ITMI910658A1 - N-(4, 5-diidrossi-e 4, 5, 8-triidrossi-9, 10-diidro-9, 10-diosso-2- antracen-il)carbonil) amminoacidi utilizzabili nella terapia delle affezioni osteoarticolari - Google Patents

N-(4, 5-diidrossi-e 4, 5, 8-triidrossi-9, 10-diidro-9, 10-diosso-2- antracen-il)carbonil) amminoacidi utilizzabili nella terapia delle affezioni osteoarticolari

Info

Publication number
ITMI910658A1
ITMI910658A1 IT000658A ITMI910658A ITMI910658A1 IT MI910658 A1 ITMI910658 A1 IT MI910658A1 IT 000658 A IT000658 A IT 000658A IT MI910658 A ITMI910658 A IT MI910658A IT MI910658 A1 ITMI910658 A1 IT MI910658A1
Authority
IT
Italy
Prior art keywords
osteoarticular
affections
anthracen
trihydroxy
dioxy
Prior art date
Application number
IT000658A
Other languages
English (en)
Inventor
Maurizio Mian
Sergio Rosini
Original Assignee
Gentili Ist Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentili Ist Spa filed Critical Gentili Ist Spa
Publication of ITMI910658A0 publication Critical patent/ITMI910658A0/it
Priority to ITMI910658A priority Critical patent/IT1244773B/it
Priority to SK947-93A priority patent/SK280134B6/sk
Priority to JP4505494A priority patent/JP2979054B2/ja
Priority to DE69208464T priority patent/DE69208464T2/de
Priority to EP92905647A priority patent/EP0588797B1/en
Priority to KR1019930702709A priority patent/KR100224330B1/ko
Priority to DK92905647.1T priority patent/DK0588797T3/da
Priority to RU93057732A priority patent/RU2111959C1/ru
Priority to AU13596/92A priority patent/AU661475B2/en
Priority to ES92905647T priority patent/ES2084348T3/es
Priority to CS931829A priority patent/CZ282997B6/cs
Priority to HU9803011A priority patent/HU219346B/hu
Priority to AT92905647T priority patent/ATE134363T1/de
Priority to US08/117,065 priority patent/US5451606A/en
Priority to CA002105683A priority patent/CA2105683C/en
Priority to PCT/EP1992/000479 priority patent/WO1992016496A1/en
Priority to HU9302510A priority patent/HU215436B/hu
Priority to PT100216A priority patent/PT100216B/pt
Priority to MX9201055A priority patent/MX9201055A/es
Publication of ITMI910658A1 publication Critical patent/ITMI910658A1/it
Priority to FI933925A priority patent/FI113167B/fi
Priority to NO933241A priority patent/NO304592B1/no
Application granted granted Critical
Publication of IT1244773B publication Critical patent/IT1244773B/it
Priority to GR960400457T priority patent/GR3019069T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ITMI910658A 1991-03-12 1991-03-12 N-(4,5-diidrossi-e 4,5,8-triidrossi-9,10-diidro-9,10-diosso-2- antracen-il)carbonil) amminoacidi utilizzabili nella terapia delle affezioni osteoarticolari IT1244773B (it)

Priority Applications (22)

Application Number Priority Date Filing Date Title
ITMI910658A IT1244773B (it) 1991-03-12 1991-03-12 N-(4,5-diidrossi-e 4,5,8-triidrossi-9,10-diidro-9,10-diosso-2- antracen-il)carbonil) amminoacidi utilizzabili nella terapia delle affezioni osteoarticolari
CS931829A CZ282997B6 (cs) 1991-03-12 1992-03-04 N-//4,5-dihydroxy- a 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo-2-anthracenyl/karbonyl/aminokyseliny, způsob výroby a farmaceutický prostředek s jejich obsahem
AT92905647T ATE134363T1 (de) 1991-03-12 1992-03-04 N-((4,5-dihydroxy- und 4,5,8-trihydroxy-9,10- dihydro-9,10-dioxo-2-anthracen- yl)carbonyl)aminosäure zur therapie osteoartikulärer leiden
DE69208464T DE69208464T2 (de) 1991-03-12 1992-03-04 N-((4,5-dihydroxy- und 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo-2-anthracen-yl)carbonyl)aminosäure zur therapie osteoartikulärer leiden
EP92905647A EP0588797B1 (en) 1991-03-12 1992-03-04 N- 4,5-dihydroxy- and 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo-2-anthracene-yl]carbonyl]amino acids useful in the therapy of osteoarticular affections
KR1019930702709A KR100224330B1 (ko) 1991-03-12 1992-03-04 골관절 질환의 치료에 유용한 n-((4,5-디히드록시-및 4,5,8-트리히드록시-9,10-디히드로-9,10-디옥소-2-안트라센-일)카르보닐)아미노산
DK92905647.1T DK0588797T3 (da) 1991-03-12 1992-03-04 N- 4,5-dihydroxy- og 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo-2-anthracen-yl carbonyl aminosyrer nyttige ved behandling af osteoartikulære lidelser
RU93057732A RU2111959C1 (ru) 1991-03-12 1992-03-04 N-//4,5-диокси- и 4,5,8-тригидрокси-9,10-дигидро-9,10-диоксо-2-антраценил/карбонил/аминокислоты, способ их получения и фармацевтическая композиция на их основе
AU13596/92A AU661475B2 (en) 1991-03-12 1992-03-04 N-((4,5-dihydroxy- and 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo-2-anthracene-yl) carbonyl)amino acids useful in the therapy of osteoarticular affections
ES92905647T ES2084348T3 (es) 1991-03-12 1992-03-04 N-((4,5-dihidroxi- y 4,5,8-trihidroxi-9,10-dihidro-9,10-dioxo-2-antracen-il)carbonil)aminoacidos utiles en la terapia de afecciones osteoarticulares.
SK947-93A SK280134B6 (sk) 1991-03-12 1992-03-04 N-[[4,5-dihydroxy- a 4,5,8-trihydroxy-9,10-dihydro
HU9803011A HU219346B (en) 1991-03-12 1992-03-04 N-[(4,5-dihydroxi-9,10-dihydro-9,10-dioxo-2-anthracenyl)-carbonyl]-amino acids and pharmaceutical compositions containing the same
JP4505494A JP2979054B2 (ja) 1991-03-12 1992-03-04 骨関節疾患の治療に有用なｎ−〔｛４，５−ジヒドロキシ−及び４，５，８−トリヒドロキシ−９，１０−ジヒドロ−９，１０−ジオキソ−２−アントラセン−イル｝カルボニル〕アミノ酸
US08/117,065 US5451606A (en) 1991-03-12 1992-03-04 Anthraquinone compounds useful to treat osteoarticular conditions, pharmaceutical compositions and method of treatment
CA002105683A CA2105683C (en) 1991-03-12 1992-03-04 N-¬¬4,5-dihydroxy-and 4,5,8-trihydroxy-9,10-dihydro-9, 10-dioxo-2-anthracene-yl|carbonyl|amino acids useful in the therapy of osteoarticular affections
PCT/EP1992/000479 WO1992016496A1 (en) 1991-03-12 1992-03-04 N-[[4,5-dihydroxy- and 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo-2-anthracene-yl]carbonyl]amino acids useful in the therapy of osteoarticular affections
HU9302510A HU215436B (hu) 1991-03-12 1992-03-04 Eljárás N-[(4,5-dihidroxi-9,10-dihidro-9,10-dioxo-2-antracenil)-karbonil]-aminosav-származékok és ilyen hatóanyagot tartalmazó gyógyszerkészítmények előállítására
PT100216A PT100216B (pt) 1991-03-12 1992-03-09 N-{{4,5-di-hidroxi- e 4,5,8-tri-hidroxi-9,10-di-hidro-9,10-dioxo-2-antracentil} carbonil}-aminoacidos uteis na terapia de afeccoes osteoarticulares, processo para a sua preparacao e composicoes farmaceuticas que os contem
MX9201055A MX9201055A (es) 1991-03-12 1992-03-11 N-[[4,5-dihidroxi- y 4,5,8-trihidroxi-9,10-dihidro-9,10-dioxo-2-antracen-il] carbonil] aminoacidos utiles en la terapia de afecciones osteoarticulares.
FI933925A FI113167B (fi) 1991-03-12 1993-09-08 Menetelmä osteoartikulaaristen sairauksien hoidossa käyttökelpoisten N-[(4,5-dihydroksi- ja 4,5,8-trihydroksi-9,10-dihydro-9,10-diokso-2-antrasenyyli)karbonyyli]aminohappojen valmistamiseksi
NO933241A NO304592B1 (no) 1991-03-12 1993-09-10 Aminosyrer nyttige ved terapi av osteoartikulµre pÕvirkninger, farmas°ytiske blandinger og anvendelse derav
GR960400457T GR3019069T3 (en) 1991-03-12 1996-02-22 N- 4,5-dihydroxy- and 4,5,8-trihydroxy-9,10-dihydro-9,10-dioxo-2-anthracene-yl)carbonyl)amino acids useful in the therapy of osteoarticular affections

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI910658A IT1244773B (it) 1991-03-12 1991-03-12 N-(4,5-diidrossi-e 4,5,8-triidrossi-9,10-diidro-9,10-diosso-2- antracen-il)carbonil) amminoacidi utilizzabili nella terapia delle affezioni osteoarticolari

Publications (3)

Publication Number Publication Date
ITMI910658A0 ITMI910658A0 (it) 1991-03-12
ITMI910658A1 true ITMI910658A1 (it) 1992-09-12
IT1244773B IT1244773B (it) 1994-08-08

Family

ID=11359001

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI910658A IT1244773B (it) 1991-03-12 1991-03-12 N-(4,5-diidrossi-e 4,5,8-triidrossi-9,10-diidro-9,10-diosso-2- antracen-il)carbonil) amminoacidi utilizzabili nella terapia delle affezioni osteoarticolari

Country Status (21)

Country Link
US (1) US5451606A (it)
EP (1) EP0588797B1 (it)
JP (1) JP2979054B2 (it)
KR (1) KR100224330B1 (it)
AT (1) ATE134363T1 (it)
AU (1) AU661475B2 (it)
CA (1) CA2105683C (it)
CZ (1) CZ282997B6 (it)
DE (1) DE69208464T2 (it)
DK (1) DK0588797T3 (it)
ES (1) ES2084348T3 (it)
FI (1) FI113167B (it)
GR (1) GR3019069T3 (it)
HU (1) HU215436B (it)
IT (1) IT1244773B (it)
MX (1) MX9201055A (it)
NO (1) NO304592B1 (it)
PT (1) PT100216B (it)
RU (1) RU2111959C1 (it)
SK (1) SK280134B6 (it)
WO (1) WO1992016496A1 (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU666704B2 (en) * 1992-02-28 1996-02-22 Lilly Industries Limited Anthraquinone compounds and pharmaceutical compositions containing them
GB9417102D0 (en) * 1994-08-24 1994-10-12 Lilly Industries Ltd Pharmaceutical compounds
IT1276781B1 (it) * 1995-06-23 1997-11-03 Gentili Ist Spa Derivati antrachinonmono- e disolfon- sostituiti e composizioni farmaceutiche che li contengono per il trattamento delle patologie
GB2398780A (en) * 2003-02-26 2004-09-01 Arakis Ltd 1,8-dihydroxyanthraquinone-6-carboxamide derivatives as inhibitors of T-cell proliferation for treatment of autoimmune or inflammatory conditions
CN102060809B (zh) * 2009-05-01 2015-05-20 常州高新技术产业开发区三维工业技术研究所有限公司 一种大黄酸衍生物及其制备和用途
CN102225913B (zh) * 2011-04-07 2013-09-04 栗进才 大黄酸衍生物以及它们的治疗用途
RU2466134C1 (ru) * 2011-06-24 2012-11-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Иркутский государственный университет" Способ получения катионных комплексов палладия
CN104557603A (zh) * 2014-12-08 2015-04-29 石河子大学 一种大黄酸类化合物及制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA761627B (en) * 1976-03-16 1978-01-25 C Friedmann Improvements in or relating to the treatment of arthritis
US4966918A (en) * 1989-01-27 1990-10-30 Sloan-Kettering Institute For Cancer Research Derivatives of chryosphanol

Also Published As

Publication number Publication date
HU9302510D0 (en) 1993-12-28
SK94793A3 (en) 1994-03-09
FI933925A0 (fi) 1993-09-08
JPH10502050A (ja) 1998-02-24
ATE134363T1 (de) 1996-03-15
PT100216A (pt) 1993-05-31
MX9201055A (es) 1992-09-01
DK0588797T3 (da) 1996-06-17
ES2084348T3 (es) 1996-05-01
SK280134B6 (sk) 1999-08-06
NO933241L (no) 1993-09-10
FI933925A (fi) 1993-09-08
NO304592B1 (no) 1999-01-18
GR3019069T3 (en) 1996-05-31
CA2105683C (en) 2003-09-16
DE69208464T2 (de) 1996-07-11
PT100216B (pt) 1999-06-30
JP2979054B2 (ja) 1999-11-15
RU2111959C1 (ru) 1998-05-27
AU1359692A (en) 1992-10-21
IT1244773B (it) 1994-08-08
CA2105683A1 (en) 1992-09-13
HUT65218A (en) 1994-05-02
KR100224330B1 (ko) 1999-10-15
US5451606A (en) 1995-09-19
FI113167B (fi) 2004-03-15
CZ282997B6 (cs) 1997-12-17
EP0588797B1 (en) 1996-02-21
HU215436B (hu) 1999-09-28
ITMI910658A0 (it) 1991-03-12
DE69208464D1 (en) 1996-03-28
EP0588797A1 (en) 1994-03-30
CZ182993A3 (en) 1994-07-13
AU661475B2 (en) 1995-07-27
WO1992016496A1 (en) 1992-10-01
NO933241D0 (no) 1993-09-10

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950329