ATE169916T1 - Neue makrocyclische stickstoff-liganden, verfahren zu ihrer herstellung, metallkomplexe, diagnostische und therapeutische zusammensetzungen - Google Patents
Neue makrocyclische stickstoff-liganden, verfahren zu ihrer herstellung, metallkomplexe, diagnostische und therapeutische zusammensetzungenInfo
- Publication number
- ATE169916T1 ATE169916T1 AT92400174T AT92400174T ATE169916T1 AT E169916 T1 ATE169916 T1 AT E169916T1 AT 92400174 T AT92400174 T AT 92400174T AT 92400174 T AT92400174 T AT 92400174T AT E169916 T1 ATE169916 T1 AT E169916T1
- Authority
- AT
- Austria
- Prior art keywords
- diagnostic
- preparation
- image
- metal complexes
- therapeutic compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9100811A FR2672051B1 (fr) | 1991-01-24 | 1991-01-24 | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes polymetalliques, composition de diagnostic et therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE169916T1 true ATE169916T1 (de) | 1998-09-15 |
Family
ID=9409017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92400174T ATE169916T1 (de) | 1991-01-24 | 1992-01-22 | Neue makrocyclische stickstoff-liganden, verfahren zu ihrer herstellung, metallkomplexe, diagnostische und therapeutische zusammensetzungen |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5374416A (de) |
| EP (1) | EP0499501B1 (de) |
| JP (1) | JPH0735381B2 (de) |
| KR (1) | KR960014355B1 (de) |
| AT (1) | ATE169916T1 (de) |
| AU (1) | AU650325B2 (de) |
| CA (1) | CA2078983A1 (de) |
| CZ (1) | CZ281225B6 (de) |
| DE (1) | DE69226669T2 (de) |
| FR (1) | FR2672051B1 (de) |
| HU (1) | HUT70023A (de) |
| IE (1) | IE920204A1 (de) |
| IL (1) | IL100717A (de) |
| MX (1) | MX9200319A (de) |
| NO (1) | NO923673L (de) |
| NZ (1) | NZ241356A (de) |
| WO (1) | WO1992012978A1 (de) |
| ZA (1) | ZA92470B (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990009379A1 (en) * | 1989-02-10 | 1990-08-23 | Celltech Limited | Aza-macrocycles and processes for their preparation |
| US5645818A (en) * | 1989-03-24 | 1997-07-08 | Guerbet S.A. | Diagnostic compositions comprising a complex formed by a nitrogenous macrocyclic ligand with metal ions |
| GB9126677D0 (en) * | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
| US5462725A (en) * | 1993-05-06 | 1995-10-31 | The Dow Chemical Company | 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| DE4318369C1 (de) * | 1993-05-28 | 1995-02-09 | Schering Ag | Verwendung von makrocyclischen Metallkomplexen als Temperatursonden |
| US6693190B1 (en) | 1994-05-11 | 2004-02-17 | Bracco International B.V. | Enhanced relaxivity monomeric and multimeric compounds |
| TR199902673T2 (en) * | 1997-03-07 | 2000-04-21 | The Procter & Gamble Company | A�art�c� bile�imler. |
| US20080125344A1 (en) * | 2006-11-28 | 2008-05-29 | Daryle Hadley Busch | Bleach compositions |
| ZA981883B (en) * | 1997-03-07 | 1998-09-01 | Univ Kansas | Catalysts and methods for catalytic oxidation |
| US20030017941A1 (en) * | 1997-03-07 | 2003-01-23 | The Procter & Gamble Company | Catalysts and methods for catalytic oxidation |
| US20050187126A1 (en) * | 2002-08-27 | 2005-08-25 | Busch Daryle H. | Catalysts and methods for catalytic oxidation |
| US6565828B2 (en) | 2000-04-07 | 2003-05-20 | Bristol-Myers Squibb Company | Macrocyclic chelants for metallopharmaceuticals |
| EP2022787B1 (de) * | 2000-09-29 | 2012-11-28 | Genzyme Corporation | Verfahren zur Herstellung von N-1-geschütztem N-Ringstickstoff, der cyclische Polyamine enthält, und entsprechende Produkte |
| DE10117242C1 (de) * | 2001-04-06 | 2002-05-16 | Schering Ag | Unsymmetrische dimere Metallkomplexe, Liganden für diese Metallkomplexe, Verfahren zu deren Herstellung, Arzneimittel bzw. Diagnosemittel, die die Metallkomplexe enthalten, insbesondere Kontrastmittel |
| SI1411918T1 (sl) * | 2001-07-31 | 2012-04-30 | Genzyme Global S A R L | Postopki za mobilizacijo progenitorskih/matičnih celic |
| US20040048763A1 (en) * | 2002-08-27 | 2004-03-11 | The Procter & Gamble Co. | Bleach compositions |
| EP1637524A1 (de) * | 2004-09-20 | 2006-03-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | 10-substituierte 1-, 4, 7,-tris (carboxymethyl)-1,4,7,10-tetraazacyclo-dodecanederivate zur Verwendung als Kontrastmittel |
| TWI429404B (zh) * | 2008-03-03 | 2014-03-11 | Senomyx Inc | 異山梨醇衍生物及彼等作為風味改良劑、促味劑及促味增強劑之用途 |
| JP5735791B2 (ja) * | 2010-12-07 | 2015-06-17 | 住友化学株式会社 | 金属錯体を含む素子 |
| FR2968999B1 (fr) | 2010-12-20 | 2013-01-04 | Guerbet Sa | Nanoemulsion de chelate pour irm |
| US10918742B2 (en) | 2016-03-25 | 2021-02-16 | Nanoprobes, Inc. | Iodine-based particles |
| WO2017178301A1 (en) | 2016-04-13 | 2017-10-19 | Bracco Imaging Spa | Contrast agents |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53144592A (en) * | 1977-05-19 | 1978-12-15 | Tabuse Iwao | 122alkyll1*4*7*100tetrazacyclotridecane |
| DE3869251D1 (de) * | 1987-07-16 | 1992-04-23 | Nycomed As | Aminopolycarbonsaeure und ihre derivate. |
| DE3728525A1 (de) * | 1987-08-24 | 1989-03-16 | Schering Ag | Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
| BR8907277A (pt) * | 1988-12-22 | 1991-03-26 | Dow Chemical Co | Processo para preparar poliazamacrociclos mono-n-alquilados |
-
1991
- 1991-01-24 FR FR9100811A patent/FR2672051B1/fr not_active Expired - Fee Related
-
1992
- 1992-01-21 IL IL10071792A patent/IL100717A/en not_active IP Right Cessation
- 1992-01-22 AT AT92400174T patent/ATE169916T1/de not_active IP Right Cessation
- 1992-01-22 HU HU9203029A patent/HUT70023A/hu unknown
- 1992-01-22 WO PCT/FR1992/000057 patent/WO1992012978A1/fr not_active Ceased
- 1992-01-22 JP JP4505010A patent/JPH0735381B2/ja not_active Expired - Lifetime
- 1992-01-22 KR KR1019920702286A patent/KR960014355B1/ko not_active Expired - Lifetime
- 1992-01-22 NZ NZ241356A patent/NZ241356A/en unknown
- 1992-01-22 AU AU12562/92A patent/AU650325B2/en not_active Ceased
- 1992-01-22 EP EP92400174A patent/EP0499501B1/de not_active Expired - Lifetime
- 1992-01-22 US US07/924,016 patent/US5374416A/en not_active Expired - Fee Related
- 1992-01-22 CZ CS922909A patent/CZ281225B6/cs unknown
- 1992-01-22 DE DE69226669T patent/DE69226669T2/de not_active Expired - Fee Related
- 1992-01-22 CA CA002078983A patent/CA2078983A1/fr not_active Abandoned
- 1992-01-23 IE IE020492A patent/IE920204A1/en unknown
- 1992-01-23 ZA ZA92470A patent/ZA92470B/xx unknown
- 1992-01-24 MX MX9200319A patent/MX9200319A/es unknown
- 1992-09-22 NO NO92923673A patent/NO923673L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR960014355B1 (ko) | 1996-10-15 |
| US5374416A (en) | 1994-12-20 |
| CA2078983A1 (fr) | 1992-07-25 |
| HU9203029D0 (en) | 1992-12-28 |
| NZ241356A (en) | 1995-02-24 |
| IL100717A (en) | 1996-06-18 |
| ZA92470B (en) | 1993-07-23 |
| JPH05504361A (ja) | 1993-07-08 |
| IL100717A0 (en) | 1992-09-06 |
| AU1256292A (en) | 1992-08-27 |
| FR2672051A1 (fr) | 1992-07-31 |
| NO923673L (no) | 1992-11-24 |
| DE69226669D1 (de) | 1998-09-24 |
| CZ281225B6 (cs) | 1996-07-17 |
| IE920204A1 (en) | 1992-07-29 |
| JPH0735381B2 (ja) | 1995-04-19 |
| NO923673D0 (no) | 1992-09-22 |
| EP0499501B1 (de) | 1998-08-19 |
| AU650325B2 (en) | 1994-06-16 |
| CZ290992A3 (en) | 1993-02-17 |
| HUT70023A (en) | 1995-09-28 |
| EP0499501A3 (de) | 1992-08-26 |
| FR2672051B1 (fr) | 1993-05-21 |
| DE69226669T2 (de) | 1999-04-15 |
| WO1992012978A1 (fr) | 1992-08-06 |
| MX9200319A (es) | 1992-07-01 |
| EP0499501A2 (de) | 1992-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |