NO980648L - Fremgangsmåte for diagnostisk bildeanalyse ved anvendelse av metallkomplekser av nitrogeninneholdende makrocykliske ligander - Google Patents

Fremgangsmåte for diagnostisk bildeanalyse ved anvendelse av metallkomplekser av nitrogeninneholdende makrocykliske ligander

Info

Publication number
NO980648L
NO980648L NO980648A NO980648A NO980648L NO 980648 L NO980648 L NO 980648L NO 980648 A NO980648 A NO 980648A NO 980648 A NO980648 A NO 980648A NO 980648 L NO980648 L NO 980648L
Authority
NO
Norway
Prior art keywords
nitrogen
image analysis
metal complexes
diagnostic image
macrocyclic ligands
Prior art date
Application number
NO980648A
Other languages
English (en)
Other versions
NO980648D0 (no
Inventor
William L Neumann
Dennis P Riley
Randy H Weiss
Susan L Henke
Patrick J Lennon
Karl W Aston
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Publication of NO980648D0 publication Critical patent/NO980648D0/no
Publication of NO980648L publication Critical patent/NO980648L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Det er beskrevet komplekser representert ved formel (I), hvori R, R1, R,, R',, R2, R'2> R3, R'3> R4, R'4) R5, R'5) RS, R'6) R7, R'7) R8, R'8> R,, R'9, M, X, Y, Z og n er definert heri for anvendelse som kontrastmidler ved diagnostisk billeddannelse.
NO980648A 1995-08-17 1998-02-16 Fremgangsmåte for diagnostisk bildeanalyse ved anvendelse av metallkomplekser av nitrogeninneholdende makrocykliske ligander NO980648L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US242295P 1995-08-17 1995-08-17
PCT/US1996/013045 WO1997006831A1 (en) 1995-08-17 1996-08-16 Methods of diagnostic image analysis using metal complexes of nitrogen-containing macrocyclic ligands

Publications (2)

Publication Number Publication Date
NO980648D0 NO980648D0 (no) 1998-02-16
NO980648L true NO980648L (no) 1998-03-31

Family

ID=21700681

Family Applications (1)

Application Number Title Priority Date Filing Date
NO980648A NO980648L (no) 1995-08-17 1998-02-16 Fremgangsmåte for diagnostisk bildeanalyse ved anvendelse av metallkomplekser av nitrogeninneholdende makrocykliske ligander

Country Status (9)

Country Link
US (1) US5976498A (no)
EP (1) EP0844889A1 (no)
JP (1) JPH11514971A (no)
AU (1) AU6722496A (no)
BR (1) BR9610240A (no)
CA (1) CA2229777A1 (no)
NO (1) NO980648L (no)
NZ (1) NZ315505A (no)
WO (1) WO1997006831A1 (no)

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US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
BR9610241A (pt) * 1995-08-17 1999-06-29 Monsanto Co Processos para análise de imagem de diagnóstico utilizando bioconjgados de complexos de metal de ligandos macrocíclicos contendo nitrogênio
US20050171198A1 (en) * 1997-06-20 2005-08-04 Metaphore Pharmaceuticals, Inc. SODm therapy for treatment, prevention, inhibition and reversal of inflammatory disease
IL135949A0 (en) 1997-11-03 2001-05-20 Univ Duke Substituted porphyrins
JP4501128B2 (ja) * 1999-01-25 2010-07-14 ナショナル ジュウィッシュ ヘルス 置換ポルフィリン
US20030069281A1 (en) * 2000-06-14 2003-04-10 Irwin Fridovich Tetrapyrroles
US20030050297A1 (en) 2001-01-19 2003-03-13 Crapo James D. Cancer therapy
WO2002098431A1 (en) * 2001-06-01 2002-12-12 National Jewish Medical And Research Center Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
EP1513537A4 (en) * 2002-06-07 2006-09-06 Univ Duke SUBSTITUTED PORPHYRINS
WO2006037050A2 (en) * 2004-09-24 2006-04-06 Metaphore Pharmaceuticals, Inc. Methods for treating congestive heart failure
US20120301403A1 (en) 2007-06-21 2012-11-29 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
US8217166B2 (en) * 2005-05-05 2012-07-10 Galera Therapeutics, Llc Polyethylene glycolated superoxide dismutase mimetics
EP2056675B1 (en) 2006-10-12 2019-01-09 Galera Labs, LLC Methods of treating oral mucositis
EP2296645B1 (en) 2008-05-22 2014-11-19 Galera Therapeutics, LLC Combination antitumor therapy
CN102105146A (zh) 2008-05-23 2011-06-22 国立犹太保健医院 用于治疗与暴露于烷化物质有关的损伤的方法
EP2760874A4 (en) 2011-09-26 2015-04-08 Galera Therapeutics Llc METHOD FOR THE TREATMENT OF ILLNESSES
CA2994845A1 (en) 2015-08-11 2017-02-16 Galera Labs, Llc Pentaaza macrocyclic ring complexes possessing oral bioavailability
US11246950B2 (en) 2017-04-13 2022-02-15 Galera Labs, Llc Combination cancer immunotherapy with pentaaza macrocyclic ring complex
AU2019215032A1 (en) 2018-01-31 2020-09-10 Board Of Regents Of The University Of Texas System Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent

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US4001212A (en) * 1973-10-03 1977-01-04 E. I. Du Pont De Nemours And Company Macrocyclic polyamines
NO149961C (no) * 1981-06-01 1984-07-25 Borregaard Ind Fremgangsmaate for fremstilling av n-(2-hydroksyetyl)-derivater av makrocykliske polyaminer, inneholdende flere nitrogenatomer i 1,4-forhold i ringen
US5316757A (en) * 1984-10-18 1994-05-31 Board Of Regents, The University Of Texas System Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
US5049667A (en) * 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
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US5064956A (en) * 1987-06-24 1991-11-12 The Dow Chemical Company Process for preparing mono-n-alkylated polyazamacrocycles
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JP3131219B2 (ja) * 1990-01-19 2001-01-31 ニユコメド・イメージング・アクシエセルカペト キレート化合物
GB9001245D0 (en) * 1990-01-19 1990-03-21 Salutar Inc Compounds
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CA2072934C (en) * 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
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AU5928396A (en) * 1995-06-07 1996-12-30 Monsanto Company Process for preparing substituted polyazamacrocycles

Also Published As

Publication number Publication date
NZ315505A (en) 2000-01-28
WO1997006831A1 (en) 1997-02-27
CA2229777A1 (en) 1997-02-27
JPH11514971A (ja) 1999-12-21
BR9610240A (pt) 1999-06-29
EP0844889A1 (en) 1998-06-03
NO980648D0 (no) 1998-02-16
US5976498A (en) 1999-11-02
AU6722496A (en) 1997-03-12

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