IS4790A - Málmsamstæður sem innihalda Perflúoróalkýl og notkun þeirra við segulsneiðmyndunar-greiningar - Google Patents

Málmsamstæður sem innihalda Perflúoróalkýl og notkun þeirra við segulsneiðmyndunar-greiningar

Info

Publication number
IS4790A
IS4790A IS4790A IS4790A IS4790A IS 4790 A IS4790 A IS 4790A IS 4790 A IS4790 A IS 4790A IS 4790 A IS4790 A IS 4790A IS 4790 A IS4790 A IS 4790A
Authority
IS
Iceland
Prior art keywords
magnetic resonance
resonance imaging
containing perfluoroalkyl
metallic constituents
constituents containing
Prior art date
Application number
IS4790A
Other languages
English (en)
Other versions
IS2127B (is
Inventor
Platzek Johannes
Schlecker Wolfgang
Niedballa Ulrich
Radüchel Bernd
Weinmann Hanns-Joachim
Frenzel Thomas
Misselwitz Bernd
Ebert Wolfgang
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of IS4790A publication Critical patent/IS4790A/is
Publication of IS2127B publication Critical patent/IS2127B/is

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/14—Linings or internal coatings
    • B65D25/16—Loose, or loosely-attached, linings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/08—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages having articulated or hinged closures
    • B65D47/0804—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages having articulated or hinged closures integrally formed with the base element provided with the spout or discharge passage
    • B65D47/0833—Hinges without elastic bias
    • B65D47/0847—Hinges without elastic bias located within a flat surface of the base element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/0055—Containers or packages provided with a flexible bag or a deformable membrane or diaphragm for expelling the contents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76—Metal complexes of amino carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
IS4790A 1996-01-19 1998-06-30 Málmsamstæður sem innihalda Perflúoróalkýl og notkun þeirra við segulsneiðmyndunar-greiningar IS2127B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19603033A DE19603033A1 (de) 1996-01-19 1996-01-19 Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
PCT/EP1997/000209 WO1997026017A2 (de) 1996-01-19 1997-01-16 Perfluoralkylhaltige metallkomplexe und ihre verwendung in der nmr-diagnostik

Publications (2)

Publication Number Publication Date
IS4790A true IS4790A (is) 1998-06-30
IS2127B IS2127B (is) 2006-07-14

Family

ID=7783921

Family Applications (1)

Application Number Title Priority Date Filing Date
IS4790A IS2127B (is) 1996-01-19 1998-06-30 Málmsamstæður sem innihalda Perflúoróalkýl og notkun þeirra við segulsneiðmyndunar-greiningar

Country Status (28)

Country Link
US (3) US6468502B1 (is)
EP (1) EP0874645B1 (is)
JP (1) JP2000506511A (is)
KR (1) KR100539041B1 (is)
CN (1) CN1203898C (is)
AT (1) ATE215386T1 (is)
AU (1) AU716788B2 (is)
BG (1) BG62914B1 (is)
BR (1) BR9707053B1 (is)
CZ (1) CZ298769B6 (is)
DE (2) DE19603033A1 (is)
DK (1) DK0874645T3 (is)
EE (1) EE04298B1 (is)
ES (1) ES2174215T3 (is)
HK (1) HK1018404A1 (is)
HU (1) HU226199B1 (is)
IL (1) IL125311A (is)
IS (1) IS2127B (is)
NO (1) NO319680B1 (is)
NZ (1) NZ330579A (is)
PL (1) PL187466B1 (is)
PT (1) PT874645E (is)
RU (1) RU2242477C2 (is)
SK (1) SK283576B6 (is)
TW (1) TW542841B (is)
UA (1) UA65533C2 (is)
WO (1) WO1997026017A2 (is)
ZA (1) ZA97419B (is)

Families Citing this family (39)

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DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
UA59384C2 (uk) 1996-12-20 2003-09-15 Пфайзер, Інк. Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6495118B1 (en) * 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
US6461587B1 (en) 1999-03-22 2002-10-08 Schering Aktiengesellschaft Perfluoroalkylamides, their production and their use in diagnosis
EP1088559A3 (de) * 1999-09-29 2002-10-02 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Galenische Formulierungen
DE19948651B4 (de) * 1999-09-29 2006-10-05 Schering Ag Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung
DE19948650A1 (de) * 1999-09-29 2001-07-19 Diagnostikforschung Inst Galenische Formulierungen
DE10040381C1 (de) * 2000-08-11 2002-06-06 Schering Ag Perfluoralkylhaltige Komplexe mit Zuckerresten, Verfahren zu deren Herstellung und ihre Verwendung
DE10066210B4 (de) * 2000-08-11 2008-02-28 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
DE10040380B4 (de) * 2000-08-11 2006-03-09 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Plaques
US6676928B2 (en) 2000-08-11 2004-01-13 Schering Aktiengesellschaft Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use
DE10040858C2 (de) * 2000-08-11 2003-12-18 Schering Ag Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung
US6818203B2 (en) * 2000-08-11 2004-11-16 Schering Aktiengesellschaft Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
US6641797B2 (en) 2000-08-11 2003-11-04 Schering Aktiengesellschaft Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use
DE10135356C1 (de) 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
WO2003013610A2 (en) * 2001-08-03 2003-02-20 Glaxo Group Limited Surfactant compounds and uses thereof
NO20015814D0 (no) * 2001-11-28 2001-11-28 Amersham Health As Metallkompleksforbindelser
WO2004006934A2 (de) * 2002-07-10 2004-01-22 Hans Robert Kalbitzer 1,4,7,10-tetraazacyclododecane als modulatoren des guanin-nukleotid bindenden roteins zur behandlung von tumoren
US7344704B2 (en) 2002-07-10 2008-03-18 Schering Ag Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
DE10231799B4 (de) * 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
EP2014728A1 (en) 2005-01-13 2009-01-14 Cinvention Ag Composite material coatings
DE102005008309A1 (de) * 2005-02-17 2006-08-24 Schering Ag Pharmazeutische Mittel enthaltend fluoralkylhaltige Metallkomplexe und Epothilone
DE102005033902B3 (de) * 2005-07-15 2007-04-05 Schering Ag Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel
DE102005033903B4 (de) * 2005-07-15 2007-08-09 Bayer Schering Pharma Ag Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel
DE102006021495A1 (de) * 2006-05-09 2007-11-15 Bayer Schering Pharma Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel zur Diagnose der Alzheimer Krankheit
US8463358B2 (en) * 2006-06-09 2013-06-11 Koninklijke Philips Electronics N.V. Elimination of contrast agent concentration dependency in MRI
DE102006049821A1 (de) 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
GB0708411D0 (en) * 2007-05-01 2007-06-06 Univ Durham Lanthanide probes
US20110217241A1 (en) * 2008-11-14 2011-09-08 University Of Maryland, Baltimore Conjugates of 19f mr imaging tracers for use in multi-chromic mri imaging
US20170369755A1 (en) * 2014-12-08 2017-12-28 3M Innovative Properties Company Hydrofluoroolefins and methods for using same
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CN114890941A (zh) 2015-08-13 2022-08-12 通用医疗公司 用于mr分子成像的基于锰的螯合缀合物
EP3544964B1 (en) 2016-11-28 2020-06-17 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
AU2019382881A1 (en) 2018-11-23 2021-05-20 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
US20200397924A1 (en) * 2019-01-28 2020-12-24 Hubei Tianshu Pharmaceutical Co., Ltd Preparation method of intermediate of gadolinium-based ionic contrast agent and use thereof
CN110922365B (zh) * 2019-12-13 2021-04-27 山东铂源药业有限公司 一种高纯度轮环藤宁的制备方法

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US6461587B1 (en) * 1999-03-22 2002-10-08 Schering Aktiengesellschaft Perfluoroalkylamides, their production and their use in diagnosis
EP1088559A3 (de) * 1999-09-29 2002-10-02 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Galenische Formulierungen
US6676928B2 (en) * 2000-08-11 2004-01-13 Schering Aktiengesellschaft Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use
US6818203B2 (en) * 2000-08-11 2004-11-16 Schering Aktiengesellschaft Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
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Also Published As

Publication number Publication date
BR9707053B1 (pt) 2008-11-18
US6916461B2 (en) 2005-07-12
WO1997026017A2 (de) 1997-07-24
KR19990077374A (ko) 1999-10-25
KR100539041B1 (ko) 2006-04-12
ES2174215T3 (es) 2002-11-01
CZ298769B6 (cs) 2008-01-23
DE59706863D1 (de) 2002-05-08
ATE215386T1 (de) 2002-04-15
US6468502B1 (en) 2002-10-22
NO983287L (no) 1998-09-21
DE19603033A1 (de) 1997-07-24
BG62914B1 (bg) 2000-11-30
IL125311A0 (en) 1999-03-12
CZ226398A3 (cs) 1998-11-11
IS2127B (is) 2006-07-14
AU1597797A (en) 1997-08-11
DK0874645T3 (da) 2002-07-01
HUP9901295A2 (hu) 1999-07-28
TW542841B (en) 2003-07-21
NO319680B1 (no) 2005-09-05
SK99098A3 (en) 1998-12-02
CN1209754A (zh) 1999-03-03
EP0874645A2 (de) 1998-11-04
RU2242477C2 (ru) 2004-12-20
PL187466B1 (pl) 2004-07-30
SK283576B6 (sk) 2003-09-11
US20050147563A1 (en) 2005-07-07
IL125311A (en) 2002-11-10
HUP9901295A3 (en) 2004-05-28
NO983287D0 (no) 1998-07-16
PL327931A1 (en) 1999-01-04
BG102632A (en) 1999-06-30
EE04298B1 (et) 2004-06-15
EE9800204A (et) 1998-12-15
WO1997026017A3 (de) 1997-11-20
HK1018404A1 (en) 1999-12-24
NZ330579A (en) 2000-01-28
AU716788B2 (en) 2000-03-09
US7226578B2 (en) 2007-06-05
BR9707053A (pt) 1999-07-20
EP0874645B1 (de) 2002-04-03
JP2000506511A (ja) 2000-05-30
PT874645E (pt) 2002-09-30
HU226199B1 (en) 2008-06-30
CN1203898C (zh) 2005-06-01
UA65533C2 (en) 2004-04-15
US20030232012A1 (en) 2003-12-18
ZA97419B (en) 1997-07-30

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