DE68925904D1 - Makrocyclische chelate und verwendungsverfahren - Google Patents

Makrocyclische chelate und verwendungsverfahren

Info

Publication number
DE68925904D1
DE68925904D1 DE68925904T DE68925904T DE68925904D1 DE 68925904 D1 DE68925904 D1 DE 68925904D1 DE 68925904 T DE68925904 T DE 68925904T DE 68925904 T DE68925904 T DE 68925904T DE 68925904 D1 DE68925904 D1 DE 68925904D1
Authority
DE
Germany
Prior art keywords
formula
chelate
group
use method
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68925904T
Other languages
English (en)
Other versions
DE68925904T2 (de
Inventor
Otto Gansow
Martin Brechbiel
Michael Magerstadt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Commerce
Original Assignee
US Department of Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Commerce filed Critical US Department of Commerce
Application granted granted Critical
Publication of DE68925904D1 publication Critical patent/DE68925904D1/de
Publication of DE68925904T2 publication Critical patent/DE68925904T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
DE68925904T 1988-05-25 1989-05-24 Makrocyclische chelate und verwendungsverfahren Expired - Fee Related DE68925904T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19853888A 1988-05-25 1988-05-25
PCT/US1989/002201 WO1989011475A1 (en) 1988-05-25 1989-05-24 Macrocyclic chelates and methods of use thereof

Publications (2)

Publication Number Publication Date
DE68925904D1 true DE68925904D1 (de) 1996-04-11
DE68925904T2 DE68925904T2 (de) 1996-10-31

Family

ID=22733797

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68925904T Expired - Fee Related DE68925904T2 (de) 1988-05-25 1989-05-24 Makrocyclische chelate und verwendungsverfahren

Country Status (9)

Country Link
US (1) US5428154A (de)
EP (1) EP0416033B1 (de)
JP (2) JPH0720989B2 (de)
AT (1) ATE134999T1 (de)
AU (2) AU630362B2 (de)
CA (1) CA1339015C (de)
DE (1) DE68925904T2 (de)
IL (1) IL90409A (de)
WO (1) WO1989011475A1 (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
WO1989012631A1 (en) * 1988-06-24 1989-12-28 The Dow Chemical Company Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US6139603A (en) * 1989-02-22 2000-10-31 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Process for recovering oxygen
US5292868A (en) * 1989-05-26 1994-03-08 Akzo N.V. Chelating agents for attaching metal ions to proteins
JPH04154729A (ja) * 1990-10-16 1992-05-27 Nippon Mejifuijitsukusu Kk 磁気共鳴造影剤
US6403771B1 (en) 1991-02-19 2002-06-11 Actinium Pharmaceuticals, Limited Method and means for site directed therapy
US5541287A (en) * 1992-06-09 1996-07-30 Neorx Corporation Pretargeting methods and compounds
US6022966A (en) * 1993-11-22 2000-02-08 Neorx Corporation Pretargeting methods and compounds
CA2100709C (en) * 1992-07-27 2004-03-16 Maurits W. Geerlings Method and means for site directed therapy
EP0590766B1 (de) * 1992-07-31 2000-02-02 Australian Nuclear Science And Technology Organisation Hydroxyaryl enthaltenden aminocarboxylsäure-chelatbildnern
US5807535A (en) * 1992-07-31 1998-09-15 Australian Nuclear Science & Technology Organisation Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
AU7384394A (en) * 1993-06-30 1995-01-24 Akzo Nobel N.V. Chelating compounds
CA2179990A1 (en) * 1994-01-12 1995-07-20 Gary Robert Bower Biological targeting agents
US6693190B1 (en) 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
GB9417873D0 (en) * 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US6770261B2 (en) * 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US5814521A (en) * 1995-10-06 1998-09-29 Bayer Corporation Metal ion determination by sandwich aggregation assay
US6713046B1 (en) * 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
WO1999025389A2 (en) 1997-11-17 1999-05-27 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
US6372187B1 (en) 1998-12-07 2002-04-16 Mcdermott Technology, Inc. Alkaline sorbent injection for mercury control
US20020102208A1 (en) * 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
MY133346A (en) * 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
US6284199B1 (en) * 1999-03-31 2001-09-04 Mcdermott Technology, Inc. Apparatus for control of mercury
US6855859B2 (en) * 1999-03-31 2005-02-15 The Babcock & Wilcox Company Method for controlling elemental mercury emissions
US6328939B1 (en) 1999-03-31 2001-12-11 Mcdermott Technology, Inc. Mercury removal in utility wet scrubber using a chelating agent
US6680993B2 (en) 1999-11-30 2004-01-20 Stanley Satz Method of producing Actinium-225 and daughters
HUP0203743A2 (en) * 2000-02-25 2003-02-28 R Keith Frank Actinium-225 complexes and conjugates for radioimmunotherapy
LU90544B1 (en) * 2000-03-14 2001-09-17 Europ Economic Community Bifunctional chelating agent
US6565828B2 (en) 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
EP1317268A4 (de) * 2000-09-15 2004-12-15 Sloan Kettering Institutefor C Gezielte therapie mit alpha-teilchen unter verwendung von actinium-225 konjugaten
US6517814B2 (en) 2001-01-09 2003-02-11 Bristol-Myers Squibb Pharma Company Macrocyclic chelants useful for metallopharmaceuticals
JP2004530654A (ja) * 2001-02-23 2004-10-07 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー アテローム硬化症および脆弱性プラークを画像診断するための標識マクロファージスカベンジャー受容体拮抗薬
US20030004236A1 (en) * 2001-04-20 2003-01-02 Meade Thomas J. Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
US20030135108A1 (en) * 2001-05-02 2003-07-17 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
US20020197648A1 (en) * 2001-05-02 2002-12-26 Silva Robin M. High throughput screening methods using magnetic resonance imaging agents
AU2002350991A1 (en) * 2001-06-25 2003-01-08 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Macromolecular imaging agents for liver imaging
US20030198597A1 (en) * 2002-04-22 2003-10-23 Meade Thomas J. Novel macrocyclic activatible magnetic resonance imaging contrast agents
US20030086868A1 (en) * 2002-08-12 2003-05-08 Dangshe Ma Actinium-225 complexes and conjugates for radioimmunotherapy
WO2004021996A2 (en) 2002-09-06 2004-03-18 The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services Backbone-substituted bifunctional dota ligands, complexes and compositions thereof, and methods of using same
EP1551292B1 (de) 2002-09-24 2016-04-27 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Bildgebungsmethode für die konvektionsverstärkte abgabe von therapeutischen mitteln
GB0308731D0 (en) * 2003-04-15 2003-05-21 Anticancer Therapeutic Inv Sa Method of radiotherapy
EP1706452B1 (de) 2003-12-30 2008-09-03 The Regents of the University of California, Office of the President Aromatische triamid-lanthanid-komplexe
US20050171424A1 (en) * 2004-01-13 2005-08-04 The Gov. Of The Usa As Rep. By The Secretary Of The Dept. Of Health And Human Services Methods for imaging the lymphatic system using dendrimer-based contrast agents
CA2581639C (en) * 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
US20060204443A1 (en) * 2005-03-11 2006-09-14 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services Methods for tumor treatment using dendrimer conjugates
US20070025910A1 (en) 2005-07-29 2007-02-01 Norenberg Jeffrey P Anticancer therapy
WO2008008797A2 (en) 2006-07-10 2008-01-17 The Regents Of The University Of California Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides
US8173800B2 (en) 2006-08-15 2012-05-08 The Regents Of The University Of California Luminescent macrocyclic lanthanide complexes
US8388936B2 (en) * 2008-02-22 2013-03-05 Mcw Research Foundation, Inc. In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging
US8388931B2 (en) 2008-02-29 2013-03-05 Marcos Lopez 99m Tc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors
US8440827B2 (en) 2008-07-31 2013-05-14 Duke University Photolabile caged transition metal complexes and methods of using the same
US9603954B2 (en) 2009-07-22 2017-03-28 Actinium Pharmaceuticals Inc. Methods for generating radioimmunoconjugates
WO2011025790A1 (en) 2009-08-24 2011-03-03 Lumiphore, Inc. Macrocyclic hopo chelators
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product
KR101253100B1 (ko) * 2010-02-16 2013-04-10 경북대학교 산학협력단 폴리아자마크로사이클릭 화합물, 그 제조 방법 및 생의학적 적용
US11453652B2 (en) 2013-03-15 2022-09-27 Lumiphore, Inc. Di-macrocycles
FR3006688B1 (fr) * 2013-06-06 2015-08-14 Centre Nat Rech Scient Chelates du plomb (ii) et du bismuth (iii) a base de tetraazacycloalcanes trans-di-n-picolinates
KR102630614B1 (ko) * 2015-02-26 2024-01-26 사이언콘스 에이에스 이로운 특성을 갖는 방사성약물 용액들
CN105807055B (zh) * 2016-03-15 2017-10-10 中国烟草总公司郑州烟草研究院 一种检测二氯喹啉酸的试纸条及其制备方法和应用
EP3409297A1 (de) 2017-05-30 2018-12-05 AlfaRim Medial Holding B.V. Optimaler 225actinium-213bismut-generator für alpha-partikelradioimmunotherapie
US20200230266A1 (en) 2017-09-20 2020-07-23 Alfarim Medical Holding B.V. The optimal 225actinium--213bismuth generator for alpha-particle radioimmunotherapy

