RU96119782A - Производные 7-амино-1h-индола - Google Patents
Производные 7-амино-1h-индолаInfo
- Publication number
- RU96119782A RU96119782A RU96119782/04A RU96119782A RU96119782A RU 96119782 A RU96119782 A RU 96119782A RU 96119782/04 A RU96119782/04 A RU 96119782/04A RU 96119782 A RU96119782 A RU 96119782A RU 96119782 A RU96119782 A RU 96119782A
- Authority
- RU
- Russia
- Prior art keywords
- derivatives
- amino
- indola
- group
- indole
- Prior art date
Links
- WTFWZOSMUGZKNZ-UHFFFAOYSA-N 1H-indol-7-amine Chemical class NC1=CC=CC2=C1NC=C2 WTFWZOSMUGZKNZ-UHFFFAOYSA-N 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
Claims (2)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5/248614 | 1993-09-10 | ||
JP24861493 | 1993-09-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU96119782A true RU96119782A (ru) | 1998-11-20 |
RU2121997C1 RU2121997C1 (ru) | 1998-11-20 |
Family
ID=17180741
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU96119782A RU2121997C1 (ru) | 1993-09-10 | 1994-09-08 | Производные 7-амино-1н-индола |
RU95112848A RU2128648C1 (ru) | 1993-09-10 | 1994-09-08 | Производные сульфонамида, способы их получения, фармацевтическая композиция и способ лечения |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU95112848A RU2128648C1 (ru) | 1993-09-10 | 1994-09-08 | Производные сульфонамида, способы их получения, фармацевтическая композиция и способ лечения |
Country Status (16)
Country | Link |
---|---|
US (1) | US5767283A (ru) |
EP (1) | EP0673937B1 (ru) |
KR (2) | KR0174752B1 (ru) |
CN (2) | CN1079097C (ru) |
AT (1) | ATE255106T1 (ru) |
AU (2) | AU683492B2 (ru) |
CA (1) | CA2146961C (ru) |
DE (1) | DE69433353T2 (ru) |
DK (1) | DK0673937T3 (ru) |
ES (1) | ES2206469T3 (ru) |
HU (1) | HU224069B1 (ru) |
NO (1) | NO303778B1 (ru) |
NZ (1) | NZ273073A (ru) |
PT (1) | PT673937E (ru) |
RU (2) | RU2121997C1 (ru) |
WO (1) | WO1995007276A1 (ru) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1048246C (zh) * | 1993-06-25 | 2000-01-12 | 组合化学工业株式会社 | 吲唑磺酰脲类衍生物、用途及其制造中的中间体 |
WO1996034866A1 (en) * | 1995-05-01 | 1996-11-07 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivatives and their use as bone resorption inhibitors |
EP0923932B1 (en) * | 1996-02-26 | 2011-06-29 | Eisai R&D Management Co., Ltd. | Composition containing antitumor agent |
JP2000247949A (ja) * | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
JP4516942B2 (ja) * | 1999-02-26 | 2010-08-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド含有インドール化合物 |
US6653309B1 (en) | 1999-04-26 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme technical field of the invention |
US6521658B1 (en) | 1999-05-28 | 2003-02-18 | Abbott Laboratories | Cell proliferation inhibitors |
KR100767002B1 (ko) * | 2000-02-03 | 2007-10-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 인테그린 발현 저해제 |
DE60141889D1 (de) * | 2000-02-03 | 2010-06-02 | Eisai R&D Man Co Ltd | Inhibitoren der integrinexpression |
TWI283575B (en) * | 2000-10-31 | 2007-07-11 | Eisai Co Ltd | Medicinal compositions for concomitant use as anticancer agent |
CN100342030C (zh) * | 2000-11-24 | 2007-10-10 | 卫材R&D管理有限公司 | 试验肿瘤细胞对于抗癌药剂敏感性的方法 |
KR20030080013A (ko) * | 2001-02-21 | 2003-10-10 | 에자이 가부시키가이샤 | 인테그린 발현 억제를 통한 혈관 신생 억제제의 효과를검정하는 방법 |
EP1370527A1 (en) | 2001-03-06 | 2003-12-17 | AstraZeneca AB | Indolone derivatives having vascular-damaging activity |
TW589181B (en) * | 2001-09-05 | 2004-06-01 | Eisai Co Ltd | Lymphocytic activation inhibitor and remedial agent for autoimmune disease |
CN100549011C (zh) | 2002-09-19 | 2009-10-14 | 先灵公司 | 用作细胞周期蛋白依赖性激酶抑制剂的新颖咪唑并吡啶 |
US8772269B2 (en) | 2004-09-13 | 2014-07-08 | Eisai R&D Management Co., Ltd. | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors |
WO2006030941A1 (ja) | 2004-09-13 | 2006-03-23 | Eisai R & D Management Co., Ltd. | スルホンアミド含有化合物の血管新生阻害物質との併用 |
US7521472B2 (en) | 2004-11-17 | 2009-04-21 | Eisai R&D Management Co., Ltd. | Crystal of two-ring heterocyclic sulfonamide compound |
EP1859793B1 (en) * | 2005-02-28 | 2011-04-20 | Eisai R&D Management Co., Ltd. | Novel combinational use of a sulfonamide compound in the treatment of cancer |
JP5094394B2 (ja) * | 2005-04-20 | 2012-12-12 | 武田薬品工業株式会社 | 縮合複素環化合物 |
NZ561609A (en) * | 2005-05-12 | 2010-03-26 | Abbott Lab | 3-((trifluoromethyl)sulfonyl)benzenesulfonamide and 3-((chloro(difluoro)methyl)sulfonyl)benzenesulfonamide apoptosis promoters |
JPWO2007123274A1 (ja) | 2006-04-20 | 2009-09-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の新規感受性マーカー |
NZ576570A (en) * | 2006-10-19 | 2010-11-26 | Takeda Pharmaceutical | 7-sulfonylamino-2-thiazol and 2-thiadiazol -indole compounds |
AU2008242983B2 (en) * | 2007-04-16 | 2013-07-11 | Abbvie Inc. | 7-substituted indole Mcl-1 inhibitors |
DK2178870T3 (en) | 2007-08-17 | 2018-10-22 | Lg Chemical Ltd | INDOLE AND INDAZOLIC COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSE |
CN101952281B (zh) | 2008-01-04 | 2014-04-02 | 株式会社Lg生命科学 | 具有细胞、组织及器官保存效果的吲哚及吲唑衍生物 |
EP2229929B1 (en) | 2009-03-18 | 2017-06-14 | DENTSPLY DETREY GmbH | Temporary root canal sealer dispersion |
TWI410408B (zh) * | 2010-03-16 | 2013-10-01 | Purzer Pharmaceutical Co Ltd | 苯磺醯胺衍生物及其醫藥組合物 |
CN102199148A (zh) * | 2010-03-25 | 2011-09-28 | 瑞安大药厂股份有限公司 | 苯磺酰胺衍生物及其医药组合物 |
EP2632920A1 (en) | 2010-10-27 | 2013-09-04 | Dynamix Pharmaceuticals Ltd. | Sulfonamides for the modulation of pkm2 |
CN102875549B (zh) * | 2012-09-14 | 2015-11-04 | 浙江大学 | 7-芳(甲)胺基-5-胺基-6-氮杂吲哚衍生物及制备与用途 |
WO2015026172A1 (ko) | 2013-08-22 | 2015-02-26 | 주식회사 엘지생명과학 | 세포괴사 저해제로서의 인돌아미드 화합물 |
US10927097B2 (en) | 2013-08-22 | 2021-02-23 | Lg Chem, Ltd. | Indole compound as inhibitor of necrosis |
WO2020256432A1 (ko) | 2019-06-19 | 2020-12-24 | 주식회사 엘지화학 | 인돌 또는 인다졸 화합물의 제조방법 |
CN114080383A (zh) | 2019-06-19 | 2022-02-22 | 株式会社Lg化学 | 制备吲哚或吲唑化合物的方法 |
EP3971186B1 (en) | 2019-06-19 | 2023-08-02 | LG Chem, Ltd. | Preparation method for indole or indazole compound |
CN114080382B (zh) | 2019-06-19 | 2024-05-24 | 株式会社Lg化学 | 制备吲哚或吲唑化合物的方法 |
WO2023064669A2 (en) * | 2021-09-21 | 2023-04-20 | The Trustees Of Princeton University | Inhibitors of the mtdh-snd1 protein complex for cancer therapy |
MA54773B1 (fr) * | 2021-10-29 | 2023-10-31 | Univ Euro Mediterraneenne De Fes Uemf | Nouvelles familles de composés à base de sulfonamides pour le traitement du cancer du sein triple négatif |
US20240092770A1 (en) * | 2022-08-15 | 2024-03-21 | Recursion Pharmaceuticals, Inc. | Heterocycle RMB39 Modulators |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS539256A (en) * | 1976-07-14 | 1978-01-27 | Hitachi Kiden Kogyo Kk | Two hook type club |
DE3686688T2 (de) * | 1985-06-24 | 1993-03-18 | Merck & Co Inc | Verwendung von sulfanilamido quinoxalinen zur behandlung von neoplastischen krankheiten. |
JP2790926B2 (ja) * | 1990-08-20 | 1998-08-27 | エーザイ株式会社 | スルホンアミド誘導体 |
LU87814A1 (fr) * | 1990-09-27 | 1992-05-25 | Oreal | Composition cosmetique comportant une dispersion de vesicules lipidiques ainsi que des pigments melaniques,et son utilisation |
-
1994
- 1994-09-08 RU RU96119782A patent/RU2121997C1/ru not_active IP Right Cessation
- 1994-09-08 RU RU95112848A patent/RU2128648C1/ru not_active IP Right Cessation
- 1994-09-08 PT PT94926372T patent/PT673937E/pt unknown
- 1994-09-08 ES ES94926372T patent/ES2206469T3/es not_active Expired - Lifetime
- 1994-09-08 WO PCT/JP1994/001487 patent/WO1995007276A1/ja active IP Right Grant
- 1994-09-08 DE DE69433353T patent/DE69433353T2/de not_active Expired - Lifetime
- 1994-09-08 AU AU76237/94A patent/AU683492B2/en not_active Ceased
- 1994-09-08 CN CN94190672A patent/CN1079097C/zh not_active Expired - Fee Related
- 1994-09-08 HU HU9501363A patent/HU224069B1/hu not_active IP Right Cessation
- 1994-09-08 EP EP94926372A patent/EP0673937B1/en not_active Expired - Lifetime
- 1994-09-08 KR KR1019950701862A patent/KR0174752B1/ko not_active IP Right Cessation
- 1994-09-08 NZ NZ273073A patent/NZ273073A/en not_active IP Right Cessation
- 1994-09-08 CA CA002146961A patent/CA2146961C/en not_active Expired - Fee Related
- 1994-09-08 AT AT94926372T patent/ATE255106T1/de active
- 1994-09-08 DK DK94926372T patent/DK0673937T3/da active
- 1994-09-08 CN CNB011194561A patent/CN1221533C/zh not_active Expired - Fee Related
-
1995
- 1995-05-09 NO NO19951813A patent/NO303778B1/no not_active IP Right Cessation
-
1997
- 1997-01-17 US US08/785,610 patent/US5767283A/en not_active Expired - Lifetime
- 1997-04-09 AU AU17785/97A patent/AU711438B2/en not_active Ceased
-
1998
- 1998-09-07 KR KR1019980707044A patent/KR100188846B1/ko not_active IP Right Cessation
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