ATE120457T1 - Macrocyclische bifunktionelle chelatbildner, komplexe davon und ihre konjugierten antikörper. - Google Patents
Macrocyclische bifunktionelle chelatbildner, komplexe davon und ihre konjugierten antikörper.Info
- Publication number
- ATE120457T1 ATE120457T1 AT89111497T AT89111497T ATE120457T1 AT E120457 T1 ATE120457 T1 AT E120457T1 AT 89111497 T AT89111497 T AT 89111497T AT 89111497 T AT89111497 T AT 89111497T AT E120457 T1 ATE120457 T1 AT E120457T1
- Authority
- AT
- Austria
- Prior art keywords
- complexes
- chelating agents
- bifunctional chelating
- conjugate antibodies
- macrocyclic bifunctional
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
- A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21149688A | 1988-06-24 | 1988-06-24 | |
US37095689A | 1989-06-21 | 1989-06-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE120457T1 true ATE120457T1 (de) | 1995-04-15 |
Family
ID=26906194
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89111497T ATE120457T1 (de) | 1988-06-24 | 1989-06-23 | Macrocyclische bifunktionelle chelatbildner, komplexe davon und ihre konjugierten antikörper. |
Country Status (20)
Country | Link |
---|---|
US (1) | US5435990A (de) |
EP (2) | EP0353450B1 (de) |
JP (1) | JP2831073B2 (de) |
KR (1) | KR0137930B1 (de) |
AT (1) | ATE120457T1 (de) |
AU (1) | AU634167B2 (de) |
BR (1) | BR8907507A (de) |
CA (1) | CA1341373C (de) |
DE (2) | DE353450T1 (de) |
DK (1) | DK175393B1 (de) |
ES (1) | ES2013978A4 (de) |
FI (2) | FI103792B1 (de) |
GR (1) | GR900300034T1 (de) |
HK (1) | HK60696A (de) |
HU (1) | HU219485B (de) |
IE (1) | IE67273B1 (de) |
IL (1) | IL90730A0 (de) |
NO (1) | NO179008C (de) |
NZ (1) | NZ229700A (de) |
WO (1) | WO1989012631A1 (de) |
Families Citing this family (100)
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WO1990007342A1 (en) * | 1988-12-23 | 1990-07-12 | The Dow Chemical Company | Process for preparing isothiocyanato functionalized metal complexes |
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US5686410A (en) * | 1989-07-20 | 1997-11-11 | Novartis Ag | Polypeptide derivatives |
JPH05503072A (ja) * | 1989-08-28 | 1993-05-27 | ザ・ゼネラル・ホスピタル・コーポレーション | 診断用nmr映像化の為のヒドロキシ―アリール金属キレート |
DE3938992A1 (de) | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
US5410043A (en) * | 1991-12-06 | 1995-04-25 | Schering Aktiengesellschaft | Process for the production of mono-N-substituted tetraaza macrocycles |
CA2092596A1 (en) * | 1992-03-27 | 1993-09-28 | Kan Kubomura | Tetraazacyclododecane derivative and its use |
CA2117775A1 (en) * | 1992-04-13 | 1993-10-28 | Roberta C. Cheng | Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof |
US5310535A (en) * | 1992-04-24 | 1994-05-10 | The Dow Chemical Company | Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies |
DE4218744C2 (de) * | 1992-06-04 | 1997-11-06 | Schering Ag | Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe |
US5505931A (en) * | 1993-03-04 | 1996-04-09 | The Dow Chemical Company | Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents |
US5462725A (en) * | 1993-05-06 | 1995-10-31 | The Dow Chemical Company | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
DE69426811T2 (de) * | 1993-12-30 | 2001-09-13 | Guerbet Villepinte | Polyaminierte Liganden, Metallkomplexe, Verfahren zur Herstellung und diagnostische und therapeutische Verwendungen |
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Family Cites Families (17)
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DE3772785D1 (de) * | 1986-01-23 | 1991-10-17 | Squibb & Sons Inc | 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga. |
GB8603537D0 (en) * | 1986-02-13 | 1986-03-19 | Parker D | Conjugate compound |
DE3625417C2 (de) * | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
DE3713842A1 (de) * | 1987-04-22 | 1988-11-17 | Schering Ag | Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
US5006643A (en) * | 1987-06-24 | 1991-04-09 | The Dow Chemical Company | Process for preparing isothiocyanato functionalized metal complexes |
US4994560A (en) * | 1987-06-24 | 1991-02-19 | The Dow Chemical Company | Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies |
GB8719041D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
GB8719042D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
EP0416033B1 (de) * | 1988-05-25 | 1996-03-06 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Makrocyclische chelate und verwendungsverfahren |
ZA894792B (en) * | 1988-06-24 | 1991-04-24 | Dow Chemical Co | Macrocyclic bifunctional chelants,complexes thereof and their antibody conjugates |
-
1989
- 1989-06-23 ES ES89111497T patent/ES2013978A4/es active Pending
- 1989-06-23 BR BR898907507A patent/BR8907507A/pt not_active Application Discontinuation
- 1989-06-23 JP JP1508008A patent/JP2831073B2/ja not_active Expired - Lifetime
- 1989-06-23 EP EP89111497A patent/EP0353450B1/de not_active Expired - Lifetime
- 1989-06-23 EP EP89908599A patent/EP0420942A1/de not_active Withdrawn
- 1989-06-23 NZ NZ229700A patent/NZ229700A/xx unknown
- 1989-06-23 WO PCT/US1989/002788 patent/WO1989012631A1/en active IP Right Grant
- 1989-06-23 AU AU39794/89A patent/AU634167B2/en not_active Expired
- 1989-06-23 HU HU432/89A patent/HU219485B/hu unknown
- 1989-06-23 IL IL90730A patent/IL90730A0/xx unknown
- 1989-06-23 CA CA000603894A patent/CA1341373C/en not_active Expired - Fee Related
- 1989-06-23 AT AT89111497T patent/ATE120457T1/de not_active IP Right Cessation
- 1989-06-23 DE DE198989111497T patent/DE353450T1/de active Pending
- 1989-06-23 IE IE204589A patent/IE67273B1/en not_active IP Right Cessation
- 1989-06-23 DE DE68921941T patent/DE68921941T2/de not_active Expired - Lifetime
-
1990
- 1990-02-23 NO NO900869A patent/NO179008C/no not_active IP Right Cessation
- 1990-02-23 KR KR90700403A patent/KR0137930B1/ko not_active IP Right Cessation
- 1990-02-23 DK DK199000493A patent/DK175393B1/da not_active IP Right Cessation
- 1990-12-21 FI FI906368A patent/FI103792B1/fi active IP Right Grant
-
1991
- 1991-07-31 GR GR90300034T patent/GR900300034T1/el unknown
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1992
- 1992-10-15 US US07/962,168 patent/US5435990A/en not_active Expired - Lifetime
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1996
- 1996-04-11 HK HK60696A patent/HK60696A/xx not_active IP Right Cessation
-
1998
- 1998-10-23 FI FI982303A patent/FI117889B/fi active IP Right Grant
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UEP | Publication of translation of european patent specification | ||
EELA | Cancelled due to lapse of time |