DE68922686D1 - Zyklische, Stickstoff enthaltende Liganden, ihre Metallkomplexe, diese enthaltende Diagnostik-Mittel und Verfahren zur Herstellung der Liganden. - Google Patents

Zyklische, Stickstoff enthaltende Liganden, ihre Metallkomplexe, diese enthaltende Diagnostik-Mittel und Verfahren zur Herstellung der Liganden.

Info

Publication number
DE68922686D1
DE68922686D1 DE68922686T DE68922686T DE68922686D1 DE 68922686 D1 DE68922686 D1 DE 68922686D1 DE 68922686 T DE68922686 T DE 68922686T DE 68922686 T DE68922686 T DE 68922686T DE 68922686 D1 DE68922686 D1 DE 68922686D1
Authority
DE
Germany
Prior art keywords
ligands
metal complexes
nitrogen
cyclic
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68922686T
Other languages
English (en)
Other versions
DE68922686T2 (de
Inventor
Michel Schaefer
Dominique Paris
Dominique Meyer
Didier Doucet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guerbet SA
Original Assignee
Guerbet SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet SA filed Critical Guerbet SA
Publication of DE68922686D1 publication Critical patent/DE68922686D1/de
Application granted granted Critical
Publication of DE68922686T2 publication Critical patent/DE68922686T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE68922686T 1988-10-14 1989-10-13 Zyklische, Stickstoff enthaltende Liganden, ihre Metallkomplexe, diese enthaltende Diagnostik-Mittel und Verfahren zur Herstellung der Liganden. Expired - Fee Related DE68922686T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8813585A FR2637895B1 (fr) 1988-10-14 1988-10-14 Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands

Publications (2)

Publication Number Publication Date
DE68922686D1 true DE68922686D1 (de) 1995-06-22
DE68922686T2 DE68922686T2 (de) 1995-10-12

Family

ID=9371053

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68922686T Expired - Fee Related DE68922686T2 (de) 1988-10-14 1989-10-13 Zyklische, Stickstoff enthaltende Liganden, ihre Metallkomplexe, diese enthaltende Diagnostik-Mittel und Verfahren zur Herstellung der Liganden.

Country Status (6)

Country Link
EP (1) EP0365412B1 (de)
JP (1) JPH02196776A (de)
AT (1) ATE122665T1 (de)
DE (1) DE68922686T2 (de)
ES (1) ES2072912T3 (de)
FR (1) FR2637895B1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE145337T1 (de) * 1988-05-02 1996-12-15 Phanos Tech Inc Verbindungen, zusammensetzungen und verfahren zum binden von bio-affektions-substanzen an oberflächenmembranen von bioteilchen
DE3911816A1 (de) * 1989-04-11 1990-10-25 Hoechst Ag Substituierte 1,4,7,10-tetraazacyclotridecane, verfahren zu deren herstellung sowie verwendung derselben zur markierung von substanzen mit radionukliden
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US6693190B1 (en) * 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
EP0232751B1 (de) * 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 1-Substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und Analoga
FR2596992B1 (fr) * 1986-04-11 1988-12-16 Guerbet Sa Sel de lysine du complexe gadolinium-dota et ses applications au diagnostic
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.

Also Published As

Publication number Publication date
JPH02196776A (ja) 1990-08-03
EP0365412B1 (de) 1995-05-17
ES2072912T3 (es) 1995-08-01
FR2637895A1 (fr) 1990-04-20
FR2637895B1 (fr) 1992-11-06
EP0365412A1 (de) 1990-04-25
ATE122665T1 (de) 1995-06-15
DE68922686T2 (de) 1995-10-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee