NO932418L - Pyrimidinderivater, fremgangsmaate for deres fremstilling og terapeutiske anvendelse derav - Google Patents

Pyrimidinderivater, fremgangsmaate for deres fremstilling og terapeutiske anvendelse derav

Info

Publication number
NO932418L
NO932418L NO932418A NO932418A NO932418L NO 932418 L NO932418 L NO 932418L NO 932418 A NO932418 A NO 932418A NO 932418 A NO932418 A NO 932418A NO 932418 L NO932418 L NO 932418L
Authority
NO
Norway
Prior art keywords
group
processes
preparation
therapeutic use
pyrimidine derivatives
Prior art date
Application number
NO932418A
Other languages
English (en)
Other versions
NO932418D0 (no
Inventor
Pascal George
Benoit Marabout
Jacques Froissant
Jean-Pierre Merly
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9208199A external-priority patent/FR2693195B1/fr
Priority claimed from FR9215037A external-priority patent/FR2699171B1/fr
Application filed by Synthelabo filed Critical Synthelabo
Publication of NO932418D0 publication Critical patent/NO932418D0/no
Publication of NO932418L publication Critical patent/NO932418L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Forbindelser med den generelle formel (I) hvori m står for O eller l, n står for O eller l, R; står for en metylgruppe hvor da R2 står for en f enoksy (Cj-CJ- alkylgruppe, eller også danner Rj og R2 sammen med det nitrogenatom som bærer dem en 4-fenoksypiperidin-l-yl- gruppe, en fenoksymetylpiperidin-1-yl-gruppe, eller en 4- fenylpiperazin-1-yl-gruppe, og R3 står for et hydrogenatom, idet når n er lik l, står R3 også for en hydroksygruppe eller en metoksygruppe. Forbindelsene har terapeutisk anvendelse. Deres fremstilling er beskrevet.
NO932418A 1992-07-03 1993-07-02 Pyrimidinderivater, fremgangsmaate for deres fremstilling og terapeutiske anvendelse derav NO932418L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9208199A FR2693195B1 (fr) 1992-07-03 1992-07-03 Dérivés de 2-amino-N-[[[(4-aminocarbonyl)pyrimidin-2-yl]amino]alkyl] pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.
FR9215037A FR2699171B1 (fr) 1992-12-14 1992-12-14 Dérivés de 2-amino-N[[[4-aminocarbonyl) pyrimidin-2-yl]amino]alkyl]pyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.

Publications (2)

Publication Number Publication Date
NO932418D0 NO932418D0 (no) 1993-07-02
NO932418L true NO932418L (no) 1994-01-04

Family

ID=26229565

Family Applications (1)

Application Number Title Priority Date Filing Date
NO932418A NO932418L (no) 1992-07-03 1993-07-02 Pyrimidinderivater, fremgangsmaate for deres fremstilling og terapeutiske anvendelse derav

Country Status (21)

Country Link
US (1) US5330985A (no)
EP (1) EP0577470B1 (no)
JP (1) JP3285421B2 (no)
KR (1) KR940005619A (no)
CN (1) CN1100416A (no)
AT (1) ATE123025T1 (no)
AU (1) AU660815B2 (no)
CA (1) CA2099556A1 (no)
CZ (1) CZ282079B6 (no)
DE (1) DE69300162T2 (no)
DK (1) DK0577470T3 (no)
ES (1) ES2073951T3 (no)
FI (1) FI933064A (no)
HU (2) HUT65533A (no)
IL (1) IL106213A (no)
MX (1) MX9303976A (no)
NO (1) NO932418L (no)
NZ (1) NZ248051A (no)
PL (1) PL172583B1 (no)
RU (1) RU2111963C1 (no)
SK (1) SK69993A3 (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4425143A1 (de) * 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung
FR2744722B1 (fr) * 1996-02-14 1998-03-13 Synthelabo Devires de 2-((3-(piperazin-1-yl)propyl)amino)pyrimidine-4- carboxamide et leur application en therapeutique
EP1075486A1 (en) * 1998-05-06 2001-02-14 Duke University Method of treating bladder and lower urinary tract syndromes
KR20070043806A (ko) * 2004-07-29 2007-04-25 사노피-아벤티스 ｐＨ에 매우 의존적인 용해도를 가지는 활성 성분의 제어방출을 위한 약제학적 다층 정제
US9113629B2 (en) * 2013-03-15 2015-08-25 Dow Agrosciences Llc 4-amino-6-(4-substituted-phenyl)-picolinates and 6-amino-2-(4-substituted-phenyl)-pyrimidine-4-carboxylates and their use as herbicides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2618436B1 (fr) * 1987-07-23 1989-10-27 Synthelabo Derives de piperidine, leur preparation et leur application en therapeutique
JP2814600B2 (ja) * 1989-08-31 1998-10-22 正幸 石川 排尿障害治療剤
CA2024428A1 (en) * 1989-09-06 1991-03-07 Masayuki Ishikawa Agent for treating urinary obstruction
FR2656609B1 (fr) * 1989-12-28 1992-03-27 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2667317B1 (fr) * 1990-10-02 1992-12-04 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2675799B1 (fr) * 1991-04-24 1993-12-24 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2678271B1 (fr) * 1991-06-27 1995-01-13 Synthelabo Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2678272B1 (fr) * 1991-06-27 1994-01-14 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
IL106213A (en) 1998-02-22
NO932418D0 (no) 1993-07-02
ES2073951T3 (es) 1995-08-16
FI933064A0 (fi) 1993-07-02
JPH06100545A (ja) 1994-04-12
RU2111963C1 (ru) 1998-05-27
IL106213A0 (en) 1993-11-15
AU4171293A (en) 1994-01-06
HU211462A9 (en) 1995-11-28
DE69300162D1 (de) 1995-06-29
PL172583B1 (pl) 1997-10-31
PL299541A1 (en) 1994-01-10
HU9301937D0 (en) 1993-09-28
MX9303976A (es) 1994-02-28
AU660815B2 (en) 1995-07-06
CA2099556A1 (en) 1994-01-04
DE69300162T2 (de) 1995-11-02
CN1100416A (zh) 1995-03-22
DK0577470T3 (da) 1995-10-02
EP0577470B1 (fr) 1995-05-24
HUT65533A (en) 1994-06-28
CZ282079B6 (cs) 1997-05-14
FI933064A (fi) 1994-01-04
CZ135193A3 (en) 1994-02-16
JP3285421B2 (ja) 2002-05-27
KR940005619A (ko) 1994-03-21
NZ248051A (en) 1994-10-26
US5330985A (en) 1994-07-19
SK69993A3 (en) 1994-04-06
EP0577470A1 (fr) 1994-01-05
ATE123025T1 (de) 1995-06-15

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