AU6501794A - Chelating agents of the type xn1s1o1 for radioactive isotopes, metal complexes thereof, and their use in diagnosis and therapy - Google Patents
Chelating agents of the type xn1s1o1 for radioactive isotopes, metal complexes thereof, and their use in diagnosis and therapyInfo
- Publication number
- AU6501794A AU6501794A AU65017/94A AU6501794A AU6501794A AU 6501794 A AU6501794 A AU 6501794A AU 65017/94 A AU65017/94 A AU 65017/94A AU 6501794 A AU6501794 A AU 6501794A AU 6501794 A AU6501794 A AU 6501794A
- Authority
- AU
- Australia
- Prior art keywords
- chelating agents
- diagnosis
- therapy
- xn1s1o1
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Abstract
Novel bifunctional chalcogenic-atom-discontinuous chelating agents, pharmaceutical preparations containing them, their use in radio diagnosis and radio therapy, and methods of preparing them. The invention concerns compounds of the general formula (I): M-L, in which M is a radioisotope of Tc or Re, and L is a ligand of general formula (II). Surprisingly, it has been found that the bifunctional chalcogenic-atom-discontinuous chelating agents described, and their coupling products with specifically enriching compounds, are eminently suitable for use in the production of radiodiagnostic or radiotherapeutic compounds.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4311023A DE4311023C2 (en) | 1993-03-31 | 1993-03-31 | Bifunctional chalcogen atom-interrupted chelating agents of type XN¶1¶S¶1¶O¶1¶ for radioactive isotopes, their metal complexes, processes for their preparation and pharmaceutical compositions containing them |
DE4311023 | 1993-03-31 | ||
PCT/DE1994/000371 WO1994022497A1 (en) | 1993-03-31 | 1994-03-29 | Chelating agents of the type xn1s1o1 for radioactive isotopes, metal complexes thereof, and their use in diagnosis and therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
AU6501794A true AU6501794A (en) | 1994-10-24 |
AU691806B2 AU691806B2 (en) | 1998-05-28 |
Family
ID=6484687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU65017/94A Ceased AU691806B2 (en) | 1993-03-31 | 1994-03-29 | Chelating agents of the type XN1S1O1 for radioactive isotopes, metal complexes thereof, and their use in diagnosis and therapy |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0692976B1 (en) |
JP (1) | JPH08508263A (en) |
KR (1) | KR960700777A (en) |
AT (1) | ATE179076T1 (en) |
AU (1) | AU691806B2 (en) |
CA (1) | CA2156620A1 (en) |
DE (2) | DE4311023C2 (en) |
HU (1) | HUT73665A (en) |
NO (1) | NO953867L (en) |
NZ (1) | NZ263794A (en) |
WO (1) | WO1994022497A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU692154B2 (en) * | 1993-03-31 | 1998-06-04 | Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin | Chelators of type XN1S1X' for radioactive isotopes, their metal complexes and their diagnostic and therapeutical uses |
AU692153B2 (en) * | 1993-03-31 | 1998-06-04 | Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin | Type S3N2 chelators for radioactive isotopes, their metal complexes and their diagnostic and therapeutical use |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4425778A1 (en) * | 1994-07-13 | 1996-01-18 | Diagnostikforschung Inst | Complex compounds for the diagnosis of vascular diseases |
DE19652374A1 (en) * | 1996-12-04 | 1998-06-10 | Schering Ag | Use of endothelin conjugates in therapy, new endothelin conjugates, agents containing them, and processes for their preparation |
WO1998018497A2 (en) * | 1996-10-28 | 1998-05-07 | Nycomed Imaging As | Contrast agents |
ES2241313T3 (en) | 1998-03-31 | 2005-10-16 | Bristol-Myers Squibb Pharma Company | PHARMACEUTICAL COMPOUNDS FOR THE FORMATION OF IMAGES OF ANGIOGENIC DISORDERS. |
US6548663B1 (en) | 1998-03-31 | 2003-04-15 | Bristol-Myers Squibb Pharma Company | Benzodiazepine vitronectin receptor antagonist pharmaceuticals |
US6524553B2 (en) | 1998-03-31 | 2003-02-25 | Bristol-Myers Squibb Pharma Company | Quinolone vitronectin receptor antagonist pharmaceuticals |
US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
NZ511677A (en) | 1998-12-18 | 2003-10-31 | Du Pont Pharm Co | Vitronectin receptor antagonist pharmaceuticals |
US6794518B1 (en) | 1998-12-18 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
US6511649B1 (en) | 1998-12-18 | 2003-01-28 | Thomas D. Harris | Vitronectin receptor antagonist pharmaceuticals |
US6569402B1 (en) | 1998-12-18 | 2003-05-27 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
TR200101757T2 (en) | 1998-12-18 | 2001-12-21 | Dupont Pharmaceuticais Company | Vitronectin receptor antagonist pharmaceuticals |
PT2151250E (en) * | 2002-05-06 | 2013-12-09 | Endocyte Inc | Vitamin-targeted imaging agents |
SE526214C2 (en) | 2003-02-28 | 2005-07-26 | Amersham Biosciences Ab | One way to generate metal chelating affinity ligands |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57188527A (en) * | 1981-04-21 | 1982-11-19 | Amersham Int Plc | Diagnosis of kidney function |
US4980147A (en) * | 1984-06-25 | 1990-12-25 | University Of Utah Research Foundation | Radiolabeled technetium chelates for use in renal function determinations |
EP0188256B1 (en) * | 1985-01-14 | 1991-08-21 | NeoRx | Metal radionuclide labeled proteins for diagnosis and therapy |
ATE52516T1 (en) * | 1986-05-28 | 1990-05-15 | Mallinckrodt Inc | TECHNETIUM CHELATE FOR DETERMINING KIDNEY FUNCTION. |
US4861869A (en) * | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
ES2033433T3 (en) * | 1987-07-16 | 1993-03-16 | Nycomed As | PROCEDURE TO PREPARE AMINOPOLICARBOXILIC ACIDS AND THEIR DERIVATIVES. |
JPH0570481A (en) * | 1991-09-12 | 1993-03-23 | Hitachi Chem Co Ltd | Peptide and its salt |
-
1993
- 1993-03-31 DE DE4311023A patent/DE4311023C2/en not_active Expired - Lifetime
-
1994
- 1994-03-29 AT AT94912441T patent/ATE179076T1/en active
- 1994-03-29 EP EP94912441A patent/EP0692976B1/en not_active Expired - Lifetime
- 1994-03-29 CA CA002156620A patent/CA2156620A1/en not_active Abandoned
- 1994-03-29 AU AU65017/94A patent/AU691806B2/en not_active Ceased
- 1994-03-29 KR KR1019950703669A patent/KR960700777A/en not_active Application Discontinuation
- 1994-03-29 WO PCT/DE1994/000371 patent/WO1994022497A1/en active IP Right Grant
- 1994-03-29 HU HU9502868A patent/HUT73665A/en unknown
- 1994-03-29 JP JP6521542A patent/JPH08508263A/en active Pending
- 1994-03-29 NZ NZ263794A patent/NZ263794A/en unknown
- 1994-03-29 DE DE59408142T patent/DE59408142D1/en not_active Expired - Lifetime
-
1995
- 1995-09-29 NO NO953867A patent/NO953867L/en unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU692154B2 (en) * | 1993-03-31 | 1998-06-04 | Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin | Chelators of type XN1S1X' for radioactive isotopes, their metal complexes and their diagnostic and therapeutical uses |
AU692153B2 (en) * | 1993-03-31 | 1998-06-04 | Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin | Type S3N2 chelators for radioactive isotopes, their metal complexes and their diagnostic and therapeutical use |
Also Published As
Publication number | Publication date |
---|---|
WO1994022497A1 (en) | 1994-10-13 |
NZ263794A (en) | 1996-10-28 |
HU9502868D0 (en) | 1995-11-28 |
KR960700777A (en) | 1996-02-24 |
HUT73665A (en) | 1996-09-30 |
NO953867L (en) | 1995-11-23 |
EP0692976B1 (en) | 1999-04-21 |
AU691806B2 (en) | 1998-05-28 |
DE59408142D1 (en) | 1999-05-27 |
EP0692976A1 (en) | 1996-01-24 |
DE4311023A1 (en) | 1994-10-06 |
JPH08508263A (en) | 1996-09-03 |
CA2156620A1 (en) | 1994-10-13 |
DE4311023C2 (en) | 1996-05-02 |
NO953867D0 (en) | 1995-09-29 |
ATE179076T1 (en) | 1999-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |