut Bilgic Solubility enhancing pharmaceutical composition
EP2448575A2 (en) 2009-07-02 2012-05-09 Bilgic Mahmut Pharmaceutical composition increasing solubility and stability
EP2377521A1 (en) 2010-03-26 2011-10-19 Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi Pharmaceutical formulations of telmisartan and diuretic combination
JP6599852B2 (en) 2013-06-21 2019-10-30 ゼニス・エピジェネティクス・リミテッド Novel substituted bicyclic compounds as bromodomain inhibitors
NZ714669A (en) 2013-06-21 2021-07-30 Zenith Epigenetics Ltd Novel bicyclic bromodomain inhibitors
AU2014298051B2 (en) 2013-07-31 2018-11-15 Zenith Epigenetics Ltd. Novel quinazolinones as bromodomain inhibitors
WO2016087936A1 (en) 2014-12-01 2016-06-09 Zenith Epigenetics Corp. Substituted pyridinones as bromodomain inhibitors
CN107207474B (en) 2014-12-11 2021-05-07 恒翼生物医药科技(上海)有限公司 Substituted heterocycles as bromodomain inhibitors
EP3233846A4 (en) 2014-12-17 2018-07-18 Zenith Epigenetics Ltd. Inhibitors of bromodomains

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3928177A1 (en) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K BENZIMIDAZOLE, MEDICAMENTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
CA2016710A1 (en) * 1989-05-15 1990-11-15 Prasun K. Chakravarty Substituted benzimidazoles as angiotensin ii antagonists
RU1836357C (en) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Benzimidazole derivatives, their isomers, mixtures of isomers, hydrates or their physiologically bearable salts possessing properties antagonistic to angiotenzine
SI9210098B (en) 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoles, drugs with this compounds, and process for their preparation

Also Published As

Publication number Publication date
GR3021303T3 (en) 1997-01-31
DK0552765T3 (en) 1997-01-13
EP0552765A1 (en) 1993-07-28
HU9300168D0 (en) 1993-04-28
IL104485A (en) 1999-10-28
DE59303388D1 (en) 1996-09-19
AU3196293A (en) 1993-07-29
CZ394492A3 (en) 1993-11-17
CA2087800A1 (en) 1993-07-23
ES2093286T3 (en) 1996-12-16
IL104485A0 (en) 1993-05-13
SK279409B6 (en) 1998-11-04
HUT63626A (en) 1993-09-28
PL297472A1 (en) 1994-01-24
AU660209B2 (en) 1995-06-15
MX9300306A (en) 1993-07-01
EP0552765B1 (en) 1996-08-14
PL172782B1 (en) 1997-11-28
NO930205D0 (en) 1993-01-21
SK394492A3 (en) 1998-11-04
FI930236A (en) 1993-07-23
FI930236A0 (en) 1993-01-21
NZ245741A (en) 1995-07-26
DE4225756A1 (en) 1994-03-10
NO303689B1 (en) 1998-08-17
JPH05279341A (en) 1993-10-26
HU217816B (en) 2000-04-28
ATE141270T1 (en) 1996-08-15

Similar Documents

Publication Publication Date Title
DK0392317T3 (en) Benzimidazoles, drugs containing these compounds and methods for their preparation
DK0468470T3 (en) Benzimidazoles, drugs containing such compounds and methods for their preparation
ATE231505T1 (en) NEW HETEROCYCLIC/CYCLIC AMINE
DK0590428T3 (en) Azaquinoxalins, methods for their preparation and their use
SE8406585L (en) benzoic acid
ATE128985T1 (en) HYDANTONE DERIVATIVES.
DK0532515T3 (en) Preparation of substituted piperidines
NO930205D0 (en) BENZIMIDAZOLES, PHARMACEUTICALS CONTAINING THESE, AND PROCEDURE FOR THEIR PREPARATION
DK0758312T3 (en) Substituted fused and bridged bicyclic compounds as therapeutic agents
DK0623620T3 (en) 5-HT 3 pyrrolopyrazinderivater
DK0418990T3 (en) 13-bromo- and 13,14-dibromo-ergolines, their preparation and use in pharmaceuticals
FI960588A0 (en) Thiocarbamoyl compounds for use as microbicides
DK0635491T3 (en) (Thia) cycloalkylab indoles, processes for their preparation and pharmaceutical compositions containing these compounds.
ATE89555T1 (en) 3-SUBSTITUTED 1-(2-HALOGENALKOXYBENZENESULFONYL)-3-HETEROARYL UREAS.
DK1105388T3 (en) N-substituted azabicycloheptane derivatives, preparation and use thereof