ATE222244T1 - Mono -und multimere verbindungen mit erhöhter relaxation - Google Patents

Mono -und multimere verbindungen mit erhöhter relaxation

Info

Publication number
ATE222244T1
ATE222244T1 AT95915988T AT95915988T ATE222244T1 AT E222244 T1 ATE222244 T1 AT E222244T1 AT 95915988 T AT95915988 T AT 95915988T AT 95915988 T AT95915988 T AT 95915988T AT E222244 T1 ATE222244 T1 AT E222244T1
Authority
AT
Austria
Prior art keywords
metal
multimer
mono
connections
och2ch
Prior art date
Application number
AT95915988T
Other languages
English (en)
Inventor
Ramachandran S Ranganathan
Radhakrishna Pillai
Peter C Ratsep
Rajesh Shulka
Michael F Tweedle
Xun Zhang
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Application granted granted Critical
Publication of ATE222244T1 publication Critical patent/ATE222244T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
AT95915988T 1994-05-11 1995-05-09 Mono -und multimere verbindungen mit erhöhter relaxation ATE222244T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/241,253 US6693190B1 (en) 1994-05-11 1994-05-11 Enhanced relaxivity monomeric and multimeric compounds
PCT/IB1995/000337 WO1995031444A1 (en) 1994-05-11 1995-05-09 Enhanced relaxivity monomeric and multimeric compounds

Publications (1)

Publication Number Publication Date
ATE222244T1 true ATE222244T1 (de) 2002-08-15

Family

ID=22909910

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95915988T ATE222244T1 (de) 1994-05-11 1995-05-09 Mono -und multimere verbindungen mit erhöhter relaxation

Country Status (11)

Country Link
US (2) US6693190B1 (de)
EP (1) EP0708761B1 (de)
JP (1) JPH09500660A (de)
KR (1) KR960703874A (de)
CN (1) CN1128534A (de)
AT (1) ATE222244T1 (de)
CA (1) CA2164944A1 (de)
CZ (1) CZ8596A3 (de)
DE (1) DE69527759T2 (de)
NO (1) NO306722B1 (de)
WO (1) WO1995031444A1 (de)

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US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
DE19608307C1 (de) * 1996-02-26 1997-08-28 Schering Ag Verfahren zur Herstellung von 1,4,7,10-Tetraazacyclododecan und dessen Derivaten
US5744616A (en) * 1996-02-26 1998-04-28 Schering Aktiengesellschaft Process for the production of 1,4,7,10-tetraazacyclododecane and its derivatives
US6107090A (en) 1996-05-06 2000-08-22 Cornell Research Foundation, Inc. Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
EP1032430A2 (de) 1997-11-17 2000-09-06 Research Corporation Technologies, Inc. Mri-mittel zum nachweis von physiologischen mitteln
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
AU2001276956A1 (en) 2000-07-17 2002-01-30 California Institute Of Technology Macrocyclic mri contrast agents
US7029655B2 (en) 2000-10-04 2006-04-18 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
ATE535258T1 (de) 2001-06-01 2011-12-15 Cornell Res Foundation Inc Modifizierte antikörper gegen prostata- spezifisches membranantigen und ihre verwendungen
US7514078B2 (en) 2001-06-01 2009-04-07 Cornell Research Foundation, Inc. Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
US20040167330A1 (en) * 2001-07-17 2004-08-26 Ivan Lukes Novel chelating agents and conjugates thereof, their synthesis and use as diagnois and therapeutic agents
DE10135356C1 (de) * 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
DE10135355C1 (de) * 2001-07-20 2003-04-17 Schering Ag Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie
JP2005527474A (ja) 2001-09-20 2005-09-15 コーネル リサーチ ファンデーション インコーポレーテッド 前立腺特異的膜抗原に特異的な結合剤を用いて、皮膚障害を治療するかまたは防止するための方法および組成物
US7368100B2 (en) 2002-09-06 2008-05-06 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Backbone-substituted bifunctional DOTA ligands, complexes and compositions thereof, and methods of using same
DE60323677D1 (de) 2003-01-10 2008-10-30 Millennium Pharm Inc Verfahren zur bestimmung des wiederauftretens von prostata krebs
EP1641770A4 (de) * 2003-07-08 2008-12-31 Univ Hong Kong Synthese von tris-n-alkylierten 1,4,7,10-tetraazacyclododecanen
US7012140B1 (en) * 2003-07-14 2006-03-14 Board Of Regents, The University Of Texas System Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
EP1699466A4 (de) * 2003-12-23 2009-03-11 Bracco Spa Neue verbindungen als metallchelatoren
KR100864561B1 (ko) * 2004-07-29 2008-10-20 오츠카 세이야쿠 가부시키가이샤 고체 시료의 핵 자기 공명 측정 방법
DE102004038134B4 (de) 2004-08-05 2013-07-25 Johann Wolfgang Goethe-Universität Frankfurt am Main Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung
JP2008508333A (ja) * 2004-08-05 2008-03-21 ヨハン ウォルフガング ゲーテ−ウニベルジテート フランクフルト アム マイン 標的分子の改変および組織化のための多価キレーター
US20080312430A1 (en) * 2004-10-20 2008-12-18 Therapharm Gmbh Method of Preparing or Synthesizing Polyazamacrocycle Derivatives
CN101166547B (zh) * 2005-04-26 2013-02-06 皇家飞利浦电子股份有限公司 包含cest活性的顺磁性配合物的mri造影剂
CN101845112B (zh) * 2010-06-02 2011-09-14 华东理工大学 一种基于高分子纳米粒子的高灵敏性核磁共振成像造影剂的制备方法
EP3101012A1 (de) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung
US11357873B2 (en) 2016-09-19 2022-06-14 The Hong Kong Polytechnic University Chiral cyclen compounds and their uses
CN110035996B (zh) * 2016-11-28 2022-08-09 拜耳医药股份公司 用于磁共振成像的新型高弛豫性钆螯合物
EP3883613A1 (de) 2018-11-23 2021-09-29 Bayer Aktiengesellschaft Formulierung für kontrastmittel und verfahren zur herstellung davon
CN118955761B (zh) * 2024-09-12 2025-08-05 广东安道科技有限公司 一种抗菌水溶性甜菜碱改性壳聚糖及其膜的制备方法

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DE3129906C3 (de) 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
SE465907B (sv) 1984-11-01 1991-11-18 Nyegaard & Co As Diagnosticeringsmedel innehaallande en paramagnetisk metall
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US4678667A (en) 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
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US5271927A (en) 1986-02-13 1993-12-21 Celltech Limited Antibody conjugates with macrocyclic ligands
DE3625417C2 (de) 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
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US5049667A (en) 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
FR2637895B1 (fr) 1988-10-14 1992-11-06 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands
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GB8719041D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
EP0416033B1 (de) 1988-05-25 1996-03-06 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Makrocyclische chelate und verwendungsverfahren
US4923985A (en) 1988-05-25 1990-05-08 The United States Of America As Represented By The Department Of Health & Human Services Process for synthesizing macrocyclic chelates
ATE120457T1 (de) 1988-06-24 1995-04-15 Dow Chemical Co Macrocyclische bifunktionelle chelatbildner, komplexe davon und ihre konjugierten antikörper.
BR8907282A (pt) 1988-12-23 1991-03-12 Dow Chemical Co Processo para preparar complexos de metal funcionalizados com isotiocianato
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Also Published As

Publication number Publication date
DE69527759D1 (de) 2002-09-19
NO960115D0 (no) 1996-01-10
CN1128534A (zh) 1996-08-07
DE69527759T2 (de) 2003-04-10
CA2164944A1 (en) 1995-11-23
KR960703874A (ko) 1996-08-31
JPH09500660A (ja) 1997-01-21
EP0708761B1 (de) 2002-08-14
WO1995031444A1 (en) 1995-11-23
NO306722B1 (no) 1999-12-13
US6693190B1 (en) 2004-02-17
EP0708761A1 (de) 1996-05-01
US20040131551A1 (en) 2004-07-08
NO960115L (no) 1996-03-05
CZ8596A3 (en) 1996-06-12

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Legal Events

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