DE69019584T2 - Makrocyclische Stickstoffliganden Verfahren zu ihrer Herstellung, ihre Metallkomplexe, sie enthaltende Diagnostische und therapeutische Mittel. - Google Patents
Makrocyclische Stickstoffliganden Verfahren zu ihrer Herstellung, ihre Metallkomplexe, sie enthaltende Diagnostische und therapeutische Mittel.Info
- Publication number
- DE69019584T2 DE69019584T2 DE69019584T DE69019584T DE69019584T2 DE 69019584 T2 DE69019584 T2 DE 69019584T2 DE 69019584 T DE69019584 T DE 69019584T DE 69019584 T DE69019584 T DE 69019584T DE 69019584 T2 DE69019584 T2 DE 69019584T2
- Authority
- DE
- Germany
- Prior art keywords
- diagnostic
- preparation
- therapeutic agents
- ligands
- complexes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8903938A FR2644785B1 (fr) | 1989-03-24 | 1989-03-24 | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69019584D1 DE69019584D1 (de) | 1995-06-29 |
DE69019584T2 true DE69019584T2 (de) | 1995-11-09 |
Family
ID=9380062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69019584T Expired - Fee Related DE69019584T2 (de) | 1989-03-24 | 1990-03-23 | Makrocyclische Stickstoffliganden Verfahren zu ihrer Herstellung, ihre Metallkomplexe, sie enthaltende Diagnostische und therapeutische Mittel. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0391766B1 (de) |
JP (1) | JPH04506955A (de) |
AT (1) | ATE123032T1 (de) |
DE (1) | DE69019584T2 (de) |
FR (1) | FR2644785B1 (de) |
WO (1) | WO1990011282A1 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5334371A (en) * | 1988-07-20 | 1994-08-02 | Schering Aktiengesellschaft | Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI |
DE4001655A1 (de) * | 1990-01-18 | 1991-07-25 | Schering Ag | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
GB9001245D0 (en) * | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
WO1991010669A1 (en) * | 1990-01-19 | 1991-07-25 | Cockbain, Julian, Roderick, Michaelson | Chelating compounds |
US5367080A (en) * | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
CA2072934C (en) * | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
US5480990A (en) * | 1991-12-10 | 1996-01-02 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents |
US5428139A (en) * | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
ZA929578B (en) * | 1991-12-10 | 1994-06-10 | Dow Chemical Co | Bicyclopolyazamacrocyclocarboxylic acid complexes their conjugates processes for their preparation and use as radiopharmaceuticals |
IL104060A (en) * | 1991-12-10 | 1998-12-06 | Dow Chemical Co | Bicyclopolyazamacyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation |
SG48889A1 (en) * | 1991-12-10 | 1998-05-18 | Dow Chemical Co | Bicycle-polyamacrocyclocarboxylic acid complexes conjugates preparation and use as contrast agents |
WO1994026313A1 (en) * | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents |
WO1994026754A1 (en) * | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation |
US5739294A (en) * | 1991-12-10 | 1998-04-14 | The Dow Chemical Company | Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents |
US6204259B1 (en) | 1993-01-14 | 2001-03-20 | Monsanto Company | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
AU4239893A (en) * | 1993-05-06 | 1994-12-12 | Dow Chemical Company, The | Bicyclopolyazamacrocyclophosphonic acid complexes, a process for their preparation, and their conjugates, for use as radiopharmaceuticals |
WO1994026315A1 (en) * | 1993-05-06 | 1994-11-24 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals |
US6207826B1 (en) | 1995-03-27 | 2001-03-27 | Isis Pharmaceuticals, Inc. | Macrocyclic compounds having nitrogen-containing linkages |
EP0817787A4 (de) | 1995-03-27 | 2000-09-13 | Isis Pharmaceuticals Inc | Makrozyklische stickstoffverbindungen |
US6525041B1 (en) | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
CA2229781A1 (en) | 1995-08-17 | 1997-02-27 | Monsanto Company | Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands |
EP0898574B1 (de) * | 1996-04-19 | 2003-11-12 | Dow Global Technologies Inc. | Fluoreszierende chelate als gewebespezifische bildgebende mittel |
FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
CN103534262A (zh) * | 2011-03-11 | 2014-01-22 | B.R.A.H.M.S有限公司 | 具有菲咯啉化合物作为配体的稀土金属络合物 |
US10568976B2 (en) | 2015-11-26 | 2020-02-25 | Debreceni Egyetem | 3,6,9, 15-tetraaza-bicyclo [9.3.1 ]pentadeca-1(14), 11(15), 12-triene based compounds and their application as ligands of essential metal ion based MRI and 52MN based PET contrast agents |
WO2017089849A1 (en) * | 2015-11-26 | 2017-06-01 | Debreceni Egyetem | New 6-oxa-3,9, 15-triaza-bicyclo[9.3.1 ]pentadec a- 1 ( 14), 1 1 ( 15), 12-triene derivatives based compounds and their application as ligands of essential metal ion based mri and 52mn based pet contrast agents |
EP3380473A1 (de) | 2015-11-26 | 2018-10-03 | Debreceni Egyetem | Neue 2,1-l-diaza-[3.3](2,6)pyridinophan-verbindungen und deren anwendung als liganden von auf essentiellen metallionen basierenden mrt-kontrastmitteln und 52mn-basierenden pet-kontrastmitteln |
FR3046172B1 (fr) * | 2015-12-24 | 2019-05-31 | Guerbet | Ligands macrocycliques avec groupement(s) picolinate(s), leurs complexes ainsi que leurs utilisations medicales |
GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8502573D0 (sv) * | 1985-05-23 | 1985-05-23 | Jouko Kanakre | Fluorescent lanthanide chelates useful as labels of physiologically active materials |
DE4001655A1 (de) * | 1990-01-18 | 1991-07-25 | Schering Ag | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
WO1991010669A1 (en) * | 1990-01-19 | 1991-07-25 | Cockbain, Julian, Roderick, Michaelson | Chelating compounds |
GB9001245D0 (en) * | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
US5114688A (en) * | 1990-01-23 | 1992-05-19 | L'air Liquide, Societe Anonyme Pour L'etude Et Exploitation Des Procedes Georges Claude | Binuclear metal macrocyclic and macrobicyclic complexes for oxygen separation and transport |
-
1989
- 1989-03-24 FR FR8903938A patent/FR2644785B1/fr not_active Expired - Fee Related
-
1990
- 1990-03-23 JP JP2505803A patent/JPH04506955A/ja active Pending
- 1990-03-23 WO PCT/FR1990/000198 patent/WO1990011282A1/fr unknown
- 1990-03-23 EP EP90400815A patent/EP0391766B1/de not_active Expired - Lifetime
- 1990-03-23 AT AT90400815T patent/ATE123032T1/de not_active IP Right Cessation
- 1990-03-23 DE DE69019584T patent/DE69019584T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH04506955A (ja) | 1992-12-03 |
ATE123032T1 (de) | 1995-06-15 |
EP0391766B1 (de) | 1995-05-24 |
DE69019584D1 (de) | 1995-06-29 |
EP0391766A1 (de) | 1990-10-10 |
WO1990011282A1 (fr) | 1990-10-04 |
FR2644785B1 (fr) | 1991-07-05 |
FR2644785A1 (fr) | 1990-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |