KR900701765A - 마이크로사이클릭 이작용성 킬레이트제, 이들의 착화합물 및 이들의 항체 결합물 - Google Patents

마이크로사이클릭 이작용성 킬레이트제, 이들의 착화합물 및 이들의 항체 결합물

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Publication number
KR900701765A
KR900701765A KR1019900700403A KR900700403A KR900701765A KR 900701765 A KR900701765 A KR 900701765A KR 1019900700403 A KR1019900700403 A KR 1019900700403A KR 900700403 A KR900700403 A KR 900700403A KR 900701765 A KR900701765 A KR 900701765A
Authority
KR
South Korea
Prior art keywords
microcyclic
chelating agents
complex compounds
antibody combinations
bifunctional chelating
Prior art date
Application number
KR1019900700403A
Other languages
English (en)
Other versions
KR0137930B1 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of KR900701765A publication Critical patent/KR900701765A/ko
Application granted granted Critical
Publication of KR0137930B1 publication Critical patent/KR0137930B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
    • A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR90700403A 1988-06-24 1990-02-23 Process for preparing isothiocyanato functionalized metal complexes KR0137930B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21149688A 1988-06-24 1988-06-24
US37095689A 1989-06-21 1989-06-21
PCT/US1989/002788 WO1989012631A1 (en) 1988-06-24 1989-06-23 Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates

Publications (2)

Publication Number Publication Date
KR900701765A true KR900701765A (ko) 1990-12-04
KR0137930B1 KR0137930B1 (en) 1998-05-15

Family

ID=26906194

Family Applications (1)

Application Number Title Priority Date Filing Date
KR90700403A KR0137930B1 (en) 1988-06-24 1990-02-23 Process for preparing isothiocyanato functionalized metal complexes

Country Status (20)

Country Link
US (1) US5435990A (ko)
EP (2) EP0420942A1 (ko)
JP (1) JP2831073B2 (ko)
KR (1) KR0137930B1 (ko)
AT (1) ATE120457T1 (ko)
AU (1) AU634167B2 (ko)
BR (1) BR8907507A (ko)
CA (1) CA1341373C (ko)
DE (2) DE353450T1 (ko)
DK (1) DK175393B1 (ko)
ES (1) ES2013978A4 (ko)
FI (2) FI103792B (ko)
GR (1) GR900300034T1 (ko)
HK (1) HK60696A (ko)
HU (1) HU219485B (ko)
IE (1) IE67273B1 (ko)
IL (1) IL90730A0 (ko)
NO (1) NO179008C (ko)
NZ (1) NZ229700A (ko)
WO (1) WO1989012631A1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101253100B1 (ko) * 2010-02-16 2013-04-10 경북대학교 산학협력단 폴리아자마크로사이클릭 화합물, 그 제조 방법 및 생의학적 적용

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KR101253100B1 (ko) * 2010-02-16 2013-04-10 경북대학교 산학협력단 폴리아자마크로사이클릭 화합물, 그 제조 방법 및 생의학적 적용

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FI117889B (fi) 2007-04-13
ATE120457T1 (de) 1995-04-15
DE68921941D1 (de) 1995-05-04
HU894432D0 (en) 1992-02-28
KR0137930B1 (en) 1998-05-15
IL90730A0 (en) 1990-01-18
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JPH04504247A (ja) 1992-07-30
CA1341373C (en) 2002-07-02
DE353450T1 (de) 1990-09-06
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FI906368A0 (fi) 1990-12-21
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DK49390A (da) 1990-02-23
HUT70200A (en) 1995-09-28
FI982303A (fi) 1998-10-23
DE68921941T2 (de) 1995-07-27
FI982303A0 (fi) 1998-10-23
NO179008B (no) 1996-04-09
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NZ229700A (en) 1993-01-27
FI103792B (fi) 1999-09-30
AU634167B2 (en) 1993-02-18
NO179008C (no) 1996-07-17
IE67273B1 (en) 1996-03-20
HK60696A (en) 1996-04-19
DK49390D0 (da) 1990-02-23
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US5435990A (en) 1995-07-25

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