DK0418990T3 - 13-bromo- and 13,14-dibromo-ergolines, their preparation and use in pharmaceuticals - Google Patents

13-bromo- and 13,14-dibromo-ergolines, their preparation and use in pharmaceuticals

Info

Publication number
DK0418990T3
DK0418990T3 DK90250235.0T DK90250235T DK0418990T3 DK 0418990 T3 DK0418990 T3 DK 0418990T3 DK 90250235 T DK90250235 T DK 90250235T DK 0418990 T3 DK0418990 T3 DK 0418990T3
Authority
DK
Denmark
Prior art keywords
preparation
ergolines
dibromo
pharmaceuticals
bromo
Prior art date
Application number
DK90250235.0T
Other languages
Danish (da)
Inventor
Gerhard Dr Sauer
Thomas Dr Brumby
Helmut Dr Wachtel
Jonathan Dr Turner
Peter Andreas Loeschmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0418990T3 publication Critical patent/DK0418990T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Abstract

Compounds of the formula I <IMAGE> and their preparation and use in pharmaceutical compositions and intermediates for the preparation of the compounds are described.
DK90250235.0T 1989-09-20 1990-09-13 13-bromo- and 13,14-dibromo-ergolines, their preparation and use in pharmaceuticals DK0418990T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3931819A DE3931819A1 (en) 1989-09-20 1989-09-20 13-BROM AND 13, 14-DIBROM-ERGOLINE, THEIR PRODUCTION AND USE IN MEDICINAL PRODUCTS

Publications (1)

Publication Number Publication Date
DK0418990T3 true DK0418990T3 (en) 1994-03-14

Family

ID=6390055

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90250235.0T DK0418990T3 (en) 1989-09-20 1990-09-13 13-bromo- and 13,14-dibromo-ergolines, their preparation and use in pharmaceuticals

Country Status (12)

Country Link
EP (1) EP0418990B1 (en)
JP (1) JPH03120277A (en)
AT (1) ATE97130T1 (en)
CA (1) CA2025744A1 (en)
CZ (1) CZ278319B6 (en)
DD (1) DD295848A5 (en)
DE (2) DE3931819A1 (en)
DK (1) DK0418990T3 (en)
ES (1) ES2062313T3 (en)
HU (1) HU206346B (en)
IE (1) IE65416B1 (en)
PT (1) PT95350A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4123587A1 (en) * 1991-07-12 1993-01-14 Schering Ag 2,14-DISUBSTITUTED ERGOLINE, THEIR PRODUCTION AND USE IN MEDICINAL PRODUCTS
AU2016209490B2 (en) 2015-01-20 2020-09-03 Xoc Pharmaceuticals, Inc. Isoergoline compounds and uses thereof
AU2016209492B2 (en) 2015-01-20 2020-10-22 Xoc Pharmaceuticals, Inc Ergoline compounds and uses thereof
EP3630758A1 (en) 2017-06-01 2020-04-08 Xoc Pharmaceuticals, Inc Ergoline derivatives for use in medicine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2330912C3 (en) * 1972-06-22 1979-01-11 Societa Farmaceutici Italia S.P.A., Mailand (Italien) Process for the preparation of bromergoline compounds
DE2802023A1 (en) * 1977-01-28 1978-08-03 Sandoz Ag NEW ERGOT DERIVATIVES, THEIR PRODUCTION AND USE
GB2074566B (en) * 1980-04-03 1983-11-02 Erba Farmitalia Ergoline derivatives
DE3533675A1 (en) * 1985-09-19 1987-03-26 Schering Ag NEW 12- AND 13-BROMINE ERGOL DERIVATIVES
DE3730124A1 (en) * 1987-09-08 1989-03-16 Eich Eckart NEW FESTUCLAVIN AND PYROCLAVIN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT

Also Published As

Publication number Publication date
DD295848A5 (en) 1991-11-14
EP0418990A3 (en) 1991-07-03
IE903369A1 (en) 1991-04-10
EP0418990A2 (en) 1991-03-27
CZ458290A3 (en) 1993-04-14
DE3931819A1 (en) 1991-03-28
CZ278319B6 (en) 1993-11-17
HU206346B (en) 1992-10-28
HUT54682A (en) 1991-03-28
IE65416B1 (en) 1995-10-18
ES2062313T3 (en) 1994-12-16
CA2025744A1 (en) 1991-03-21
JPH03120277A (en) 1991-05-22
ATE97130T1 (en) 1993-11-15
PT95350A (en) 1991-05-22
EP0418990B1 (en) 1993-11-10
DE59003446D1 (en) 1993-12-16

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