DE69032761T2 - HYDROXY ARYL METAL CHELATE FOR IMAGING FOR NMR DIAGNOSTICS - Google Patents

HYDROXY ARYL METAL CHELATE FOR IMAGING FOR NMR DIAGNOSTICS

Info

Publication number
DE69032761T2
DE69032761T2 DE69032761T DE69032761T DE69032761T2 DE 69032761 T2 DE69032761 T2 DE 69032761T2 DE 69032761 T DE69032761 T DE 69032761T DE 69032761 T DE69032761 T DE 69032761T DE 69032761 T2 DE69032761 T2 DE 69032761T2
Authority
DE
Germany
Prior art keywords
iii
nitrogens
ligand
hydroxy
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69032761T
Other languages
German (de)
Other versions
DE69032761D1 (en
Inventor
Randall Lauffer
Scott Larsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Application granted granted Critical
Publication of DE69032761D1 publication Critical patent/DE69032761D1/en
Publication of DE69032761T2 publication Critical patent/DE69032761T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Abstract

An NMR contrast agent composition contains a complex of a selected metal ion and a selected ligand. The ion is selected from the group consisting of gadolinium (III), iron (III), manganese (II), manganese (III), chromium (III), copper (II), dysprosium (III), terbium (III), holmium (III), erbium (III), europium (II), and europium (III); and the ligand is a linear two-nitrogen compound having one 2-hydroxy-aryl group at one of the nitrogens; or the ligand is a linear two-nitrogen compound having one or two 2-hydroxy-aryl groups at each of the nitrogens; or the ligand is a linear three-, four-, or five-nitrogen compound having one or two 2-hydroxy-aryl substituents at each of one or more of the nitrogens, or the ligand is a heterocyclic compound having a ring containing three or four nitrogens, and having a 2-hydroxy-aryl substituent at one or more of the nitrogens; or the ligand is a heterocyclic compound having a ring containing 4 nitrogens, and having a carboxyl group at two of the nitrogens and an aromatic substituent at the other two of the nitrogens. Also, a method for enhancing the contrast in NMR imaging in a patient includes steps of preparing an NMR contrast enhancing agent by mixing an NMR contrast compound of the invention with a pharmaceutically acceptable carrier, introducing the NMR contrast enhancing agent into the patient, and subjecting the patient to NMR imaging.
DE69032761T 1989-08-28 1990-08-28 HYDROXY ARYL METAL CHELATE FOR IMAGING FOR NMR DIAGNOSTICS Expired - Fee Related DE69032761T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39973789A 1989-08-28 1989-08-28
PCT/US1990/004887 WO1991003200A1 (en) 1989-08-28 1990-08-28 Hydroxy-aryl metal chelates for diagnostic nmr imaging

Publications (2)

Publication Number Publication Date
DE69032761D1 DE69032761D1 (en) 1998-12-17
DE69032761T2 true DE69032761T2 (en) 1999-04-22

Family

ID=23580762

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69032761T Expired - Fee Related DE69032761T2 (en) 1989-08-28 1990-08-28 HYDROXY ARYL METAL CHELATE FOR IMAGING FOR NMR DIAGNOSTICS

Country Status (7)

Country Link
EP (1) EP0489869B1 (en)
JP (1) JPH05503072A (en)
AT (1) ATE173336T1 (en)
CA (1) CA2065290C (en)
DE (1) DE69032761T2 (en)
HK (1) HK1012707A1 (en)
WO (1) WO1991003200A1 (en)

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ES2692166T3 (en) 2003-03-03 2018-11-30 Dyax Corp. Peptides that specifically bind to the HGF receptor (cMet) and uses thereof
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US20110077396A1 (en) * 2009-09-30 2011-03-31 General Electric Company Intermediates for hydroxylated contrast enhancement agents
US8378134B2 (en) 2009-09-30 2013-02-19 General Electric Company Hydroxylated contrast enhancement agents
US8722020B2 (en) * 2010-03-31 2014-05-13 General Electric Company Hydroxylated contrast enhancement agents
JP6297440B2 (en) * 2013-07-31 2018-03-20 キヤノンメディカルシステムズ株式会社 Contrast agent
WO2015038968A1 (en) 2013-09-13 2015-03-19 The General Hospital Corporation Activatable fibrin-binding probes
WO2015171543A1 (en) 2014-05-05 2015-11-12 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
WO2015196208A2 (en) 2014-06-20 2015-12-23 The General Hospital Corporation Collagen targeted imaging probes
CN107624115B (en) 2015-03-16 2021-10-26 加州理工学院 Botulinum neurotoxin specific capture agents, compositions, methods of use, and methods of manufacture
CN104910030B (en) * 2015-05-14 2018-03-23 石家庄杰克化工有限公司 A kind of synthesis technique of high purity ethanol amine amino carboxy chelating agent
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CN108290927B (en) 2015-07-15 2022-06-24 加州理工学院 IL-17F-specific capture agents, compositions, and methods of use and manufacture
US9829474B2 (en) * 2015-10-16 2017-11-28 General Electric Company Acetate complexes and methods for acetate quantification
US20170319722A1 (en) 2016-04-04 2017-11-09 Indi Molecular, Inc. Cd8-specific capture agents, compositions, and methods of using and making
US11884707B2 (en) 2016-09-29 2024-01-30 Regeneron Pharmaceuticals, Inc. Compositions for detection, inhibition and imaging of indoleamine 2, 3-dioxygenase 1 (IDO1) and methods of making and using same
WO2018085375A1 (en) 2016-11-01 2018-05-11 Ohio State Innovation Foundation Methods for the iodination of biomolecules
JP7034160B2 (en) 2016-11-28 2022-03-11 バイエル・ファルマ・アクティエンゲゼルシャフト High relaxation gadolinium chelate compound for use in magnetic resonance imaging
US11719705B2 (en) 2017-06-15 2023-08-08 Indi Molecular, Inc. IL-17F and IL-17A-specific capture agents, compositions, and methods of using and making
US11919972B2 (en) 2018-11-02 2024-03-05 Regeneron Pharmaceuticals, Inc. Peptide libraries with non-canonical amino acids
US11638764B2 (en) 2018-11-08 2023-05-02 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
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US20200291391A1 (en) 2019-03-12 2020-09-17 Indi Molecular, Inc. Cross-linked epitopes and methods of use thereof
US20200371101A1 (en) 2019-05-20 2020-11-26 Indi Molecular, Inc. Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1)
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
KR20230017207A (en) 2020-04-30 2023-02-03 사이로파 비.브이. Anti-CD103 antibody
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Also Published As

Publication number Publication date
CA2065290A1 (en) 1991-03-01
EP0489869A1 (en) 1992-06-17
JPH05503072A (en) 1993-05-27
ATE173336T1 (en) 1998-11-15
HK1012707A1 (en) 1999-08-06
EP0489869A4 (en) 1993-03-17
CA2065290C (en) 2000-12-12
WO1991003200A1 (en) 1991-03-21
EP0489869B1 (en) 1998-11-11
DE69032761D1 (en) 1998-12-17

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