ATE199550T1 - Polyaminierte liganden, metallkomplexe, verfahren zur herstellung und diagnostische und therapeutische verwendungen - Google Patents
Polyaminierte liganden, metallkomplexe, verfahren zur herstellung und diagnostische und therapeutische verwendungenInfo
- Publication number
- ATE199550T1 ATE199550T1 AT94403038T AT94403038T ATE199550T1 AT E199550 T1 ATE199550 T1 AT E199550T1 AT 94403038 T AT94403038 T AT 94403038T AT 94403038 T AT94403038 T AT 94403038T AT E199550 T1 ATE199550 T1 AT E199550T1
- Authority
- AT
- Austria
- Prior art keywords
- polyaminated
- ligands
- diagnostic
- preparation
- metal complexes
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title 1
- 239000002184 metal Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 230000005298 paramagnetic effect Effects 0.000 abstract 1
- -1 poly(amino acid) Polymers 0.000 abstract 1
- 229920001308 poly(aminoacid) Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9315933 | 1993-12-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE199550T1 true ATE199550T1 (de) | 2001-03-15 |
Family
ID=9454621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94403038T ATE199550T1 (de) | 1993-12-30 | 1994-12-27 | Polyaminierte liganden, metallkomplexe, verfahren zur herstellung und diagnostische und therapeutische verwendungen |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5712389A (de) |
| EP (1) | EP0661279B1 (de) |
| JP (1) | JP3862299B2 (de) |
| KR (1) | KR100328575B1 (de) |
| CN (1) | CN1056162C (de) |
| AT (1) | ATE199550T1 (de) |
| AU (1) | AU687120B2 (de) |
| CA (1) | CA2139374C (de) |
| CZ (1) | CZ289751B6 (de) |
| DE (1) | DE69426811T2 (de) |
| DK (1) | DK0661279T3 (de) |
| ES (1) | ES2156143T3 (de) |
| FI (1) | FI113171B (de) |
| GR (1) | GR3035913T3 (de) |
| IL (1) | IL112175A (de) |
| NO (1) | NO306721B1 (de) |
| NZ (1) | NZ270289A (de) |
| PT (1) | PT661279E (de) |
| ZA (1) | ZA9410382B (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0661279B1 (de) * | 1993-12-30 | 2001-03-07 | Guerbet | Polyaminierte Liganden, Metallkomplexe, Verfahren zur Herstellung und diagnostische und therapeutische Verwendungen |
| FI954967A7 (fi) * | 1994-10-21 | 1996-04-22 | Nihon Mediphysics Co Ltd | Diagnostinen kuvausaine |
| TW319763B (de) * | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| US6713045B1 (en) | 1995-06-02 | 2004-03-30 | Research Corporation Technologies, Inc. | Targeted magnetic resonance imaging agents for the detection of physiological processes |
| US6770261B2 (en) | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| IT1283218B1 (it) * | 1996-03-08 | 1998-04-16 | Bracco Spa | Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi |
| US5900228A (en) | 1996-07-31 | 1999-05-04 | California Institute Of Technology | Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye |
| US6019959A (en) * | 1997-07-31 | 2000-02-01 | Schering Aktiengesellschaft | Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis |
| US7632651B2 (en) | 1997-09-15 | 2009-12-15 | Mds Analytical Technologies (Us) Inc. | Molecular modification assays |
| US6713046B1 (en) | 1997-10-27 | 2004-03-30 | Research Corporation Technologies | Magnetic resonance imaging agents for the delivery of therapeutic agents |
| WO1999025389A2 (en) * | 1997-11-17 | 1999-05-27 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
| FR2772025B1 (fr) * | 1997-12-10 | 2000-03-03 | Guerbet Sa | Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique |
| FR2793795B1 (fr) * | 1999-05-21 | 2001-08-03 | Guerbet Sa | Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale |
| US20040170562A1 (en) * | 1999-12-01 | 2004-09-02 | Uzgiris Egidijus Edward | Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging |
| US6685915B2 (en) * | 1999-12-01 | 2004-02-03 | General Electric Company | Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging |
| US6673333B1 (en) | 2000-05-04 | 2004-01-06 | Research Corporation Technologies, Inc. | Functional MRI agents for cancer imaging |
| US6656450B2 (en) | 2000-07-17 | 2003-12-02 | California Institute Of Technology, Inc. | Macrocyclic magnetic resonance imaging contrast agents |
| WO2002028441A2 (en) | 2000-10-04 | 2002-04-11 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
| WO2002043775A2 (en) | 2000-11-20 | 2002-06-06 | GODFREY, Cullen, M. | Paramagnetic metal ion-based macrocyclic contrast agents |
| US20030050452A1 (en) * | 2000-12-26 | 2003-03-13 | Yuji Hashiguchi | Process for producing metal complex of aminooligosaccharide derivative |
| US20030215391A1 (en) * | 2001-07-19 | 2003-11-20 | Carlos Rabito | Fluorescent agents for real-time measurement of organ function |
| DE10135356C1 (de) * | 2001-07-20 | 2003-04-17 | Schering Ag | Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen |
| FR2829493B1 (fr) * | 2001-09-10 | 2005-08-05 | Commissariat Energie Atomique | Composes thermosensibles presentant un point de trouble, utilisables comme extractants pour la separation de metaux en solution aqueuse |
| EP1369134A1 (de) * | 2002-06-05 | 2003-12-10 | Bracco Imaging S.p.A. | Mittel fur magnetisches Bildformungsverfahren |
| US20040018576A1 (en) * | 2002-07-24 | 2004-01-29 | Dematteo Todd M. | Bence Jones protein testing cassette |
| US20040022857A1 (en) * | 2002-07-31 | 2004-02-05 | Uzgiris Egidijus E. | Synthesis of highly conjugated polymers |
| FR2856063B1 (fr) * | 2003-06-13 | 2005-10-07 | Air Liquide | Procede de preparation du cis-8b-methyldecahydro-2a,4a,6a, 8a-tetraazacyclopenta[fg]acenaphthylene,ou du cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg] acenaphthylene, du cyclene, et de cyclenes fonctionnalises |
| FR2856689A1 (fr) * | 2003-06-25 | 2004-12-31 | Guerbet Sa | Composes specifiques a forte relaxivite |
| FR2857967B1 (fr) * | 2003-07-25 | 2015-04-24 | Centre Nat Rech Scient | Complexes de lanthanide, leur preparation et leurs utilisations |
| FR2867473B1 (fr) | 2004-03-12 | 2006-06-23 | Guerbet Sa | Compose de porphyrines et utilisation a haut champ en irm |
| JP5106107B2 (ja) * | 2004-07-02 | 2012-12-26 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | ポリヒドロキシル化置換基を有するキレート化部分を含む磁気共鳴画像法（ｍｒｉ）用高緩和能造影剤 |
| EP1805188A4 (de) | 2004-09-30 | 2010-03-03 | Mds Analytical Technologies Us | Lumineszente lanthanidkomplexe |
| WO2006121889A2 (en) * | 2005-05-06 | 2006-11-16 | Epix Pharmaceuticals, Inc. | Chemical exchange saturation transfer contrast agents |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| EP1940841B9 (de) | 2005-10-07 | 2017-04-19 | Guerbet | Verbindungen mit einem eine biologische zielstruktur erkennenden teil, das mit einem zum komplexieren von gallium fähigen signalteil gekoppelt ist |
| FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| EP1964846A1 (de) * | 2007-02-27 | 2008-09-03 | Bracco Imaging, S.P.A. | Herstellungsverfahren für Kontrastmittel |
| FR2914303A1 (fr) | 2007-03-28 | 2008-10-03 | Guerbet Sa | Composes pour le diagnostic de l'apoptose. |
| FR2914304B1 (fr) | 2007-03-28 | 2012-11-16 | Guerbet Sa | Composes pour le diagnostic de maladies liees a l'expression de vcam. |
| FR2942227B1 (fr) | 2009-02-13 | 2011-04-15 | Guerbet Sa | Utilisation de tampons pour la complexation de radionucleides |
| JP5735791B2 (ja) * | 2010-12-07 | 2015-06-17 | 住友化学株式会社 | 金属錯体を含む素子 |
| US9528946B2 (en) | 2012-08-15 | 2016-12-27 | Nova Measuring Instruments Ltd. | Optical metrology for in-situ measurements |
| US20160287726A1 (en) * | 2015-04-06 | 2016-10-06 | The Trustees Of The University Of Pennsylvania | Cationic contrast agents and methods of using the same |
| US10918742B2 (en) | 2016-03-25 | 2021-02-16 | Nanoprobes, Inc. | Iodine-based particles |
| WO2025045168A1 (zh) | 2023-09-01 | 2025-03-06 | 江苏恒瑞医药股份有限公司 | 一种大环化合物及其用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