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2186464A (en) * 1939-10-18 1940-01-09 Alframine Corp Condensation product and method of preparing same
US3860576A (en) * 1972-04-26 1975-01-14 Dow Chemical Co N-substituted-tetra-azacyclotetradecanes
US3936445A (en) * 1973-07-04 1976-02-03 Badische Anilin- & Soda-Fabrik Aktiengesellschaft Process for the production of iron complexes of tetraazaannulenes
US3979379A (en) * 1975-04-25 1976-09-07 The United States Of America As Represented By The Secretary Of The Army Process for producing 1,3,5,7-tetraalkanoyl-1,3,5,7-octahydrotetrazocines
DE2803528C2 (de) * 1977-03-09 1984-10-18 Tabushi, Iwao, Kyoto Schwermetallionen-Adsorbens und dessen Verwendung zum Adsorbieren von Schwermetallionen
JPS53144592A (en) * 1977-05-19 1978-12-15 Tabuse Iwao 122alkyll1*4*7*100tetrazacyclotridecane
DE2740170C2 (de) * 1977-05-17 1982-02-04 Tabushi, Iwao, Kyoto Alkylsubstituierte cyclische Tetraalkylentetramine
US4543213A (en) * 1978-07-24 1985-09-24 The United States Of America As Represented By The United States Department Of Energy Process for preparing 2,3-dihydroxybenzoic acid amides of tetraazaalkanes and cycloalkanes
US4578517A (en) * 1983-09-16 1986-03-25 Air Products And Chemicals, Inc. Polyalkylene polyamines from alkanolamine and ammonia or amines using group IIIB metal acid phosphate catalysts
JPS61226751A (ja) * 1985-03-30 1986-10-08 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料用処理液及びその処理方法
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
US5132409A (en) * 1987-01-12 1992-07-21 Bracco Industria Chimica S.P.A. Macrocyclic chelating agents and chelates thereof
US5049667A (en) * 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
DE3713842A1 (de) * 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5064956A (en) * 1987-06-24 1991-11-12 The Dow Chemical Company Process for preparing mono-n-alkylated polyazamacrocycles
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
US4923985A (en) * 1988-05-25 1990-05-08 The United States Of America As Represented By The Department Of Health & Human Services Process for synthesizing macrocyclic chelates
US4987227A (en) * 1988-10-21 1991-01-22 The Research Foundation Of State University Of New York Polyazamacrocycles and their metal complexes
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents

Also Published As

Publication number Publication date
AU630362B2 (en) 1992-10-29
JPH03503531A (ja) 1991-08-08
WO1989011475A1 (en) 1989-11-30
AU655704B2 (en) 1995-01-05
JPH07258281A (ja) 1995-10-09
IL90409A0 (en) 1990-01-18
DE68925904T2 (de) 1996-10-31
ATE134999T1 (de) 1996-03-15
US5428154A (en) 1995-06-27
JP2582341B2 (ja) 1997-02-19
EP0416033B1 (de) 1996-03-06
AU3842889A (en) 1989-12-12
CA1339015C (en) 1997-03-25
EP0416033A4 (en) 1991-04-17
JPH0720989B2 (ja) 1995-03-08
EP0416033A1 (de) 1991-03-13
AU3210893A (en) 1993-04-01
IL90409A (en) 1996-09-12

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