IT1276781B1 - Derivati antrachinonmono- e disolfon- sostituiti e composizioni farmaceutiche che li contengono per il trattamento delle patologie - Google Patents

Derivati antrachinonmono- e disolfon- sostituiti e composizioni farmaceutiche che li contengono per il trattamento delle patologie

Info

Publication number
IT1276781B1
IT1276781B1 IT95MI001357A ITMI951357A IT1276781B1 IT 1276781 B1 IT1276781 B1 IT 1276781B1 IT 95MI001357 A IT95MI001357 A IT 95MI001357A IT MI951357 A ITMI951357 A IT MI951357A IT 1276781 B1 IT1276781 B1 IT 1276781B1
Authority
IT
Italy
Prior art keywords
treatment
disolfon
anthrachinonmon
diseases
pct
Prior art date
Application number
IT95MI001357A
Other languages
English (en)
Inventor
Dino Benetti
Ruggero Aloisi
Giuseppe Guainai
Sergio Rosini
Original Assignee
Gentili Ist Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentili Ist Spa filed Critical Gentili Ist Spa
Publication of ITMI951357A0 publication Critical patent/ITMI951357A0/it
Priority to IT95MI001357A priority Critical patent/IT1276781B1/it
Priority to EP96922001A priority patent/EP0833626B1/en
Priority to PCT/EP1996/002597 priority patent/WO1997000675A1/en
Priority to CA002225277A priority patent/CA2225277A1/en
Priority to US08/981,287 priority patent/US5856358A/en
Priority to RU98101090/14A priority patent/RU2202534C2/ru
Priority to AU63039/96A priority patent/AU6303996A/en
Priority to PT96922001T priority patent/PT833626E/pt
Priority to ES96922001T priority patent/ES2193248T3/es
Priority to DE69626514T priority patent/DE69626514T2/de
Priority to DK96922001T priority patent/DK0833626T3/da
Priority to JP50356397A priority patent/JP3307650B2/ja
Priority to CZ19974193A priority patent/CZ293326B6/cs
Priority to SK1760-97A priority patent/SK281853B6/sk
Priority to AT96922001T priority patent/ATE233553T1/de
Publication of ITMI951357A1 publication Critical patent/ITMI951357A1/it
Application granted granted Critical
Publication of IT1276781B1 publication Critical patent/IT1276781B1/it
Priority to MX9800049A priority patent/MX9800049A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
IT95MI001357A 1995-06-23 1995-06-23 Derivati antrachinonmono- e disolfon- sostituiti e composizioni farmaceutiche che li contengono per il trattamento delle patologie IT1276781B1 (it)

Priority Applications (16)

Application Number Priority Date Filing Date Title
IT95MI001357A IT1276781B1 (it) 1995-06-23 1995-06-23 Derivati antrachinonmono- e disolfon- sostituiti e composizioni farmaceutiche che li contengono per il trattamento delle patologie
ES96922001T ES2193248T3 (es) 1995-06-23 1996-06-17 Antraquinonas mono- y disulfosustituidas y su uso para el tratamiento de desordenes de la matriz osea.
DK96922001T DK0833626T3 (da) 1995-06-23 1996-06-17 Mono- og disulfosubstituerede anthraquioner og deres anvendelse til behandlingen af knoglematrixforstyrrelser
CA002225277A CA2225277A1 (en) 1995-06-23 1996-06-17 Mono- and disulfo-substituted anthraquinones and their use for the treatment of bone matrix disorders
US08/981,287 US5856358A (en) 1995-06-23 1996-06-17 Mono- and disulfo-substituted anthraquinones and their use for the treatment of bone matrix disorders
RU98101090/14A RU2202534C2 (ru) 1995-06-23 1996-06-17 Моно- и дисульфозамещенные антрахиноны и их применение для лечения нарушений костного матрикса
AU63039/96A AU6303996A (en) 1995-06-23 1996-06-17 Mono- and disulfo-substituted anthraquinones and their use for the treatment of bone matrix disorders
PT96922001T PT833626E (pt) 1995-06-23 1996-06-17 Antraquinonas mono- e di-sulfo- substituidas e a sua utilizacao para o tratamento de disturbios da matriz do osso
EP96922001A EP0833626B1 (en) 1995-06-23 1996-06-17 Mono- and disulfo-substituted anthraquinones and their use for the treatment of bone matrix disorders
DE69626514T DE69626514T2 (de) 1995-06-23 1996-06-17 Mono-und disulfosubstituierte anthrachinone und deren verwendung zur behandlung von knochenmatrixerkrankungen
PCT/EP1996/002597 WO1997000675A1 (en) 1995-06-23 1996-06-17 Mono- and disulfo-substituted anthraquinones and their use for the treatment of bone matrix disorders
JP50356397A JP3307650B2 (ja) 1995-06-23 1996-06-17 モノ−およびジスルホ置換アントラキノンおよび骨基質疾患の治療のためのそれらの使用
CZ19974193A CZ293326B6 (cs) 1995-06-23 1996-06-17 Použití mono- a disulfosubstituovaných anthrachinonů pro přípravu léčiva, mono- a disulfosubstituované anthrachinony, způsob jejich přípravy a farmaceutický prostředek
SK1760-97A SK281853B6 (sk) 1995-06-23 1996-06-17 Použitie mono- a disulfo-substituovaných antrachinónov, zlúčeniny, ich spôsob výroby a farmaceutický prostriedok s ich obsahom
AT96922001T ATE233553T1 (de) 1995-06-23 1996-06-17 Mono-und disulfosubstituierte anthrachinone und deren verwendung zur behandlung von knochenmatrixerkrankungen
MX9800049A MX9800049A (es) 1995-06-23 1998-01-07 Antraquinonas mono- y disulfo-substituidas y su uso para el tratamiento de trastornos de la matriz del hueso.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001357A IT1276781B1 (it) 1995-06-23 1995-06-23 Derivati antrachinonmono- e disolfon- sostituiti e composizioni farmaceutiche che li contengono per il trattamento delle patologie

Publications (3)

Publication Number Publication Date
ITMI951357A0 ITMI951357A0 (it) 1995-06-23
ITMI951357A1 ITMI951357A1 (it) 1996-12-23
IT1276781B1 true IT1276781B1 (it) 1997-11-03

Family

ID=11371864

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI001357A IT1276781B1 (it) 1995-06-23 1995-06-23 Derivati antrachinonmono- e disolfon- sostituiti e composizioni farmaceutiche che li contengono per il trattamento delle patologie

Country Status (16)

Country Link
US (1) US5856358A (it)
EP (1) EP0833626B1 (it)
JP (1) JP3307650B2 (it)
AT (1) ATE233553T1 (it)
AU (1) AU6303996A (it)
CA (1) CA2225277A1 (it)
CZ (1) CZ293326B6 (it)
DE (1) DE69626514T2 (it)
DK (1) DK0833626T3 (it)
ES (1) ES2193248T3 (it)
IT (1) IT1276781B1 (it)
MX (1) MX9800049A (it)
PT (1) PT833626E (it)
RU (1) RU2202534C2 (it)
SK (1) SK281853B6 (it)
WO (1) WO1997000675A1 (it)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9608133D0 (en) * 1996-04-19 1996-06-26 Gemini International Holdings Diagnostic method and apparatus
FR2757397B1 (fr) * 1996-12-23 1999-03-05 Mazal Pharma Composition pharmaceutique a base de rheine ou de diacerheine a biodisponibilite amelioree
JPH11236333A (ja) * 1997-12-30 1999-08-31 Pfizer Prod Inc 抗ガン剤として有用なイミダゾリン−４−オン誘導体
US6117869A (en) * 1998-08-04 2000-09-12 Warner-Lambert Company Compounds for and methods of inhibiting matrix metalloproteinases
US6174903B1 (en) 1998-12-28 2001-01-16 Pfizer Inc. Imidazolidin-4-one derivatives useful as anticancer agents
US6610750B1 (en) * 2000-09-15 2003-08-26 Laboratoires Negma Treatment of osteoarthritis
AUPR229600A0 (en) * 2000-12-22 2001-01-25 Commonwealth Scientific And Industrial Research Organisation New oxygen scavenging compositions
US6600057B2 (en) * 2000-12-29 2003-07-29 Kimberly-Clark Worldwide, Inc. Matrix metalloproteinase inhibitors
CA2695504C (en) 2007-08-03 2017-05-30 Nucitec S.A. De C.V. Compositions and methods for treatment and prevention of osteoarthritis
CA2781706A1 (en) * 2009-11-24 2011-06-03 The Ohio State University Transcription factor inhibitors and related compositions, formulations and methods
PT2555618E (pt) * 2010-04-08 2016-03-08 Twi Biotechnology Inc Métodos de utilização da diacereína como terapia adjuvante para a diabetes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2025954A (en) * 1978-07-21 1980-01-30 Ciba Geigy Ag Anthraquinone Sulphonamides
IT1244773B (it) * 1991-03-12 1994-08-08 Gentili Ist Spa N-(4,5-diidrossi-e 4,5,8-triidrossi-9,10-diidro-9,10-diosso-2- antracen-il)carbonil) amminoacidi utilizzabili nella terapia delle affezioni osteoarticolari

Also Published As

Publication number Publication date
JPH11509186A (ja) 1999-08-17
PT833626E (pt) 2003-07-31
JP3307650B2 (ja) 2002-07-24
ITMI951357A0 (it) 1995-06-23
SK176097A3 (en) 1998-06-03
DK0833626T3 (da) 2003-06-30
CZ293326B6 (cs) 2004-04-14
ES2193248T3 (es) 2003-11-01
ITMI951357A1 (it) 1996-12-23
DE69626514D1 (de) 2003-04-10
SK281853B6 (sk) 2001-08-06
EP0833626A1 (en) 1998-04-08
WO1997000675A1 (en) 1997-01-09
CZ419397A3 (cs) 1998-07-15
DE69626514T2 (de) 2003-12-24
RU2202534C2 (ru) 2003-04-20
AU6303996A (en) 1997-01-22
EP0833626B1 (en) 2003-03-05
US5856358A (en) 1999-01-05
MX9800049A (es) 1998-11-30
ATE233553T1 (de) 2003-03-15
CA2225277A1 (en) 1997-01-09

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Legal Events

Date Code Title Description
0001 Granted