| US4687658A (en) * | 1984-10-04 | 1987-08-18 | Salutar, Inc. | Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging |
| EP0484989B1 (de) * | 1986-09-05 | 1996-04-24 | GANSOW, Otto A. | Polysubstituierte Diethylentriamin Chelate zur Bildung einer Metall-Chelat-Protein Konjugierung |
| WO1989012631A1 (en) * | 1988-06-24 | 1989-12-28 | The Dow Chemical Company | Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates |
| EP0382583B1 (de) * | 1989-02-10 | 1996-01-17 | Celltech Therapeutics Limited | Aza-Macrozyklen und Verfahren zu deren Herstellung |
| DE4035760A1 (de) * | 1990-11-08 | 1992-05-14 | Schering Ag | Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| US5141740A (en) * | 1990-11-21 | 1992-08-25 | Mallinckrodt Medical, Inc. | Complexes and compositions for magnetic resonance imaging and usage methods |
| JPH0565930A (ja) * | 1991-09-06 | 1993-03-19 | Kayaba Ind Co Ltd | フロントフオーク |
| EP0565930A1 (de) * | 1992-03-27 | 1993-10-20 | Nihon Medi-Physics Co., Ltd. | Tetracyclododecan-Tetraessigsäurederivate und ihre Verwendung als diagnostische Mittel |
| EP0661279B1 (de) * | 1993-12-30 | 2001-03-07 | Guerbet | Polyaminierte Liganden, Metallkomplexe, Verfahren zur Herstellung und diagnostische und therapeutische Verwendungen |
-
1994
- 1994-12-27 EP EP94403038A patent/EP0661279B1/de not_active Expired - Lifetime
- 1994-12-27 DK DK94403038T patent/DK0661279T3/da active
- 1994-12-27 DE DE69426811T patent/DE69426811T2/de not_active Expired - Fee Related
- 1994-12-27 PT PT94403038T patent/PT661279E/pt unknown
- 1994-12-27 AT AT94403038T patent/ATE199550T1/de not_active IP Right Cessation
- 1994-12-27 ES ES94403038T patent/ES2156143T3/es not_active Expired - Lifetime
- 1994-12-28 CZ CZ19943322A patent/CZ289751B6/cs not_active IP Right Cessation
- 1994-12-28 IL IL11217594A patent/IL112175A/xx not_active IP Right Cessation
- 1994-12-29 NO NO945069A patent/NO306721B1/no unknown
- 1994-12-29 CN CN94120759A patent/CN1056162C/zh not_active Expired - Fee Related
- 1994-12-29 ZA ZA9410382A patent/ZA9410382B/xx unknown
- 1994-12-29 KR KR1019940038925A patent/KR100328575B1/ko not_active Expired - Fee Related
- 1994-12-29 AU AU81780/94A patent/AU687120B2/en not_active Ceased
- 1994-12-29 FI FI946157A patent/FI113171B/fi active
- 1994-12-29 JP JP33978594A patent/JP3862299B2/ja not_active Expired - Fee Related
- 1994-12-30 CA CA002139374A patent/CA2139374C/en not_active Expired - Fee Related
-
1995
- 1995-01-05 NZ NZ270289A patent/NZ270289A/en not_active IP Right Cessation
-
1997
- 1997-02-28 US US08/808,568 patent/US5712389A/en not_active Expired - Lifetime
- 1997-10-28 US US08/959,083 patent/US5919432A/en not_active Expired - Fee Related
-
2001
- 2001-05-22 GR GR20010400767T patent/GR3035913T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP3862299B2 (ja) | 2006-12-27 |
| NO945069D0 (no) | 1994-12-29 |
| FI946157A0 (fi) | 1994-12-29 |
| EP0661279B1 (de) | 2001-03-07 |
| DK0661279T3 (da) | 2001-07-16 |
| ZA9410382B (en) | 1996-06-29 |
| GR3035913T3 (en) | 2001-08-31 |
| IL112175A (en) | 1999-08-17 |
| US5919432A (en) | 1999-07-06 |
| FI113171B (fi) | 2004-03-15 |
| CA2139374A1 (en) | 1995-07-01 |
| AU687120B2 (en) | 1998-02-19 |
| KR100328575B1 (ko) | 2002-11-16 |
| NZ270289A (en) | 1996-05-28 |
| JPH07224050A (ja) | 1995-08-22 |
| DE69426811T2 (de) | 2001-09-13 |
| AU8178094A (en) | 1995-07-06 |
| CN1056162C (zh) | 2000-09-06 |
| ES2156143T3 (es) | 2001-06-16 |
| FI946157L (fi) | 1995-07-01 |
| IL112175A0 (en) | 1995-03-15 |
| PT661279E (pt) | 2001-06-29 |
| US5712389A (en) | 1998-01-27 |
| CZ289751B6 (cs) | 2002-03-13 |
| CZ332294A3 (en) | 1995-07-12 |
| DE69426811D1 (de) | 2001-04-12 |
| CN1110974A (zh) | 1995-11-01 |
| KR950017976A (ko) | 1995-07-22 |
| NO945069L (no) | 1995-07-03 |
| CA2139374C (en) | 2007-11-20 |
| NO306721B1 (no) | 1999-12-13 |
| EP0661279A1 (de) | 1995-07-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |