PT100216A - N- 4,5-di-hidroxi- e 4,5,8-tri-hidroxi-9,10-di-hidro-9,10-dioxo-2-antracentil carbonil -aminoacidos uteis na terapia de afeccoes osteoarticulares, processo para a sua preparacao e composicoes farmaceuticas que os contem - Google Patents

N- 4,5-di-hidroxi- e 4,5,8-tri-hidroxi-9,10-di-hidro-9,10-dioxo-2-antracentil carbonil -aminoacidos uteis na terapia de afeccoes osteoarticulares, processo para a sua preparacao e composicoes farmaceuticas que os contem

Info

Publication number
PT100216A
PT100216A PT100216A PT10021692A PT100216A PT 100216 A PT100216 A PT 100216A PT 100216 A PT100216 A PT 100216A PT 10021692 A PT10021692 A PT 10021692A PT 100216 A PT100216 A PT 100216A
Authority
PT
Portugal
Prior art keywords
hydroxy
anthracentyl
osteoarticular
affections
dioxo
Prior art date
Application number
PT100216A
Other languages
English (en)
Other versions
PT100216B (pt
Inventor
Sergio Rosini
Maurizio Mian
Original Assignee
Gentili Ist Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentili Ist Spa filed Critical Gentili Ist Spa
Publication of PT100216A publication Critical patent/PT100216A/pt
Publication of PT100216B publication Critical patent/PT100216B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PT100216A 1991-03-12 1992-03-09 N-{{4,5-di-hidroxi- e 4,5,8-tri-hidroxi-9,10-di-hidro-9,10-dioxo-2-antracentil} carbonil}-aminoacidos uteis na terapia de afeccoes osteoarticulares, processo para a sua preparacao e composicoes farmaceuticas que os contem PT100216B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI910658A IT1244773B (it) 1991-03-12 1991-03-12 N-(4,5-diidrossi-e 4,5,8-triidrossi-9,10-diidro-9,10-diosso-2- antracen-il)carbonil) amminoacidi utilizzabili nella terapia delle affezioni osteoarticolari

Publications (2)

Publication Number Publication Date
PT100216A true PT100216A (pt) 1993-05-31
PT100216B PT100216B (pt) 1999-06-30

Family

ID=11359001

Family Applications (1)

Application Number Title Priority Date Filing Date
PT100216A PT100216B (pt) 1991-03-12 1992-03-09 N-{{4,5-di-hidroxi- e 4,5,8-tri-hidroxi-9,10-di-hidro-9,10-dioxo-2-antracentil} carbonil}-aminoacidos uteis na terapia de afeccoes osteoarticulares, processo para a sua preparacao e composicoes farmaceuticas que os contem

Country Status (21)

Country Link
US (1) US5451606A (pt)
EP (1) EP0588797B1 (pt)
JP (1) JP2979054B2 (pt)
KR (1) KR100224330B1 (pt)
AT (1) ATE134363T1 (pt)
AU (1) AU661475B2 (pt)
CA (1) CA2105683C (pt)
CZ (1) CZ282997B6 (pt)
DE (1) DE69208464T2 (pt)
DK (1) DK0588797T3 (pt)
ES (1) ES2084348T3 (pt)
FI (1) FI113167B (pt)
GR (1) GR3019069T3 (pt)
HU (1) HU215436B (pt)
IT (1) IT1244773B (pt)
MX (1) MX9201055A (pt)
NO (1) NO304592B1 (pt)
PT (1) PT100216B (pt)
RU (1) RU2111959C1 (pt)
SK (1) SK280134B6 (pt)
WO (1) WO1992016496A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0570091A1 (en) * 1992-02-28 1993-11-18 Lilly Industries Limited Anthraquinone derivatives, process for their preparation and their use as medicaments
GB9417102D0 (en) * 1994-08-24 1994-10-12 Lilly Industries Ltd Pharmaceutical compounds
IT1276781B1 (it) * 1995-06-23 1997-11-03 Gentili Ist Spa Derivati antrachinonmono- e disolfon- sostituiti e composizioni farmaceutiche che li contengono per il trattamento delle patologie
GB2398780A (en) * 2003-02-26 2004-09-01 Arakis Ltd 1,8-dihydroxyanthraquinone-6-carboxamide derivatives as inhibitors of T-cell proliferation for treatment of autoimmune or inflammatory conditions
CN102060809B (zh) * 2009-05-01 2015-05-20 常州高新技术产业开发区三维工业技术研究所有限公司 一种大黄酸衍生物及其制备和用途
CN102225913B (zh) * 2011-04-07 2013-09-04 栗进才 大黄酸衍生物以及它们的治疗用途
RU2466134C1 (ru) * 2011-06-24 2012-11-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Иркутский государственный университет" Способ получения катионных комплексов палладия
CN104557603A (zh) * 2014-12-08 2015-04-29 石河子大学 一种大黄酸类化合物及制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA761627B (en) * 1976-03-16 1978-01-25 C Friedmann Improvements in or relating to the treatment of arthritis
US4966918A (en) * 1989-01-27 1990-10-30 Sloan-Kettering Institute For Cancer Research Derivatives of chryosphanol

Also Published As

Publication number Publication date
CA2105683A1 (en) 1992-09-13
NO933241L (no) 1993-09-10
HUT65218A (en) 1994-05-02
HU215436B (hu) 1999-09-28
ITMI910658A1 (it) 1992-09-12
SK280134B6 (sk) 1999-08-06
EP0588797A1 (en) 1994-03-30
AU661475B2 (en) 1995-07-27
NO933241D0 (no) 1993-09-10
GR3019069T3 (en) 1996-05-31
PT100216B (pt) 1999-06-30
DE69208464T2 (de) 1996-07-11
SK94793A3 (en) 1994-03-09
JP2979054B2 (ja) 1999-11-15
KR100224330B1 (ko) 1999-10-15
ES2084348T3 (es) 1996-05-01
ATE134363T1 (de) 1996-03-15
CZ282997B6 (cs) 1997-12-17
FI933925A (fi) 1993-09-08
US5451606A (en) 1995-09-19
IT1244773B (it) 1994-08-08
JPH10502050A (ja) 1998-02-24
CA2105683C (en) 2003-09-16
DK0588797T3 (da) 1996-06-17
CZ182993A3 (en) 1994-07-13
FI113167B (fi) 2004-03-15
DE69208464D1 (en) 1996-03-28
WO1992016496A1 (en) 1992-10-01
NO304592B1 (no) 1999-01-18
RU2111959C1 (ru) 1998-05-27
HU9302510D0 (en) 1993-12-28
FI933925A0 (fi) 1993-09-08
MX9201055A (es) 1992-09-01
EP0588797B1 (en) 1996-02-21
ITMI910658A0 (it) 1991-03-12
AU1359692A (en) 1992-10-21

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19930122

FG3A Patent granted, date of granting

Effective date: 19990325

PC3A Transfer or assignment

Free format text: 19990628 ABIOGEN PHARMA S.R.L. IT