DE69226022D1 - Hydroxamat- und hydrazidderivate von polyaminen und ihre medizinische verwendung als chelatierende wirkstoffe - Google Patents

Hydroxamat- und hydrazidderivate von polyaminen und ihre medizinische verwendung als chelatierende wirkstoffe

Info

Publication number
DE69226022D1
DE69226022D1 DE69226022T DE69226022T DE69226022D1 DE 69226022 D1 DE69226022 D1 DE 69226022D1 DE 69226022 T DE69226022 T DE 69226022T DE 69226022 T DE69226022 T DE 69226022T DE 69226022 D1 DE69226022 D1 DE 69226022D1
Authority
DE
Germany
Prior art keywords
pct
chelative
hydroxamate
polyamines
active substances
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69226022T
Other languages
English (en)
Other versions
DE69226022T2 (de
Inventor
Richard Himmelsbach
P L Rongved
Jo Klaveness
Per Strande
Harald Dugstad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amersham Health Salutar Inc
Original Assignee
Nycomed Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Salutar Inc filed Critical Nycomed Salutar Inc
Application granted granted Critical
Publication of DE69226022D1 publication Critical patent/DE69226022D1/de
Publication of DE69226022T2 publication Critical patent/DE69226022T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
    • C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C243/34—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a carbon skeleton further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
DE69226022T 1991-07-17 1992-07-16 Hydroxamat- und hydrazidderivate von polyaminen und ihre medizinische verwendung als chelatierende wirkstoffe Expired - Fee Related DE69226022T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919115375A GB9115375D0 (en) 1991-07-17 1991-07-17 Compounds
PCT/EP1992/001598 WO1993002045A1 (en) 1991-07-17 1992-07-16 Hydroxamate and hydrazide derivatives of polyamines and their medical use as chelating agents

Publications (2)

Publication Number Publication Date
DE69226022D1 true DE69226022D1 (de) 1998-07-30
DE69226022T2 DE69226022T2 (de) 1999-04-01

Family

ID=10698465

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69226022T Expired - Fee Related DE69226022T2 (de) 1991-07-17 1992-07-16 Hydroxamat- und hydrazidderivate von polyaminen und ihre medizinische verwendung als chelatierende wirkstoffe

Country Status (9)

Country Link
US (1) US5869651A (de)
EP (1) EP0594734B1 (de)
JP (1) JPH07500574A (de)
AT (1) ATE167665T1 (de)
AU (1) AU2320392A (de)
DE (1) DE69226022T2 (de)
ES (1) ES2117670T3 (de)
GB (1) GB9115375D0 (de)
WO (1) WO1993002045A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009884A1 (en) * 1990-11-21 1992-06-11 Mallinckrodt Medical, Inc. Alkoxyamide derivatized chelates for mri
GB2267494B (en) * 1992-06-02 1995-09-20 Ciba Geigy Ag Trisamidodithionodiphosphates
KR100311851B1 (ko) * 1993-02-23 2002-04-24 슈테펜엘.네스비트 방사선보호제로서의폴리아민유도체
DE4340809C2 (de) * 1993-11-24 2000-08-03 Schering Ag 1.4,7,10-Tetraazacyclododecan-Derivate, diese enthaltende pharmazeutische Mittel und Verfahren zu deren Herstellung
ES2119371T3 (es) * 1993-12-27 1998-10-01 Novartis Ag Aminocompuestos insaturados para usar como un agente anticancerigeno y antiprotozoico.
CN1035997C (zh) * 1994-01-12 1997-10-01 勃勒柯国际有限公司 配位体及其金属配合物
ES2096517B1 (es) * 1994-02-21 1998-02-01 Diaz Agustin Espina Equipo para el control de suministro de servicios a viviendas, locales y similares.
US5476644A (en) * 1994-04-13 1995-12-19 Sterling Winthrop Inc. Cyclic triamine chelating agents
US6693190B1 (en) 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
KR100832956B1 (ko) * 2000-04-24 2008-05-27 로무 가부시키가이샤 측면발광반도체 발광장치
NO20051911D0 (no) * 2005-04-19 2005-04-19 Amersham Health As Synthesis
KR20080072686A (ko) * 2005-11-29 2008-08-06 말린크로트, 인코포레이티드 이관능성 금속 킬레이팅 컨쥬게이트
CN103965128B (zh) 2008-01-08 2018-04-03 兰休斯医疗成像公司 作为显像剂的n‑烷氧基酰胺共轭物
CA2803520C (en) * 2009-07-08 2019-10-22 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
EP4073045B1 (de) 2019-12-13 2024-03-20 Bracco Imaging SPA Herstellung geschützter do3a

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1197798A (en) * 1967-08-18 1970-07-08 Frederick Charles Bersworth Chelating Compounds Derived from Amino Acid Derivatives
US4609757A (en) * 1983-08-10 1986-09-02 Nuclear Technology Corporation Hydrazides of amino-polyacetic acids as chelants
US5198208A (en) * 1987-07-16 1993-03-30 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
GB8900732D0 (en) * 1989-01-13 1989-03-08 Nycomed As Agents
US5384108A (en) * 1989-04-24 1995-01-24 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
WO1991001144A1 (en) * 1989-07-20 1991-02-07 Sandoz Ltd Labeled polypeptide derivatives
CA2072080A1 (en) * 1990-01-19 1991-07-20 Jo Klaveness Chelating compounds

Also Published As

Publication number Publication date
AU2320392A (en) 1993-02-23
DE69226022T2 (de) 1999-04-01
GB9115375D0 (en) 1991-09-04
ES2117670T3 (es) 1998-08-16
JPH07500574A (ja) 1995-01-19
WO1993002045A1 (en) 1993-02-04
ATE167665T1 (de) 1998-07-15
US5869651A (en) 1999-02-09
EP0594734A1 (de) 1994-05-04
EP0594734B1 (de) 1998-06-24

Similar Documents

Publication Publication Date Title
DE69226022D1 (de) Hydroxamat- und hydrazidderivate von polyaminen und ihre medizinische verwendung als chelatierende wirkstoffe
NO942560D0 (no) Mikropartikulære kontrastmidler med amfifile organiske syrer
ES2088492T3 (es) Uso de particulas superparamagneticas para analisis magnetometricos (squid).
DE68927230T2 (de) Vaskulares magnetisches bildformungsverfahren
DE69819309D1 (de) Verabreichbare formulierugen und ihre anwendung in mri
NL300177I1 (nl) Nmr contrastmiddelen voor het lever-galsysteem.
DE59109082D1 (de) Mono-N-substituierte 1,4,7,10-Tetraazacyclododecan-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE69219337D1 (de) Verbesserungen an kontrastmitteln
DE69328550T2 (de) Verwendung von fulleren-derivaten in diagnostischen und/oder therapeutischen mitteln
EP1806350A3 (de) Amphipatische Polycarboxylchelaten und Komplexen mit paramagnetischen Metallen als MRI kontrastmitteln
NO904514L (no) Paramagnetisk oljeemulsjon for anvendelse som kontrastmiddel i bildedannelse med magnetisk resonans.
ATE169200T1 (de) Kontrastmittel
BR9508435A (pt) Quelentes macrocíclicos seus quelatos e usos dos mesmos no campo diagnóstico
ATE162718T1 (de) Verwendung von prostacyclin-derivaten zur verhinderung oder behandlung von störungen der mikrozirkulation bei gabe von röntgen-, nmr- oder ultraschallkontrastmitteln
Jackson et al. Metal speciation in biofluids-Application to magnetic resonance imaging.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee