NO306722B1 - Karbocykliske ringforbindelser samt metallchelater omfattende disse - Google Patents
Karbocykliske ringforbindelser samt metallchelater omfattende disseInfo
- Publication number
- NO306722B1 NO306722B1 NO960115A NO960115A NO306722B1 NO 306722 B1 NO306722 B1 NO 306722B1 NO 960115 A NO960115 A NO 960115A NO 960115 A NO960115 A NO 960115A NO 306722 B1 NO306722 B1 NO 306722B1
- Authority
- NO
- Norway
- Prior art keywords
- carbocyclic ring
- metal
- well
- metal chelates
- ring compounds
- Prior art date
Links
- 239000002184 metal Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 title 1
- 125000003627 8 membered carbocyclic group Chemical group 0.000 abstract 1
- 101100379079 Emericella variicolor andA gene Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Farming Of Fish And Shellfish (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/241,253 US6693190B1 (en) | 1994-05-11 | 1994-05-11 | Enhanced relaxivity monomeric and multimeric compounds |
PCT/IB1995/000337 WO1995031444A1 (en) | 1994-05-11 | 1995-05-09 | Enhanced relaxivity monomeric and multimeric compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
NO960115D0 NO960115D0 (no) | 1996-01-10 |
NO960115L NO960115L (no) | 1996-03-05 |
NO306722B1 true NO306722B1 (no) | 1999-12-13 |
Family
ID=22909910
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO960115A NO306722B1 (no) | 1994-05-11 | 1996-01-10 | Karbocykliske ringforbindelser samt metallchelater omfattende disse |
Country Status (11)
Country | Link |
---|---|
US (2) | US6693190B1 (no) |
EP (1) | EP0708761B1 (no) |
JP (1) | JPH09500660A (no) |
KR (1) | KR960703874A (no) |
CN (1) | CN1128534A (no) |
AT (1) | ATE222244T1 (no) |
CA (1) | CA2164944A1 (no) |
CZ (1) | CZ8596A3 (no) |
DE (1) | DE69527759T2 (no) |
NO (1) | NO306722B1 (no) |
WO (1) | WO1995031444A1 (no) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6770261B2 (en) | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
US6713045B1 (en) | 1995-06-02 | 2004-03-30 | Research Corporation Technologies, Inc. | Targeted magnetic resonance imaging agents for the detection of physiological processes |
DE19608307C1 (de) * | 1996-02-26 | 1997-08-28 | Schering Ag | Verfahren zur Herstellung von 1,4,7,10-Tetraazacyclododecan und dessen Derivaten |
US5744616A (en) * | 1996-02-26 | 1998-04-28 | Schering Aktiengesellschaft | Process for the production of 1,4,7,10-tetraazacyclododecane and its derivatives |
US6107090A (en) | 1996-05-06 | 2000-08-22 | Cornell Research Foundation, Inc. | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
US5900228A (en) | 1996-07-31 | 1999-05-04 | California Institute Of Technology | Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye |
US6713046B1 (en) | 1997-10-27 | 2004-03-30 | Research Corporation Technologies | Magnetic resonance imaging agents for the delivery of therapeutic agents |
AU752812B2 (en) | 1997-11-17 | 2002-10-03 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
US6565828B2 (en) * | 2000-04-07 | 2003-05-20 | Bristol-Myers Squibb Company | Macrocyclic chelants for metallopharmaceuticals |
US6673333B1 (en) | 2000-05-04 | 2004-01-06 | Research Corporation Technologies, Inc. | Functional MRI agents for cancer imaging |
AU2001276956A1 (en) | 2000-07-17 | 2002-01-30 | California Institute Of Technology | Macrocyclic mri contrast agents |
WO2002028441A2 (en) | 2000-10-04 | 2002-04-11 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
WO2002098897A2 (en) | 2001-06-01 | 2002-12-12 | Cornell Research Foundation, Inc. | Modified antibodies to prostate-specific membrane antigen and uses thereof |
JP2005523235A (ja) * | 2001-07-17 | 2005-08-04 | テラファルム ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規のキレート化剤およびその接合体、該キレート化剤およびその接合体の診断剤および治療剤としての合成および使用 |
DE10135356C1 (de) * | 2001-07-20 | 2003-04-17 | Schering Ag | Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen |
DE10135355C1 (de) * | 2001-07-20 | 2003-04-17 | Schering Ag | Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie |
JP2005527474A (ja) | 2001-09-20 | 2005-09-15 | コーネル リサーチ ファンデーション インコーポレーテッド | 前立腺特異的膜抗原に特異的な結合剤を用いて、皮膚障害を治療するかまたは防止するための方法および組成物 |
AU2003270347B2 (en) | 2002-09-06 | 2007-05-24 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Backbone-substituted bifunctional dota ligands, complexes and compositions thereof, and methods of using same |
US7771953B2 (en) | 2003-01-10 | 2010-08-10 | Millenium Pharmaceuticals, Inc. | Methods of diagnosing and treating cancer |
EP1641770A4 (en) * | 2003-07-08 | 2008-12-31 | Univ Hong Kong | SYNTHESIS OF TRIS-N-ALKYLATED 1,4,7,10-TETRAAZACYCLODODECANES |
US7012140B1 (en) * | 2003-07-14 | 2006-03-14 | Board Of Regents, The University Of Texas System | Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents |
US20080124270A1 (en) * | 2003-12-23 | 2008-05-29 | Bracco Imaging S.P.A. | Compounds Useful as Metal Chelators |
DE602005021969D1 (de) * | 2004-07-29 | 2010-08-05 | Otsuka Pharma Co Ltd | Festproben-kern-magnetresonanzmessverfahren |
DE102004038134B4 (de) | 2004-08-05 | 2013-07-25 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung |
JP2008508333A (ja) * | 2004-08-05 | 2008-03-21 | ヨハン ウォルフガング ゲーテ−ウニベルジテート フランクフルト アム マイン | 標的分子の改変および組織化のための多価キレーター |
WO2006045546A1 (en) * | 2004-10-20 | 2006-05-04 | Therapharm Gmbh | Method of preparing or synthesizing polyazamacrocycle derivatives |
DE602006008604D1 (de) * | 2005-04-26 | 2009-10-01 | Koninkl Philips Electronics Nv | Kontrastmittel für die magnetresonanzbildgebung mit cest-aktivem paramagnetischem komplex |
CN101845112B (zh) * | 2010-06-02 | 2011-09-14 | 华东理工大学 | 一种基于高分子纳米粒子的高灵敏性核磁共振成像造影剂的制备方法 |
EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
WO2018051197A1 (en) | 2016-09-19 | 2018-03-22 | The Hong Kong Polytechnic University | Chiral cyclen compounds and their uses |
WO2018096082A1 (en) | 2016-11-28 | 2018-05-31 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
BR112021007707A2 (pt) | 2018-11-23 | 2021-07-27 | Bayer Aktiengesellschaft | formulação de meios de contraste e processo de preparação da mesma |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3129906C3 (de) | 1981-07-24 | 1996-12-19 | Schering Ag | Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik |
SE465907B (sv) | 1984-11-01 | 1991-11-18 | Nyegaard & Co As | Diagnosticeringsmedel innehaallande en paramagnetisk metall |
US4899755A (en) | 1985-05-08 | 1990-02-13 | The General Hospital Corporation | Hepatobiliary NMR contrast agents |
US4880008A (en) | 1985-05-08 | 1989-11-14 | The General Hospital Corporation | Vivo enhancement of NMR relaxivity |
US4678667A (en) | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
US5271927A (en) | 1986-02-13 | 1993-12-21 | Celltech Limited | Antibody conjugates with macrocyclic ligands |
DE3625417C2 (de) | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
IT1224416B (it) | 1987-12-24 | 1990-10-04 | Bracco Ind Chimica Spa | Chelanti macrociclici e loro chelati |
FR2637895B1 (fr) | 1988-10-14 | 1992-11-06 | Guerbet Sa | Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands |
US5049667A (en) | 1987-04-14 | 1991-09-17 | Guerbet S.A. | Nitrogen-containing cyclic ligands |
DE3869251D1 (de) | 1987-07-16 | 1992-04-23 | Nycomed As | Aminopolycarbonsaeure und ihre derivate. |
GB8719041D0 (en) * | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
US4923985A (en) | 1988-05-25 | 1990-05-08 | The United States Of America As Represented By The Department Of Health & Human Services | Process for synthesizing macrocyclic chelates |
AU630362B2 (en) | 1988-05-25 | 1992-10-29 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Macrocyclic chelates & methods of use thereof |
AU634167B2 (en) | 1988-06-24 | 1993-02-18 | Dow Chemical Company, The | Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates |
BR8907282A (pt) | 1988-12-23 | 1991-03-12 | Dow Chemical Co | Processo para preparar complexos de metal funcionalizados com isotiocianato |
WO1990009379A1 (en) | 1989-02-10 | 1990-08-23 | Celltech Limited | Aza-macrocycles and processes for their preparation |
US5053503A (en) | 1989-02-17 | 1991-10-01 | Centocor | Chelating agents |
US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
DE3911816A1 (de) | 1989-04-11 | 1990-10-25 | Hoechst Ag | Substituierte 1,4,7,10-tetraazacyclotridecane, verfahren zu deren herstellung sowie verwendung derselben zur markierung von substanzen mit radionukliden |
IT1243801B (it) | 1990-08-29 | 1994-06-28 | Bracco Ind Chimica Spa | Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione |
US5162109A (en) | 1990-09-13 | 1992-11-10 | Mallinckrodt Medical, Inc. | Magnetic resonance imaging agents |
JPH04154729A (ja) | 1990-10-16 | 1992-05-27 | Nippon Mejifuijitsukusu Kk | 磁気共鳴造影剤 |
DE4035760A1 (de) | 1990-11-08 | 1992-05-14 | Schering Ag | Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
EP0660925A1 (en) | 1990-11-21 | 1995-07-05 | Mallinckrodt Medical, Inc. | Alkoxyamide derivatized chelates for mri |
FR2672051B1 (fr) | 1991-01-24 | 1993-05-21 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes polymetalliques, composition de diagnostic et therapeutique. |
GB9115375D0 (en) | 1991-07-17 | 1991-09-04 | Salutar Inc | Compounds |
KR930019648A (ko) | 1992-03-27 | 1993-10-18 | 도키 가츠유키 | 테트라아자시클로도덴칸 유도체 및 그의 용도 |
US6120768A (en) * | 1993-05-17 | 2000-09-19 | Immunomedics, Inc. | Dota-biotin derivatives |
-
1994
- 1994-05-11 US US08/241,253 patent/US6693190B1/en not_active Expired - Fee Related
-
1995
- 1995-05-09 DE DE69527759T patent/DE69527759T2/de not_active Expired - Fee Related
- 1995-05-09 AT AT95915988T patent/ATE222244T1/de not_active IP Right Cessation
- 1995-05-09 JP JP7529486A patent/JPH09500660A/ja active Pending
- 1995-05-09 CN CN95190415A patent/CN1128534A/zh active Pending
- 1995-05-09 WO PCT/IB1995/000337 patent/WO1995031444A1/en active IP Right Grant
- 1995-05-09 CA CA002164944A patent/CA2164944A1/en not_active Abandoned
- 1995-05-09 CZ CZ9685A patent/CZ8596A3/cs unknown
- 1995-05-09 EP EP95915988A patent/EP0708761B1/en not_active Expired - Lifetime
- 1995-05-09 KR KR1019960700111A patent/KR960703874A/ko not_active Application Discontinuation
-
1996
- 1996-01-10 NO NO960115A patent/NO306722B1/no not_active IP Right Cessation
-
2003
- 2003-12-19 US US10/741,872 patent/US20040131551A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0708761B1 (en) | 2002-08-14 |
CA2164944A1 (en) | 1995-11-23 |
NO960115D0 (no) | 1996-01-10 |
US6693190B1 (en) | 2004-02-17 |
WO1995031444A1 (en) | 1995-11-23 |
ATE222244T1 (de) | 2002-08-15 |
KR960703874A (ko) | 1996-08-31 |
EP0708761A1 (en) | 1996-05-01 |
JPH09500660A (ja) | 1997-01-21 |
DE69527759T2 (de) | 2003-04-10 |
US20040131551A1 (en) | 2004-07-08 |
NO960115L (no) | 1996-03-05 |
CZ8596A3 (en) | 1996-06-12 |
CN1128534A (zh) | 1996-08-07 |
DE69527759D1 (de) | 2002-09-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |