ES2117670T3 - Derivado de hidroxamato e hidrazida de poliaminas y su uso medico como agentes quelantes. - Google Patents

Derivado de hidroxamato e hidrazida de poliaminas y su uso medico como agentes quelantes.

Info

Publication number
ES2117670T3
ES2117670T3 ES92915605T ES92915605T ES2117670T3 ES 2117670 T3 ES2117670 T3 ES 2117670T3 ES 92915605 T ES92915605 T ES 92915605T ES 92915605 T ES92915605 T ES 92915605T ES 2117670 T3 ES2117670 T3 ES 2117670T3
Authority
ES
Spain
Prior art keywords
pct
agents
polyamins
hydroxamate
hydrazide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92915605T
Other languages
English (en)
Inventor
Richard J Himmelsbach
P L Rongved
Jo Klaveness
Per Strande
Harald Dugstad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amersham Health Salutar Inc
Original Assignee
Nycomed Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Salutar Inc filed Critical Nycomed Salutar Inc
Application granted granted Critical
Publication of ES2117670T3 publication Critical patent/ES2117670T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/34—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a carbon skeleton further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Abstract

LA PRESENTE INVENCION SE REFIERE A UN COMPUESTO DE FORMULA (I): A[X(CR1R2)N]MXA O UN COMPLEJO DE QUELATO DE SAL DE ESTE, PARA SU USO COMO AGENTE TERAPEUTICO O AGENTE DE DIAGNOSTICO DONDE EN LA FORMULA (I), CADA UNO DE LOS GRUPOS R1 Y R2 PUEDEN REPRESENTAR INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO O ALCOXI, QUE LLEVA OPCIONALMENTE UNO O MAS SUSTITUYENTES ELEGIDOS A PARTIR DE GRUPOS HIDROXI, ALCOXI Y ARILO; CADA X REPRESENTA INDEPENDIENTEMENTE UN ATOMO DE OXIGENO O AZUFRE O UN GRUPO NA; CADA A REPRESENTA INDEPENDIENTEMENTE UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO OPCIONALMENTE SUSTITUIDO POR UN GRUPO Y; CADA Y REPRESENTA UN ATOMO DE HIDROGENO, O UN GRUPO Z COZ, SO3R6, CSZ, PO2Z O B; O UNO O MAS PARES DE GRUPOS A SOBRE DIFERENTES UNIDADES X PUEDEN FORMAR JUNTOS UN GRUPO [CCR1R2)NX1]P (CR1R2)N O UN GRUPO A SOBRE UN NITROGENO DE MEDIA CADENA PUEDE REPRESENTAR UN GRUPO (CR1R2)NX1)A DONDE P REPRESENTA UN NUMERO ENTERO DE 0 A 6, Y CADA X1 REPRESENTA INDEPENDIENTEMENTE UN ATOMO DEOXIGENO O AZUFRE O UN GRUPO NA1 DONDE A1 ES TAL COMO SE DEFINE PARA A PERO PUEDE NO FORMAR PARTE DE UN GRUPO LIGADO A MAS DE UN ATOMO DE NITROGENO: O DOS GRUPOS ADYACENTES R1 Y/O A PUEDEN JUNTOS FORMAR UN ANILLO DE CINCO A 7 ELEMENTOS HOMO 2 HETEROATOMOS DE ANILLO ELEGIDOS A PARTIR DE OXIGENO, NITROGENO Y AZUFRE; M ES UN NUMERO ENTERO DE 2 A 8; N ES UN NUMERO ENTERO DE 2 A 4.
ES92915605T 1991-07-17 1992-07-16 Derivado de hidroxamato e hidrazida de poliaminas y su uso medico como agentes quelantes. Expired - Lifetime ES2117670T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919115375A GB9115375D0 (en) 1991-07-17 1991-07-17 Compounds

Publications (1)

Publication Number Publication Date
ES2117670T3 true ES2117670T3 (es) 1998-08-16

Family

ID=10698465

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92915605T Expired - Lifetime ES2117670T3 (es) 1991-07-17 1992-07-16 Derivado de hidroxamato e hidrazida de poliaminas y su uso medico como agentes quelantes.

Country Status (9)

Country Link
US (1) US5869651A (es)
EP (1) EP0594734B1 (es)
JP (1) JPH07500574A (es)
AT (1) ATE167665T1 (es)
AU (1) AU2320392A (es)
DE (1) DE69226022T2 (es)
ES (1) ES2117670T3 (es)
GB (1) GB9115375D0 (es)
WO (1) WO1993002045A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009884A1 (en) * 1990-11-21 1992-06-11 Mallinckrodt Medical, Inc. Alkoxyamide derivatized chelates for mri
GB2267494B (en) * 1992-06-02 1995-09-20 Ciba Geigy Ag Trisamidodithionodiphosphates
KR100311851B1 (ko) * 1993-02-23 2002-04-24 슈테펜엘.네스비트 방사선보호제로서의폴리아민유도체
DE4340809C2 (de) * 1993-11-24 2000-08-03 Schering Ag 1.4,7,10-Tetraazacyclododecan-Derivate, diese enthaltende pharmazeutische Mittel und Verfahren zu deren Herstellung
ES2119371T3 (es) * 1993-12-27 1998-10-01 Novartis Ag Aminocompuestos insaturados para usar como un agente anticancerigeno y antiprotozoico.
CN1035997C (zh) * 1994-01-12 1997-10-01 勃勒柯国际有限公司 配位体及其金属配合物
ES2096517B1 (es) * 1994-02-21 1998-02-01 Diaz Agustin Espina Equipo para el control de suministro de servicios a viviendas, locales y similares.
US5476644A (en) * 1994-04-13 1995-12-19 Sterling Winthrop Inc. Cyclic triamine chelating agents
US6693190B1 (en) 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
KR100832956B1 (ko) * 2000-04-24 2008-05-27 로무 가부시키가이샤 측면발광반도체 발광장치
NO20051911D0 (no) * 2005-04-19 2005-04-19 Amersham Health As Synthesis
KR20080072686A (ko) * 2005-11-29 2008-08-06 말린크로트, 인코포레이티드 이관능성 금속 킬레이팅 컨쥬게이트
CN103965128B (zh) 2008-01-08 2018-04-03 兰休斯医疗成像公司 作为显像剂的n‑烷氧基酰胺共轭物
CA2803520C (en) * 2009-07-08 2019-10-22 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
EP4073045B1 (en) 2019-12-13 2024-03-20 Bracco Imaging SPA Manufacturing of protected do3a

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1197798A (en) * 1967-08-18 1970-07-08 Frederick Charles Bersworth Chelating Compounds Derived from Amino Acid Derivatives
US4609757A (en) * 1983-08-10 1986-09-02 Nuclear Technology Corporation Hydrazides of amino-polyacetic acids as chelants
US5198208A (en) * 1987-07-16 1993-03-30 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
GB8900732D0 (en) * 1989-01-13 1989-03-08 Nycomed As Agents
US5384108A (en) * 1989-04-24 1995-01-24 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
WO1991001144A1 (en) * 1989-07-20 1991-02-07 Sandoz Ltd Labeled polypeptide derivatives
CA2072080A1 (en) * 1990-01-19 1991-07-20 Jo Klaveness Chelating compounds

Also Published As

Publication number Publication date
AU2320392A (en) 1993-02-23
DE69226022T2 (de) 1999-04-01
GB9115375D0 (en) 1991-09-04
JPH07500574A (ja) 1995-01-19
WO1993002045A1 (en) 1993-02-04
ATE167665T1 (de) 1998-07-15
US5869651A (en) 1999-02-09
EP0594734A1 (en) 1994-05-04
EP0594734B1 (en) 1998-06-24
DE69226022D1 (de) 1998-07-30

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