DE69503055D1 - Makrozyclische chelante, ihre chelate und verwendungen in diagnostik - Google Patents

Makrozyclische chelante, ihre chelate und verwendungen in diagnostik

Info

Publication number
DE69503055D1
DE69503055D1 DE69503055T DE69503055T DE69503055D1 DE 69503055 D1 DE69503055 D1 DE 69503055D1 DE 69503055 T DE69503055 T DE 69503055T DE 69503055 T DE69503055 T DE 69503055T DE 69503055 D1 DE69503055 D1 DE 69503055D1
Authority
DE
Germany
Prior art keywords
chelates
diagnostics
macrocyclic chelants
metal ions
chelants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69503055T
Other languages
English (en)
Other versions
DE69503055T2 (de
Inventor
Fulvio Uggeri
Pier Anelli
Giuseppe Manfredi
Marino Brocchetta
Franco Fedeli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco SpA
Original Assignee
Bracco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco SpA filed Critical Bracco SpA
Application granted granted Critical
Publication of DE69503055D1 publication Critical patent/DE69503055D1/de
Publication of DE69503055T2 publication Critical patent/DE69503055T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69503055T 1994-07-29 1995-07-24 Makrozyclische chelante, ihre chelate und verwendungen in diagnostik Expired - Fee Related DE69503055T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI941646A IT1274038B (it) 1994-07-29 1994-07-29 Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
PCT/EP1995/002931 WO1996004259A1 (en) 1994-07-29 1995-07-24 Macrocyclic chelants, their chelates and uses thereof in the diagnostic field

Publications (2)

Publication Number Publication Date
DE69503055D1 true DE69503055D1 (de) 1998-07-23
DE69503055T2 DE69503055T2 (de) 1998-10-15

Family

ID=11369406

Family Applications (2)

Application Number Title Priority Date Filing Date
DE0773936T Pending DE773936T1 (de) 1994-07-29 1995-07-24 Makrozyclische chelante, ihre chelate und verwendungen in diagnostik
DE69503055T Expired - Fee Related DE69503055T2 (de) 1994-07-29 1995-07-24 Makrozyclische chelante, ihre chelate und verwendungen in diagnostik

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE0773936T Pending DE773936T1 (de) 1994-07-29 1995-07-24 Makrozyclische chelante, ihre chelate und verwendungen in diagnostik

Country Status (21)

Country Link
US (2) US5622688A (de)
EP (1) EP0773936B1 (de)
JP (1) JP2941062B2 (de)
KR (1) KR100376950B1 (de)
CN (1) CN1064355C (de)
AT (1) ATE167477T1 (de)
AU (1) AU691024B2 (de)
BR (1) BR9508435A (de)
CA (1) CA2196041A1 (de)
DE (2) DE773936T1 (de)
DK (1) DK0773936T3 (de)
ES (1) ES2100827T3 (de)
FI (1) FI970327A (de)
GR (1) GR970300019T1 (de)
HU (1) HUT76805A (de)
IL (1) IL114732A0 (de)
IT (1) IT1274038B (de)
MX (1) MX9700674A (de)
NO (1) NO307214B1 (de)
WO (1) WO1996004259A1 (de)
ZA (1) ZA956174B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1274038B (it) * 1994-07-29 1997-07-14 Bracco Spa Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
JP4432000B2 (ja) * 1996-12-23 2010-03-17 ブラッコ・リサーチ・ソシエテ・アノニム 患者の消化管の視覚化におけるｍｒｉ造影の増加用組成物
IT1291624B1 (it) * 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
FR2772025B1 (fr) * 1997-12-10 2000-03-03 Guerbet Sa Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique
WO2000047111A1 (en) * 1999-02-09 2000-08-17 Board Of Regents The University Of Texas System Ph sensitive mri contrast agents
US20020146371A1 (en) * 2000-10-18 2002-10-10 Li King Chuen Methods for development and use of diagnostic and therapeutic agents
EP1326523A4 (de) * 2000-10-19 2005-01-05 Gen Hospital Corp Bilddarstellung von enzymatischer aktivität
US20030100829A1 (en) * 2001-11-27 2003-05-29 Sheng-Ping Zhong Medical devices with magnetic resonance visibility enhancing material
US20040215240A1 (en) * 2003-04-11 2004-10-28 Lovett Eric G. Reconfigurable subcutaneous cardiac device
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
US20050107838A1 (en) * 2003-09-18 2005-05-19 Lovett Eric G. Subcutaneous cardiac rhythm management with disordered breathing detection and treatment
WO2006002875A1 (en) 2004-07-02 2006-01-12 Bracco Imaging Spa Contrast agents endowed with high relaxivity for use in magnetic resonance imaging (mri) which contain a chelating moiety with polyhydroxylated substituents
CN109384737A (zh) * 2017-08-04 2019-02-26 天津科伦药物研究有限公司 一种四氮杂环钇络合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
IT1224416B (it) * 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
IT1274038B (it) * 1994-07-29 1997-07-14 Bracco Spa Chelanti macrociclici loro chelati e relativi usi in campo diagnostico
GB9504910D0 (en) * 1995-03-10 1995-04-26 Nycomed Imaging As Compounds

Also Published As

Publication number Publication date
JP2941062B2 (ja) 1999-08-25
NO307214B1 (no) 2000-02-28
AU3221195A (en) 1996-03-04
DE773936T1 (de) 1997-09-25
US5708166A (en) 1998-01-13
ES2100827T1 (es) 1997-07-01
KR970704713A (ko) 1997-09-06
ATE167477T1 (de) 1998-07-15
ITMI941646A0 (it) 1994-07-29
IT1274038B (it) 1997-07-14
CN1154108A (zh) 1997-07-09
US5622688A (en) 1997-04-22
CN1064355C (zh) 2001-04-11
FI970327A (fi) 1997-03-25
NO970342D0 (no) 1997-01-27
AU691024B2 (en) 1998-05-07
BR9508435A (pt) 1997-12-23
EP0773936B1 (de) 1998-06-17
FI970327A0 (fi) 1997-01-27
DE69503055T2 (de) 1998-10-15
MX9700674A (es) 1997-04-30
ZA956174B (en) 1996-03-07
WO1996004259A1 (en) 1996-02-15
ES2100827T3 (es) 1998-09-16
GR970300019T1 (en) 1997-07-30
DK0773936T3 (da) 1999-04-06
EP0773936A1 (de) 1997-05-21
NO970342L (no) 1997-04-01
ITMI941646A1 (it) 1996-01-29
HUT76805A (en) 1997-11-28
KR100376950B1 (ko) 2003-07-16
CA2196041A1 (en) 1996-02-15
JPH10503505A (ja) 1998-03-31
IL114732A0 (en) 1995-11-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee