DE69426811T2 - Polyaminierte Liganden, Metallkomplexe, Verfahren zur Herstellung und diagnostische und therapeutische Verwendungen - Google Patents

Polyaminierte Liganden, Metallkomplexe, Verfahren zur Herstellung und diagnostische und therapeutische Verwendungen

Info

Publication number
DE69426811T2
DE69426811T2 DE69426811T DE69426811T DE69426811T2 DE 69426811 T2 DE69426811 T2 DE 69426811T2 DE 69426811 T DE69426811 T DE 69426811T DE 69426811 T DE69426811 T DE 69426811T DE 69426811 T2 DE69426811 T2 DE 69426811T2
Authority
DE
Germany
Prior art keywords
polyaminated
ligands
diagnostic
manufacturing processes
metal complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69426811T
Other languages
English (en)
Other versions
DE69426811D1 (de
Inventor
Dominique Meyer
Olivier Rousseaux
Michel Schaeffer
Christian Simonot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GUERBET VILLEPINTE
Original Assignee
GUERBET VILLEPINTE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GUERBET VILLEPINTE filed Critical GUERBET VILLEPINTE
Publication of DE69426811D1 publication Critical patent/DE69426811D1/de
Application granted granted Critical
Publication of DE69426811T2 publication Critical patent/DE69426811T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69426811T 1993-12-30 1994-12-27 Polyaminierte Liganden, Metallkomplexe, Verfahren zur Herstellung und diagnostische und therapeutische Verwendungen Expired - Fee Related DE69426811T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9315933 1993-12-30

Publications (2)

Publication Number Publication Date
DE69426811D1 DE69426811D1 (de) 2001-04-12
DE69426811T2 true DE69426811T2 (de) 2001-09-13

Family

ID=9454621

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69426811T Expired - Fee Related DE69426811T2 (de) 1993-12-30 1994-12-27 Polyaminierte Liganden, Metallkomplexe, Verfahren zur Herstellung und diagnostische und therapeutische Verwendungen

Country Status (19)

Country Link
US (2) US5712389A (de)
EP (1) EP0661279B1 (de)
JP (1) JP3862299B2 (de)
KR (1) KR100328575B1 (de)
CN (1) CN1056162C (de)
AT (1) ATE199550T1 (de)
AU (1) AU687120B2 (de)
CA (1) CA2139374C (de)
CZ (1) CZ289751B6 (de)
DE (1) DE69426811T2 (de)
DK (1) DK0661279T3 (de)
ES (1) ES2156143T3 (de)
FI (1) FI113171B (de)
GR (1) GR3035913T3 (de)
IL (1) IL112175A (de)
NO (1) NO306721B1 (de)
NZ (1) NZ270289A (de)
PT (1) PT661279E (de)
ZA (1) ZA9410382B (de)

Families Citing this family (44)

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ATE199550T1 (de) * 1993-12-30 2001-03-15 Guerbet Sa Polyaminierte liganden, metallkomplexe, verfahren zur herstellung und diagnostische und therapeutische verwendungen
NZ280272A (en) * 1994-10-21 1996-11-26 Nihon Mediphysics Co Ltd Diagnostic imaging agent comprising a metal ion and bifunctional ligand bonded to an amino- or dialdehyde- oligosaccharide
TW319763B (de) 1995-02-01 1997-11-11 Epix Medical Inc
US6770261B2 (en) 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
IT1283218B1 (it) * 1996-03-08 1998-04-16 Bracco Spa Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US7632651B2 (en) * 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
EP1032430A2 (de) 1997-11-17 2000-09-06 Research Corporation Technologies, Inc. Mri-mittel zum nachweis von physiologischen mitteln
FR2772025B1 (fr) * 1997-12-10 2000-03-03 Guerbet Sa Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
US6685915B2 (en) * 1999-12-01 2004-02-03 General Electric Company Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging
US20040170562A1 (en) * 1999-12-01 2004-09-02 Uzgiris Egidijus Edward Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
WO2002006287A2 (en) 2000-07-17 2002-01-24 California Institute Of Technology Macrocyclic mri contrast agents
US7029655B2 (en) 2000-10-04 2006-04-18 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
AU2002241576A1 (en) 2000-11-20 2002-06-11 Board Of Regents University Of Texas System Paramagnetic metal ion-based macrocyclic contrast agents
US20030050452A1 (en) * 2000-12-26 2003-03-13 Yuji Hashiguchi Process for producing metal complex of aminooligosaccharide derivative
US20030215391A1 (en) * 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
DE10135356C1 (de) * 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
FR2829493B1 (fr) * 2001-09-10 2005-08-05 Commissariat Energie Atomique Composes thermosensibles presentant un point de trouble, utilisables comme extractants pour la separation de metaux en solution aqueuse
EP1369134A1 (de) 2002-06-05 2003-12-10 Bracco Imaging S.p.A. Mittel fur magnetisches Bildformungsverfahren
US20040018576A1 (en) * 2002-07-24 2004-01-29 Dematteo Todd M. Bence Jones protein testing cassette
US20040022857A1 (en) * 2002-07-31 2004-02-05 Uzgiris Egidijus E. Synthesis of highly conjugated polymers
FR2856063B1 (fr) * 2003-06-13 2005-10-07 Air Liquide Procede de preparation du cis-8b-methyldecahydro-2a,4a,6a, 8a-tetraazacyclopenta[fg]acenaphthylene,ou du cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg] acenaphthylene, du cyclene, et de cyclenes fonctionnalises
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
JP4956426B2 (ja) * 2004-07-02 2012-06-20 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 高緩和能造影剤
CA2581639C (en) 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
US20060275217A1 (en) * 2005-05-06 2006-12-07 Caravan Peter D Chemical exchange saturation transfer contrast agents
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
EP1940841B9 (de) 2005-10-07 2017-04-19 Guerbet Verbindungen mit einem eine biologische zielstruktur erkennenden teil, das mit einem zum komplexieren von gallium fähigen signalteil gekoppelt ist
EP1964846A1 (de) * 2007-02-27 2008-09-03 Bracco Imaging, S.P.A. Herstellungsverfahren für Kontrastmittel
FR2914303A1 (fr) 2007-03-28 2008-10-03 Guerbet Sa Composes pour le diagnostic de l'apoptose.
FR2914304B1 (fr) 2007-03-28 2012-11-16 Guerbet Sa Composes pour le diagnostic de maladies liees a l'expression de vcam.
FR2942227B1 (fr) 2009-02-13 2011-04-15 Guerbet Sa Utilisation de tampons pour la complexation de radionucleides
JP5735791B2 (ja) * 2010-12-07 2015-06-17 住友化学株式会社 金属錯体を含む素子
WO2014027354A1 (en) 2012-08-15 2014-02-20 Nova Measuring Instruments Ltd. Optical metrology for in-situ measurements
US20160287726A1 (en) * 2015-04-06 2016-10-06 The Trustees Of The University Of Pennsylvania Cationic contrast agents and methods of using the same
US10918742B2 (en) 2016-03-25 2021-02-16 Nanoprobes, Inc. Iodine-based particles

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US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4687658A (en) * 1984-10-04 1987-08-18 Salutar, Inc. Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging
EP0529645B1 (de) * 1986-09-05 1996-10-23 GANSOW, Otto A. Verfahren zur Herstellung hauptkettenpolysubstituierter Chelate
CA1341373C (en) * 1988-06-24 2002-07-02 Roberta C. Cheng Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
WO1990009379A1 (en) * 1989-02-10 1990-08-23 Celltech Limited Aza-macrocycles and processes for their preparation
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5141740A (en) * 1990-11-21 1992-08-25 Mallinckrodt Medical, Inc. Complexes and compositions for magnetic resonance imaging and usage methods
JPH0565930A (ja) * 1991-09-06 1993-03-19 Kayaba Ind Co Ltd フロントフオーク
KR930019648A (ko) * 1992-03-27 1993-10-18 도키 가츠유키 테트라아자시클로도덴칸 유도체 및 그의 용도
ATE199550T1 (de) * 1993-12-30 2001-03-15 Guerbet Sa Polyaminierte liganden, metallkomplexe, verfahren zur herstellung und diagnostische und therapeutische verwendungen

Also Published As

Publication number Publication date
KR100328575B1 (ko) 2002-11-16
FI946157A (fi) 1995-07-01
DK0661279T3 (da) 2001-07-16
AU687120B2 (en) 1998-02-19
DE69426811D1 (de) 2001-04-12
NZ270289A (en) 1996-05-28
JPH07224050A (ja) 1995-08-22
CZ289751B6 (cs) 2002-03-13
FI946157A0 (fi) 1994-12-29
CA2139374C (en) 2007-11-20
GR3035913T3 (en) 2001-08-31
ZA9410382B (en) 1996-06-29
NO945069L (no) 1995-07-03
US5712389A (en) 1998-01-27
CN1110974A (zh) 1995-11-01
IL112175A (en) 1999-08-17
FI113171B (fi) 2004-03-15
CZ332294A3 (en) 1995-07-12
CA2139374A1 (en) 1995-07-01
AU8178094A (en) 1995-07-06
EP0661279B1 (de) 2001-03-07
ES2156143T3 (es) 2001-06-16
ATE199550T1 (de) 2001-03-15
JP3862299B2 (ja) 2006-12-27
EP0661279A1 (de) 1995-07-05
CN1056162C (zh) 2000-09-06
NO945069D0 (no) 1994-12-29
NO306721B1 (no) 1999-12-13
PT661279E (pt) 2001-06-29
US5919432A (en) 1999-07-06
IL112175A0 (en) 1995-03-15
KR950017976A (ko) 1995-07-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee