WO1997010852A3 - Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ xsns für radioaktive isotope - Google Patents
Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ xsns für radioaktive isotope Download PDFInfo
- Publication number
- WO1997010852A3 WO1997010852A3 PCT/DE1996/001821 DE9601821W WO9710852A3 WO 1997010852 A3 WO1997010852 A3 WO 1997010852A3 DE 9601821 W DE9601821 W DE 9601821W WO 9710852 A3 WO9710852 A3 WO 9710852A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- xsns
- sulphide
- functional
- type
- chelating agents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96945139A EP0853488A2 (de) | 1995-09-21 | 1996-09-19 | Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ xsns für radioaktive isotope |
AU14359/97A AU1435997A (en) | 1995-09-21 | 1996-09-19 | Xsns-type bi-functional sulphide-containing sulphonamide chelating agents for radioactive isotopes |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19536781.2 | 1995-09-21 | ||
DE1995136781 DE19536781A1 (de) | 1995-09-21 | 1995-09-21 | Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ XSNS für radioaktive Isotope |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997010852A2 WO1997010852A2 (de) | 1997-03-27 |
WO1997010852A3 true WO1997010852A3 (de) | 1997-08-28 |
Family
ID=7773888
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE1996/001821 WO1997010852A2 (de) | 1995-09-21 | 1996-09-19 | Bifunktionelle sulfidhaltige sulfonamid-chelatbildner vom typ xsns für radioaktive isotope |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0853488A2 (de) |
AU (1) | AU1435997A (de) |
CA (1) | CA2232391A1 (de) |
DE (1) | DE19536781A1 (de) |
WO (1) | WO1997010852A2 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19652374A1 (de) * | 1996-12-04 | 1998-06-10 | Schering Ag | Verwendung von Endothelin-Konjugaten in der Therapie, neue Endothelin-Konjugate, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung |
EP0946202B1 (de) * | 1996-10-28 | 2003-09-10 | Amersham Health AS | Kontrastmittel |
US6524553B2 (en) | 1998-03-31 | 2003-02-25 | Bristol-Myers Squibb Pharma Company | Quinolone vitronectin receptor antagonist pharmaceuticals |
AU5541799A (en) | 1998-03-31 | 1999-11-29 | Du Pont Pharmaceuticals Company | Pharmaceuticals for the imaging of angiogenic disorders |
US6548663B1 (en) | 1998-03-31 | 2003-04-15 | Bristol-Myers Squibb Pharma Company | Benzodiazepine vitronectin receptor antagonist pharmaceuticals |
US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
US6794518B1 (en) | 1998-12-18 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
US6569402B1 (en) | 1998-12-18 | 2003-05-27 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
EP1140204A2 (de) | 1998-12-18 | 2001-10-10 | Du Pont Pharmaceuticals Company | Vitronektin-rezeptor antagonist arzeimittheln |
CA2349333A1 (en) | 1998-12-18 | 2000-06-22 | Du Pont Pharmaceuticals Company | Vitronectin receptor antagonist pharmaceuticals |
US6511649B1 (en) | 1998-12-18 | 2003-01-28 | Thomas D. Harris | Vitronectin receptor antagonist pharmaceuticals |
GB0105224D0 (en) | 2001-03-02 | 2001-04-18 | Nycomed Amersham Plc | Improved peptide-chelate conjugates |
WO2005044313A2 (en) * | 2003-11-06 | 2005-05-19 | Amersham Health As | Conjugates of angiotensin ii and an imaging moiety |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994022493A1 (de) * | 1993-03-31 | 1994-10-13 | Institut für Diagnostikforschung GmbH an der Freien Universität Berlin | Chelatbildner vom typ xn1s1x' für radioaktive isotope, deren metallkomplexe und ihre verwendung in diagnostik und therapie |
WO1995003280A1 (en) * | 1993-07-19 | 1995-02-02 | Resolution Pharmaceuticals Inc. | Hydrazino-type radionuclide chelators having an n3s configuration |
WO1995005398A1 (en) * | 1993-08-17 | 1995-02-23 | Neorx Corporation | S3n chelating compounds for the radiolabeling of ligands, anti-ligands or other proteins |
-
1995
- 1995-09-21 DE DE1995136781 patent/DE19536781A1/de not_active Withdrawn
-
1996
- 1996-09-19 WO PCT/DE1996/001821 patent/WO1997010852A2/de not_active Application Discontinuation
- 1996-09-19 AU AU14359/97A patent/AU1435997A/en not_active Abandoned
- 1996-09-19 CA CA 2232391 patent/CA2232391A1/en not_active Abandoned
- 1996-09-19 EP EP96945139A patent/EP0853488A2/de not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994022493A1 (de) * | 1993-03-31 | 1994-10-13 | Institut für Diagnostikforschung GmbH an der Freien Universität Berlin | Chelatbildner vom typ xn1s1x' für radioaktive isotope, deren metallkomplexe und ihre verwendung in diagnostik und therapie |
WO1995003280A1 (en) * | 1993-07-19 | 1995-02-02 | Resolution Pharmaceuticals Inc. | Hydrazino-type radionuclide chelators having an n3s configuration |
WO1995005398A1 (en) * | 1993-08-17 | 1995-02-23 | Neorx Corporation | S3n chelating compounds for the radiolabeling of ligands, anti-ligands or other proteins |
Non-Patent Citations (2)
Title |
---|
ANDERSON CJ ET AL: "N,N'-ethylene-di-L-cysteine (EC) complexes of Ga(III) and In(III): molecular modeling, thermodynamic stability and in vivo studies.", NUCL MED BIOL, FEB 1995, VOL. 22, NO. 2, PAGES 165-73, XP002034516 * |
KWAMENA E BAIDOO ET AL: "SYNTHESIS OF A DIAMINEDITHIOL BIFUNCTIONAL CHELATING AGENT FOR INCORPORATION OF TECHNETIUM-99M INTO BIOMOLECULES", BIOCONJUGATE CHEMISTRY, vol. 1, no. 2, 1 January 1990 (1990-01-01), pages 132 - 137, XP000371813 * |
Also Published As
Publication number | Publication date |
---|---|
WO1997010852A2 (de) | 1997-03-27 |
CA2232391A1 (en) | 1997-03-27 |
DE19536781A1 (de) | 1997-03-27 |
EP0853488A2 (de) | 1998-07-22 |
AU1435997A (en) | 1997-04-09 |
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