ATE138809T1 - Anwendung von chelat-komplexen - Google Patents
Anwendung von chelat-komplexenInfo
- Publication number
- ATE138809T1 ATE138809T1 AT91116072T AT91116072T ATE138809T1 AT E138809 T1 ATE138809 T1 AT E138809T1 AT 91116072 T AT91116072 T AT 91116072T AT 91116072 T AT91116072 T AT 91116072T AT E138809 T1 ATE138809 T1 AT E138809T1
- Authority
- AT
- Austria
- Prior art keywords
- paramagnetic
- atomic number
- contrast medium
- application
- complex
- Prior art date
Links
- 239000013522 chelant Substances 0.000 title abstract 2
- 230000005298 paramagnetic effect Effects 0.000 abstract 3
- 239000002872 contrast media Substances 0.000 abstract 2
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 150000004697 chelate complex Chemical class 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 229910052747 lanthanoid Inorganic materials 0.000 abstract 1
- 150000002602 lanthanoids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- High Energy & Nuclear Physics (AREA)
- Signal Processing (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Soft Magnetic Materials (AREA)
- Polyamides (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Thin Magnetic Films (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89313686A | 1986-08-04 | 1986-08-04 | |
| US90093086A | 1986-08-27 | 1986-08-27 | |
| US07/057,709 US5039512A (en) | 1986-08-04 | 1987-06-15 | NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE138809T1 true ATE138809T1 (de) | 1996-06-15 |
Family
ID=27369315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91116072T ATE138809T1 (de) | 1986-08-04 | 1987-07-25 | Anwendung von chelat-komplexen |
Country Status (16)
| Country | Link |
|---|---|
| EP (2) | EP0463644B1 (de) |
| JP (1) | JP2667666B2 (de) |
| AT (1) | ATE138809T1 (de) |
| AU (1) | AU608759B2 (de) |
| CA (1) | CA1321346C (de) |
| DE (2) | DE3777727D1 (de) |
| DK (1) | DK167797B1 (de) |
| ES (2) | ES2087938T3 (de) |
| FI (1) | FI88677C (de) |
| GR (1) | GR3004576T3 (de) |
| HK (1) | HK96597A (de) |
| IE (1) | IE64108B1 (de) |
| IL (2) | IL83377A0 (de) |
| NO (1) | NO173767C (de) |
| NZ (1) | NZ221288A (de) |
| SG (1) | SG78250A1 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5064633A (en) * | 1984-06-04 | 1991-11-12 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes, their formulations and use |
| US5422096A (en) * | 1985-05-08 | 1995-06-06 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic NMR imaging |
| US5250285A (en) * | 1985-05-08 | 1993-10-05 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic NMR imaging |
| AU629171B2 (en) * | 1987-06-30 | 1992-10-01 | Mallinckrodt, Inc. | Method for enhancing the safety of metal-ligand chelates as magnetic resonants imaging agents and x-ray contrast agents |
| GB8813144D0 (en) * | 1988-06-03 | 1988-07-06 | Nycomed As | Compositions |
| GB8900732D0 (en) * | 1989-01-13 | 1989-03-08 | Nycomed As | Agents |
| GB8900719D0 (en) * | 1989-01-13 | 1989-03-08 | Nycomed As | Compounds |
| GB8916781D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
| US5087440A (en) * | 1989-07-31 | 1992-02-11 | Salutar, Inc. | Heterocyclic derivatives of DTPA used for magnetic resonance imaging |
| US5516503A (en) * | 1989-11-16 | 1996-05-14 | Guerbet S.A. | Diagnostic composition comprising a binuclear complex, its method of preparation and its use in magnetic resonance imaging |
| FR2654344B1 (fr) * | 1989-11-16 | 1994-09-23 | Cis Bio Int | Complexe paramagnetique de gadolinium, son procede de preparation et son utilisation pour le diagnostic par irm. |
| US5236695A (en) * | 1989-11-27 | 1993-08-17 | Concat, Ltd. | MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands |
| AU649001B2 (en) * | 1989-11-27 | 1994-05-12 | Chelator Llc | MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands |
| DE4011684A1 (de) | 1990-04-06 | 1991-10-10 | Schering Ag | Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
| US5843399A (en) * | 1990-04-06 | 1998-12-01 | Schering Aktiengesellschaft | DTPA monoamides for MRI |
| US5562894A (en) * | 1991-08-09 | 1996-10-08 | Regents Of The University Of California | Amino-acyl-type and catecholamine-type contrast agents for MRI |
| IT1252145B (it) * | 1991-11-29 | 1995-06-05 | Bracco Ind Chimica Spa | Metodo e formulazioni adatte a migliorare lo studio degli organi cavi nell'uomo |
| DE4302287A1 (de) * | 1993-01-25 | 1994-07-28 | Schering Ag | Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung |
| US5409689A (en) * | 1993-08-13 | 1995-04-25 | Concat, Ltd. | MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms |
| US5476644A (en) * | 1994-04-13 | 1995-12-19 | Sterling Winthrop Inc. | Cyclic triamine chelating agents |
| US5582814A (en) * | 1994-04-15 | 1996-12-10 | Metasyn, Inc. | 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging |
| US5639746A (en) * | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
| TW319763B (de) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| WO1997001360A2 (en) * | 1995-06-26 | 1997-01-16 | Concat, Ltd. | Compounds with chelation affinity and selectivity for first transition series elements and their use in medical therapy and diagnosis |
| IT1297035B1 (it) | 1997-12-30 | 1999-08-03 | Bracco Spa | Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico |
| US5980863A (en) * | 1998-11-02 | 1999-11-09 | Eagle Vision Pharmaceutical Corporation | Manganese compositions and methods for MRI |
| EP1191948A2 (de) | 1999-06-11 | 2002-04-03 | Neorx Corporation | Hochdosierte radionuklide komplexe zur knochenmark-unterdrückung |
| US7094885B2 (en) | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
| AU2002249935A1 (en) | 2001-01-08 | 2002-08-19 | Neorx Corporation | Radioactively labelled conjugates of phosphonates |
| JP2007062462A (ja) * | 2005-08-30 | 2007-03-15 | Nifco Inc | 多用途収容装置 |
| US8378134B2 (en) | 2009-09-30 | 2013-02-19 | General Electric Company | Hydroxylated contrast enhancement agents |
| NO331773B1 (no) | 2009-12-18 | 2012-03-26 | Ge Healthcare As | Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) |
| CA2909919C (fr) | 2013-04-26 | 2022-07-12 | Guerbet | Formulation de produit de contraste et son procede de preparation associe |
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| CN110290815A (zh) | 2016-12-21 | 2019-09-27 | 通用电气医疗集团股份有限公司 | 适合作为mri显像剂的基于四氮杂双环-大环的锰螯合化合物 |
| US11110186B2 (en) | 2017-12-20 | 2021-09-07 | General Electric Company | Anionic chelate compounds |
| GB201919073D0 (en) | 2019-12-20 | 2020-02-05 | Ge Healthcare As | Novel manufacturing process |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3818061A (en) * | 1971-11-09 | 1974-06-18 | Merck Sharp & Dohme | Transparent nmr shift reagents |
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| DE3129906C3 (de) * | 1981-07-24 | 1996-12-19 | Schering Ag | Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik |
| NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
| DE3324235A1 (de) * | 1983-07-01 | 1985-01-10 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue komplexbildner, komplexe und komplexsalze |
| CA1242643A (en) * | 1983-08-12 | 1988-10-04 | Eric T. Fossel | Nmr imaging utilizing chemical shift reagents |
| FR2550449B1 (fr) * | 1983-08-12 | 1986-01-31 | Commissariat Energie Atomique | Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire |
| US4749560A (en) * | 1984-08-13 | 1988-06-07 | Research Corporation | Metal organo phosphorous compounds for NMR analysis |
| US4687659A (en) * | 1984-11-13 | 1987-08-18 | Salutar, Inc. | Diamide-DTPA-paramagnetic contrast agents for MR imaging |
| US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
| GB8518300D0 (en) * | 1985-07-19 | 1985-08-29 | Amersham Int Plc | Contrast agent |
| AU629171B2 (en) * | 1987-06-30 | 1992-10-01 | Mallinckrodt, Inc. | Method for enhancing the safety of metal-ligand chelates as magnetic resonants imaging agents and x-ray contrast agents |
-
1987
- 1987-07-16 AU AU75735/87A patent/AU608759B2/en not_active Expired
- 1987-07-22 CA CA000542735A patent/CA1321346C/en not_active Expired - Lifetime
- 1987-07-25 EP EP91116072A patent/EP0463644B1/de not_active Expired - Lifetime
- 1987-07-25 AT AT91116072T patent/ATE138809T1/de not_active IP Right Cessation
- 1987-07-25 ES ES91116072T patent/ES2087938T3/es not_active Expired - Lifetime
- 1987-07-25 SG SG1996004804A patent/SG78250A1/en unknown
- 1987-07-25 ES ES198787110801T patent/ES2030023T3/es not_active Expired - Lifetime
- 1987-07-25 EP EP87110801A patent/EP0258616B1/de not_active Expired - Lifetime
- 1987-07-25 DE DE8787110801T patent/DE3777727D1/de not_active Expired - Lifetime
- 1987-07-25 DE DE3751829T patent/DE3751829T2/de not_active Expired - Lifetime
- 1987-07-30 IL IL83377A patent/IL83377A0/xx not_active IP Right Cessation
- 1987-07-31 NZ NZ221288A patent/NZ221288A/xx unknown
- 1987-07-31 JP JP62190530A patent/JP2667666B2/ja not_active Expired - Lifetime
- 1987-07-31 DK DK401087A patent/DK167797B1/da not_active IP Right Cessation
- 1987-07-31 IE IE207687A patent/IE64108B1/en not_active IP Right Cessation
- 1987-08-03 NO NO873237A patent/NO173767C/no not_active IP Right Cessation
- 1987-08-04 FI FI873382A patent/FI88677C/fi not_active IP Right Cessation
-
1992
- 1992-03-12 IL IL10121092A patent/IL101210A/en not_active IP Right Cessation
- 1992-05-12 GR GR920400924T patent/GR3004576T3/el unknown
-
1997
- 1997-06-26 HK HK96597A patent/HK96597A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU608759B2 (en) | 1991-04-18 |
| DE3777727D1 (de) | 1992-04-30 |
| DK401087A (da) | 1988-02-05 |
| FI88677C (fi) | 1993-06-28 |
| IL83377A0 (en) | 1987-12-31 |
| GR3004576T3 (de) | 1993-04-28 |
| AU7573587A (en) | 1988-02-11 |
| IE64108B1 (en) | 1995-07-12 |
| FI873382A0 (fi) | 1987-08-04 |
| EP0463644B1 (de) | 1996-06-05 |
| FI873382L (fi) | 1988-02-05 |
| ES2030023T3 (es) | 1992-10-16 |
| HK96597A (en) | 1997-08-08 |
| DE3751829T2 (de) | 1996-10-31 |
| FI88677B (fi) | 1993-03-15 |
| SG78250A1 (en) | 2001-02-20 |
| DK401087D0 (da) | 1987-07-31 |
| JP2667666B2 (ja) | 1997-10-27 |
| ES2087938T3 (es) | 1996-08-01 |
| CA1321346C (en) | 1993-08-17 |
| EP0463644A2 (de) | 1992-01-02 |
| NO173767C (no) | 1994-02-02 |
| NZ221288A (en) | 1990-10-26 |
| EP0463644A3 (en) | 1992-11-19 |
| EP0258616B1 (de) | 1992-03-25 |
| NO873237D0 (no) | 1987-08-03 |
| JPS63119446A (ja) | 1988-05-24 |
| EP0258616A1 (de) | 1988-03-09 |
| IE872076L (en) | 1988-02-04 |
| NO873237L (no) | 1988-02-05 |
| IL101210A (en) | 1996-10-31 |
| NO173767B (no) | 1993-10-25 |
| DK167797B1 (da) | 1993-12-20 |
| DE3751829D1 (de) | 1996-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |