FI946157A - Polyaminoituja ligandeja ja niiden metallikomplekseja - Google Patents

Polyaminoituja ligandeja ja niiden metallikomplekseja Download PDF

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Publication number
FI946157A
FI946157A FI946157A FI946157A FI946157A FI 946157 A FI946157 A FI 946157A FI 946157 A FI946157 A FI 946157A FI 946157 A FI946157 A FI 946157A FI 946157 A FI946157 A FI 946157A
Authority
FI
Finland
Prior art keywords
polyaminated
ligands
metal complexes
alkyl
groups
Prior art date
Application number
FI946157A
Other languages
English (en)
Swedish (sv)
Other versions
FI113171B (fi
FI946157A0 (fi
Inventor
Dominique Meyer
Olivier Rousseaux
Michel Schaefer
Christian Simonot
Original Assignee
Guerbet Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet Sa filed Critical Guerbet Sa
Publication of FI946157A0 publication Critical patent/FI946157A0/fi
Publication of FI946157A publication Critical patent/FI946157A/fi
Application granted granted Critical
Publication of FI113171B publication Critical patent/FI113171B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI946157A 1993-12-30 1994-12-29 Ydinmagneettiresonanssikuvauksessa käytettävä preparaatti, joka sisältää paramagneettisen metallikelaatin FI113171B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9315933 1993-12-30
FR9315933 1993-12-30

Publications (3)

Publication Number Publication Date
FI946157A0 FI946157A0 (fi) 1994-12-29
FI946157A true FI946157A (fi) 1995-07-01
FI113171B FI113171B (fi) 2004-03-15

Family

ID=9454621

Family Applications (1)

Application Number Title Priority Date Filing Date
FI946157A FI113171B (fi) 1993-12-30 1994-12-29 Ydinmagneettiresonanssikuvauksessa käytettävä preparaatti, joka sisältää paramagneettisen metallikelaatin

Country Status (19)

Country Link
US (2) US5712389A (fi)
EP (1) EP0661279B1 (fi)
JP (1) JP3862299B2 (fi)
KR (1) KR100328575B1 (fi)
CN (1) CN1056162C (fi)
AT (1) ATE199550T1 (fi)
AU (1) AU687120B2 (fi)
CA (1) CA2139374C (fi)
CZ (1) CZ289751B6 (fi)
DE (1) DE69426811T2 (fi)
DK (1) DK0661279T3 (fi)
ES (1) ES2156143T3 (fi)
FI (1) FI113171B (fi)
GR (1) GR3035913T3 (fi)
IL (1) IL112175A (fi)
NO (1) NO306721B1 (fi)
NZ (1) NZ270289A (fi)
PT (1) PT661279E (fi)
ZA (1) ZA9410382B (fi)

Families Citing this family (44)

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Publication number Priority date Publication date Assignee Title
ATE199550T1 (de) * 1993-12-30 2001-03-15 Guerbet Sa Polyaminierte liganden, metallkomplexe, verfahren zur herstellung und diagnostische und therapeutische verwendungen
US5863518A (en) * 1994-10-21 1999-01-26 Nihon Medi-Physics Co., Ltd. Diagnostic imaging agent with backbone with modified sugar chain end
TW319763B (fi) 1995-02-01 1997-11-11 Epix Medical Inc
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
US6770261B2 (en) 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
IT1283218B1 (it) * 1996-03-08 1998-04-16 Bracco Spa Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US7632651B2 (en) * 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
EP1032430A2 (en) 1997-11-17 2000-09-06 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
FR2772025B1 (fr) * 1997-12-10 2000-03-03 Guerbet Sa Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
US20040170562A1 (en) * 1999-12-01 2004-09-02 Uzgiris Egidijus Edward Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging
US6685915B2 (en) * 1999-12-01 2004-02-03 General Electric Company Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
WO2002006287A2 (en) 2000-07-17 2002-01-24 California Institute Of Technology Macrocyclic mri contrast agents
WO2002028441A2 (en) 2000-10-04 2002-04-11 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
US6875419B2 (en) 2000-11-20 2005-04-05 Board Of Regents The University Of Texas System Paramagnetic metal ion-based macrocyclic magnetization transfer contrast agents and method of use
US20030050452A1 (en) * 2000-12-26 2003-03-13 Yuji Hashiguchi Process for producing metal complex of aminooligosaccharide derivative
US20030215391A1 (en) * 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
DE10135356C1 (de) * 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
FR2829493B1 (fr) * 2001-09-10 2005-08-05 Commissariat Energie Atomique Composes thermosensibles presentant un point de trouble, utilisables comme extractants pour la separation de metaux en solution aqueuse
EP1369134A1 (en) 2002-06-05 2003-12-10 Bracco Imaging S.p.A. New agents for magnetic imaging method
US20040018576A1 (en) * 2002-07-24 2004-01-29 Dematteo Todd M. Bence Jones protein testing cassette
US20040022857A1 (en) * 2002-07-31 2004-02-05 Uzgiris Egidijus E. Synthesis of highly conjugated polymers
FR2856063B1 (fr) * 2003-06-13 2005-10-07 Air Liquide Procede de preparation du cis-8b-methyldecahydro-2a,4a,6a, 8a-tetraazacyclopenta[fg]acenaphthylene,ou du cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg] acenaphthylene, du cyclene, et de cyclenes fonctionnalises
FR2856689A1 (fr) * 2003-06-25 2004-12-31 Guerbet Sa Composes specifiques a forte relaxivite
FR2857967B1 (fr) * 2003-07-25 2015-04-24 Centre Nat Rech Scient Complexes de lanthanide, leur preparation et leurs utilisations
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
ATE430146T1 (de) * 2004-07-02 2009-05-15 Bracco Imaging Spa Kontrastmittel mit hoher relaxivität zur verwendung in der magnetresonanzbilddarstellung (mri), enthaltend eine chelatbildende gruppe mit polyhydroxylierten substituenten
CA2581639C (en) 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
US20060275217A1 (en) * 2005-05-06 2006-12-07 Caravan Peter D Chemical exchange saturation transfer contrast agents
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
US8926945B2 (en) 2005-10-07 2015-01-06 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
EP1964846A1 (en) * 2007-02-27 2008-09-03 Bracco Imaging, S.P.A. Process for the preparation of contrast agents
FR2914303A1 (fr) * 2007-03-28 2008-10-03 Guerbet Sa Composes pour le diagnostic de l'apoptose.
FR2914304B1 (fr) 2007-03-28 2012-11-16 Guerbet Sa Composes pour le diagnostic de maladies liees a l'expression de vcam.
FR2942227B1 (fr) 2009-02-13 2011-04-15 Guerbet Sa Utilisation de tampons pour la complexation de radionucleides
JP5735791B2 (ja) * 2010-12-07 2015-06-17 住友化学株式会社 金属錯体を含む素子
TWI600895B (zh) 2012-08-15 2017-10-01 諾發測量儀器股份有限公司 原位控制製程的方法及設備
US20160287726A1 (en) * 2015-04-06 2016-10-06 The Trustees Of The University Of Pennsylvania Cationic contrast agents and methods of using the same
US10918742B2 (en) 2016-03-25 2021-02-16 Nanoprobes, Inc. Iodine-based particles

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US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4687658A (en) * 1984-10-04 1987-08-18 Salutar, Inc. Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging
EP0529645B1 (en) * 1986-09-05 1996-10-23 GANSOW, Otto A. Process for the preparation of backbone polysubstituted chelates
NZ229700A (en) * 1988-06-24 1993-01-27 Dow Chemical Co Tetraazacyclododecane derivatives containing a linker/spacer moiety capable of forming antibody conjugates; complexes with radionuclides and conjugates of such compounds and complexes with antibodies or antibody fragments
WO1990009379A1 (en) * 1989-02-10 1990-08-23 Celltech Limited Aza-macrocycles and processes for their preparation
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5141740A (en) * 1990-11-21 1992-08-25 Mallinckrodt Medical, Inc. Complexes and compositions for magnetic resonance imaging and usage methods
JPH0565930A (ja) * 1991-09-06 1993-03-19 Kayaba Ind Co Ltd フロントフオーク
AU663572B2 (en) * 1992-03-27 1995-10-12 Nihon Medi-Physics Co., Ltd. Tetraazacyclododecane derivative and its use
ATE199550T1 (de) * 1993-12-30 2001-03-15 Guerbet Sa Polyaminierte liganden, metallkomplexe, verfahren zur herstellung und diagnostische und therapeutische verwendungen

Also Published As

Publication number Publication date
CA2139374C (en) 2007-11-20
ZA9410382B (en) 1996-06-29
NZ270289A (en) 1996-05-28
US5712389A (en) 1998-01-27
JP3862299B2 (ja) 2006-12-27
US5919432A (en) 1999-07-06
PT661279E (pt) 2001-06-29
CA2139374A1 (en) 1995-07-01
KR100328575B1 (ko) 2002-11-16
AU8178094A (en) 1995-07-06
EP0661279B1 (fr) 2001-03-07
FI113171B (fi) 2004-03-15
NO306721B1 (no) 1999-12-13
ES2156143T3 (es) 2001-06-16
DK0661279T3 (da) 2001-07-16
CN1110974A (zh) 1995-11-01
DE69426811T2 (de) 2001-09-13
ATE199550T1 (de) 2001-03-15
FI946157A0 (fi) 1994-12-29
CZ289751B6 (cs) 2002-03-13
NO945069D0 (no) 1994-12-29
IL112175A (en) 1999-08-17
KR950017976A (ko) 1995-07-22
GR3035913T3 (en) 2001-08-31
DE69426811D1 (de) 2001-04-12
EP0661279A1 (fr) 1995-07-05
CZ332294A3 (en) 1995-07-12
JPH07224050A (ja) 1995-08-22
NO945069L (no) 1995-07-03
IL112175A0 (en) 1995-03-15
AU687120B2 (en) 1998-02-19
CN1056162C (zh) 2000-09-06

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