NO953868L - Chelatorer av typen XN1S1X' for radioaktive isotoper, deres metallkomplekser og deres anvendelse i diagnostikk og terapi - Google Patents

Chelatorer av typen XN1S1X' for radioaktive isotoper, deres metallkomplekser og deres anvendelse i diagnostikk og terapi

Info

Publication number
NO953868L
NO953868L NO953868A NO953868A NO953868L NO 953868 L NO953868 L NO 953868L NO 953868 A NO953868 A NO 953868A NO 953868 A NO953868 A NO 953868A NO 953868 L NO953868 L NO 953868L
Authority
NO
Norway
Prior art keywords
pct
compounds
xn1s1x
chelators
diagnostics
Prior art date
Application number
NO953868A
Other languages
English (en)
Other versions
NO953868D0 (no
Inventor
Ludger Dinkelborg
Hans-Martin Schier
Cristoph Stephan Hilger
Wolfgang Kramp
Original Assignee
Diagnostikforschung Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diagnostikforschung Inst filed Critical Diagnostikforschung Inst
Publication of NO953868D0 publication Critical patent/NO953868D0/no
Publication of NO953868L publication Critical patent/NO953868L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Det beskrives nye bifunksjonelle chalkogenatom-av- brutte chelatdannere, farmasøytiske midler innehol- dende disse forbindelser, deres anvendelse innen radiodiagnostikk og radioterapi, samt fremgangsmåter ved fremstilling av disse forbindelser. I forbindelsen med den generelle formel M-L (I) betyr M en radioisotop av Te eller Re, og L betyr en ligand med den generelle formel B-CO-CR'R2-A-CRJR«-CR5RS-A'-R12 (II) hvor A, A' kan være like eller forskjellige og betyr O, S eller Se; R1, R2, Rs, R4, R5 og R* kan være like eller forskjellige og betyr H eller C,-C6-alkyl, B betyr -NH-(CR7RI)-(CR9RIO)B.,.2-S-R11, hvor R7 og R8 kan være like eller forskjellige og betyr H eller ufor- grenet, forgrenet, cyklisk eller polycyklisk C^C^- alkyl-, alkenyl-, polyalkenyl-, alkinyl-, polyalkin- yl-, aryl-, alkylaryl- eller arylalkyl, som eventuelt kan være substituert med karboksy, aminokarbonyl, alkoksykarbonyl, amino, aldehyd, hydroksy, okso, oksy eller alkoksy med inntil 20 C-atomer og eventuelt er avbrutt og/eller substituert med heteroatomer fra rekken O, N, S, P, As, Se; R* og R10 kan være like eller forskjellige og betyr H og/eller C,-C6-alkyl; R" betyr en S-beskyttelsesgruppe eller rester med betyd- ningen av R7 eller R*; og R7 og R11 sammen med gruppe- ne, som forbinder dem, eventuelt danner en 4- til 8- leddet ring som kan være substituert med hydroksy, okso, oksy eller alkoksy med inntil 6 karbonatomer; R12 betyr H eller en chalkogenbeskyttelsesgruppe. Overraskende nok er det blitt funnet at de nye, bifunksjonelle, chalkogenatom-avbrutte chelatdannere og deres koblingsprodukter ned forbindelser som akkumuleres spesifikt, egner seg utmerket for frem- stilling av radiodiagnostika hhv. radioterapeutika.
NO953868A 1993-03-31 1995-09-29 Chelatorer av typen XN1S1X' for radioaktive isotoper, deres metallkomplekser og deres anvendelse i diagnostikk og terapi NO953868L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4310999A DE4310999C2 (de) 1993-03-31 1993-03-31 Bifunktionelle chalkogenatom-unterbrochene Chelatbildner vom Typ XN¶1¶S¶1¶X' für radioaktive Isotope und deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel
PCT/DE1994/000372 WO1994022493A1 (de) 1993-03-31 1994-03-29 Chelatbildner vom typ xn1s1x' für radioaktive isotope, deren metallkomplexe und ihre verwendung in diagnostik und therapie

Publications (2)

Publication Number Publication Date
NO953868D0 NO953868D0 (no) 1995-09-29
NO953868L true NO953868L (no) 1995-11-23

Family

ID=6484671

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953868A NO953868L (no) 1993-03-31 1995-09-29 Chelatorer av typen XN1S1X' for radioaktive isotoper, deres metallkomplekser og deres anvendelse i diagnostikk og terapi

Country Status (12)

Country Link
US (1) US5961954A (no)
EP (1) EP0692981B1 (no)
JP (1) JPH08511237A (no)
KR (1) KR960700762A (no)
AT (1) ATE179078T1 (no)
AU (1) AU692154B2 (no)
CA (1) CA2156619A1 (no)
DE (2) DE4310999C2 (no)
HU (1) HUT73489A (no)
NO (1) NO953868L (no)
NZ (1) NZ263795A (no)
WO (1) WO1994022493A1 (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4311022C2 (de) * 1993-03-31 1996-07-11 Diagnostikforschung Inst Bifunktionelle chalkogenatom-unterbrochene Chelatbildner vom Typ S¶3¶N¶2¶ für radioaktive Isotope und deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel
DE19536785A1 (de) * 1995-09-21 1997-03-27 Diagnostikforschung Inst Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ S¶2¶NY für radioaktive Isotope
DE19536781A1 (de) * 1995-09-21 1997-03-27 Diagnostikforschung Inst Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ XSNS für radioaktive Isotope
DE19652374A1 (de) * 1996-12-04 1998-06-10 Schering Ag Verwendung von Endothelin-Konjugaten in der Therapie, neue Endothelin-Konjugate, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung
ES2500922T3 (es) * 2002-05-06 2014-10-01 Endocyte, Inc. Agentes de formación de imágenes dirigidos al receptor de folato
US20080058674A1 (en) * 2006-08-29 2008-03-06 Lex Jansen Tissue extraction device and method of using the same

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063946A1 (en) * 1981-04-21 1982-11-03 AMERSHAM INTERNATIONAL plc Diagnosis of kidney function
EP0089143A1 (en) * 1982-03-16 1983-09-21 AMERSHAM INTERNATIONAL plc Diagnosis of kidney function
US4980147A (en) * 1984-06-25 1990-12-25 University Of Utah Research Foundation Radiolabeled technetium chelates for use in renal function determinations
DE3680924D1 (de) * 1985-01-14 1991-09-26 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
ES2017088B3 (es) * 1986-05-28 1991-01-01 Mallinckrodt Inc (A Missouri Corporation) Quelatos de tecnecio a utilizar para determinar la funcion renal.
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US5198208A (en) * 1987-07-16 1993-03-30 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
AU1995392A (en) * 1991-05-08 1992-12-21 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
JPH0570484A (ja) * 1991-09-12 1993-03-23 Hitachi Chem Co Ltd ペプチドおよびその塩
CA2129036A1 (en) * 1992-02-06 1993-08-19 Mallinckrodt Inc. Ligands for improving metal chelate formation kinetics
DE4311023C2 (de) * 1993-03-31 1996-05-02 Diagnostikforschung Inst Bifunktionelle chalkogenatom-unterbrochene Chelatbildner von Typ XN¶1¶S¶1¶O¶1¶ für radioaktive Isotope, deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel
DE4311021A1 (de) * 1993-03-31 1994-10-27 Diagnostikforschung Inst Bifunktionelle Chelatbildner, deren Technetium- und Rhenium-Komplexe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Mittel
DE4311022C2 (de) * 1993-03-31 1996-07-11 Diagnostikforschung Inst Bifunktionelle chalkogenatom-unterbrochene Chelatbildner vom Typ S¶3¶N¶2¶ für radioaktive Isotope und deren Metallkomplexe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Mittel

Also Published As

Publication number Publication date
AU692154B2 (en) 1998-06-04
DE4310999A1 (de) 1994-10-06
KR960700762A (ko) 1996-02-24
NZ263795A (en) 1997-01-29
DE59408144D1 (de) 1999-05-27
EP0692981A1 (de) 1996-01-24
DE4310999C2 (de) 1996-07-18
ATE179078T1 (de) 1999-05-15
HU9502869D0 (en) 1995-11-28
WO1994022493A1 (de) 1994-10-13
HUT73489A (en) 1996-08-28
JPH08511237A (ja) 1996-11-26
NO953868D0 (no) 1995-09-29
EP0692981B1 (de) 1999-04-21
US5961954A (en) 1999-10-05
AU6501894A (en) 1994-10-24
CA2156619A1 (en) 1994-10-13

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