DE69032761T2 - Hydroxy-aryl metallchelate für bildformung zur nmr diagnose - Google Patents

Hydroxy-aryl metallchelate für bildformung zur nmr diagnose

Info

Publication number
DE69032761T2
DE69032761T2 DE69032761T DE69032761T DE69032761T2 DE 69032761 T2 DE69032761 T2 DE 69032761T2 DE 69032761 T DE69032761 T DE 69032761T DE 69032761 T DE69032761 T DE 69032761T DE 69032761 T2 DE69032761 T2 DE 69032761T2
Authority
DE
Germany
Prior art keywords
iii
nitrogens
ligand
hydroxy
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69032761T
Other languages
English (en)
Other versions
DE69032761D1 (de
Inventor
Randall Lauffer
Scott Larsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Application granted granted Critical
Publication of DE69032761D1 publication Critical patent/DE69032761D1/de
Publication of DE69032761T2 publication Critical patent/DE69032761T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
DE69032761T 1989-08-28 1990-08-28 Hydroxy-aryl metallchelate für bildformung zur nmr diagnose Expired - Fee Related DE69032761T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39973789A 1989-08-28 1989-08-28
PCT/US1990/004887 WO1991003200A1 (en) 1989-08-28 1990-08-28 Hydroxy-aryl metal chelates for diagnostic nmr imaging

Publications (2)

Publication Number Publication Date
DE69032761D1 DE69032761D1 (de) 1998-12-17
DE69032761T2 true DE69032761T2 (de) 1999-04-22

Family

ID=23580762

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69032761T Expired - Fee Related DE69032761T2 (de) 1989-08-28 1990-08-28 Hydroxy-aryl metallchelate für bildformung zur nmr diagnose

Country Status (7)

Country Link
EP (1) EP0489869B1 (de)
JP (1) JPH05503072A (de)
AT (1) ATE173336T1 (de)
CA (1) CA2065290C (de)
DE (1) DE69032761T2 (de)
HK (1) HK1012707A1 (de)
WO (1) WO1991003200A1 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5562894A (en) * 1991-08-09 1996-10-08 Regents Of The University Of California Amino-acyl-type and catecholamine-type contrast agents for MRI
DE4136489A1 (de) * 1991-11-06 1993-05-13 Bayer Ag Neue diethylentriamin-derivate und deren verwendung zu diagnostischen und therapeutischen zwecken
US5532006A (en) * 1993-04-23 1996-07-02 The Board Of Trustees Of The University Of Illinois Magnetic gels which change volume in response to voltage changes for MRI
US5480970A (en) * 1993-12-22 1996-01-02 Resolution Pharmaceuticals Metal chelators
US5569745A (en) * 1994-02-25 1996-10-29 Resolution Pharmaceuticals Inc. Peptide-Chelator conjugates
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
TW319763B (de) * 1995-02-01 1997-11-11 Epix Medical Inc
CN1108824C (zh) 1996-04-01 2003-05-21 Epix医学公司 生物活化的诊断成像造影剂
AU2002241576A1 (en) * 2000-11-20 2002-06-11 Board Of Regents University Of Texas System Paramagnetic metal ion-based macrocyclic contrast agents
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
WO2003074005A2 (en) 2002-03-01 2003-09-12 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
DK2949658T3 (en) 2003-03-03 2018-10-01 Dyax Corp Peptides that specifically bind HGF receptor (cMet) and uses thereof
WO2010107832A1 (en) 2009-03-17 2010-09-23 Bracco Imaging Spa Lhrh-ii peptide analogs
CN102356087A (zh) 2009-03-19 2012-02-15 惠氏有限责任公司 [2-(8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1(7)-烯-2-基)乙基]膦酸及其前体的制备方法
WO2010121133A2 (en) 2009-04-17 2010-10-21 The General Hospital Corporation Multimodal imaging of fibrin
US8378134B2 (en) 2009-09-30 2013-02-19 General Electric Company Hydroxylated contrast enhancement agents
US20110077396A1 (en) * 2009-09-30 2011-03-31 General Electric Company Intermediates for hydroxylated contrast enhancement agents
US8722020B2 (en) * 2010-03-31 2014-05-13 General Electric Company Hydroxylated contrast enhancement agents
JP6297440B2 (ja) * 2013-07-31 2018-03-20 キヤノンメディカルシステムズ株式会社 造影剤
US10471163B2 (en) 2013-09-13 2019-11-12 The General Hospital Corporation Activatable fibrin-binding probes
WO2015171543A1 (en) 2014-05-05 2015-11-12 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
WO2015196208A2 (en) 2014-06-20 2015-12-23 The General Hospital Corporation Collagen targeted imaging probes
WO2016149404A1 (en) 2015-03-16 2016-09-22 California Institute Of Technology Botulinum neurotoxin-specific capture agents, compositions, and methods of using and making
CN104910030B (zh) * 2015-05-14 2018-03-23 石家庄杰克化工有限公司 一种高纯度乙醇胺类氨羧螯合剂的合成工艺
EP3101012A1 (de) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung
CN115112898A (zh) 2015-07-15 2022-09-27 加州理工学院 Il-17f-特异性捕获剂、组合物以及使用和制造的方法
US9829474B2 (en) * 2015-10-16 2017-11-28 General Electric Company Acetate complexes and methods for acetate quantification
WO2017176769A1 (en) 2016-04-04 2017-10-12 Indi Molecular, Inc. Cd8-specific capture agents, compositions, and methods of using and making
US11884707B2 (en) 2016-09-29 2024-01-30 Regeneron Pharmaceuticals, Inc. Compositions for detection, inhibition and imaging of indoleamine 2, 3-dioxygenase 1 (IDO1) and methods of making and using same
EP3535278A4 (de) 2016-11-01 2020-06-24 Ohio State Innovation Foundation Verfahren zur jodierung von biomolekülen
CN110035996B (zh) 2016-11-28 2022-08-09 拜耳医药股份公司 用于磁共振成像的新型高弛豫性钆螯合物
EP3638687A1 (de) 2017-06-15 2020-04-22 Indi Molecular, Inc. Il-17f- und il-17a-spezifische fänger, zusammensetzungen und verfahren zur verwendung und herstellung davon
US11919972B2 (en) 2018-11-02 2024-03-05 Regeneron Pharmaceuticals, Inc. Peptide libraries with non-canonical amino acids
WO2020097531A1 (en) 2018-11-08 2020-05-14 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
WO2020104602A1 (en) 2018-11-23 2020-05-28 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
WO2020186091A1 (en) 2019-03-12 2020-09-17 Indi Molecular, Inc. Cross-linked epitopes and methods of use thereof
WO2020236969A1 (en) 2019-05-20 2020-11-26 Indi Molecular, Inc. Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1)
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
EP4143227A2 (de) 2020-04-30 2023-03-08 Sairopa B.V. Anti-cd103 antikörper
WO2022098745A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy
WO2022098743A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632637A (en) * 1968-02-13 1972-01-04 Arthur E Martell Hydroxyaryl-containing aminocarboxylic chelating agents
FR2354993A1 (fr) * 1976-06-16 1978-01-13 Dabeer Procede pour la preparation de derives phenoliques d'acides hydroxyalcoyl-alcoylene-diaminoacetiques et de leurs sels
US4687658A (en) * 1984-10-04 1987-08-18 Salutar, Inc. Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
US4746507A (en) * 1985-04-02 1988-05-24 Salutar, Inc. EDHPA based contrast agents for MR imaging, apparatus and methods
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
DE3772785D1 (de) * 1986-01-23 1991-10-17 Squibb & Sons Inc 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga.
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
GB2205128A (en) * 1987-05-22 1988-11-30 Daniel Stefanini Pumps
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
GB8719041D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
DE3728600A1 (de) * 1987-08-27 1989-03-09 Hoechst Ag Verfahren zur markierung von substanzen mit technetium oder rhenium
HU219485B (hu) * 1988-06-24 2001-04-28 Dow Chemical Co. Eljárás 1,4,7,10-tetraaza-ciklododekán-származékok, ezek komplexei, valamint antitestekkel képzett konjugátumai, és ilyeneket tartalmazó gyógyszerkészítmények előállítására és a komplexeket, illetve konjugátumokat tartalmazó diagnosztikai készítmények
BR8907282A (pt) * 1988-12-23 1991-03-12 Dow Chemical Co Processo para preparar complexos de metal funcionalizados com isotiocianato
FR2643370B1 (fr) * 1989-02-22 1991-08-23 Air Liquide Derives polyazotes et leurs complexes metalliques utilisables pour la fixation de l'oxygene

Also Published As

Publication number Publication date
WO1991003200A1 (en) 1991-03-21
HK1012707A1 (en) 1999-08-06
EP0489869A4 (en) 1993-03-17
CA2065290C (en) 2000-12-12
DE69032761D1 (de) 1998-12-17
EP0489869B1 (de) 1998-11-11
CA2065290A1 (en) 1991-03-01
EP0489869A1 (de) 1992-06-17
JPH05503072A (ja) 1993-05-27
ATE173336T1 (de) 1998-11-15

Similar Documents

Publication Publication Date Title
DE69032761D1 (de) Hydroxy-aryl metallchelate für bildformung zur nmr diagnose
AU561599B2 (en) Nmr contrast agents
DE68925904T2 (de) Makrocyclische chelate und verwendungsverfahren
AU1461188A (en) Nitrogen-containing cyclic ligands, metallic complexes formed by these ligands, diagnostic compositions containing these complexes and process for the preparation of the ligands
DE69019584D1 (de) Makrocyclische Stickstoffliganden Verfahren zu ihrer Herstellung, ihre Metallkomplexe, sie enthaltende Diagnostische und therapeutische Mittel.
DE69527759D1 (de) Mono -und multimere verbindungen mit erhöhter relaxation
PL327931A1 (en) Perfluorine-bearing metal complexes, method of obtaining them and their application in nmr diagnostics
NO873237L (no) Fremgangsmaate ved nmr-avbilding.
NZ333264A (en) Chelates from macrocyclic polyaminocarboxylic acids with metal cations and their use in magnetic resonance imaging (MRI) for magnetic cations
IL106164A0 (en) Polyazamacrocyclic compounds and their complexes with metal ions
ES2100827T3 (es) Quelatantes macrociclicos, sus quelatos y usos de los mismos en el campo diagnostico.
DE69009758D1 (de) Mittel für magnetische resonanzbilderzeugung.
US5118499A (en) Quinoline polymers, their chelates and process of preparation and use
ATE122665T1 (de) Zyklische, stickstoff enthaltende liganden, ihre metallkomplexe, diese enthaltende diagnostik- mittel und verfahren zur herstellung der liganden.
ES2021944A6 (es) Procedimiento para preparar nuevos derivados de 1,3,5,-triamino-2,4,6-triyodobenceno.
Hofer Konformationsanalyse mittels Lanthaniden-induzierter Verschiebungen. II 1 2-und 3-alkylsubstituierte 1-Indanone
GRISWOLD THE SYNTHESIS AND POLAROGRAPHIC REDUCTION OF THE COPPER (II) CHELATES OF SOME BETA-KETO IMINES.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee