ES2030023T3 - Formacion de imagenes por rmn con sales metalicas polivalentes paramagneticas de poli- (acido-alquilen-amino)-alcanos. - Google Patents
Formacion de imagenes por rmn con sales metalicas polivalentes paramagneticas de poli- (acido-alquilen-amino)-alcanos.Info
- Publication number
- ES2030023T3 ES2030023T3 ES198787110801T ES87110801T ES2030023T3 ES 2030023 T3 ES2030023 T3 ES 2030023T3 ES 198787110801 T ES198787110801 T ES 198787110801T ES 87110801 T ES87110801 T ES 87110801T ES 2030023 T3 ES2030023 T3 ES 2030023T3
- Authority
- ES
- Spain
- Prior art keywords
- paramagnetic
- alquilen
- alcanos
- acido
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000005298 paramagnetic effect Effects 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000002184 metal Substances 0.000 title 1
- 239000002872 contrast media Substances 0.000 abstract 2
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 239000013522 chelant Substances 0.000 abstract 1
- 150000004697 chelate complex Chemical class 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 229910052747 lanthanoid Inorganic materials 0.000 abstract 1
- 150000002602 lanthanoids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
- C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Signal Processing (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Thin Magnetic Films (AREA)
- Soft Magnetic Materials (AREA)
- Polyamides (AREA)
- Cosmetics (AREA)
Abstract
EN UN METODO DE SIMULACION DE UN TEJIDO DEL CUERPO EN UN PACIENTE QUE COMPRENDE ADMINISTRAR AL PACIENTE UNA CANTIDAD EFECTIVA DE UN AGENTE FARMACEUTICO PARA INFLUIR EN LOS TIEMPOS DE REPOSO DE ATOMOS EN TEJIDOS DE UN CUERPO QUE ESTA SOMETIDO A DIAGNOSTICO DE NMR, POR LO CUAL EL CONTRASTE DE SIMULACION SE REALZA; DICHO AGENTE COMPRENDE UNA CANTIDAD EFECTIVA PARA AFECTAR DICHOS TIEMPOS DE REPOSO, DE UNA SAL PARAMAGNETICA, FISIOLOGICAMENTE COMPATIBLE, DE UN COMPLEJO QUELATO FISIOLOGICAMENTE COMPATIBLE DE UN ION DE UN ELEMENTO LANTANIDO DE NUMEROS ATOMICOS 57-70, O DE UN METAL DE TRANSICION DE NUMEROS ATOMICOS 21-29, 42 A 44 Y UN CONDUCTOR FARMACEUTICAMENTE ACEPTABLE Y SOMETER AL PACIENTE A UNA TOMOGRAFIA NMR, EN DONDE LA MENCIONADA SAL DE DICHO COMPLEJO DE QUELATO ES LA SAL DE CALCIO O MAGNESIO. ESTAS SALES SON NUEVAS ASI COMO ALQUENOS DE LOS COMPUESTOS DE QUELATO.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89313686A | 1986-08-04 | 1986-08-04 | |
US90093086A | 1986-08-27 | 1986-08-27 | |
US07/057,709 US5039512A (en) | 1986-08-04 | 1987-06-15 | NMR imaging with paramagnetic polyvalent metal salts of poly-(acid-alkylene-amino)-alkanes |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2030023T3 true ES2030023T3 (es) | 1992-10-16 |
Family
ID=27369315
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787110801T Expired - Lifetime ES2030023T3 (es) | 1986-08-04 | 1987-07-25 | Formacion de imagenes por rmn con sales metalicas polivalentes paramagneticas de poli- (acido-alquilen-amino)-alcanos. |
ES91116072T Expired - Lifetime ES2087938T3 (es) | 1986-08-04 | 1987-07-25 | Uso de complejos quelatos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91116072T Expired - Lifetime ES2087938T3 (es) | 1986-08-04 | 1987-07-25 | Uso de complejos quelatos. |
Country Status (16)
Country | Link |
---|---|
EP (2) | EP0258616B1 (es) |
JP (1) | JP2667666B2 (es) |
AT (1) | ATE138809T1 (es) |
AU (1) | AU608759B2 (es) |
CA (1) | CA1321346C (es) |
DE (2) | DE3751829T2 (es) |
DK (1) | DK167797B1 (es) |
ES (2) | ES2030023T3 (es) |
FI (1) | FI88677C (es) |
GR (1) | GR3004576T3 (es) |
HK (1) | HK96597A (es) |
IE (1) | IE64108B1 (es) |
IL (2) | IL83377A0 (es) |
NO (1) | NO173767C (es) |
NZ (1) | NZ221288A (es) |
SG (1) | SG78250A1 (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5064633A (en) * | 1984-06-04 | 1991-11-12 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes, their formulations and use |
US5250285A (en) * | 1985-05-08 | 1993-10-05 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic NMR imaging |
US5422096A (en) * | 1985-05-08 | 1995-06-06 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic NMR imaging |
DE3854717T3 (de) * | 1987-06-30 | 1999-04-15 | Mallinckrodt Inc | Verfahren zur erhöhung der sicherheit von metall-ligandchelaten als röntgenstrahlen-kontrastmittel. |
GB8813144D0 (en) * | 1988-06-03 | 1988-07-06 | Nycomed As | Compositions |
GB8900719D0 (en) * | 1989-01-13 | 1989-03-08 | Nycomed As | Compounds |
GB8900732D0 (en) * | 1989-01-13 | 1989-03-08 | Nycomed As | Agents |
GB8916781D0 (en) * | 1989-07-21 | 1989-09-06 | Nycomed As | Compositions |
US5087440A (en) * | 1989-07-31 | 1992-02-11 | Salutar, Inc. | Heterocyclic derivatives of DTPA used for magnetic resonance imaging |
FR2654344B1 (fr) * | 1989-11-16 | 1994-09-23 | Cis Bio Int | Complexe paramagnetique de gadolinium, son procede de preparation et son utilisation pour le diagnostic par irm. |
US5516503A (en) * | 1989-11-16 | 1996-05-14 | Guerbet S.A. | Diagnostic composition comprising a binuclear complex, its method of preparation and its use in magnetic resonance imaging |
ES2091251T3 (es) * | 1989-11-27 | 1996-11-01 | Concat Ltd | Perfeccionamiento de la imagen en la mri del hueso y del tejido emparentado utilizando complejos de cationes paramagneticos y ligandos polifosfonato. |
US5236695A (en) * | 1989-11-27 | 1993-08-17 | Concat, Ltd. | MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands |
US5843399A (en) * | 1990-04-06 | 1998-12-01 | Schering Aktiengesellschaft | DTPA monoamides for MRI |
DE4011684A1 (de) * | 1990-04-06 | 1991-10-10 | Schering Ag | Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
US5562894A (en) * | 1991-08-09 | 1996-10-08 | Regents Of The University Of California | Amino-acyl-type and catecholamine-type contrast agents for MRI |
IT1252145B (it) * | 1991-11-29 | 1995-06-05 | Bracco Ind Chimica Spa | Metodo e formulazioni adatte a migliorare lo studio degli organi cavi nell'uomo |
DE4302287A1 (de) * | 1993-01-25 | 1994-07-28 | Schering Ag | Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung |
US5409689A (en) * | 1993-08-13 | 1995-04-25 | Concat, Ltd. | MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms |
US5476644A (en) * | 1994-04-13 | 1995-12-19 | Sterling Winthrop Inc. | Cyclic triamine chelating agents |
US5582814A (en) * | 1994-04-15 | 1996-12-10 | Metasyn, Inc. | 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging |
US5639746A (en) * | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
TW319763B (es) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
EP0955044B1 (en) * | 1995-06-26 | 2005-11-16 | Chelator LLC | Method of inhibiting bacterial or fungal growth using a complexing agent |
IT1297035B1 (it) | 1997-12-30 | 1999-08-03 | Bracco Spa | Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico |
US5980863A (en) * | 1998-11-02 | 1999-11-09 | Eagle Vision Pharmaceutical Corporation | Manganese compositions and methods for MRI |
CA2371728C (en) | 1999-06-11 | 2009-06-02 | Neorx Corporation | High dose radionuclide complexes for bone marrow suppression |
US7094885B2 (en) | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
JP2007062462A (ja) * | 2005-08-30 | 2007-03-15 | Nifco Inc | 多用途収容装置 |
US8378134B2 (en) | 2009-09-30 | 2013-02-19 | General Electric Company | Hydroxylated contrast enhancement agents |
NO331773B1 (no) | 2009-12-18 | 2012-03-26 | Ge Healthcare As | Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) |
PL2988756T5 (pl) | 2013-04-26 | 2022-09-26 | Guerbet | Formulacja środka kontrastowego i powiązany sposób jego wytwarzania |
GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
WO2018115314A1 (en) | 2016-12-21 | 2018-06-28 | Ge Healthcare As | Tetraazabicyclo-macrocycle based manganese chelate compounds suitable as mri imaging agents |
US11110186B2 (en) | 2017-12-20 | 2021-09-07 | General Electric Company | Anionic chelate compounds |
GB201919073D0 (en) | 2019-12-20 | 2020-02-05 | Ge Healthcare As | Novel manufacturing process |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3818061A (en) * | 1971-11-09 | 1974-06-18 | Merck Sharp & Dohme | Transparent nmr shift reagents |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
DE3129906C3 (de) * | 1981-07-24 | 1996-12-19 | Schering Ag | Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik |
NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
DE3324235A1 (de) * | 1983-07-01 | 1985-01-10 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue komplexbildner, komplexe und komplexsalze |
CA1242643A (en) * | 1983-08-12 | 1988-10-04 | Eric T. Fossel | Nmr imaging utilizing chemical shift reagents |
FR2550449B1 (fr) * | 1983-08-12 | 1986-01-31 | Commissariat Energie Atomique | Agents de relaxation specifiques d'organes ou de pathologies, utilisables pour modifier les contrastes en imagerie medicale par resonance magnetique nucleaire |
US4749560A (en) * | 1984-08-13 | 1988-06-07 | Research Corporation | Metal organo phosphorous compounds for NMR analysis |
US4687659A (en) * | 1984-11-13 | 1987-08-18 | Salutar, Inc. | Diamide-DTPA-paramagnetic contrast agents for MR imaging |
US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
GB8518300D0 (en) * | 1985-07-19 | 1985-08-29 | Amersham Int Plc | Contrast agent |
DE3854717T3 (de) * | 1987-06-30 | 1999-04-15 | Mallinckrodt Inc | Verfahren zur erhöhung der sicherheit von metall-ligandchelaten als röntgenstrahlen-kontrastmittel. |
-
1987
- 1987-07-16 AU AU75735/87A patent/AU608759B2/en not_active Expired
- 1987-07-22 CA CA000542735A patent/CA1321346C/en not_active Expired - Lifetime
- 1987-07-25 ES ES198787110801T patent/ES2030023T3/es not_active Expired - Lifetime
- 1987-07-25 DE DE3751829T patent/DE3751829T2/de not_active Expired - Lifetime
- 1987-07-25 EP EP87110801A patent/EP0258616B1/en not_active Expired - Lifetime
- 1987-07-25 EP EP91116072A patent/EP0463644B1/en not_active Expired - Lifetime
- 1987-07-25 AT AT91116072T patent/ATE138809T1/de not_active IP Right Cessation
- 1987-07-25 ES ES91116072T patent/ES2087938T3/es not_active Expired - Lifetime
- 1987-07-25 SG SG1996004804A patent/SG78250A1/en unknown
- 1987-07-25 DE DE8787110801T patent/DE3777727D1/de not_active Expired - Lifetime
- 1987-07-30 IL IL83377A patent/IL83377A0/xx not_active IP Right Cessation
- 1987-07-31 JP JP62190530A patent/JP2667666B2/ja not_active Expired - Lifetime
- 1987-07-31 NZ NZ221288A patent/NZ221288A/xx unknown
- 1987-07-31 IE IE207687A patent/IE64108B1/en not_active IP Right Cessation
- 1987-07-31 DK DK401087A patent/DK167797B1/da not_active IP Right Cessation
- 1987-08-03 NO NO873237A patent/NO173767C/no not_active IP Right Cessation
- 1987-08-04 FI FI873382A patent/FI88677C/fi not_active IP Right Cessation
-
1992
- 1992-03-12 IL IL10121092A patent/IL101210A/en not_active IP Right Cessation
- 1992-05-12 GR GR920400924T patent/GR3004576T3/el unknown
-
1997
- 1997-06-26 HK HK96597A patent/HK96597A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL83377A0 (en) | 1987-12-31 |
DE3777727D1 (de) | 1992-04-30 |
DE3751829T2 (de) | 1996-10-31 |
SG78250A1 (en) | 2001-02-20 |
EP0258616A1 (en) | 1988-03-09 |
IE872076L (en) | 1988-02-04 |
DK401087D0 (da) | 1987-07-31 |
NO173767B (no) | 1993-10-25 |
DK167797B1 (da) | 1993-12-20 |
EP0463644A3 (en) | 1992-11-19 |
FI873382A (fi) | 1988-02-05 |
CA1321346C (en) | 1993-08-17 |
JPS63119446A (ja) | 1988-05-24 |
NO873237L (no) | 1988-02-05 |
ATE138809T1 (de) | 1996-06-15 |
HK96597A (en) | 1997-08-08 |
FI88677B (fi) | 1993-03-15 |
JP2667666B2 (ja) | 1997-10-27 |
GR3004576T3 (es) | 1993-04-28 |
AU608759B2 (en) | 1991-04-18 |
IL101210A (en) | 1996-10-31 |
ES2087938T3 (es) | 1996-08-01 |
AU7573587A (en) | 1988-02-11 |
DK401087A (da) | 1988-02-05 |
NO173767C (no) | 1994-02-02 |
IE64108B1 (en) | 1995-07-12 |
NO873237D0 (no) | 1987-08-03 |
EP0463644B1 (en) | 1996-06-05 |
DE3751829D1 (de) | 1996-07-11 |
EP0463644A2 (en) | 1992-01-02 |
EP0258616B1 (en) | 1992-03-25 |
NZ221288A (en) | 1990-10-26 |
FI873382A0 (fi) | 1987-08-04 |
FI88677C (fi) | 1993-06-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2030023T3 (es) | Formacion de imagenes por rmn con sales metalicas polivalentes paramagneticas de poli- (acido-alquilen-amino)-alcanos. | |
ES2085617T3 (es) | Ion paramagnetico incluido en tamiz molecular para diagnostico. | |
NO176839C (no) | Ligander og fremgangsmåte for deres fremstilling, metallkomplekser dannet med disse ligander samt diagnostisk preparat og röntgenkontrastmiddel omfattende ovennevnte metallkomplekser | |
ATE52247T1 (de) | Verwendung von paramagnetischen komplexsalzen zur herstellung von mitteln fuer die nmr-diagnostik. | |
NO306466B1 (no) | Blandinger som omfatter tetraazamakrocyklisk forbindelse-metallkomplekser for å forbedre et röntgenbilde, eventuelt en scintigrafiavbildning av et individ, samt tetraazamakrocyklisk forbindelse-metallkomplekser og anvendelse av dem | |
DE3852906T2 (de) | Dipyridoxyl-Phosphat als magnetisches Kernresonanz-Bildgebungsmittel. | |
DE69116637D1 (de) | Mittel zur magnetischen Resonanzabbildung | |
BR9508435A (pt) | Quelentes macrocíclicos seus quelatos e usos dos mesmos no campo diagnóstico | |
EP0230027A3 (en) | Magnet shimming using information derived from chemical shift imaging | |
ES2094853T3 (es) | Agente de formacion de imagenes por resonancia magnetica nuclear. | |
DE69100842T2 (de) | Unlösliche salze von lanthaniden zur bildlichen darstellung des magen-darmtrakts mittels nuklearmagnetischer resonanz. | |
KR930019728A (ko) | 금속 이온의 착화용 폴리아자마크로사이클릭 화합물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 258616 Country of ref document: ES |